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公开(公告)号：US10391095B2
公开(公告)日：2019-08-27
申请号：US16042206
申请日：2018-07-23
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/5377 , A61K47/55 , A61K47/54 , A61K31/53
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20190255062A1
公开(公告)日：2019-08-22
申请号：US16282083
申请日：2019-02-21
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D403/12 , C07D241/42 , A61K31/506 , C07D513/04 , C07D498/08 , C07D491/048 , C07D487/04 , C07D475/00 , C07D473/40 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D401/14 , C07D241/40 , C07D491/08 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/052 , C07D241/44 , C07D413/04 , A61K31/5386
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180208579A1
公开(公告)日：2018-07-26
申请号：US15860304
申请日：2018-01-02
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , C07D417/04 , C07D495/04 , C07D403/10 , C07D239/42 , C07D401/12 , C07D521/00 , C07D413/14 , C07D417/14 , C07D491/048 , C07D405/14 , C07D413/04 , C07D403/12 , C07D471/04 , C07D409/04 , C07D413/10 , C07D403/14 , C07D403/04 , C07D491/056 , C07D409/14 , C07D401/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180193341A1
公开(公告)日：2018-07-12
申请号：US15912074
申请日：2018-03-05
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D521/00 , A61K47/54 , C07D491/056 , C07D491/048 , C07D471/04 , C07D417/14 , C07D417/10 , C07D417/04 , C07D413/14 , C07D413/10 , C07D413/04 , C07D409/14 , C07D409/04 , C07D405/14 , C07D403/10 , C07D403/04 , C07D401/14 , C07D401/04 , C07D239/42 , A61K41/00 , A61K31/5377 , A61K31/53 , A61K9/48 , A61K9/20 , C07D495/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20180161336A1
公开(公告)日：2018-06-14
申请号：US15659306
申请日：2017-07-25
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D403/12 , C07D241/42 , A61K31/506 , C07D513/04 , C07D498/08 , C07D491/048 , C07D487/04 , C07D475/00 , C07D473/40 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/14 , C07D405/12 , C07D403/14 , C07D401/14 , C07D241/40 , C07D491/08 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/052 , C07D241/44 , C07D413/04 , A61K31/5386
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09878993B2
公开(公告)日：2018-01-30
申请号：US15159378
申请日：2016-05-19
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , C07D403/12 , C07D403/14 , C07D471/04 , C07D491/048 , C07D401/12 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D491/056 , C07D495/04 , C07D521/00
CPC分类号： C07D401/14 , C07D239/42 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US09592232B2
公开(公告)日：2017-03-14
申请号：US14515793
申请日：2014-10-16
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： A61K31/506 , C07D401/14 , A61K47/48 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D239/42 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , A61K41/00 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/5377
CPC分类号： A61K31/506 , A61K9/20 , A61K9/48 , A61K31/53 , A61K31/5377 , A61K41/0038 , A61K47/481 , A61K47/545 , A61K47/55 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/10 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作DNA-PK抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US09340557B2
公开(公告)日：2016-05-17
申请号：US14205657
申请日：2014-03-12
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin M. Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/498 , C07D241/44 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D241/42 , C07D413/04 , C07D491/052
CPC分类号： A61K31/5377 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D241/42 , C07D241/44 , C07D271/12 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D491/08 , C07D498/08 , C07D513/04
摘要： The compounds represented by Formula (I) and pharmaceutically acceptable salts thereof are useful as inhibitors of DNA-PK: where each of R1, R2, X, Ring A, Ring B and Ring C is as described herein. Pharmaceutically acceptable compositions comprise said compounds. These compounds and pharmaceutical compositions are used in the treatment of various disease, conditions, or disorders.
摘要翻译： 由式（I）表示的化合物及其药学上可接受的盐可用作DNA-PK的抑制剂：其中R1，R2，X，环A，环B和环C均如本文所述。 药学上可接受的组合物包含所述化合物。 这些化合物和药物组合物用于治疗各种疾病，病症或病症。
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公开(公告)号：US11021465B2
公开(公告)日：2021-06-01
申请号：US16654084
申请日：2019-10-16
发明人： Paul S. Charifson , Kevin Michael Cottrell , Hongbo Deng , John P. Duffy , Huai Gao , Simon Giroux , Jeremy Green , Katrina Lee Jackson , Joseph M. Kennedy , David J. Lauffer , Mark Willem Ledeboer , Pan Li , John Patrick Maxwell , Mark A. Morris , Albert Charles Pierce , Nathan D. Waal , Jinwang Xu
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D403/10 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/10 , C07D417/04 , C07D417/14 , C07D471/04 , C07D491/048 , C07D491/056 , C07D495/04 , C07D521/00 , C07D239/42 , C07D417/10 , A61K9/20 , A61K9/48 , A61K31/506 , A61K31/5377 , A61K47/55 , A61K47/54 , A61K31/53 , C07D401/12 , C07D403/12 , C07D403/14 , A61K41/00
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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公开(公告)号：US20210069203A1
公开(公告)日：2021-03-11
申请号：US17023597
申请日：2020-09-17
发明人： John Patrick Maxwell , Paul S. Charifson , Qing Tang , Steven M. Ronkin , Katrina Lee Jackson , Albert Charles Pierce , David J. Lauffer , Pan Li , Simon Giroux , Jinwang Xu , Kevin Michael Cottrell , Mark A. Morris , Nathan D. Waal , John J. Court , Wenxin Gu , Hongbo Deng
IPC分类号： A61K31/5377 , C07D513/04 , A61K31/506 , A61K31/5386 , C07D241/40 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/40 , C07D475/00 , C07D487/04 , C07D491/048 , C07D498/08 , C07D413/04 , C07D241/44 , C07D491/052 , C07D241/42 , C07D271/12 , C07D401/12 , C07D413/14 , C07D491/056 , C07D491/08
摘要： The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
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