公开(公告)号：US10794921B2

公开(公告)日：2020-10-06

申请号：US16047911

申请日：2018-07-27

Applicant: University of Washington through its Center for Commercialization ,  Bloodworks

Inventor： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC: G01N33/80 ,  G01N33/543 ,  G01N21/77 ,  G01N21/75

Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.

公开(公告)号：US20190070300A1

公开(公告)日：2019-03-07

申请号：US16192321

申请日：2018-11-15

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Andrew Keefe ,  Hong Xue

IPC: A61K47/58 ,  A61K38/48

Abstract: Zwitterionic polymer and mixed charge copolymer bioconjugates, methods for making and using the bioconjugates.

公开(公告)号：US10031138B2

公开(公告)日：2018-07-24

申请号：US13747290

申请日：2013-01-22

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Norman David Brault, Jr. ,  Harihara S. Sundaram ,  Chun-Jen Huang ,  Qiuming Yu ,  Yuting Li

IPC: G01N33/543 ,  G01N21/552

CPC classification number: G01N33/54393 ,  G01N21/553

Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

公开(公告)号：US09394435B2

公开(公告)日：2016-07-19

申请号：US14457801

申请日：2014-08-12

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Hong Xue ,  Wei Yang ,  Louisa R. Carr

IPC: C08L33/10 ,  A61K41/00 ,  A61L27/34 ,  A61L27/52 ,  A61L29/08 ,  A61L29/14 ,  A61L31/10 ,  A61L31/14 ,  C07C229/12 ,  C08F26/02

CPC classification number: C08L33/14 ,  A61K41/0019 ,  A61L27/34 ,  A61L27/52 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  C07C229/12 ,  C08F26/02 ,  C08J3/075 ,  C08J2433/14 ,  C08L33/10 ,  C08L2201/54 ,  C08L2312/00 ,  C12Q1/54 ,  C12Y101/03004 ,  G01N2333/904 ,  Y10T428/31786

Abstract: Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

Abstract translation: 两性离子交联剂，由两性离子交联剂的两性离子单体共聚制备的交联的两性离子水凝胶，用于制备交联的两性离子水凝胶的方法，以及包括使用交联的两性离子水凝胶的方法的装置。

公开(公告)号：US20150322189A1

公开(公告)日：2015-11-12

申请号：US14698721

申请日：2015-04-28

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Shengfu Chen

IPC: C08F220/10

CPC classification number: C08F220/10 ,  B29C39/20 ,  C08F220/26 ,  C08F220/34 ,  C08F222/1006 ,  C08L51/04

Abstract: Nonfouling copolymers and hydrogels comprising positively charged repeating units or latent positively charged repeating units and negatively charged units or latent positively charged units.

公开(公告)号：US20150037598A1

公开(公告)日：2015-02-05

申请号：US14457801

申请日：2014-08-12

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Hong Xue ,  Wei Yang ,  Louisa R. Carr

IPC: C08L33/10

CPC classification number: C08L33/14 ,  A61K41/0019 ,  A61L27/34 ,  A61L27/52 ,  A61L29/085 ,  A61L29/145 ,  A61L31/10 ,  A61L31/145 ,  C07C229/12 ,  C08F26/02 ,  C08J3/075 ,  C08J2433/14 ,  C08L33/10 ,  C08L2201/54 ,  C08L2312/00 ,  C12Q1/54 ,  C12Y101/03004 ,  G01N2333/904 ,  Y10T428/31786

Abstract: Zwitterionic crosslinking agents, crosslinked zwitterionic hydrogels prepared from copolymerization of zwitterionic monomers with the zwitterionic crosslinking agent, methods for making crosslinked zwitterionic hydrogels, and devices that include and methods that use the crosslinked zwitterionic hydrogels.

Abstract translation: 两性离子交联剂，由两性离子交联剂的两性离子单体共聚制备的交联的两性离子水凝胶，用于制备交联的两性离子水凝胶的方法，以及包括使用交联的两性离子水凝胶的方法的装置。

公开(公告)号：US20130244249A1

公开(公告)日：2013-09-19

申请号：US13747290

申请日：2013-01-22

Applicant: University of Washington through its Center for Commercialization

Inventor： Shaoyi Jiang ,  Norman David Brault, JR. ,  Harihara S. Sundaram ,  Chun-Jen Huang ,  Qiuming Yu ,  Yuting Li

IPC: G01N33/543

CPC classification number: G01N33/54393 ,  G01N21/553

Abstract: Hierarchical films with structurally regulated functionalities through the integration of two-dimensional and three-dimensional structures to achieve ultra low nonspecific binding and high loading of molecular recognition elements, and methods for making and using the films.

Abstract translation: 通过整合二维和三维结构来获得具有结构调节功能的分层膜，以实现超低非特异性结合和分子识别元件的高负载，以及制备和使用膜的方法。

公开(公告)号：US11752212B2

公开(公告)日：2023-09-12

申请号：US16627068

申请日：2018-06-29

Applicant: University of Washington

Inventor： Shaoyi Jiang ,  Priyesh Jain ,  Jinrong Ma ,  Bowen Li

IPC: A61K47/58 ,  A61K9/51 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  C08F220/60 ,  C08J3/075 ,  C09D5/16 ,  C12N5/078 ,  C08F222/22

CPC classification number: A61K47/58 ,  A61K9/5138 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  C08F220/60 ,  C08J3/075 ,  C09D5/16 ,  C12N5/0644 ,  C08F220/603 ,  C08F222/225 ,  C08J2300/206 ,  C08J2333/26 ,  C09D4/00 ,  C08F220/60 ,  C08F220/603 ,  C08F222/385

Abstract: N-oxide and monomers, N-oxide polymers and copolymers, methods for making the N-oxide monomers, polymers, and copolymers, compositions and materials that include N-oxide polymers and copolymers, and methods for using the N-oxide monomers, N-oxide polymers, and N-oxide copolymers.

公开(公告)号：US20210324010A1

公开(公告)日：2021-10-21

申请号：US17283708

申请日：2019-10-10

Applicant: University of Washington

Inventor： Caroline Tsao ,  Sijin Luozhong ,  Trevor Corrigan ,  Shaoyi Jiang ,  Erik Liu ,  Patrick McMullen

IPC: C07K14/00 ,  A61K47/64 ,  C07K14/535 ,  C07K14/56 ,  C07K14/435

Abstract: Charged polypeptides, their conjugates, and fusion proteins comprising such polypeptides are disclosed. Inclusion of such a polypeptide in a fusion protein increases the protein's properties such as stability and circulation half-life, which results in a better therapeutic efficacy compared to an active protein alone. Thus, a fusion protein or a conjugate of the disclosure can be useful in developing a protein or peptide drug, treating or preventing diseases, disorders, or conditions, or improving a subjects health or wellbeing.

公开(公告)号：US20210088535A1

公开(公告)日：2021-03-25

申请号：US17035130

申请日：2020-09-28

Applicant: University of Washington through its Center for Commercialization ,  Bloodworks

Inventor： Daniel M. Ratner ,  Jill M. Johnsen ,  James T. Kirk ,  José A. López ,  Norman D. Brault ,  Shaoyi Jiang

IPC: G01N33/80 ,  G01N33/543 ,  G01N21/77

Abstract: Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters. Due to the compact size of these devices, many resonators can be disposed on a single substrate and tested simultaneously as a sample is passed over the devices. Typical analytes include blood cells, antibodies, and pathogens, as well as compounds indicative of the presence of blood cells or pathogens (e.g., serology). In certain embodiments, blood type can be determined through photonic sensing using a combination of direct detection of blood cells and serology. By combining the detection signals of multiple devices, the type of blood can be determined.