-
公开(公告)号：US4314554A
公开(公告)日：1982-02-09
申请号：US57744
申请日：1979-07-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: A method and apparatus for providing germicidal and healing treatment of tissue such as bone wherein an electrode of silver or like material is applied to a living tissue site to be healed, initially a direct voltage is applied to the electrode of a polarity driving the electrode as an anode to release silver ions to create a germicidal environment at the site, and thereafter a direct voltage of opposite polarity is applied to the electrode driving it as a cathode to stimulate healing of the tissue at the site. The apparatus is implanted in the body of a patient, and in one embodiment a battery is connected through a switch to the electrode and a reference electrode, the switch initially connecting the electrode as an anode and thereafter changeable by an external operator such as a magnet to connect the electrode as a cathode. In another embodiment, another electrode and an element cooperate with the treating electrode to form a galvanic couple with the treating electrode to create a germicidal environment and a predetermined time thereafter the arrangement changes to a biogalvanic couple with body fluid to cause healing of the tissue. In either embodiment a wave shaping circuit can be operatively associated with the treating electrode to facilitate external monitoring of the apparatus when implanted.
Abstract translation: 一种用于提供诸如骨的组织的杀菌和愈合治疗的方法和装置，其中将银或类似材料的电极施加到待愈合的生物体组织部位，最初将直流电压施加到驱动电极的极性的电极，如 阳极以释放银离子以在该位置产生杀菌环境，之后将极性相反的直流电压施加到驱动其作为阴极的电极上，以刺激该部位组织的愈合。 该装置植入患者体内，在一个实施例中，电池通过开关连接到电极和参考电极，开关最初将电极连接为阳极，然后可由诸如磁体的外部操作者 将电极连接成阴极。 在另一个实施方案中，另一个电极和元件与处理电极配合，以与处理电极形成电偶，以产生杀菌环境，此后，预定时间将布置改变为与体液的生物金属联接，从而引起组织愈合。 在任一实施例中，波形整形电路可以与处理电极可操作地相关联，以便于在植入时对装置进行外部监测。
-
公开(公告)号：US4294256A
公开(公告)日：1981-10-13
申请号：US57745
申请日：1979-07-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
CPC classification number: A61N1/37211
Abstract: An artificial cardiac pacer including a pulse source of relatively high and constant frequency, such as a quartz crystal oscillator, and a frequency divider for converting the source pulses to a lower frequency suitable for application to pacer electrodes for heart stimulation is provided with a pulse rate controller operatively connected to the frequency converter for inhibiting a predetermined number of pulses in each time interval to change the frequency of pulses applied to the pacer electrodes. An external controller operatively coupled to the pulse rate control generates first and second command signals in response to manual selection which are received by the pulse rate control and cause an increase or decrease in the number of pulses inhibited.
Abstract translation: 提供了包括相对高和恒定频率的脉冲源的人造心脏起搏器，例如石英晶体振荡器和用于将源脉冲转换成适合于用于心脏刺激的起搏电极的较低频率的分频器，脉冲频率 控制器可操作地连接到变频器，用于在每个时间间隔中抑制预定数量的脉冲，以改变施加到起搏器电极的脉冲频率。 可操作地耦合到脉搏速率控制的外部控制器响应于由脉冲速率控制接收的手动选择产生第一和第二命令信号，并且导致抑制的脉冲数量的增加或减少。
-
23.发明授权
公开(公告)号：US4135519A
公开(公告)日：1979-01-23
申请号：US853136
申请日：1977-11-21
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: A cardiac pacer having an alkali metal-halogen cell comprising an alkali metal anode, preferably lithium, a solid alkali metal-halogen electrolyte and a cathode comprising a mixture of two halogens, for example iodine and bromine, the two halogens providing discharge of the cell at two different levels of cell output voltage. The two halogens are in different proportions by weight of the mixture thereby providing a two step output voltage-time characteristic. The second step or plateau in the output voltage characteristic provides an early warning of pacer battery exhaustion.
Abstract translation: 一种具有碱金属卤素电池的心脏起搏器，其包含碱金属阳极，优选锂，固体碱金属 - 卤素电解质和包含两种卤素如碘和溴的混合物的阴极，所述两种卤素提供电池的放电 在两个不同级别的电池输出电压。 两种卤素按混合物的重量不同，由此提供两步输出电压 - 时间特性。 输出电压特性的第二步或平台提供了电池耗尽的预警。
-
公开(公告)号：US4128703A
公开(公告)日：1978-12-05
申请号：US812641
申请日：1977-07-05
Applicant: Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph , Norbert W. Frenz, Jr.
Inventor： Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph , Norbert W. Frenz, Jr.
CPC classification number: H01M6/182
Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The anode operative surface is provided with a coating of an organic electron donor material. The anode is enclosed within an insulator element within the casing and a ferrule having one end within the insulator and the other end extending from the casing.
Abstract translation: 一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极 与壳体和锂元素。 阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。 阳极工作表面设置有有机电子给体材料的涂层。 阳极被封装在壳体内的绝缘体元件内，并且套管具有在绝缘体内的一端，另一端从壳体延伸。
-
公开(公告)号：US4071662A
公开(公告)日：1978-01-31
申请号：US647002
申请日：1976-01-07
Applicant: Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph
Inventor： Ralph T. Mead , Wilson Greatbatch , Frank W. Rudolph
Abstract: A lithium-iodine cell comprising a cathode including a charge transfer complex of an organic donor component and iodine, an anode including a lithium element having a surface operatively contacting the charge transfer complex material, and a coating on the lithium surface of an organic electron donor material, preferably but not necessarily the organic donor component of the charge transfer complex. The organic electron donor material preferably comprises polyvinyl pyridine polymer and in particular two-vinyl pyridine polymer. A solution of two-vinyl pyridine polymer in benzene is brushed onto the anode lithium surface and then exposed to a desiccant. A number of coatings preferably are applied successively to provide a resulting or finished coating of increased thickness.
Abstract translation: 一种锂碘电池，其包含阴极，其包括有机供体组分和碘的电荷转移络合物，包含具有可操作地接触电荷转移络合物材料的表面的锂元素的阳极和有机电子给体的锂表面上的涂层 材料，优选但不一定是电荷转移络合物的有机供体组分。 有机电子给体材料优选包含聚乙烯基吡啶聚合物，特别是二乙烯基吡啶聚合物。 将二乙烯基吡啶聚合物在苯中的溶液刷在阳极锂表面上，然后暴露于干燥剂中。 优选连续施加多个涂层以提供增加厚度的所得或成品涂层。
-
Patent Agency Ranking
公开(公告)号：US07047074B2
公开(公告)日：2006-05-16
申请号：US10077988
申请日：2002-02-19
Applicant: Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
Inventor： Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
IPC: A61N1/362
CPC classification number: G01R33/285 , A61N1/056 , A61N1/086 , A61N1/3718 , A61N1/375 , G01R33/288
Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.
-
公开(公告)号：US5580761A
公开(公告)日：1996-12-03
申请号：US217210
申请日：1994-03-23
Applicant: Wilson Greatbatch , John C. Sanford
Inventor： Wilson Greatbatch , John C. Sanford
IPC: A61K48/00 , C07K14/15 , C07K14/155 , C12N15/113 , C12N15/867 , C12N15/11 , C07H21/02 , C07H21/04 , C12N5/10
CPC classification number: C12N15/1131 , C07K14/005 , C12N15/1132 , C12N15/86 , A61K48/00 , C12N2740/13022 , C12N2740/15022 , C12N2740/16043
Abstract: In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or corresponding, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting one or more steps in the retroviral infection process by interfering with retroviral replication, reverse transcription, translation, or assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using the nucleic acid constructs, or cells upon which resistance to infection has been conferred.
Abstract translation: 根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。 所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，其指导宿主细胞内的RNA，所述RNA是a）互补或相应的（取决于靶区域）的核酸序列与一个或多个 逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，通过干扰逆转录病毒复制，逆转录，翻译或组装成病毒颗粒来有效抑制逆转录病毒感染过程中的一个或多个步骤。 还公开了使用核酸构建体或其赋予抗感染性的细胞的治疗方法。
-
公开(公告)号：US4291125A
公开(公告)日：1981-09-22
申请号：US112704
申请日：1980-01-16
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
CPC classification number: A01N59/16 , A61L2/035 , C02F1/4606 , Y10S435/80 , Y10S47/01
Abstract: A method and apparatus for killing plant and animal bacteria and plant viroids by electrically generated silver ions. The silver ions serve as germicidal agents in infection control and are generated by very slow electrical anodic corrosion of a silver wire located closely adjacent the infection site. In particular, a silver anode and a cathode of non-corroding metal are located in an electrolytic nutrient medium with the silver anode being within five millimeters of the infection site, and a direct voltage is applied to the anode and cathode in a manner passing a positive current in the microampere range into the silver anode causing it to corrode slightly and give off silver ions which produce a germicidal environment about the infection site.
Abstract translation: 一种用于通过电产生的银离子杀死植物和动物细菌并植入类病毒的方法和装置。 银离子在感染控制中用作杀菌剂，并且通过位于紧邻感染部位的银丝的非常缓慢的电阳极腐蚀产生。 特别地，非腐蚀金属的银阳极和阴极位于电解营养介质中，银阳极在感染部位的5毫米内，并且以通过一个方式的方式向阳极和阴极施加直流电压 在阳极范围内的正电流进入银阳极，导致其轻微腐蚀，并释放产生关于感染部位的杀菌环境的银离子。
-
公开(公告)号：US4210708A
公开(公告)日：1980-07-01
申请号：US891636
申请日：1978-03-30
Applicant: Ralph T. Mead , Norbert W. Frenz, Jr. , Frank W. Rudolph , Wilson Greatbatch
Inventor： Ralph T. Mead , Norbert W. Frenz, Jr. , Frank W. Rudolph , Wilson Greatbatch
Abstract: A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The lithium anode element is shaped in a manner increasing the area of the operative surface thereof and enhancing the bond to the anode conductor, and the anode operative surface is provided with a coating of an organic electron donor material. The anode conductor is enclosed within the combination of an insulator element within the casing, an isolator element between the insulator and the conductor, and a ferrule having one end associated with the insulator within the casing and the other end extending from the casing. After assembly, the cathode material is introduced in heated form by means of a filling element through an opening in the lid of the casing which subsequently is closed.
Abstract translation: 一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极 与壳体和锂元素。 阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。 锂阳极元件以增加其工作表面的面积并增强与阳极导体的结合的方式成形，并且阳极操作表面设置有有机电子给体材料的涂层。 阳极导体封装在壳体内的绝缘体元件的组合中，绝缘体和导体之间的隔离元件，以及一个套管，其一端与壳体内的绝缘体相关联，另一端从外壳延伸。 在组装之后，阴极材料通过填充元件以加热的形式通过壳体的盖中的开口引入，该开口随后被封闭。
-
公开(公告)号：US4132836A
公开(公告)日：1979-01-02
申请号：US853108
申请日：1977-11-21
Applicant: Wilson Greatbatch
Inventor： Wilson Greatbatch
Abstract: An alkali metal-halogen cell comprising an alkali metal anode, preferably lithium, a solid alkali metal-halogen electrolyte and a cathode comprising a mixture of two halogens, for example iodine and bromine, the two halogens providing discharge of the cell at two different levels of cell output voltage. The two halogens are in different proportions by weight of the mixture thereby providing a two step output voltage-time characteristic. The cell advantageously can be employed in a battery for an artificial cardiac pacer.
Abstract translation: 包含碱金属卤素电池，其包含碱金属阳极，优选锂，固体碱金属 - 卤素电解质和包含两种卤素（例如碘和溴）的混合物的阴极，所述两种卤素提供电池在两个不同水平的放电 的电池输出电压。 两种卤素按混合物的重量不同，由此提供两步输出电压 - 时间特性。 该细胞有利地可用于人造心脏起搏器的电池。
-
-
-
-
-
-
-
-
-
Search Results
45
records
(took 0.023 seconds)
