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公开(公告)号：US20210236505A1
公开(公告)日：2021-08-05
申请号：US17171061
申请日：2021-02-09
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D413/04 , C07D241/44 , C07D491/052 , C07D241/42 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US11008305B2
公开(公告)日：2021-05-18
申请号：US16538992
申请日：2019-08-13
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , A61K41/00 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , C07D239/42 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/506 , A61K31/5377 , A61K47/55 , A61K47/54 , A61K31/53 , C07D401/12 , C07D403/12 , C07D403/14 , C07D403/04 , C07D413/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US10973830B2
公开(公告)日：2021-04-13
申请号：US16372080
申请日：2019-04-01
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/498 , C07D241/44 , A61K31/5377 , C07D513/04 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D413/04 , C07D491/052 , C07D241/42 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08
摘要： The present invention relates to Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.
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公开(公告)号：US10258627B2
公开(公告)日：2019-04-16
申请号：US15659306
申请日：2017-07-25
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D513/04 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D498/08 , C07D413/04 , C07D491/052 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08 , C07D491/048
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09987284B2
公开(公告)日：2018-06-05
申请号：US15133378
申请日：2016-04-20
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/4245 , C07D271/12 , A61K31/5377 , C07D513/04 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D241/42 , C07D413/04 , C07D241/44 , C07D491/052 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.
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公开(公告)号：US20160340341A1
公开(公告)日：2016-11-24
申请号：US15133378
申请日：2016-04-20
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steve M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： C07D403/12 , C07D405/12 , C07D491/08 , C07D271/12 , C07D413/12 , C07D401/12 , C07D417/12 , C07D405/14 , C07D403/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D401/14 , C07D413/14 , C07D513/04 , C07D491/056 , C07D241/42
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20160250212A1
公开(公告)日：2016-09-01
申请号：US15056137
申请日：2016-02-29
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , A61K9/20 , A61K31/5377 , A61K9/48
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20150111871A1
公开(公告)日：2015-04-23
申请号：US14515793
申请日：2014-10-16
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D239/42 , C07D471/04 , C07D413/10 , C07D405/14 , A61K41/00 , C07D417/10 , C07D413/14 , C07D495/04 , C07D491/048 , C07D491/056 , C07D401/04 , C07D409/14
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作DNA-PK抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US12005127B2
公开(公告)日：2024-06-11
申请号：US16962442
申请日：2019-01-16
发明人： John Patrick Maxwell , Katrina Lee Jackson , Qing Tang , Mark A. Morris , Steven M. Ronkin , Jinwang Xu , Kevin M. Cottrell , Paul S. Charifson
IPC分类号： C07D239/74 , A61K48/00 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D417/12 , C07D491/048
CPC分类号： A61K48/0066 , A61K48/0075 , C07D239/74 , C07D239/88 , C07D239/94 , C07D401/12 , C07D403/12 , C07D417/12 , C07D491/048
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various diseases, conditions, or disorders.
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公开(公告)号：US20230277547A1
公开(公告)日：2023-09-07
申请号：US18175515
申请日：2023-02-27
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D413/04 , C07D241/44 , C07D491/052 , C07D241/42 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08
CPC分类号： A61K31/5377 , C07D513/04 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D413/04 , C07D241/44 , C07D491/052 , C07D241/42 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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