公开(公告)号：US11666446B2

公开(公告)日：2023-06-06

申请号：US15656112

申请日：2017-07-21

申请人： Warsaw Orthopedic, Inc.

发明人： Kerem N. Kalpakci ,  Jared J. Diegmueller ,  Jason A. Rister ,  Daniel A. Shimko ,  Scott M. Vickers ,  Jeffrey L. Scifert

IPC分类号： A61F2/28 ,  A61F2/30

CPC分类号： A61F2/2846 ,  A61F2/30907 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/30383 ,  A61F2002/30467 ,  A61F2002/30914 ,  A61F2310/00293 ,  A61F2310/00359 ,  A61F2310/00371

摘要： A bone implant for enclosing bone material is provided. The bone implant comprises a mesh having an inner surface and an outer surface opposing the inner surface. The inner surface is configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh. The plurality of projections extend from at least the portion of the inner surface of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both sections of the inner and outer surfaces of the mesh in a closed configuration so as to enclose the bone material. A tray, a kit and a method of making the bone implant are also provided.

公开(公告)号：US20170035940A1

公开(公告)日：2017-02-09

申请号：US15295445

申请日：2016-10-17

申请人： Warsaw Orthopedic, Inc.

发明人： Jeffrey L. Scifert

IPC分类号： A61L27/54 ,  A61L27/14 ,  A61L27/40 ,  A61L27/22 ,  A61L27/56

CPC分类号： A61L27/54 ,  A61K9/0024 ,  A61K9/122 ,  A61K9/1629 ,  A61K38/1875 ,  A61L27/14 ,  A61L27/227 ,  A61L27/40 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/802 ,  A61L2430/02

摘要： An improved osteogenic composition is provided. The composition comprises a foam that contains polymer beads having one or more growth factors such as bone morphogenic protein. Through use of this composition, bone, collagen and/or other tissue growth may be facilitated.

摘要翻译： 提供了改进的成骨组合物。 组合物包含含有具有一种或多种生长因子如骨形态发生蛋白的聚合物珠粒的泡沫。 通过使用该组合物，可以促进骨，胶原和/或其他组织生长。

公开(公告)号：US20190021862A1

公开(公告)日：2019-01-24

申请号：US15656112

申请日：2017-07-21

申请人： Warsaw Orthopedic, Inc.

发明人： Kerem N. Kalpakci ,  Jared J. Diegmueller ,  Jason A. Rister ,  Daniel A. Shimko ,  Scott M. Vickers ,  Jeffrey L. Scifert

IPC分类号： A61F2/28 ,  A61F2/30

摘要： A bone implant for enclosing bone material is provided. The bone implant comprises a mesh having an inner surface and an outer surface opposing the inner surface. The inner surface is configured to receive a bone material when the inner surface of the mesh is in an open configuration. A plurality of projections are disposed on or in at least a portion of the inner surface of the mesh. The plurality of projections extend from at least the portion of the inner surface of the mesh and are configured to engage a section of the inner surface of the mesh or a section of the outer surface of the mesh or both sections of the inner and outer surfaces of the mesh in a closed configuration so as to enclose the bone material. A tray, a kit and a method of making the bone implant are also provided.

公开(公告)号：US09849218B2

公开(公告)日：2017-12-26

申请号：US15295445

申请日：2016-10-17

申请人： Warsaw Orthopedic, Inc.

发明人： Jeffrey L. Scifert

IPC分类号： A61K9/16 ,  A61K38/18 ,  A61L27/54 ,  A61K9/00 ,  A61K9/12 ,  A61L27/14 ,  A61L27/56 ,  A61L27/22 ,  A61L27/40

CPC分类号： A61L27/54 ,  A61K9/0024 ,  A61K9/122 ,  A61K9/1629 ,  A61K38/1875 ,  A61L27/14 ,  A61L27/227 ,  A61L27/40 ,  A61L27/56 ,  A61L2300/414 ,  A61L2300/802 ,  A61L2430/02

摘要： An improved osteogenic composition is provided. The composition comprises a foam that contains polymer beads having one or more growth factors such as bone morphogenic protein. Through use of this composition, bone, collagen and/or other tissue growth may be facilitated.

公开(公告)号：US11324597B2

公开(公告)日：2022-05-10

申请号：US16586358

申请日：2019-09-27

申请人： Warsaw Orthopedic, Inc.

发明人： Scott M. Vickers ,  Jeffrey L. Scifert ,  Ian R. Dunkley

IPC分类号： A61F2/28 ,  A61L27/36 ,  A61L27/46 ,  A61L27/58 ,  A61K6/17 ,  A61K6/802 ,  A61K6/838 ,  A61F2/30

摘要： Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and β tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to fit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

公开(公告)号：US20200038187A1

公开(公告)日：2020-02-06

申请号：US16586358

申请日：2019-09-27

申请人： Warsaw Orthopedic, Inc.

发明人： Scott M. Vickers ,  Jeffrey L. Scifert ,  Ian R. Dunkley

IPC分类号： A61F2/28 ,  A61L27/36 ,  A61L27/46 ,  A61L27/58 ,  A61K6/00 ,  A61K6/02 ,  A61K6/033

摘要： Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and p tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to tit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

公开(公告)号：US10426621B2

公开(公告)日：2019-10-01

申请号：US15491564

申请日：2017-04-19

申请人： Warsaw Orthopedic, Inc.

发明人： Scott M. Vickers ,  Jeffrey L. Scifert ,  Ian R. Dunkley

IPC分类号： A61F2/28 ,  A61L27/36 ,  A61K6/00 ,  A61K6/02 ,  A61K6/033 ,  A61L27/46 ,  A61L27/58 ,  A61F2/30

摘要： Provided is an implantable composite which includes a plurality of resorbable ceramic particles with or without a biodegradable polymer. The resorbable ceramic particles can be granules including carbonated hydroxyapatite and tricalcium phosphate in a ratio of 5:95 to 70:30. Some resorbable ceramic particles are granules, which include carbonated hydroxyapatite and β tricalcium phosphate in a ratio of 5:95 to 70:30. The resorbable ceramic particles have a particle size from about 0.4 to about 3.5 mm. The implantable composite is configured to fit at or near a bone defect as an autograft extender to promote bone growth. Methods of using the implantable composite are also provided.

公开(公告)号：US20150306275A1

公开(公告)日：2015-10-29

申请号：US14713307

申请日：2015-05-15

申请人： Warsaw Orthopedic Inc.

发明人： Jeffrey M. Gross ,  Steve Peckham ,  Jeffrey L. Scifert ,  Jeffrey Badura ,  Nelson Scarborough ,  Scott Vickers

IPC分类号： A61L27/22

CPC分类号： A61L27/227 ,  A61K38/00 ,  A61L27/46 ,  A61L27/48 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/602 ,  A61L2400/18 ,  A61L2420/02 ,  A61L2430/02

摘要： In certain described embodiments, implantable medical materials comprise a scaffolding material, a liquid organic binder, and entrapped calcium-containing particles. The medical materials can incorporate an osteoinductive factor such as a protein. The scaffolding material can bind the factor. In additional described embodiments, implantable medical materials include an osteoconductive scaffolding material, an incorporated osteoinductive factor, and a biodegradable barrier material effective to delay release of the factor from the scaffolding material. The scaffolding material can bind the factor. Also described a methods for preparing and implanting the described medical materials.

公开(公告)号：US20150011472A1

公开(公告)日：2015-01-08

申请号：US14492957

申请日：2014-09-22

申请人： Warsaw Orthopedic Inc.

发明人： William F. McKay ,  Jeffrey L. Scifert ,  Kathy Remsen ,  Didier Billy ,  Mirian Gillissen ,  Scott M. Vickers

IPC分类号： A61K38/18 ,  A61L27/26 ,  A61L27/54 ,  A61K9/00

CPC分类号： A61K38/1875 ,  A61K9/0024 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02 ,  C08L5/04 ,  C08L89/06

摘要： Described are implantable, malleable medical materials comprising mineral particles, insoluble collagen fibers, and a gel-forming polysaccharide component and/or another added gel-former. The malleable medical materials can be used treat bone or other tissue defects in patients, including in conjunction with biologically active factors such as osteogenic proteins. Also described are methods and materials that can be used to prepare the malleable medical materials.

公开(公告)号：US20140314821A1

公开(公告)日：2014-10-23

申请号：US14226463

申请日：2014-03-26

申请人： Warsaw Orthopedic, Inc.

发明人： Jeffrey L. Scifert ,  William F. McKay

IPC分类号： A61K9/00

CPC分类号： A61L27/24 ,  A61F2/02 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/1652 ,  A61L24/0015 ,  A61L24/0036 ,  A61L24/0042 ,  A61L24/0084 ,  A61L24/02 ,  A61L24/10 ,  A61L24/102 ,  A61L27/02 ,  A61L27/46 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/112 ,  A61L2300/252 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/45 ,  A61L2300/604 ,  A61L2400/06 ,  A61L2430/02 ,  A61L2430/38

摘要： Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body defines one or more reservoirs for receiving amounts of a biocompatible wetting liquid. In certain embodiments the body is disruptable upon wetting with the biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material. Also described are methods for manufacturing such medical materials, and methods for using such medical materials to treat patients.

摘要翻译： 描述了一种医学上有用的制品，其包括包含一种或多种可植入物质的三维体，其中所述主体限定用于接收生物相容性润湿液体量的一个或多个储存器。 在某些实施方案中，身体在与生物相容性液体润湿时形成适形植入材料，例如油灰，糊状物或更易流动的润湿植入材料。 还描述了制造这种医疗材料的方法，以及使用这种医疗材料来治疗患者的方法。