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公开(公告)号：US07956185B2
公开(公告)日：2011-06-07
申请号：US11753279
申请日：2007-05-24
申请人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
发明人： Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
IPC分类号： C07D239/02
CPC分类号： C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要： Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
摘要翻译： 其中X1，C1和D1在本文中定义的式（I）化合物是polo样激酶的抑制剂。 式（I）化合物可用于治疗细胞增殖疾病，例如癌症。
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公开(公告)号：US07163939B2
公开(公告)日：2007-01-16
申请号：US10980740
申请日：2004-11-03
申请人： Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
发明人： Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
IPC分类号： C07D513/08 , A61K31/529
CPC分类号： C07D487/08
摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有下式的化合物可用于抑制蛋白激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号：US08557983B2
公开(公告)日：2013-10-15
申请号：US12793413
申请日：2010-06-03
申请人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
发明人： George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC分类号： C07D403/14 , C07D413/14
CPC分类号： C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US07456169B2
公开(公告)日：2008-11-25
申请号：US11466638
申请日：2006-08-23
申请人： Lisa A. Hasvold , Laura Hexamer , Gaoquan Li , Nan-Horng Lin , Hing Sham , Thomas J. Sowin , Gerard M. Sullivan , Le Wang , Ping Xia
发明人： Lisa A. Hasvold , Laura Hexamer , Gaoquan Li , Nan-Horng Lin , Hing Sham , Thomas J. Sowin , Gerard M. Sullivan , Le Wang , Ping Xia
IPC分类号： C07D413/00 , A61K31/5513
CPC分类号： C07D243/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10
摘要： Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译： 具有该式的化合物可用于抑制蛋白激酶。 还公开了制备化合物，含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号：US07323570B2
公开(公告)日：2008-01-29
申请号：US11459745
申请日：2006-07-25
申请人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号： C07D401/10 , C07D401/12 , A61K31/44
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译： 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号：US07211595B2
公开(公告)日：2007-05-01
申请号：US09997323
申请日：2001-11-30
申请人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
发明人： Akiyo K. Claiborne , Stephen L. Gwaltney, II , Lisa A. Hasvold , Qun Li , Tongmei Li , Nan-Horng Lin , Robert A. Mantei , Todd W. Rockway , Hing L. Sham , Gerard M. Sullivan , Yunsong Tong , Gary Wang , Le Wang , Xilu Wang , Wei-Bo Wang
IPC分类号： A61K31/415 , C07D401/04 , C07D401/12 , C07D233/32
CPC分类号： C07D233/64 , C07D401/12 , C07D405/12 , C07D409/12
摘要： Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
摘要翻译： 具有下式的取代的咪唑和噻唑可用于抑制法呢基转移酶。 还公开了法呢基转移酶抑制组合物和在患者体内抑制法尼基转移酶的方法。
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公开(公告)号：US20100184750A1
公开(公告)日：2010-07-22
申请号：US12689106
申请日：2010-01-18
申请人： Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人： Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号： A61K31/549 , C07D241/04 , A61K31/495 , C07D403/12 , A61K31/496 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D417/12 , C07D405/12 , A61P35/00 , A61P35/02
CPC分类号： C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US08426422B2
公开(公告)日：2013-04-23
申请号：US12689106
申请日：2010-01-18
申请人： Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人： Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号： A61K31/496 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14 , C07D295/155
CPC分类号： C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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9.发明申请BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES 有权用于治疗癌症和免疫疾病的BCL-2-选择性病毒诱导剂公开(公告)号：US20100152183A1
公开(公告)日：2010-06-17
申请号：US12631404
申请日：2009-12-04
申请人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura Hexamer , Aaron Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC分类号： A61K31/5377 , A61P35/04 , A61K31/497 , A61K31/4439 , A61K31/415 , A61K31/405 , A61K31/18 , C07D413/02 , C07D413/12 , C07D413/14 , C07D401/12 , C07D235/04 , C07D209/04 , C07C311/00
CPC分类号： C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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10.发明申请公开(公告)号：US20110124628A1
公开(公告)日：2011-05-26
申请号：US12951344
申请日：2010-11-22
申请人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
发明人： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC分类号： A61K31/496 , C07D471/04 , C07D401/14 , C07D403/14 , C07D405/14 , A61K31/5377 , A61K31/517 , A61K31/541 , A61P35/00 , A61P35/02
CPC分类号： C07D471/04 , C07D491/052 , C07D519/00
摘要： Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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