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公开(公告)号:US20130025606A1
公开(公告)日:2013-01-31
申请号:US13615111
申请日:2012-09-13
申请人: Eugene de Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人: Eugene de Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC分类号: A61F9/00
CPC分类号: G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
摘要翻译: 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置,以便至少部分地符合消融的基质表面,以便矫正视力。 适形的内部部分可以具有至少一些刚性,以便平滑上皮,使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量,以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。
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公开(公告)号:US09498385B2
公开(公告)日:2016-11-22
申请号:US13503842
申请日:2010-10-25
申请人: Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人: Eugene de Juan, Jr. , Cary J. Reich , Yair Alster , K. Angela MacFarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
CPC分类号: G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
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公开(公告)号:US20120310133A1
公开(公告)日:2012-12-06
申请号:US13555056
申请日:2012-07-20
申请人: Eugene De Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
发明人: Eugene De Juan, JR. , Cary J. Reich , Yair Alster , K. Angela Macfarlane , Doug Rimer , Douglas Sutton , Dean Carson , Enrique Barragan , Matt Clarke , Ashley Tuan , Brian Levy
IPC分类号: A61F9/00
CPC分类号: G02C7/047 , A61F2/145 , A61F2/147 , A61F9/00 , A61F9/0017 , A61F9/008 , A61F9/00802 , A61F9/00804 , A61F9/013 , A61F9/0136 , A61F9/04 , A61F13/124 , A61F2009/00853 , A61F2009/00893 , A61F2250/0029 , A61L27/18 , A61L2430/16 , G02C7/048 , G02C7/049 , G02C2202/06 , C08L83/04
摘要: A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.
摘要翻译: 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置,以便至少部分地符合消融的基质表面,以便矫正视力。 适形的内部部分可以具有至少一些刚性,以便平滑上皮,使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量,以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。
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公开(公告)号:US10398592B2
公开(公告)日:2019-09-03
申请号:US14129200
申请日:2012-06-28
申请人: Signe Erickson , Darren Doud , Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , Kathleen Cogan Farinas
发明人: Signe Erickson , Darren Doud , Eugene de Juan, Jr. , Yair Alster , Cary J. Reich , Kathleen Cogan Farinas
摘要: An apparatus to treat a patient comprises a container to receive fluid of a device implanted in the eye. The fluid of the device can be analyzed to determine a component of the vitreous humor of the eye.
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公开(公告)号:US10166142B2
公开(公告)日:2019-01-01
申请号:US14236863
申请日:2012-08-03
申请人: Eugene De Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人: Eugene De Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号: A61F9/00 , A61K9/00 , A61K31/382 , A61K31/407 , A61K31/519
摘要: A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
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公开(公告)号:US20140358125A1
公开(公告)日:2014-12-04
申请号:US14236863
申请日:2012-08-03
申请人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号: A61F9/00 , A61K31/382
CPC分类号: A61F9/0017 , A61F2250/0031 , A61F2250/0068 , A61K9/0051 , A61K31/382 , A61K31/407 , A61K31/519 , F04C2270/041
摘要: A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译: 一种能够释放治疗剂的治疗装置,所述治疗剂包括与包含储存器的容器相连的多孔结构。 贮存器可以包含一定量的体积,当耦合到多孔结构并且植入患者体内时,释放处理量的治疗剂延长时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第二侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。
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公开(公告)号:US20140031769A1
公开(公告)日:2014-01-30
申请号:US13988298
申请日:2011-11-18
申请人: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson , Blaine Bueche
发明人: Eugene de Juan, JR. , Yair Alster , Steven M. Chamow , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson , Blaine Bueche
IPC分类号: A61F9/00
CPC分类号: A61F9/0017 , A61K9/0051 , A61K9/1647 , A61K9/1652 , A61K31/573
摘要: An injectable formulation of therapeutic agent may comprise the therapeutic agent and a stabilizer such that a substantial portion of the stabilizer remains in the therapeutic device to stabilize the therapeutic agent when the therapeutic agent is released from the therapeutic device. The injectable formulation may comprise one or more of binding agent particles or erodible material particles, such that the formulation can be injected into the therapeutic device. The binding agent particles can bind reversibly to the therapeutic agent so as to modulate release of the therapeutic agent, and the erodible material particles can generate protons of an acid so as to increase stability of the therapeutic agent and may modulate release of the therapeutic agent. The therapeutic agent can be combined with one or more of the stabilizer, the binding agent particles or the erodible particles to increase stability of the therapeutic agent and may modulate release.
摘要翻译: 治疗剂的可注射制剂可以包含治疗剂和稳定剂,使得当治疗剂从治疗装置释放时,大部分稳定剂保留在治疗装置中以稳定治疗剂。 可注射制剂可以包含一种或多种粘合剂颗粒或可侵蚀材料颗粒,使得可以将制剂注射到治疗装置中。 结合剂颗粒可以可逆地结合治疗剂以调节治疗剂的释放,并且可侵蚀的材料颗粒可以产生酸的质子,以增加治疗剂的稳定性并且可以调节治疗剂的释放。 治疗剂可以与稳定剂,结合剂颗粒或可侵蚀颗粒中的一种或多种组合以增加治疗剂的稳定性并且可以调节释放。
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公开(公告)号:US20140028979A1
公开(公告)日:2014-01-30
申请号:US13885135
申请日:2011-10-25
申请人: Eugene De Juan ,Jr. , Yair Alster , Cary J. Reich , Ashley Tuan , Angela K. MacFarlane , Matt Clarke , Brian Levy
发明人: Eugene De Juan ,Jr. , Yair Alster , Cary J. Reich , Ashley Tuan , Angela K. MacFarlane , Matt Clarke , Brian Levy
CPC分类号: G02C7/047 , A61B3/0025 , A61B3/0041 , A61B3/1005 , A61B3/1015 , A61B3/107 , A61B3/18 , A61F9/00804 , A61F9/00806 , A61F9/04 , A61F2009/00859 , A61F2009/00872 , G02C7/027 , G02C7/04 , G02C7/048 , G02C7/049 , G02C2202/16
摘要: Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering. The covering can be identified based on an inner corneal curvature and an outer corneal curvature and one or more of a limbus sag height or a conjunctival sag height. The covering may form a chamber when placed on the eye to pump tear liquid under at least a portion of the covering. The covering may comprise an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The covering may comprise a material having high oxygen permeability, for example silicone, with a wettable coating disposed on at least an upper surface of the coating.
摘要翻译: 方法和装置可以配合护理眼睛。 可以识别覆盖物,以便在覆盖物下方提供改善的泪液流动。 可以基于内部角膜曲率和外部角膜曲率以及角膜缘下垂高度或结膜下垂高度中的一个或多个来识别覆盖物。 当覆盖物放置在眼睛上时,该覆盖物可以形成一个室,以在至少一部分覆盖物之下泵送泪液。 覆盖物可以包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分,并提供用于上皮再生的环境。 覆盖物可以包括具有高氧渗透性的材料,例如硅树脂,其中可湿性涂层设置在涂层的至少上表面上。
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公开(公告)号:US20130324942A1
公开(公告)日:2013-12-05
申请号:US13814464
申请日:2011-08-05
申请人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
发明人: Eugene de Juan, JR. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell
IPC分类号: A61F9/00
CPC分类号: A61F9/0017 , A61K9/0051
摘要: A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the 188 second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
摘要翻译: 用于释放治疗剂的治疗装置包括联接到包括储存器的容器的多孔结构。 储存器包括体积大小,当耦合到多孔结构并且植入患者体内时,释放治疗剂量的治疗剂延长的时间。 所述多孔结构可以包括联接到所述储存器的第一侧和与所述患者联接以释放所述治疗剂的第二侧。 从第一侧延伸到第二侧的通道的长度可以包括大于多孔结构从第一侧到第188侧的距离的有效长度。 治疗装置可以包括当植入患者时将治疗剂注射到装置中的可穿透屏障。
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公开(公告)号:US20130274692A1
公开(公告)日:2013-10-17
申请号:US13814470
申请日:2011-08-04
申请人: Yair Alster , Eugene De Juan, JR. , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人: Yair Alster , Eugene De Juan, JR. , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号: A61F9/00
CPC分类号: A61F9/0017 , A61K9/0051 , A61K31/00 , A61K31/573 , A61K31/58
摘要: A therapeutic device can be configured to place the reservoir substantially between the conjunctiva and the scleral such that the size of the reservoir can be increased and the size of the scleral penetration decreased so as to decrease invasiveness. The device may comprise a substantially constant reservoir volume and drug release mechanism, in which the volume of the reservoir and mechanism are tuned to receive a quantity of therapeutic agent with a volume of injected formulation and release the therapeutic agent for an extended time with a release rate profile. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent, and a plurality of interconnecting channels can extend from the first side to the second side.
摘要翻译: 治疗装置可以被配置为将储存器基本上放置在结膜和巩膜之间,使得储存器的尺寸可以增加并且巩膜穿透的尺寸减小以降低侵入性。 该装置可以包括基本上恒定的储存器体积和药物释放机构,其中储存器和机构的体积被调谐以接收一定量的具有注射制剂体积的治疗剂,并释放治疗剂延长的时间 费率简介。 多孔结构可以包括联接到储存器的第一侧和耦合到患者以释放治疗剂的第二侧,并且多个互连通道可以从第一侧延伸到第二侧。
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