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40 条记录 (耗时 0.033 秒)

    BONE MATERIAL HYDRATION DEVICES AND METHODS
    24.
    发明申请
    BONE MATERIAL HYDRATION DEVICES AND METHODS 审中-公开

    公开(公告)号：US20200069353A1

    公开(公告)日：2020-03-05

    申请号：US16116212

    申请日：2018-08-29

    申请人： Warsaw Orthopedic, Inc.

    发明人： Daniel A. Shimko ,  Jared J. Diegmueller ,  Jonathan M. Dewey ,  Kerem N. Kalpakci ,  Erick Vasquez

    IPC分类号： A61B17/88 ,  A61F2/28

    摘要： A device for hydrating particulate bone material is provided. The device comprises a tubular member having an interior surface and an exterior surface. The interior surface is configured to receive the particulate bone material and a hydration fluid. The exterior surface has a plurality of pores configured to allow the hydration fluid to flow into the interior surface of the tubular member and hydrate the particulate bone material. The plurality of pores are smaller in size than the particulate bone material. Methods of dispensing particulate the bone material are also provided.

    BONE IMPLANT FOR ENCLOSING BONE MATERIAL
    25.
    发明申请
    BONE IMPLANT FOR ENCLOSING BONE MATERIAL 审中-公开

    公开(公告)号：US20190021862A1

    公开(公告)日：2019-01-24

    申请号：US15656112

    申请日：2017-07-21

    申请人： Warsaw Orthopedic, Inc.

    发明人： Kerem N. Kalpakci ,  Jared J. Diegmueller ,  Jason A. Rister ,  Daniel A. Shimko ,  Scott M. Vickers ,  Jeffrey L. Scifert

    IPC分类号： A61F2/28 ,  A61F2/30

    摘要： A bone implant for enclosing bone material is provided. The bone implant comprises a mesh having an inner surface and an outer surface opposing the inner surface. The inner surface is configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh. The plurality of projections extend from at least the portion of the inner surface of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both sections of the inner and outer surfaces of the mesh in a closed configuration so as to enclose the bone material. A tray, a kit and a method of making the bone implant are also provided.

    Delivery systems containing bioactive materials
    26.
    发明授权
    Delivery systems containing bioactive materials 有权

    公开(公告)号：US09414939B2

    公开(公告)日：2016-08-16

    申请号：US14713455

    申请日：2015-05-15

    申请人： Warsaw Orthopedic, Inc.

    发明人： Daniel A. Shimko ,  Kerem N. Kalpakci

    IPC分类号： A61F2/28 ,  A61F2/46 ,  A61F2/30

    CPC分类号： A61F2/4601 ,  A61F2/2846 ,  A61F2002/30588 ,  A61F2002/30738

    摘要： A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end. At one end the elongated containment defines an opening configured to receive at least one substance. The at least one substance can be DBM or a mixture of demineralized fibers and particles in a ratio of 30:70. The delivery system also includes a closing member that can close the elongated containment prior to insertion at a surgical site. The closing member can be drawing strings, stitches, sutures, wing sutures, heat seals, adhesion, pressure fittings, coil ring, twist tie. The substance contained in the delivery system can also be enclosed by twisting and folding over a portion of the covering.

    BONE GRAFT MATERIALS, DEVICES AND METHODS OF USE
    27.
    发明申请
    BONE GRAFT MATERIALS, DEVICES AND METHODS OF USE 审中-公开
    骨折材料，装置和使用方法

    公开(公告)号：US20160166303A1

    公开(公告)日：2016-06-16

    申请号：US14940979

    申请日：2015-11-13

    申请人： Warsaw Orthopedic, Inc.

    发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem N. Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

    IPC分类号： A61B17/88 ,  A61L27/36 ,  B01F13/06 ,  B01F15/02 ,  B01F13/00 ,  B01F15/00

    摘要： A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.

    摘要翻译： 提供了一种用于将骨材料与液体混合的装置。 所述装置包括具有近端和远端的腔室，并且所述骨材料设置在所述腔室内，所述骨材料包括磨碎和冻干的脱矿质骨纤维的连续块; 以及柱塞，其具有可滑动地设置在所述腔的近端内的至少一部分，并且构造成当所述柱塞处于伸出位置时配置为从所述腔的远端与所述腔的远端混合的液体分配骨材料。

    METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIHYDROCHLORIDE
    29.
    发明申请
    METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIHYDROCHLORIDE 审中-公开
    制备氨基酸三氯化物的方法和组合物

    公开(公告)号：US20150197483A1

    公开(公告)日：2015-07-16

    申请号：US14153488

    申请日：2014-01-13

    申请人： Warsaw Orthopedic, Inc.

    发明人： Roger E. Harrington ,  Kerem N. Kalpakci ,  David S. Scher

    IPC分类号： C07C227/18 ,  C07C229/26

    CPC分类号： C07C227/18 ,  C07C229/26

    摘要： In some embodiments, a method of making an amino acid trihydrochloride is provided, the method comprising reacting an amino acid monohydrochloride with an alkanolamine to form the amino acid trihydrochloride. In some embodiments, the amino acid monohydrochloride comprises lysine hydrochloride, which is mixed with ethanolamine to form lysine ester trihydrochloride. In some embodiments, there is a lysine ester trihydrochloride salt having a purity of at least about 98%, the lysine ester trihydrochloride salt having a structure resulting from reacting lysine hydrochloride and ethanolamine to form the lysine ester trihydrochloride salt. The lysine ester trihydrochloride can be made in one reaction vessel.

    摘要翻译： 在一些实施方案中，提供了制备氨基酸三盐酸盐的方法，所述方法包括使氨基酸单盐酸盐与链烷醇胺反应以形成氨基酸三盐酸盐。 在一些实施方案中，氨基酸单盐酸盐包含赖氨酸盐酸盐，其与乙醇胺混合以形成赖氨酸三盐酸盐。 在一些实施方案中，存在具有至少约98％纯度的赖氨酸酯三盐酸盐，所述赖氨酸酯三盐酸盐具有由赖氨酸盐酸盐和乙醇胺反应形成赖氨酸三盐酸盐的结构。 赖氨酸三盐酸盐可以在一个反应​​容器中制备。

    DELIVERY SYSTEMS CONTAINING BIOACTIVE MATERIALS
    30.
    发明申请
    DELIVERY SYSTEMS CONTAINING BIOACTIVE MATERIALS 有权
    包含生物材料的交付系统

    公开(公告)号：US20140200676A1

    公开(公告)日：2014-07-17

    申请号：US13740357

    申请日：2013-01-14

    申请人： WARSAW ORTHOPEDIC, INC.

    发明人： Daniel A. Shimko ,  Kerem N. Kalpakci

    IPC分类号： A61F2/28

    CPC分类号： A61F2/4601 ,  A61F2/2846 ,  A61F2002/30588 ,  A61F2002/30738

    摘要： A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end. At one end the elongated containment defines an opening configured to receive at least one substance. The at least one substance can be DBM or a mixture of demineralized fibers and particles in a ratio of 30:70. The delivery system also includes a closing member that can close the elongated containment prior to insertion at a surgical site. The closing member can be drawing strings, stitches, sutures, wing sutures, heat seals, adhesion, pressure fittings, coil ring, twist tie. The substance contained in the delivery system can also be enclosed by twisting and folding over a portion of the covering.

    摘要翻译： 提供一种包含至少包含用于释放到手术部位的第一物质的覆盖物的递送系统。 覆盖物包括具有至少一个隔室的细长的容纳部分，其中所述覆盖物包括具有第一端和第二端的细长的容纳物。 在一端，细长的容纳物限定了构造成容纳至少一种物质的开口。 所述至少一种物质可以是DBM或软化纤维和颗粒的混合物，其比例为30:70。 递送系统还包括关闭构件，其可以在插入手术部位之前关闭细长的容纳物。 关闭构件可以是拉丝，缝合，缝线，翼缝合，热封，粘合，压力配件，线圈环，扭结带。 包含在输送系统中的物质也可以通过在覆盖物的一部分上扭曲和折叠来包围。