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32 条记录 (耗时 0.05 秒)

    Human CCN-like growth factor
    21.
    发明授权
    Human CCN-like growth factor 失效

    公开(公告)号：US5780263A

    公开(公告)日：1998-07-14

    申请号：US468847

    申请日：1995-06-06

    申请人： Gregg A. Hastings ,  Mark D. Adams

    发明人： Gregg A. Hastings ,  Mark D. Adams

    IPC分类号： A61K38/00 ,  C07K14/475 ,  C12N15/12

    CPC分类号： C07K14/475 ,  A61K38/00

    摘要： A human Small CCN-Like Growth Factor polypeptide (SCGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonist against such polypeptides and their use as a therapeutic to treat atherosclerosis, tumors and scarring are also disclosed. Diagnostic assays for identifying mutations in SCGF nucleic acid sequences and altered levels of the SCGF polypeptide are also disclosed.

    Human neuronal attachment factor-1 antibodies
    22.
    发明授权
    Human neuronal attachment factor-1 antibodies 失效
    人类神经元附着因子-1抗体

    公开(公告)号：US07485459B2

    公开(公告)日：2009-02-03

    申请号：US10788346

    申请日：2004-03-01

    申请人： Gregg A. Hastings ,  Patrick J. Dillon

    发明人： Gregg A. Hastings ,  Patrick J. Dillon

    IPC分类号： C12N5/22 ,  A61K39/395 ,  C07K16/28

    CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/411

    摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。 还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。 还公开了可用于预防疟疾的拮抗剂。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Human neuronal attachment factor-1
    26.
    发明授权
    Human neuronal attachment factor-1 失效
    人类神经元附着因子-1

    公开(公告)号：US08017349B2

    公开(公告)日：2011-09-13

    申请号：US12364360

    申请日：2009-02-02

    申请人： Gregg A. Hastings ,  Patrick J. Dillon

    发明人： Gregg A. Hastings ,  Patrick J. Dillon

    IPC分类号： G01N33/68 ,  G01N33/563 ,  G01N33/577

    CPC分类号： C07K14/47 ,  A61K38/00 ,  Y02A50/411

    摘要： A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

    摘要翻译： 公开了一种编码这种蛋白质的人类F-脊椎样蛋白样蛋白和DNA（RNA）以及通过重组技术产生这种蛋白质的方法。 还公开了通过促进神经细胞粘附和神经突延伸，抑制肿瘤转移和肿瘤血管发生以及刺激伤口修复来利用这种多肽来治疗脊髓损伤和损伤周围神经的方法。 还公开了可用于预防疟疾的拮抗剂。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

    Hyaluronan-binding proteins and encoding genes
    29.
    发明授权
    Hyaluronan-binding proteins and encoding genes 失效
    透明质酸结合蛋白和编码基因

    公开(公告)号：US07153670B2

    公开(公告)日：2006-12-26

    申请号：US10960275

    申请日：2004-10-08

    申请人： Gregg A. Hastings ,  Gene Liau ,  Elena Tsifrina

    发明人： Gregg A. Hastings ,  Gene Liau ,  Elena Tsifrina

    IPC分类号： C12P21/06 ,  C12N15/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： G01N33/5008 ,  C07K14/705 ,  G01N33/502 ,  G01N33/68 ,  G01N2333/47

    摘要： The present invention relates to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP, members of the hyaluronan receptor family. The invention provides isolated nucleic acid molecules encoding human to full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of full-length WF-HABP, WF-HABP, OE-HABP, and BM-HABP receptors. Further provided are therapeutic methods for treating disease states including, but not limited to, proliferative conditions, metastasis, inflammation, ischemia, host defense dysfunction, immune surveillance dysfunction, arthritis, multiple sclerosis, autoimmunity, immune dysfunction, and allergy.

    摘要翻译： 本发明涉及透明质酸受体家族的全长WF-HABP，WF-HABP，OE-HABP和BM-HABP。 本发明提供了编码人全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的分离的核酸分子。 还提供了全长WF-HABP，WF-HABP，OE-HABP和BM-HABP多肽，载体，宿主细胞和用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与全长WF-HABP，WF-HABP，OE-HABP和BM-HABP受体的异常表达相关的疾病状态的诊断方法。 进一步提供治疗疾病状态的治疗方法，包括但不限于增殖性病症，转移，炎症，缺血，宿主防御功能障碍，免疫监视功能障碍，关节炎，多发性硬化，自身免疫，免疫功能障碍和过敏。