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公开(公告)号：US11918705B2
公开(公告)日：2024-03-05
申请号：US17403314
申请日：2021-08-16
CPC分类号： A61L27/3691 , A61L2/087 , A61L27/3608 , A61L27/365 , A61L27/54 , A61L2202/11 , A61L2202/21 , A61L2300/412 , A61L2430/02
摘要： A method of making an electron beam irradiated osteoinductive implant is provided. The method comprises exposing an osteoinductive implant containing demineralized bone matrix (DBM) fibers to electron beam radiation at a dose of from about 10 kilograys to 100 kilograys for a period of time. The electron beam irradiation reduces microorganisms in the osteoinductive implant, and the electron beam irradiated osteoinductive implant retains osteoinductive properties. Methods of implantation and an irradiated osteoinductive implant are also disclosed.
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公开(公告)号：US20230241350A1
公开(公告)日：2023-08-03
申请号：US18297913
申请日：2023-04-10
CPC分类号： A61M25/0084 , A61M25/065 , A61M29/00 , A61M5/32 , A61K9/06 , A61B17/1671 , A61M2202/10 , A61M2025/09183
摘要： A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.
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公开(公告)号：US20230157843A1
公开(公告)日：2023-05-25
申请号：US18094690
申请日：2023-01-09
CPC分类号： A61F2/4601 , A61B17/8833 , A61F2/4644 , A61B50/33 , A61B17/8863 , A61B2017/8838 , A61B2017/00871
摘要： A bone material dispensing apparatus for preparing, mixing, and dispensing bone material into a foldable container is provided. In some embodiments, the dispensing apparatus comprises a tray and a foldable container. The tray includes a mixing surface, a dispensing surface and a means to measure the amount of material to be dispensed. A kit including a tray, a foldable container, and a spatula are also provided. A method of using the dispensing apparatus to deliver the bone material to a bone detect is also provided.
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公开(公告)号：US11583403B2
公开(公告)日：2023-02-21
申请号：US17005375
申请日：2020-08-28
摘要： A bone implant holding and shaping tray is provided. The tray includes a first segment having a distal end and a first surface sized to hold and shape at least a portion of the bone implant with bone material. The tray includes a second segment having a second surface sized to hold and shape at least a portion of the bone implant with bone material, the second segment having a proximal end configured to be coupled to the distal end of the first segment so as to extend the first surface to hold and shape the bone implant. Methods of making and using the bone implant holding and shaping tray are also provided.
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公开(公告)号：US11534221B2
公开(公告)日：2022-12-27
申请号：US16876828
申请日：2020-05-18
摘要： A bone material dispensing device is provided. The bone material dispensing device comprises a housing having a proximal end, a distal end, and a longitudinal axis. The proximal end has a first opening and the distal end has a second opening. The first opening and the second opening are configured to slidably receive at least a portion of a plunger. A tubular member is provided that is pivotably connected to the housing and is configured for lateral movement relative to the longitudinal axis of the housing. The tubular member comprises a proximal opening, a distal opening and a channel disposed therebetween. The proximal opening, the distal opening and the channel of the tubular member are configured to receive at least the portion of the plunger. The tubular member is movable in a first position to align the proximal opening of the tubular member with the second opening of the housing to allow the tubular member to receive at least the portion of the plunger to dispense the bone material. A method of implanting bone material with the bone material dispensing device is also provided.
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公开(公告)号：US11464888B2
公开(公告)日：2022-10-11
申请号：US15620189
申请日：2017-06-12
发明人： Benjamin T. Reves , Roger E. Harrington , Jerbrena C. Jacobs , David S. Scher , Daniel A. Shimko
摘要： Provided is an implant configured to fit at or near a bone defect to promote bone growth. The implant comprises an oxysterol uniformly disposed in an acellular tissue matrix (ATM). The acellular tissue matrix can be porcine collagen, which in some cases is crosslinked. The implant can contain an acellular porcine crosslinked collagen in an amount of about 5 wt. % to about 25 wt. % of the implant and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. The oxysterol can be Oxy133 monohydrate or an Oxy133 polymorph. Methods of making and using the implant are further provided.
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公开(公告)号：US20210180019A1
公开(公告)日：2021-06-17
申请号：US17166491
申请日：2021-02-03
摘要： A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.
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公开(公告)号：US11020160B2
公开(公告)日：2021-06-01
申请号：US15076096
申请日：2016-03-21
摘要： A surgical injection device includes at least one tubular element defining a passageway. The passageway is configured for disposal of a selected volume of an agent and an evacuator disposed within the passageway. An actuator is engageable with the evacuator to entirely expel the selected volume of the agent from the passageway to a selected site. Spinal constructs, implants, systems and methods are disclosed.
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公开(公告)号：US20200297512A1
公开(公告)日：2020-09-24
申请号：US16892882
申请日：2020-06-04
摘要： A bone material dispensing apparatus for preparing, mixing, and dispensing bone material into a foldable container is provided. In some embodiments, the dispensing apparatus comprises a tray and a foldable container. The tray includes a mixing surface, a dispensing surface and a means to measure the amount of material to be dispensed. A kit including a tray, a foldable container, and a spatula are also provided. A method of using the dispensing apparatus to deliver the bone material to a bone detect is also provided.
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公开(公告)号：US20200261625A1
公开(公告)日：2020-08-20
申请号：US16868178
申请日：2020-05-06
摘要： Provided is a lyophilized implant configured to fit at or near a bone defect to promote bone growth, the lyophilized implant containing a biodegradable polymer in an amount of about 0.1 wt. % to about 20 wt. % of the implant, mineral particles in an amount from about 0.1 wt. % to about 75 wt. % of the implant, and an oxysterol in an amount of about 5 wt. % to about 90 wt. % of the implant. Methods of making and using the implant are further provided.
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