公开(公告)号：US20100114201A1

公开(公告)日：2010-05-06

申请号：US12362838

申请日：2009-01-30

申请人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Xiaohong Zhou ,  Gerald P. Arne ,  David J. Peichel ,  James D. Reinke

发明人： William T. Donofrio ,  John E. Burnes ,  Paul G. Krause ,  Xiaohong Zhou ,  Gerald P. Arne ,  David J. Peichel ,  James D. Reinke

IPC分类号： A61N1/37 ,  A61B5/0205

CPC分类号： A61N1/3621 ,  A61B5/04288 ,  A61B5/7217 ,  A61N1/025 ,  A61N1/0551 ,  A61N1/36185 ,  A61N1/3686 ,  A61N1/3702 ,  A61N1/3706 ,  A61N1/3718 ,  A61N1/37247 ,  A61N1/37288 ,  A61N1/3962

摘要： Electrical crosstalk between two implantable medical devices or two different therapy modules of a common implantable medical device may be evaluated, and, in some examples, mitigated. In some examples, one of the implantable medical devices or therapy modules delivers electrical stimulation to a nonmyocardial tissue site or a nonvascular cardiac tissue site, and the other implantable medical device or therapy module delivers cardiac rhythm management therapy to a heart of the patient.

摘要翻译： 可以评估两个可植入医疗装置或两个不同的可植入医疗装置的不同治疗模块之间的电串扰，并且在一些示例中可以减轻。 在一些示例中，可植入医疗装置或治疗模块之一将电刺激递送至非心肌组织部位或非血管心脏组织部位，而另一种可植入医疗装置或治疗组件将心律管理治疗递送至患者的心脏。

公开(公告)号：US20080228133A1

公开(公告)日：2008-09-18

申请号：US12128046

申请日：2008-05-28

申请人： KEITH R. HILDEBRAND ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

发明人： KEITH R. HILDEBRAND ,  Michael R. Ujhelyi ,  Xiaohong Zhou ,  Daniel C. Sigg ,  Linda M. Page

IPC分类号： A61M31/00

CPC分类号： A61M5/142 ,  A61M5/14276 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2205/3523 ,  A61M2230/00 ,  A61M2230/04 ,  A61M2230/63 ,  A61N1/3962

摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).

摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和 右美托咪定）。

公开(公告)号：US20070276453A1

公开(公告)日：2007-11-29

申请号：US11837811

申请日：2007-08-13

申请人： Michael Hill ,  Gary King ,  Thomas Mullen ,  Xiaohong Zhou ,  Rahul Mehra

发明人： Michael Hill ,  Gary King ,  Thomas Mullen ,  Xiaohong Zhou ,  Rahul Mehra

IPC分类号： A61N1/36

CPC分类号： A61N1/36114 ,  A61N1/0504 ,  A61N1/36017 ,  A61N1/36021 ,  A61N1/36071

摘要： A method and apparatus are provided for protecting cardiac tissue from insult. The method comprises identifying the occurrence of an insult, such as a heart attack, and delivering electrical stimulation to one or more predetermined nerves in a patient's body in response to identifying the occurrence of the insult. The stimulation may be provided to peripheral nerves, intrinsic cardiac nerves, sympathetic ganglia, cranial nerves, and may generally be directed to the vertebral column, or within the chest wall of the patient.

摘要翻译： 提供了一种用于保护心脏组织免受侮辱的方法和装置。 所述方法包括识别呃等的发生，例如心脏病发作，并且响应于识别侮辱的发生而向患者身体中的一个或多个预定神经传递电刺激。 刺激可以提供给外周神经，内在的心脏神经，交感神经节，颅神经，并且通常可以被引导到脊柱或患者的胸壁内。

公开(公告)号：US20060116596A1

公开(公告)日：2006-06-01

申请号：US11000541

申请日：2004-12-01

申请人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

发明人： Xiaohong Zhou ,  Thomas Mullen ,  Jeffrey Gillberg ,  Robert Stadler

IPC分类号： A61B5/04

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452

摘要： A system and method are provided for assessing T-wave alternans (TWA) using cardiac EGM signals received from implanted electrodes. A T-wave signal parameter is measured from signals received by an automatic gain control sense amplifier. A TWA measurement is computed from a beat-by-beat comparison of T-wave parameter measurements or using frequency spectrum techniques. The TWA measurement magnitude and measurement conditions are used in detecting a clinically important TWA. TWA assessment further includes discriminating concordant and discordant TWA in a multi-vector TWA assessment, and determining the association of a TWA measurement with QRS alternans, mechanical alternans, and other physiological events. A prediction of a pathological cardiac event is made in response to a TWA assessment. A response to a cardiac event prediction is provided.

摘要翻译： 提供了一种使用从植入电极接收的心脏EGM信号评估T波交替（TWA）的系统和方法。 从由自动增益控制读出放大器接收的信号测量T波信号参数。 通过T波参数测量或使用频谱技术的逐拍比较来计算TWA测量。 TWA测量值和测量条件用于检测临床重要的TWA。 TWA评估还包括在多向量TWA评估中区分一致和不一致的TWA，并确定TWA测量与QRS交替，机械交替和其他生理事件的关联。 病理性心脏事件的预测是针对TWA评估做出的。 提供对心脏事件预测的响应。

公开(公告)号：US20060095081A1

公开(公告)日：2006-05-04

申请号：US11116970

申请日：2005-04-28

申请人： Xiaohong Zhou ,  Thomas Mullen ,  Michael Hill ,  Steve Laporte ,  Gary King

发明人： Xiaohong Zhou ,  Thomas Mullen ,  Michael Hill ,  Steve Laporte ,  Gary King

IPC分类号： A61N1/18

CPC分类号： A61N1/0551 ,  A61N1/36114 ,  A61N1/36135

摘要： According to the present invention at least a pair of neurological stimulation electrodes are disposed in, on, about, adjacent and/or within excitable neural tissue of a subject. Cardiac activity of a patient is detected using one or more electrodes adapted for delivery of a neurological stimulation therapy (NST). Following detection of certain types of cardiac activity one or more of the plurality of stimulation electrodes deliver or withhold NST, if desired in synchrony with the cardiac activity or in response to the detected cardiac activity. The NST delivered includes without limitation subcutaneous stimulation, peripheral, TENS and/or vagal nerve stimulation therapy or the like.

摘要翻译： 根据本发明，至少一对神经刺激电极设置在受试者的可兴奋神经组织的内部，之上，大约，相邻和/或之内。 使用适于递送神经刺激疗法（NST）的一个或多个电极检测患者的心脏活动。 在检测到某些类型的心脏活动之后，如果需要，多个刺激电极中的一个或多个刺激电极传递或阻止NST，如果需要与心脏活动同步或响应于检测到的心脏活动。 提供的NST包括但不限于皮下刺激，外周，TENS和/或迷走神经刺激疗法等。

公开(公告)号：US06528998B1

公开(公告)日：2003-03-04

申请号：US09540768

申请日：2000-03-31

申请人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff

发明人： Xiaohong Zhou ,  Joseph K. Maier ,  Steven J. Huff

IPC分类号： G01V300

CPC分类号： G01R33/56581

摘要： A method and apparatus for correcting ghosting artifacts that are related to Maxwell fields and/or other perturbation magnetic fields is disclosed. The method and apparatus includes acquiring MR image n-space data and an MR reference scan, each having perturbation field effects therein. After determining phase correction values from the MR reference scan and reconstructing an MR image using the phase correction values, a projection phase error is calculated from the reconstructed MR image and then subtracted from the reference scan, the result of which is used to determine a new set of phase correction values. The new set of phase correction values is applied to the acquired MR image data to reconstruct a new image. The reconstructed new image can then be reused to calculate a new projection phase error, which again is subtracted from the reference scan data and the process is repeated until an image of desired ghost artifact reduction is achieved.

摘要翻译： 公开了一种用于校正与麦克斯韦尔场和/或其他扰动磁场相关的重影伪像的方法和装置。 该方法和装置包括获取每个在其中具有扰动场效应的MR图像n空间数据和MR参考扫描。 在从MR参考扫描确定相位校正值并使用相位校正值重建MR图像之后，从重建的MR图像计算投影相位误差，然后从参考扫描中减去其结果，其结果用于确定新的 一组相位校正值。 将新的相位校正值集合应用于所获取的MR图像数据以重构新图像。 然后可以重新构建重建的新图像以计算新的投影相位误差，其再次从参考扫描数据中减去，并且重复该过程，直到实现期望的鬼影伪像减少的图像。

公开(公告)号：US06469505B1

公开(公告)日：2002-10-22

申请号：US09540687

申请日：2000-03-31

申请人： Joseph K. Maier ,  Xiaohong Zhou ,  Steven J. Huff

发明人： Joseph K. Maier ,  Xiaohong Zhou ,  Steven J. Huff

IPC分类号： G01V300

CPC分类号： G01R33/56563 ,  G01R33/5604 ,  G01R33/56518

摘要： A method and apparatus for correcting ghost artifacts that are related to orthogonal perturbation magnetic fields is disclosed. The technique includes acquiring MR data and an MR reference scan, each in the presence of orthogonal perturbation magnetic fields. However, the region of interest for the MR reference scan is limited to a relatively narrow band within the imaging subject. Preferably, the narrow band is selected in the vicinity of the magnet iso-center and parallel to the readout direction. Alternatively, the narrow band can also be selected in the limited region where the orthogonal perturbation fields are either minimal or constant along the phase encoding direction, and parallel to the readout direction. The selection of the relatively narrow band is accomplished by either spatially saturating surrounding regions, or using a two-dimensional spatially selective RF pulse. Phase correction values can then be calculated from a more accurately defined slope and intercept of the phase of the MR reference scan and used to correct the MR data. A reconstructed MR image using this technique has reduced ghost artifacts otherwise caused by the adverse effects of the orthogonal perturbation fields in the phase correction process.

摘要翻译： 公开了一种用于校正与正交扰动磁场相关的重影伪影的方法和装置。 该技术包括获取MR数据和MR参考扫描，每个在存在正交扰动磁场的情况下。 然而，用于MR参考扫描的感兴趣区域被限制在成像对象内的相对较窄的频带。 优选地，在磁体等中心附近并且平行于读出方向选择窄带。 或者，也可以在有限区域选择窄带，其中正交扰动场沿相位编码方向为最小或恒定，并且平行于读出方向。 通过空间饱和的周围区域或使用二维空间选择性RF脉冲来实现相对窄带的选择。 然后可以从更准确地定义的MR参考扫描的相位的斜率和截距来计算相位校正值，并用于校正MR数据。 使用该技术的重构MR图像减少了由相位校正处理中的正交扰动场的不利影响引起的鬼影。

公开(公告)号：US6114852A

公开(公告)日：2000-09-05

申请号：US236195

申请日：1999-01-23

申请人： Xiaohong Zhou ,  Graeme C. McKinnon

发明人： Xiaohong Zhou ,  Graeme C. McKinnon

IPC分类号： G01R33/567 ,  G01V3/00

CPC分类号： G01R33/56509 ,  G01R33/5673

摘要： A method is provided for determining errors in MR imaging which result from translational motion of an object. In accordance with the method, an MR point source is rigidly joined to the object in selected spatial relationship, and for movement in unison therewith. An MR system is operated to acquire an overall k-space signal which represents an image of the object and of the point source collectively, the overall k-space signal being contaminated by phase errors which result from the motion. A k-space data set which represents an image of the point source alone, and which remains contaminated by the phase errors, is filtered or separated out from the overall k-space signal. The MR system is operated in selected association with the point source to acquire a reference k-space data set, which represents an image of the point source alone but which is unaffected by the phase errors resulting from the motion. The reference k-space data set is then selectively compared with the filtered k-space data set, to determine the phase errors. Alternatively, the reference k-space data set can be replaced by a plurality of k-space alignment lines in parallel relationship to the phase-encoding axis.

摘要翻译： 提供了一种用于确定由对象的平移运动产生的MR成像中的误差的方法。 根据该方法，MR点源以选定的空间关系刚性地连接到对象，并与其一起移动。 操作MR系统用于获取表示对象和点源的图像的总体k空间信号，整体k空间信号被由运动产生的相位误差污染。 仅表示点源的图像并且被相位误差污染的k空间数据集被从整个k空间信号中滤波或分离出来。 MR系统与点源选择关联地操作以获取参考k空间数据集，其表示单独的点源的图像，但不受运动导致的相位误差的影响。 然后，将参考k空间数据集与经滤波的k空间数据集进行选择性比较，以确定相位误差。 或者，参考k空间数据集可以由与相位编码轴平行的多个k空间对准线代替。

公开(公告)号：US5864233A

公开(公告)日：1999-01-26

申请号：US803808

申请日：1997-02-22

申请人： Xiaohong Zhou ,  Joseph K. Maier ,  Hammond Glenn Reynolds

发明人： Xiaohong Zhou ,  Joseph K. Maier ,  Hammond Glenn Reynolds

IPC分类号： G01N27/90 ,  G01R33/563 ,  G01R33/565 ,  G01V3/00

CPC分类号： G01R33/56341 ,  G01R33/56518

摘要： An eddy current correction method is provided for use in an MR system disposed to generate difflusion-weighted echo planar images by employing a bipolar diffusion-weighting gradient as well as the nominal components in an echo planar imaging pulse sequence. The correction method comprises the steps of deriving eddy current parameters (i.e., amplitude and time constant) associated with each eddy-current-induced magnetic field component caused by the diffusion-weighting gradient, and generating a set of correction terms, each of the correction terms being a function of the parameters. The method includes the further steps of modifyg a set of ideal echo planar imaging gradients and the receiver phase and frequency to respectively offset the eddy current induced magnetic field gradient and the spatially independent B.sub.0 -magnetic field. The modification occurs in two stages. Prior to data acquisition, errors are exactly corrected by altering the pre-phasing and the slice-refocusing gradient areas as well as the initial receiver phase. During data acquisition, the eddy current induced errors are approximately compensated for by adding offset gradients and dynamically changing the receiver phase and frequency using either a piece-wise-constant approximation or a constant approximation. Using either method, artifacts in diffusion-weighted echo planar images can be significantly reduced.

摘要翻译： 提供涡流校正方法用于MR系统，其被布置为通过采用双极扩散加权梯度以及回波平面成像脉冲序列中的标称分量来产生散射加权回波平面图像。 校正方法包括以下步骤：导出与由扩散加权梯度引起的每个涡流感应磁场分量相关联的涡流参数（即振幅和时间常数），以及产生一组校正项，每个校正 术语是参数的函数。 该方法包括以下步骤：修改一组理想的回波平面成像梯度，以及接收器相位和频率以分别偏移涡流感应磁场梯度和空间上独立的B0磁场。 修改发生在两个阶段。 在数据采集之前，通过改变预定相和切片重新聚焦梯度区域以及初始接收器相位来精确地校正误差。 在数据采集过程中，通过增加偏移梯度和使用分段常数近似或恒定近似来动态地改变接收器相位和频率，近似补偿涡流感应误差。 使用任一种方法，扩散加权回波平面图像中的伪影可以显着减少。

公开(公告)号：US5672969A

公开(公告)日：1997-09-30

申请号：US637879

申请日：1996-04-25

申请人： Xiaohong Zhou ,  Joseph K. Maier ,  Frederick H. Epstein

发明人： Xiaohong Zhou ,  Joseph K. Maier ,  Frederick H. Epstein

IPC分类号： G01R33/54 ,  A61B5/055 ,  G01R33/561 ,  G01R33/565 ,  G01R33/20

CPC分类号： G01R33/56572 ,  G01R33/5616

摘要： In a magnetic resonance imaging (MRI) system, a method is provided for reducing oblique Nyquist ghost artifact in an image produced by an oblique EPI scan. Prior to commencing the EPI scan, referencing pre-scans are conducted to generate pre-scan echo trains respectively corresponding to the physical gradient axes. Distortion compensating parameters are derived from the pre-scan echo trains for reducing Nyquist ghost by alternatively modifying the data acquisitions stage of the oblique EPI scan, or the post-data acquisition image processing stage thereof. In one mode of operation, the pre-scan echo trains are generated while a subject is in the MRI system. In another mode of operation, pre-scan echo trains are generated while no subject is present in the MR system, so that the distortion compensating parameters represent characteristics of the MR system only, and thus may be used for EPI scans of different protocols. For such mode of operation the distortion compensating parameters may be computed as a function of readout gradient pulse spacing.

摘要翻译： 在磁共振成像（MRI）系统中，提供了一种用于减少由倾斜EPI扫描产生的图像中的倾斜奈奎斯特幻影伪像的方法。 在开始EPI扫描之前，进行参考预扫描以产生分别对应于物理梯度轴的预扫描回波列。 通过交替地修改倾斜EPI扫描的数据采集阶段或其后数据采集图像处理阶段，从预扫描回波列导出失真补偿参数，以减少奈奎斯特重影。 在一种操作模式中，当受检者在MRI系统中时，产生预扫描回波列。 在另一种操作模式中，在MR系统中不存在主体的情况下产生预扫描回波串，使得失真补偿参数仅表示MR系统的特性，因此可用于不同协议的EPI扫描。 对于这种操作模式，失真补偿参数可以作为读出梯度脉冲间隔的函数来计算。