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    FILLING SYSTEMS FOR BONE DELIVERY DEVICES
    4.
    发明申请
    FILLING SYSTEMS FOR BONE DELIVERY DEVICES 有权
    用于骨髓输送装置的填充系统

    公开(公告)号：US20160192973A1

    公开(公告)日：2016-07-07

    申请号：US15067719

    申请日：2016-03-11

    申请人： Warsaw Orthopedic, Inc.

    发明人： Daniel A. Shimko ,  Kerem N. Kalpakci ,  Jason A. Rister

    IPC分类号： A61B17/88 ,  A61F2/46

    CPC分类号： A61B17/8811 ,  A61B17/8802 ,  A61B2017/00893 ,  A61B2017/00933 ,  A61B2017/00964 ,  A61F2/28 ,  A61F2/4601 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30588 ,  A61F2002/30784 ,  A61F2002/4495

    摘要： A filling system for delivery of at least one substance to a covering is provided. The filling system comprises at least a funnel shaped container and a plunger. The funnel shaped container includes a scoop portion connected to a hollow barrel. The barrel is configured for insertion into the covering, the plunger adapted for pushing the at least one substance down the hollow barrel into the covering. The filling system can also include a spatula. A kit including a funnel shaped container, a plunger adapted to push a substance down the barrel of the funnel shaped container, a spatula, a retainer for keeping the kit elements in place and trays for protecting them from the environment are also provided. A method of use utilizing the filling system is also provided.

    摘要翻译： 提供了用于将至少一种物质输送到覆盖物的填充系统。 填充系统至少包括漏斗形容器和柱塞。 漏斗形容器包括连接到中空筒的勺部分。 筒被配置成插入到覆盖物中，柱塞适于将中空筒的至少一种物质推入覆盖物中。 填充系统还可以包括刮铲。 还提供了一种套件，其包括漏斗形容器，适于将物质向下推动漏斗形容器的筒体的柱塞，刮刀，用于将套件元件保持在适当位置的保持器以及用于将其保护于环境的托盘。 还提供了利用填充系统的使用方法。

    MILLED BONE GRAFT MATERIALS AND METHODS OF USE
    5.
    发明申请
    MILLED BONE GRAFT MATERIALS AND METHODS OF USE 有权
    铣削骨折材料和使用方法

    公开(公告)号：US20160135954A1

    公开(公告)日：2016-05-19

    申请号：US14941033

    申请日：2015-11-13

    申请人： Warsaw Orthopedic, Inc.

    发明人： Kelly W. Schlachter ,  Daniel A. Shimko ,  Kerem N. Kalpakci ,  Erick Vasquez ,  David R. Kaes ,  Subhabrata Bhattacharyya

    IPC分类号： A61F2/28 ,  A61F2/46 ,  A61F2/30

    CPC分类号： A61B17/8816 ,  A61B17/8805 ,  A61B2017/8838 ,  A61F2/28 ,  A61F2/30942 ,  A61F2/4601 ,  A61F2/4644 ,  A61F2002/2835 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L27/3691 ,  A61L27/54 ,  A61L2300/412 ,  A61L2430/02 ,  B01F13/0023 ,  B01F13/06 ,  B01F15/00506 ,  B01F15/0278

    摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.

    摘要翻译： 提供了一种用于与液体水合的骨材料，所述骨材料包括碾磨和去矿化的骨纤维的相干团块，所述相干团块没有布置在所述相干团块中或所述相干团块上的粘合剂。 在一些实施例中，提供了用于与液体水合的骨材料，所述骨材料包括筒式研磨，冻干和软化的骨纤维的相干团块，所述相干团块在所述相干团块上不具有粘合剂。 在一些实施例中，提供了一种植入骨材料的方法，所述方法包括使骨材料与液体接触，所述骨材料包括柱塞研磨的，冻干和软化的骨纤维的相干团块，所述粘合剂物质不具有粘合剂 或连贯质量; 将骨材料模制成植入骨材料的形状; 以及将骨材料植入目标组织部位。

    DEMINERALIZED BONE MATRIX HAVING IMPROVED HANDLING CHARACTERISTICS
    8.
    发明申请
    DEMINERALIZED BONE MATRIX HAVING IMPROVED HANDLING CHARACTERISTICS 有权

    公开(公告)号：US20210386910A1

    公开(公告)日：2021-12-16

    申请号：US17461867

    申请日：2021-08-30

    申请人： WARSAW ORTHOPEDIC, INC.

    发明人： Kerem N. Kalpakci ,  Daniel A. Shimko

    IPC分类号： A61L27/36 ,  A61L27/12 ,  A61L27/14 ,  A61L27/20 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58 ,  A61L27/48

    摘要： Provided is an injectable implant configured to fit at or near a bone defect to promote bone growth, the injectable implant comprising lyophilized demineralized bone matrix (DBM) being in fiber and particle forms; alginate; and a liquid carrier, wherein the DBM is in an amount of about 20 wt. % to about 40 wt. % of a total weight of the injectable implant, the alginate is in an amount of from about 3 wt. % to about 10 wt. % of the total weight of the injectable implant, and the liquid carrier is in an amount from about 50 wt. % to about 70 wt. % of the total weight of the injectable implant. A moldable implant and methods of making the implants are further provided.

    Methods and compositions for making an amino acid triisocyanate
    9.
    发明授权
    Methods and compositions for making an amino acid triisocyanate 有权
    制备氨基酸三异氰酸酯的方法和组合物

    公开(公告)号：US09573889B2

    公开(公告)日：2017-02-21

    申请号：US15048541

    申请日：2016-02-19

    申请人： Warsaw Orthopedic, Inc.

    发明人： Roger E. Harrington ,  Kerem N. Kalpakci ,  David S. Scher

    IPC分类号： C07C265/14 ,  C07C263/10 ,  C07C263/20 ,  C01B31/28 ,  C08G18/00 ,  C08G18/77 ,  C08G18/32

    CPC分类号： C07C265/14 ,  C01B32/80 ,  C07C263/10 ,  C07C263/20 ,  C08G18/3206 ,  C08G18/771

    摘要： A method of making an amino acid triisocyanate is provided, the method comprising reacting an amino acid trihydrochloride with phosgene to form the amino acid triisocyanate. In some embodiments, the amino acid trihydrochloride comprises lysine ester trihydrochloride salt and the amino acid triisocyanate comprises lysine ester triisocyanate. In some embodiments, there is a lysine ester triisocyanate having a purity of at least about 98%, the lysine ester triisocyanate having a structure resulting from reacting lysine ester trihydrochloride salt with phosgene to form the lysine ester triisocyanate. These lysine ester triisocyanates can be used to make biodegradable polyurethanes.

    摘要翻译： 提供了制备氨基酸三异氰酸酯的方法，该方法包括使氨基酸三盐酸盐与光气反应形成氨基酸三异氰酸酯。 在一些实施方案中，氨基酸三盐酸盐包含赖氨酸三盐酸盐，氨基酸三异氰酸酯包含赖氨酸三异氰酸酯。 在一些实施方案中，存在纯度为至少约98％的赖氨酸三异氰酸酯，赖氨酸三异氰酸酯具有由赖氨酸三盐酸盐与光气反应形成赖氨酸三异氰酸酯的结构。 这些赖氨酸酯三异氰酸酯可用于制造可生物降解的聚氨酯。

    Filling systems for bone delivery devices
    10.
    发明授权
    Filling systems for bone delivery devices 有权
    骨输送装置灌装系统

    公开(公告)号：US09283013B2

    公开(公告)日：2016-03-15

    申请号：US13829416

    申请日：2013-03-14

    申请人： Warsaw Orthopedic, Inc.

    发明人： Daniel A. Shimko ,  Kerem N. Kalpakci ,  Jason A. Rister

    IPC分类号： A61B17/88 ,  A61F2/28 ,  A61F2/46 ,  A61F2/30 ,  A61F2/44

    CPC分类号： A61B17/8811 ,  A61B17/8802 ,  A61B2017/00893 ,  A61B2017/00933 ,  A61B2017/00964 ,  A61F2/28 ,  A61F2/4601 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30588 ,  A61F2002/30784 ,  A61F2002/4495

    摘要： A filling system for delivery of at least one substance to a covering is provided. The filling system comprises at least a funnel shaped container and a plunger. The funnel shaped container includes a scoop portion connected to a hollow barrel. The barrel is configured for insertion into the covering, the plunger adapted for pushing the at least one substance down the hollow barrel into the covering. The filling system can also include a spatula. A kit including a funnel shaped container, a plunger adapted to push a substance down the barrel of the funnel shaped container, a spatula, a retainer for keeping the kit elements in place and trays for protecting them from the environment are also provided. A method of use utilizing the filling system is also provided.

    摘要翻译： 提供了用于将至少一种物质输送到覆盖物的填充系统。 填充系统至少包括漏斗形容器和柱塞。 漏斗形容器包括连接到中空筒的勺部分。 筒被配置成插入到覆盖物中，柱塞适于将中空筒的至少一种物质推入覆盖物中。 填充系统还可以包括刮铲。 还提供了一种套件，其包括漏斗形容器，适于将物质向下推动漏斗形容器的筒体的柱塞，刮刀，用于将套件元件保持在适当位置的保持器以及用于将其保护于环境的托盘。 还提供了利用填充系统的使用方法。