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1.
公开(公告)号:US07956185B2
公开(公告)日:2011-06-07
申请号:US11753279
申请日:2007-05-24
申请人: Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
发明人: Robert B. Diebold , Stevan W. Djuric , Vincent L. Giranda , Laura A. Hexamer , Nan-Horng Lin , Julie M. Miyashiro , Thomas D. Penning , Magdalena Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith W. Woods , Zhiren Xia , Henry Q. Zhang
IPC分类号: C07D239/02
CPC分类号: C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要: Compounds of formula (I) where X1, C1, and D1 are defined herein, are inhibitors of polo-like kinases. The compounds of formula (I) are useful for treatment of diseases of cellular proliferation, such as, for example, cancer.
摘要翻译: 其中X1,C1和D1在本文中定义的式(I)化合物是polo样激酶的抑制剂。 式(I)化合物可用于治疗细胞增殖疾病,例如癌症。
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公开(公告)号:US20080015192A1
公开(公告)日:2008-01-17
申请号:US11753279
申请日:2007-05-24
申请人: Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
发明人: Robert Diebold , Stevan Djuric , Vincent Giranda , Laura Hexamer , Nan-Horng Lin , Julie Miyashiro , Thomas Penning , Magdalena Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Anil Vasudevan , Le Wang , Keith Woods , Zhiren Xia , Henry Zhang
IPC分类号: A61K31/50 , A61K31/34 , A61K31/40 , A61K31/505 , A61P35/00 , C07D233/61 , C07D239/24 , C07D307/04 , C07D413/02 , C07D277/08 , C07D239/20 , C07D207/30 , A61K31/5377 , A61K31/4164 , A61K31/425
CPC分类号: C07D249/14 , C07C225/20 , C07C2601/02 , C07C2601/04 , C07D277/64 , C07D285/06 , C07D333/20
摘要: Compounds that inhibit Plk1, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
摘要翻译: 公开了抑制Plk1的化合物,含有该化合物的组合物和使用该化合物治疗疾病的方法。
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3.Substituted thieno[3,2-d]pyrimidine PIM kinase inhibitors as cancer chemotherapeutics 有权
标题翻译: 取代的噻吩并[3,2-d]嘧啶PIM激酶抑制剂作为癌症化学治疗剂公开(公告)号:US08148384B2
公开(公告)日:2012-04-03
申请号:US11951546
申请日:2007-12-06
申请人: Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人: Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号: C07D495/04 , A61K31/519 , A61P35/00 , C07D495/14
CPC分类号: C07D495/04
摘要: Compounds of formula I wherein A1, A2, and A3 are as defined herein are inhibitors of PIM kinase. The compounds of formula I are useful for the treatment of diseases such as cancer.
摘要翻译: 其中A1,A2和A3如本文所定义的式I化合物是PIM激酶的抑制剂。 式I化合物可用于治疗诸如癌症的疾病。
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公开(公告)号:US20080161559A1
公开(公告)日:2008-07-03
申请号:US11951546
申请日:2007-12-06
申请人: Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
发明人: Thomas D. Penning , Lisa A. Hasvold , Laura A. Hexamer , Vincent L. Giranda , Nan-horng Lin , Zhi-Fu Tao , Le Wang
IPC分类号: C07D495/04
CPC分类号: C07D495/04
摘要: Inhibitors of Pim kinases, ways to make them and methods of treating patients using them are disclosed.
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公开(公告)号:US07163939B2
公开(公告)日:2007-01-16
申请号:US10980740
申请日:2004-11-03
申请人: Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
发明人: Nan-Horng Lin , Gaoquan Li , Magdalena K. Przytulinska , Thomas J. Sowin , Gerard M. Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
IPC分类号: C07D513/08 , A61K31/529
CPC分类号: C07D487/08
摘要: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有下式的化合物可用于抑制蛋白激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US07320986B2
公开(公告)日:2008-01-22
申请号:US10792564
申请日:2004-03-03
申请人: Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao
发明人: Yunsong Tong , Akiyo K. Claiborne , Gaoquan Li , Nan-Horng Lin , Hing L. Sham , Thomas J. Sowin , Zhi-Fu Tao
IPC分类号: A61K31/4745 , A61K31/4162 , C07D487/14
CPC分类号: C07D249/08 , C07D231/12 , C07D231/54 , C07D233/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/14
摘要: Compounds having the formula (I) are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有式(I)的化合物可用于抑制蛋白激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US08557983B2
公开(公告)日:2013-10-15
申请号:US12793413
申请日:2010-06-03
申请人: George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
发明人: George A. Doherty , Laura A. Hexamer , Robert A. Mantei , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Todd M. Hansen
IPC分类号: C07D403/14 , C07D413/14
CPC分类号: C07D213/76 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D211/06 , C07D211/58 , C07D213/74 , C07D213/84 , C07D231/56 , C07D235/06 , C07D277/24 , C07D295/14 , C07D295/30 , C07D309/04 , C07D309/32 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D471/04
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号:US20050215556A1
公开(公告)日:2005-09-29
申请号:US10980740
申请日:2004-11-03
申请人: Nan-Horng Lin , Gaoquan Li , Magdalenna Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
发明人: Nan-Horng Lin , Gaoquan Li , Magdalenna Przytulinska , Thomas Sowin , Gerard Sullivan , Zhi-Fu Tao , Yunsong Tong , Le Wang
IPC分类号: A61K31/498 , C07D487/08 , C07D489/04 , C07D498/08
CPC分类号: C07D487/08
摘要: Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
摘要翻译: 具有该式的化合物可用于抑制蛋白激酶。 还公开了制备化合物,含有化合物的组合物和使用该化合物的处理方法的方法。
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公开(公告)号:US20100184750A1
公开(公告)日:2010-07-22
申请号:US12689106
申请日:2010-01-18
申请人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号: A61K31/549 , C07D241/04 , A61K31/495 , C07D403/12 , A61K31/496 , C07D401/12 , C07D413/12 , A61K31/5377 , C07D417/12 , C07D405/12 , A61P35/00 , A61P35/02
CPC分类号: C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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10.
公开(公告)号:US08426422B2
公开(公告)日:2013-04-23
申请号:US12689106
申请日:2010-01-18
申请人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
发明人: Laura A. Hexamer , Hong Ding , Steven W. Elmore , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Michael D. Wendt
IPC分类号: A61K31/496 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14 , C07D295/155
CPC分类号: C07D295/155 , C07D209/08 , C07D213/71 , C07D231/56 , C07D235/04 , C07D265/02 , C07D285/14 , C07D311/14
摘要: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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