公开(公告)号：US20140028979A1

公开(公告)日：2014-01-30

申请号：US13885135

申请日：2011-10-25

申请人： Eugene De Juan ,Jr. ,  Yair Alster ,  Cary J. Reich ,  Ashley Tuan ,  Angela K. MacFarlane ,  Matt Clarke ,  Brian Levy

发明人： Eugene De Juan ,Jr. ,  Yair Alster ,  Cary J. Reich ,  Ashley Tuan ,  Angela K. MacFarlane ,  Matt Clarke ,  Brian Levy

IPC分类号： G02C7/04 ,  G02C7/02

CPC分类号： G02C7/047 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/1015 ,  A61B3/107 ,  A61B3/18 ,  A61F9/00804 ,  A61F9/00806 ,  A61F9/04 ,  A61F2009/00859 ,  A61F2009/00872 ,  G02C7/027 ,  G02C7/04 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/16

摘要： Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering. The covering can be identified based on an inner corneal curvature and an outer corneal curvature and one or more of a limbus sag height or a conjunctival sag height. The covering may form a chamber when placed on the eye to pump tear liquid under at least a portion of the covering. The covering may comprise an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The covering may comprise a material having high oxygen permeability, for example silicone, with a wettable coating disposed on at least an upper surface of the coating.

摘要翻译： 方法和装置可以配合护理眼睛。 可以识别覆盖物，以便在覆盖物下方提供改善的泪液流动。 可以基于内部角膜曲率和外部角膜曲率以及角膜缘下垂高度或结膜下垂高度中的一个或多个来识别覆盖物。 当覆盖物放置在眼睛上时，该覆盖物可以形成一个室，以在至少一部分覆盖物之下泵送泪液。 覆盖物可以包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分，并提供用于上皮再生的环境。 覆盖物可以包括具有高氧渗透性的材料，例如硅树脂，其中可湿性涂层设置在涂层的至少上表面上。

公开(公告)号：US20130070200A1

公开(公告)日：2013-03-21

申请号：US13503842

申请日：2010-10-25

申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F9/00 ,  G02C7/04

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US09395558B2

公开(公告)日：2016-07-19

申请号：US13885135

申请日：2011-10-25

申请人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  Ashley Tuan ,  Angela K MacFarlane ,  Matt Clarke ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Yair Alster ,  Cary J. Reich ,  Ashley Tuan ,  Angela K MacFarlane ,  Matt Clarke ,  Brian Levy

IPC分类号： A61B3/00 ,  G02C7/04 ,  A61B3/18 ,  G02C7/02 ,  A61F9/008 ,  A61B3/10 ,  A61B3/107 ,  A61F9/04

CPC分类号： G02C7/047 ,  A61B3/0025 ,  A61B3/0041 ,  A61B3/1005 ,  A61B3/1015 ,  A61B3/107 ,  A61B3/18 ,  A61F9/00804 ,  A61F9/00806 ,  A61F9/04 ,  A61F2009/00859 ,  A61F2009/00872 ,  G02C7/027 ,  G02C7/04 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/16

摘要： Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering. The covering can be identified based on an inner corneal curvature and an outer corneal curvature and one or more of a limbus sag height or a conjunctival sag height. The covering may form a chamber when placed on the eye to pump tear liquid under at least a portion of the covering. The covering may comprise an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The covering may comprise a material having high oxygen permeability, for example silicone, with a wettable coating disposed on at least an upper surface of the coating.

摘要翻译： 方法和装置可以配合护理眼睛。 可以识别覆盖物，以便在覆盖物下方提供改善的泪液流动。 可以基于内部角膜曲率和外部角膜曲率以及角膜缘下垂高度或结膜下垂高度中的一个或多个来识别覆盖物。 当覆盖物放置在眼睛上时，该覆盖物可以形成一个室，以在至少一部分覆盖物之下泵送泪液。 覆盖物可以包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分，并提供用于上皮再生的环境。 覆盖物可以包括具有高氧渗透性的材料，例如硅树脂，其中可湿性涂层设置在涂层的至少上表面上。

公开(公告)号：US08459793B2

公开(公告)日：2013-06-11

申请号：US13615111

申请日：2012-09-13

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61B3/14 ,  A61B3/00

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US20130077044A1

公开(公告)日：2013-03-28

申请号：US13456168

申请日：2012-04-25

申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  Matt Clarke ,  Kuangmon Ashley Tuan ,  Brain Levy

发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  Matt Clarke ,  Kuangmon Ashley Tuan ,  Brain Levy

IPC分类号： G02C7/04 ,  G02C7/02

CPC分类号： G02C7/049 ,  G02C7/022 ,  G02C7/024 ,  G02C7/04 ,  G02C7/047

摘要： An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva. When the eye blinks, the pressure of the one or more eyelids can urge the covering toward the cornea such that tear liquid can pass through the fenestrations.

摘要翻译： 诸如隐形眼镜的眼睛覆盖物可以包括一个或多个结构，以将覆盖物下方的泪液泵送，使得覆盖物可以保留在眼睛中并且将视力延长一段时间。 在许多实施例中，覆盖物包括具有开窗以吸收覆盖物下方的泪液的材料和形状为在巩膜上接触结膜的外部部分，使得当眼睛闭合一个或多个眼睑的压力时，促使泪液通过一个或多个 开窗和在外部形状以接触结膜。 当眼睛眨眼时，一个或多个眼睑的压力可以促使覆盖物朝向角膜，使得泪液可以通过开窗。

公开(公告)号：US20130025606A1

公开(公告)日：2013-01-31

申请号：US13615111

申请日：2012-09-13

申请人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F9/00

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

摘要翻译： 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置，以便至少部分地符合消融的基质表面，以便矫正视力。 适形的内部部分可以具有至少一些刚性，以便平滑上皮，使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量，以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。

公开(公告)号：US09107773B2

公开(公告)日：2015-08-18

申请号：US13555056

申请日：2012-07-20

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US09498385B2

公开(公告)日：2016-11-22

申请号：US13503842

申请日：2010-10-25

申请人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela MacFarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene de Juan, Jr. ,  Cary J. Reich ,  Yair Alster ,  K. Angela MacFarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F13/00 ,  A61F13/12 ,  A61F9/00 ,  A61F9/013 ,  A61F9/04 ,  A61L27/18 ,  G02C7/04 ,  A61F9/008

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10−4 Pa*m3 to about 5×10−4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

公开(公告)号：US20120310133A1

公开(公告)日：2012-12-06

申请号：US13555056

申请日：2012-07-20

申请人： Eugene De Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

发明人： Eugene De Juan, JR. ,  Cary J. Reich ,  Yair Alster ,  K. Angela Macfarlane ,  Doug Rimer ,  Douglas Sutton ,  Dean Carson ,  Enrique Barragan ,  Matt Clarke ,  Ashley Tuan ,  Brian Levy

IPC分类号： A61F9/00

CPC分类号： G02C7/047 ,  A61F2/145 ,  A61F2/147 ,  A61F9/00 ,  A61F9/0017 ,  A61F9/008 ,  A61F9/00802 ,  A61F9/00804 ,  A61F9/013 ,  A61F9/0136 ,  A61F9/04 ,  A61F13/124 ,  A61F2009/00853 ,  A61F2009/00893 ,  A61F2250/0029 ,  A61L27/18 ,  A61L2430/16 ,  G02C7/048 ,  G02C7/049 ,  G02C2202/06 ,  C08L83/04

摘要： A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 1×10-4 Pa*m3 to about 5×10-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

摘要翻译： 适形覆盖物包括具有刚性以抵抗角膜上的运动的外部部分和与角膜接触的内部部分并提供用于上皮再生的环境。 覆盖物的内部部分可以以许多方式配置，以便至少部分地符合消融的基质表面，以便矫正视力。 适形的内部部分可以具有至少一些刚性，以便平滑上皮，使得上皮迅速再生并且被覆盖物引导以形成平滑的视觉层。 内部部分可以包括在约1×10 -4 Pa * m 3至约5×10 -4 Pa * m 3的范围内的刚性量，以便至少部分地偏转并符合消融的角膜并使内部部分平滑 的消融量在偏转时具有一定的压力。