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公开(公告)号：US11884672B2
公开(公告)日：2024-01-30
申请号：US15931256
申请日：2020-05-13
发明人： Upul Keerthi Bandarage , Cavan McKeon Bligh , Diane Boucher , Michael John Boyd , Michael Aaron Brodney , Michael Philip Clark , Veronique Damagnez , Lev Tyler Dewey Fanning , Robert Francis Fimognari , Gabrielle Simone Fleming , Kevin James Gagnon , Pedro Manuel Garcia Barrantes , Robert Daniel Giacometti , Simon Giroux , Ronald Lee Grey, Jr. , Samantha Guido , Amy Beth Hall , Sarah Carol Hood , Dennis James Hurley , Mac Arthur Johnson, Jr. , Peter Jones , Sarathy Kesavan , Mei-Hsiu Lai , Siying Liu , Adam Looker , Brad Maxwell , John Patrick Maxwell , Ales Medek , Philippe Marcel Nuhant , Kirk Alan Overhoff , Setu Roday , Stefanie Roeper , Steven M. Ronkin , Rupa Sawant , Yi Shi , Muna Shrestha , Marisa Sposato , Kathy Stavropoulos , Rebecca Jane Swett , Timothy Lewis Tapley , Qing Tang , Stephen Thomson , Jinwang Xu , Mariam Zaky , Kevin Michael Cottrell
IPC分类号： C07D487/04 , A61K9/16 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26
CPC分类号： C07D487/04 , A61K9/1635 , A61K9/1652 , A61K31/4162 , C07D491/18 , C07D513/04 , C07D519/00 , C07F9/6561 , C07H15/26 , C07B2200/13
摘要： The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I):
tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.-
公开(公告)号：US11623924B2
公开(公告)日：2023-04-11
申请号：US16593118
申请日：2019-10-04
发明人： Upul Keerthi Bandarage , Cavan McKeon Bligh , Michael John Boyd , Diane M. Boucher , Michael Aaron Brodney , Veronique Damagnez , Lev Tyler Dewey Fanning , Mary Elizabeth Eccles , Robert Francis Fimognari, Jr. , Kevin James Gagnon , Pedro M. Garcia Barrantes , Simon Giroux , Ronald Lee Grey, Jr. , Amy Beth Hall , Sarah Carol Hood , Dennis James Hurley , Joshua Kennedy Hussey , Mac Arthur Johnson, Jr. , Peter Jones , Sarathy Kesavan , Adam Looker , Brad D. Maxwell , John Patrick Maxwell , Ales Medek , Mettachit Navamal , Philippe Marcel Nuhant , Setu Roday , Stefanie Roeper , Rupa Sawant , Yi Shi , Rebecca Jane Swett , Qing Tang , Timothy Lewis Tapley , Stephen A. Thomson , Michael Waldo , Jinwang Xu , Kevin Michael Cottrell
IPC分类号： C07D403/04 , C07D519/00
摘要： Novel compounds, compositions, and methods of using and preparing the same, which may be useful for treating alpha-1 antitrypsin deficiency (AATD).
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公开(公告)号：US10391095B2
公开(公告)日：2019-08-27
申请号：US16042206
申请日：2018-07-23
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/5377 , A61K47/55 , A61K47/54 , A61K31/53
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20190255062A1
公开(公告)日：2019-08-22
申请号：US16282083
申请日：2019-02-21
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D403/12 , C07D241/42 , A61K31/506 , C07D513/04 , C07D498/08 , C07D491/048 , C07D487/04 , C07D475/00 , C07D473/40 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D401/14 , C07D241/40 , C07D491/08 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/052 , C07D241/44 , C07D413/04 , A61K31/5386
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180208579A1
公开(公告)日：2018-07-26
申请号：US15860304
申请日：2018-01-02
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , C07D417/04 , C07D495/04 , C07D403/10 , C07D239/42 , C07D401/12 , C07D521/00 , C07D413/14 , C07D417/14 , C07D491/048 , C07D405/14 , C07D413/04 , C07D403/12 , C07D471/04 , C07D409/04 , C07D413/10 , C07D403/14 , C07D403/04 , C07D491/056 , C07D409/14 , C07D401/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180193341A1
公开(公告)日：2018-07-12
申请号：US15912074
申请日：2018-03-05
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D521/00 , A61K47/54 , C07D491/056 , C07D491/048 , C07D471/04 , C07D417/14 , C07D417/10 , C07D417/04 , C07D413/14 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/14 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/04 , C07D239/42 , A61K41/00 , A61K31/5377 , A61K31/53 , A61K9/48 , A61K9/20 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180161336A1
公开(公告)日：2018-06-14
申请号：US15659306
申请日：2017-07-25
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D403/12 , C07D241/42 , A61K31/506 , C07D513/04 , C07D498/08 , C07D491/048 , C07D487/04 , C07D475/00 , C07D473/40 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D401/14 , C07D241/40 , C07D491/08 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/052 , C07D241/44 , C07D413/04 , A61K31/5386
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09878993B2
公开(公告)日：2018-01-30
申请号：US15159378
申请日：2016-05-19
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D491/048 , C07D401/12 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D491/056 , C07D495/04 , C07D521/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09592232B2
公开(公告)日：2017-03-14
申请号：US14515793
申请日：2014-10-16
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D401/14 , A61K47/48 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/5377
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作DNA-PK抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US09340557B2
公开(公告)日：2016-05-17
申请号：US14205657
申请日：2014-03-12
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin M. Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/498 , C07D241/44 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D241/42 , C07D413/04 , C07D491/052
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： The compounds represented by Formula (I) and pharmaceutically acceptable salts thereof are useful as inhibitors of DNA-PK: where each of R1, R2, X, Ring A, Ring B and Ring C is as described herein. Pharmaceutically acceptable compositions comprise said compounds. These compounds and pharmaceutical compositions are used in the treatment of various disease, conditions, or disorders.
摘要翻译： 由式（I）表示的化合物及其药学上可接受的盐可用作DNA-PK的抑制剂：其中R1，R2，X，环A，环B和环C均如本文所述。 药学上可接受的组合物包含所述化合物。 这些化合物和药物组合物用于治疗各种疾病，病症或病症。
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