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公开(公告)号：US20080146638A1
公开(公告)日：2008-06-19
申请号：US11970828
申请日：2008-01-08
IPC分类号： A61K31/4184 , A61P35/00 , A61K31/4188
CPC分类号： A61K31/4188 , A61K31/4184 , A61K2300/00
摘要： The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
摘要翻译： 本发明描述了式（I）的苯并咪唑衍生物，其与放射治疗组合或与其它化学治疗剂组合地构成有效的PARP抑制剂。
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![Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics](/abs-image/US/2012/04/03/US08148384B2/abs.jpg.150x150.jpg)
22.发明授权Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics 有权取代的噻吩并[3,2-d]嘧啶PIM激酶抑制剂作为癌症化学治疗剂公开(公告)号：US08148384B2
公开(公告)日：2012-04-03
申请号：US11951546
申请日：2007-12-06
申请人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号： C07D495/04 , A61K31/519 , A61P35/00 , C07D495/14
CPC分类号： C07D495/04
摘要： Compounds of formula I wherein A1, A2, and A3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are useful for the treatment of diseases such as cancer.
摘要翻译： 其中A1，A2和A3如本文所定义的式I化合物是PIM激酶的抑制剂。 式I化合物可用于治疗诸如癌症的疾病。
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公开(公告)号：US20080161559A1
公开(公告)日：2008-07-03
申请号：US11951546
申请日：2007-12-06
申请人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人： Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号： C07D495/04
CPC分类号： C07D495/04
摘要： Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
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公开(公告)号：US20120045524A1
公开(公告)日：2012-02-23
申请号：US13288165
申请日：2011-11-03
IPC分类号： A61K33/24 , A61K31/4745 , A61P35/00 , A61K31/4188
CPC分类号： C07D403/04 , A61K31/41 , A61K31/4164 , A61K41/0038 , A61K45/06 , A61N2005/1098 , A61K2300/00
摘要： The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with radiotherapy or in combination with other chemotherapeutic agents.
摘要翻译： 本发明描述了式（I）的苯并咪唑衍生物，其与放射治疗组合或与其它化学治疗剂组合地构成有效的PARP抑制剂。
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公开(公告)号：US07956185B2
公开(公告)日：2011-06-07
申请号：US11753279
申请日：2007-05-24
申请人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
发明人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
IPC分类号： C07D239/02
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
摘要翻译： 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。
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公开(公告)号：US20080280867A1
公开(公告)日：2008-11-13
申请号：US12058478
申请日：2008-03-28
IPC分类号： A61K31/4184 , A61K31/4439 , A61P35/00 , A61K31/454
CPC分类号： A61K31/4184 , A61K31/495 , A61K2300/00
摘要： The present invention describes benzimidazole derivatives of Formula (I) which constitute potent PARP inhibitors in combination with temozolomide (TMZ).
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公开(公告)号：US07790721B2
公开(公告)日：2010-09-07
申请号：US11964788
申请日：2007-12-27
IPC分类号： A61K31/495
CPC分类号： C07D241/08 , C07D241/44 , C07D243/08 , C07D243/14 , C07D471/04 , C07D487/04
摘要： Compounds of formula I where X is a bond; A1 and A2, together with the atoms to which they are attached, is pyrrole; and A3 and A4, together with the atoms to which they are attached, are benzene; are poly(ADP-ribose)polymerase inhibitors. The compounds of formula I are useful for the treatment of diseases such as cancer.
摘要翻译： 其中X为键的式I化合物; A1和A2与它们所连接的原子一起是吡咯; A3和A4与它们所连接的原子一起是苯; 是聚（ADP-核糖）聚合酶抑制剂。 式I化合物可用于治疗诸如癌症的疾病。
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公开(公告)号：US20090298858A1
公开(公告)日：2009-12-03
申请号：US12476849
申请日：2009-06-02
申请人： Thomas D. Penning , Sheela A. Thomas , Philip J. Hajduk , Daryl R. Sauer , Kathy Sarris , Vincent L. Giranda
发明人： Thomas D. Penning , Sheela A. Thomas , Philip J. Hajduk , Daryl R. Sauer , Kathy Sarris , Vincent L. Giranda
IPC分类号： A61K31/519 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
摘要翻译： 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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公开(公告)号：US20080161578A1
公开(公告)日：2008-07-03
申请号：US11951568
申请日：2007-12-06
IPC分类号： C07D213/02
CPC分类号： C07D213/63 , C07D213/70 , C07D495/04
摘要： Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
摘要翻译： 披露了Pim激酶的抑制剂，制备方法以及使用它们治疗患者的方法。
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公开(公告)号：US08183250B2
公开(公告)日：2012-05-22
申请号：US12476849
申请日：2009-06-02
申请人： Thomas D. Penning , Sheela A. Thomas , Philip J. Hajduk , Daryl R. Sauer , Kathy Sarris , Vincent L. Giranda
发明人： Thomas D. Penning , Sheela A. Thomas , Philip J. Hajduk , Daryl R. Sauer , Kathy Sarris , Vincent L. Giranda
IPC分类号： A01N43/54 , A61K31/505 , C07D239/00 , C07D487/00
CPC分类号： C07D487/04
摘要： The present invention relates to 1H-benzimidazole-4-carboxamides of formula (I), their preparation, and their use as inhibitors of the enzyme poly(ADP-ribose)polymerase for the preparation of drugs.
摘要翻译： 本发明涉及式（I）的1H-苯并咪唑-4-甲酰胺，其制备及其作为制备药物的聚（ADP-核糖）聚合酶的抑制剂的用途。
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