公开(公告)号：US20090309040A1

公开(公告)日：2009-12-17

申请号：US12499669

申请日：2009-07-08

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/14 ,  A61N5/00

CPC classification number: H05H13/04 ,  A61N5/10 ,  A61N2005/1074 ,  A61N2005/1087 ,  H05H7/04 ,  H05H7/10

Abstract: The invention comprises a charged particle beam acceleration and/or extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. Novel design features of a synchrotron are described. Particularly, turning magnets, edge focusing magnets, and extraction elements are described that minimize the overall size of the synchrotron, provide a tightly controlled proton beam, directly reduce the size of required magnetic fields, directly reduces required operating power, and allow continual acceleration of protons in a synchrotron even during a process of extracting protons from the synchrotron.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束加速和/或提取方法和装置。 描述了同步加速器的新颖设计特征。 特别地，描述了旋转磁体，边缘聚焦磁体和提取元件，其使得同步加速器的总体尺寸最小化，提供严格控制的质子束，直接减小所需磁场的尺寸，直接减少所需的操作功率，并且允许连续加速 甚至在从同步加速器提取质子的过程中同步加速器中的质子。

公开(公告)号：US20200376296A1

公开(公告)日：2020-12-03

申请号：US16996724

申请日：2020-08-18

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/02 ,  A61B6/00 ,  G21K1/093 ,  G21K1/087 ,  A61B6/03 ,  G21K5/04

Abstract: The invention relates to a method and apparatus for determining actual points along a positively charged particle beam path and/or vectors of the charged particle beam path, where the determined points and vectors aid tomographic construction of a three-dimensional image of a tumor and surrounding tissue. Further, the determined points and vectors of the positively charged particle beam are used in beam control safety, to modify a tumor treatment plan in real time, and/or in combination with co-gathered X-ray images to form a hybrid proton tomography—X-ray three-dimensional image. Preferably, common elements, such as an injector, accelerator, beam transport system, and/or patient positioning system are used for both tumor treatment and tumor imaging.

公开(公告)号：US10213626B2

公开(公告)日：2019-02-26

申请号：US15152479

申请日：2016-05-11

Applicant: Vladimir Balakin ,  Stephen L. Spotts

Inventor： Vladimir Balakin ,  Stephen L. Spotts

IPC: A61N5/10 ,  A61B6/03 ,  G21K1/093 ,  G21K5/04 ,  G21K1/087 ,  H01J35/14

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

公开(公告)号：US09616252B2

公开(公告)日：2017-04-11

申请号：US14302253

申请日：2014-06-11

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1081 ,  A61N5/1067 ,  A61N2005/1087 ,  A61N2005/1095

Abstract: A multi-field cancer therapy apparatus and method of use thereof is described increasing dimensionality of incident tumor treatment angles while minimizing distance between a final beamline focusing magnet and the patient. Increased dimensionality of incident tumor treatment angles is achieved through coordinated use of one or more of: a rotatable targeting magnet; a first patient rotation platform rotating the patient around, without intersecting, a vertical axis; a second patient rotation platform rotating a body part through a movable vertical axis; and patient tilt. The increased charged particle incident angle dimensionality distributes Bragg peak tail energy about the tumor. Dynamic energy and/or intensity control of the charged particle beam as a function of efficiency of beam delivery based on tumor shape further reduces Bragg peak tail energy delivered to healthy tissue about the tumor.

公开(公告)号：US20170043183A1

公开(公告)日：2017-02-16

申请号：US15212005

申请日：2016-07-15

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10 ,  A61B6/00 ,  A61B6/02

CPC classification number: A61N5/1039 ,  A61B6/025 ,  A61B6/03 ,  A61B6/4028 ,  A61B6/4216 ,  A61B6/4258 ,  A61B6/5205 ,  A61N5/1047 ,  A61N5/1067 ,  A61N5/107 ,  A61N5/1071 ,  A61N5/1075 ,  A61N5/1077 ,  A61N5/1081 ,  A61N5/1082 ,  A61N2005/1054 ,  A61N2005/1074 ,  A61N2005/1087 ,  A61N2005/1097 ,  G21K1/087 ,  G21K1/093 ,  G21K5/04

Abstract: The invention relates to a method and apparatus for control of a charged particle cancer therapy system. A treatment delivery control system is used to directly control multiple subsystems of the cancer therapy system without direct communication between selected subsystems, which enhances safety, simplifies quality assurance and quality control, and facilitates programming. For example, the treatment delivery control system directly controls one or more of: an imaging system, a positioning system, an injection system, a radio-frequency quadrupole system, a ring accelerator or synchrotron, an extraction system, a beam line, an irradiation nozzle, a gantry, a display system, a targeting system, and a verification system. Generally, the control system integrates subsystems and/or integrates output of one or more of the above described cancer therapy system elements with inputs of one or more of the above described cancer therapy system elements.

Abstract translation: 本发明涉及一种用于控制带电粒子癌症治疗系统的方法和装置。 治疗传递控制系统用于直接控制癌症治疗系统的多个子系统，而不选择子系统之间的直接通信，这增强了安全性，简化了质量保证和质量控制，并且有助于编程。 例如，处理递送控制系统直接控制成像系统，定位系统，注射系统，射频四极杆系统，环形加速器或同步加速器，提取系统，束线，照射中的一个或多个 喷嘴，龙门架，显示系统，瞄准系统和验证系统。 通常，控制系统集成子系统和/或将上述癌症治疗系统元件中的一个或多个的输出与上述癌症治疗系统元件中的一个或多个的输入集成。

公开(公告)号：US09302122B2

公开(公告)日：2016-04-05

申请号：US14257516

申请日：2014-04-21

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1081 ,  A61N5/1044 ,  A61N2005/1087 ,  A61N2005/1095 ,  H05H13/04 ,  H05H2007/002 ,  H05H2007/007

Abstract: A rotatable patient positioning apparatus and method of use thereof is described in combination with a rotatable magnet at a termination of a beamline arc. The rotatable patient positioning system optionally: (1) rotates a median of the person in place about a vertical axis and/or (2) rotates the entire person along a path around a vector, such as a vertical axis, where no part of the person intersects the vector. The rotatable targeting magnet rotates independently of a beamline arc at the end of the beamline arc, where the arc is after an accelerator and before the patient in a cancer therapy system. The rotatable targeting magnet directs the charged particle beam, such as vertically, using applied current to the targeting magnet while rotation of the magnet allows scanning across the tumor. The rotatable patient positioning system and targeting magnet combine to target the tumor in three-dimensions.

Abstract translation: 可旋转的患者定位装置及其使用方法与束线弧终止处的可旋转磁体一起进行描述。 可旋转的患者定位系统可选地：（1）使人的中位数围绕垂直轴旋转，和/或（2）沿着诸如垂直轴的矢量周围的路径旋转整个人，其中， 人与矢量相交。 可转动的定向磁体与束线弧的末端处的波束线弧独立地旋转，其中电弧在加速器之后并且在癌症治疗系统中的患者之前。 可旋转定向磁体通过使用施加的电流将带电粒子束（例如垂直）引导到靶向磁体，同时磁体的旋转允许跨越肿瘤扫描。 可旋转的患者定位系统和靶向磁体组合成三维靶向肿瘤。

公开(公告)号：US20150360057A1

公开(公告)日：2015-12-17

申请号：US14302253

申请日：2014-06-11

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1081 ,  A61N5/1067 ,  A61N2005/1087 ,  A61N2005/1095

Abstract: A multi-field cancer therapy apparatus and method of use thereof is described increasing dimensionality of incident tumor treatment angles while minimizing distance between a final beamline focusing magnet and the patient. Increased dimensionality of incident tumor treatment angles is achieved through coordinated use of one or more of: a rotatable targeting magnet; a first patient rotation platform rotating the patient around, without intersecting, a vertical axis; a second patient rotation platform rotating a body part through a movable vertical axis; and patient tilt. The increased charged particle incident angle dimensionality distributes Bragg peak tail energy about the tumor. Dynamic energy and/or intensity control of the charged particle beam as a function of efficiency of beam delivery based on tumor shape further reduces Bragg peak tail energy delivered to healthy tissue about the tumor.

Abstract translation: 描述了多场癌症治疗装置及其使用方法，其中增加了入射肿瘤治疗角度的维度，同时使最终束线聚焦磁体和患者之间的距离最小化。 通过协调使用以下中的一个或多个来实现事件肿瘤治疗角度的增加的尺寸：可旋转靶向磁体; 第一患者旋转平台，使患者绕垂直轴线旋转而不相交; 第二患者旋转平台，通过可移动的垂直轴旋转主体部分; 和患者倾斜。 增加的带电粒子入射角度维度围绕肿瘤分布布拉格峰尾部能量。 作为基于肿瘤形状的束传递效率的函数的带电粒子束的动态能量和/或强度控制进一步降低了递送至围绕肿瘤的健康组织的布拉格峰尾部能量。

公开(公告)号：US09177751B2

公开(公告)日：2015-11-03

申请号：US14223289

申请日：2014-03-24

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J27/00 ,  H01J27/20 ,  A61N5/10

CPC classification number: H01J27/20 ,  A61N5/1077 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04 ,  H01J35/14

Abstract: A charged particle cancer therapy system is used to accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. A first example of an electron extraction subsystem is a hydrogen gas electron stripping system. A second example of an electron extraction subsystem is a carbon foil electron stripping system. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

Abstract translation: 使用带电粒子癌症治疗系统来加速阴离子，如C-，并通过使用一个或多个电子提取子系统将阴离子转化成阳离子，如C6 +。 电子提取子系统的第一个例子是氢气电子剥离系统。 电子提取子系统的第二个例子是碳箔电子剥离系统。 所得阳离子在同步加速器中加速，沿着束线传输，并靶向肿瘤，导致肿瘤的消融。

公开(公告)号：US09168392B1

公开(公告)日：2015-10-27

申请号：US14275481

申请日：2014-05-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61N5/1067 ,  A61N5/1081 ,  A61N2005/1061 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04 ,  H01J35/045 ,  H01J37/08 ,  H01J37/1475 ,  H05H13/04 ,  H05H2007/002 ,  H05H2007/048

Abstract: An imaging system apparatus and method of use thereof is described in combination with a co-movable charged particle beamline apparatus element, such as one or more elements held and dynamically positioned by a gantry, where the method and apparatus are optionally elements of a positively charged particle cancer therapy system. In one embodiment, an X-ray imaging element is rigidly and semi-permanently attached to and co-moved with a proton directing element. For example, as the gantry relocates one or more elements of a proton beamline arc, the X-ray beam is mechanically forced to co-relocate with the proton directing element and/or the final proton beam path.

Abstract translation: 一种成像系统装置及其使用方法与可移动的带电粒子束线装置元件（诸如由台架保持和动态定位的一个或多个元件）结合在一起进行描述，其中该方法和装置可选地是带正电荷的元件 颗粒癌治疗系统。 在一个实施例中，X射线成像元件刚性地和半永久地附接到质子引导元件并与之一体移动。 例如，当台架重新定位质子束线弧的一个或多个元件时，X射线束被机械地强制与质子引导元件和/或最终质子束路径共同重定位。

公开(公告)号：US20150155126A1

公开(公告)日：2015-06-04

申请号：US14223289

申请日：2014-03-24

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J27/20 ,  A61N5/10

CPC classification number: H01J27/20 ,  A61N5/1077 ,  A61N2005/1087 ,  G21K1/093 ,  G21K5/04 ,  H01J35/14

Abstract: A charged particle cancer therapy system is used to accelerate an anion, such a C−, and to convert the anion to a cation, such as C6+, through use of one or more electron extraction subsystems. A first example of an electron extraction subsystem is a hydrogen gas electron stripping system. A second example of an electron extraction subsystem is a carbon foil electron stripping system. The resultant cation is accelerated in a synchrotron, transported along a beam-line, and targeted to a tumor resulting in ablation of the tumor.

Abstract translation: 使用带电粒子癌症治疗系统来加速阴离子，如C-，并通过使用一个或多个电子提取子系统将阴离子转化成阳离子，如C6 +。 电子提取子系统的第一个例子是氢气电子剥离系统。 电子提取子系统的第二个例子是碳箔电子剥离系统。 所得阳离子在同步加速器中加速，沿着束线传输，并靶向肿瘤，导致肿瘤的消融。