公开(公告)号：US20080262558A1

公开(公告)日：2008-10-23

申请号：US11736286

申请日：2007-04-17

申请人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

发明人： Yanting Dong ,  Quan Ni ,  Xuan Wei ,  Dan Li ,  Qian Zhong

IPC分类号： A61N1/365

CPC分类号： A61N1/3621

摘要： A system including at least one implantable sensor circuit adapted to produce an electrical sensor signal related to one or more physiologic cardiovascular events of a subject, a therapy circuit configured to provide anti-tachycardia pacing (ATP) therapy, and a controller. The controller includes a tachyarrhythmia detection circuit and an efficacy circuit. The tachyarrhythmia detection circuit is configured to detect a tachyarrhythmia episode in the subject using the electrical sensor signal, and to determine whether the tachyarrhythmia episode is of a type that is treatable with ATP. The efficacy circuit is configured to estimate an efficacy of a currently configured ATP therapy for the subject, and the controller is configured to alter a delivery regimen of the currently configured ATP therapy when the estimated ATP therapy efficacy is deemed insufficient. Other systems and methods are described.

摘要翻译： 一种系统，包括适于产生与受试者的一个或多个生理性心血管事件相关的电传感器信号的至少一个可植入传感器电路，被配置为提供抗心动过速起搏（ATP）治疗的治疗电路和控制器。 控制器包括快速性心律失常检测电路和功效电路。 快速心律失常检测电路被配置为使用电传感器信号检测受试者的快速性心律失常发作，并且确定快速性心律失常发作是否是可用ATP治疗的类型。 功效电路被配置为估计当前配置的ATP治疗对受试者的功效，并且当估计的ATP治疗功效被认为不足时，控制器被配置为改变当前配置的ATP治疗的递送方案。 描述了其他系统和方法。

公开(公告)号：US08036735B2

公开(公告)日：2011-10-11

申请号：US11835812

申请日：2007-08-08

申请人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

发明人： Shelley M. Cazares ,  Haresh G. Sachanandani ,  Benjamin Ettori ,  Dan Li ,  Yanting Dong

IPC分类号： A61B5/044 ,  A61B5/0452

CPC分类号： A61N1/37282 ,  A61B5/0031 ,  A61N1/3627 ,  A61N1/36585 ,  G06F19/00 ,  G06F19/3418 ,  G16H40/63

摘要： A system evaluates the performance of an implantable medical device, such as by using a remote external server and a user interface and stored historical physiological data of a population of congestive heart failure (CHF) patients. A processor is coupled to a patient data storage device to apply multiple algorithm variations against the same implantable physiological data from the patient to produce corresponding resulting CHF indicators. The user interface includes a display that is configured to display to a user information allowing comparison between the resulting CHF indicators from the multiple algorithm variations. The display also includes a population data selector to permit the user to select physiological data from a population that includes a different set of one or more patients or physiological data collected over a period of time from the patient. This permits optimization of an algorithm parameter or selection of a best performing algorithm.

摘要翻译： 系统评估可植入医疗装置的性能，例如通过使用远程外部服务器和用户界面以及存储充血性心力衰竭（CHF）患者群体的历史生理数据。 处理器耦合到患者数据存储装置，以对来自患者的相同的可植入生理数据应用多个算法变化，以产生相应的所得CHF指示符。 用户界面包括被配置为向用户显示信息的显示器，允许根据多个算法变化比较所得到的CHF指示符。 显示器还包括种群数据选择器，以允许用户从包括不同组的一个或多个患者或在患者的一段时间内收集的生理数据的群体中选择生理数据。 这允许优化算法参数或选择最佳执行算法。

公开(公告)号：US20100274149A1

公开(公告)日：2010-10-28

申请号：US12754932

申请日：2010-04-06

申请人： Dan Li ,  David L. Perschbacher ,  Yanting Dong ,  Julie Stephenson

发明人： Dan Li ,  David L. Perschbacher ,  Yanting Dong ,  Julie Stephenson

IPC分类号： A61B5/0464

CPC分类号： A61B5/0464 ,  A61B5/0006 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/686 ,  A61N1/3624 ,  A61N1/36592

摘要： An apparatus comprises an implantable cardiac signal sensing circuit configured to provide a sensed depolarization signal from a ventricle and a processor. The processor includes a signal analyzer module and a tachyarrhythmia discrimination module. The signal analyzer module is configured to determine a measure of stability of ventricular (V-V) depolarization intervals using the depolarization signal, and determine a rate of change of the measure of stability. The tachyarrhythmia discrimination module is configured to detect an episode of tachyarrhythmia using the depolarization signal, determine whether the detected tachyarrhythmia is indicative of atrial tachyarrhythmia using the determined rate of change, and provide the determination to a user or process.

摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室和处理器的感测去极化信号。 处理器包括信号分析器模块和快速心律失常辨别模块。 信号分析器模块被配置为使用去极化信号来确定心室（V-V）去极化间隔的稳定性的量度，并且确定稳定性测量的变化率。 快速心律失常辨别模块被配置为使用去极化信号来检测快速性心律失常发作，使用确定的变化率确定检测到的快速性心律失常是指示心房快速性心律失常，并且向用户或过程提供确定。

公开(公告)号：US09288134B2

公开(公告)日：2016-03-15

申请号：US13273143

申请日：2011-10-13

申请人： Chuanxiong Guo ,  Guohan Lv ,  Dan Li ,  Haitao Wu ,  Yunfeng Shi ,  Danfeng Zhang ,  Yongguang Zhang ,  Songwu Lu

发明人： Chuanxiong Guo ,  Guohan Lv ,  Dan Li ,  Haitao Wu ,  Yunfeng Shi ,  Danfeng Zhang ,  Yongguang Zhang ,  Songwu Lu

IPC分类号： H04L12/28 ,  H04L12/729 ,  H04L12/24 ,  H04L12/721 ,  H04L12/933 ,  H04L12/931

CPC分类号： H04L45/38 ,  H04L41/00 ,  H04L45/125 ,  H04L45/24 ,  H04L45/28 ,  H04L45/34 ,  H04L45/745 ,  H04L47/125 ,  H04L47/626 ,  H04L49/10 ,  H04L49/3009 ,  H04L49/356

摘要： Disclosed are systems and methods for network architecture that is a server-centric network architectural design.

摘要翻译： 公开的是以服务器为中心的网络架构设计的网络架构的系统和方法。

公开(公告)号：US09136805B2

公开(公告)日：2015-09-15

申请号：US14039208

申请日：2013-09-27

申请人： Dan Li ,  Hui Shen ,  Yang Pan

发明人： Dan Li ,  Hui Shen ,  Yang Pan

IPC分类号： H03F3/04 ,  H03G3/00 ,  H03F3/217

CPC分类号： H03F3/2175 ,  H03F1/025 ,  H03F3/217

摘要： A multi-level amplifier including a converter circuit being supplied with a supply voltage and operable to generate at least two output voltages, a voltage comparator circuit adapted to compare each of the output voltages with the supply voltage to generate a driving signal, and an amplifier circuit being supplied with an analog input signal, the amplifier circuit including an analog-to-digital converter coupled to a power stage driver and power stage, wherein the power stage driver receives the driving signal from the voltage comparator.

摘要翻译： 一种多电平放大器，包括被提供有电源电压并可操作以产生至少两个输出电压的转换器电路，电压比较器电路，其适于将每个输出电压与电源电压进行比较以产生驱动信号;以及放大器 电路被提供有模拟输入信号，放大器电路包括耦合到功率级驱动器和功率级的模数转换器，其中功率级驱动器接收来自电压比较器的驱动信号。

公开(公告)号：US09084898B2

公开(公告)日：2015-07-21

申请号：US13569208

申请日：2012-08-08

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61N1/365 ,  A61N1/362 ,  A61N1/36 ,  A61N1/39

CPC分类号： A61N1/3621 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/36564 ,  A61N1/3962

摘要： Various system embodiments comprise at least one sensor input adapted to receive at least one sensed signal associated with a tachyarrhythmia, a feature set extractor adapted to extract at least two features from the at least one sensed signal associated with the tachyarrhythmia, a feature set generator adapted to form a feature set using the at least two features extracted by the feature set extractor, at least one generator adapted for use to selectively apply an anti-tachycardia pacing (ATP) therapy and a neural stimulation (NS) therapy, and a controller adapted to respond to the feature set. The controller is adapted to initiate the NS therapy when the feature set corresponds to criteria for applying the NS therapy to modify the tachyarrhythmia, and initiate the ATP therapy to terminate the modified tachyarrhythmia. Other aspects and embodiments are provided herein.

摘要翻译： 各种系统实施例包括适于接收与快速性心律失常相关联的至少一个感测信号的至少一个传感器输入，适于从与快速性心律失常相关联的至少一个感测信号中提取至少两个特征的特征集提取器，适于 以使用由所述特征集提取器提取的所述至少两个特征来形成特征集合，适于用于选择性地应用抗心动过速起搏（ATP）治疗和神经刺激（NS）治疗）的至少一个发生器，以及适于 以响应功能集。 当特征集合对应于应用NS治疗来修改快速性心律失常的标准时，控制器适于启动NS治疗，并且启动ATP治疗以终止改变的快速性心律失常。 本文提供了其它方面和实施例。

公开(公告)号：US20150091644A1

公开(公告)日：2015-04-02

申请号：US14039208

申请日：2013-09-27

申请人： Dan Li ,  Hui Shen ,  Yang Pan

发明人： Dan Li ,  Hui Shen ,  Yang Pan

IPC分类号： H03F3/217

CPC分类号： H03F3/2175 ,  H03F1/025 ,  H03F3/217

摘要： A multi-level amplifier including a converter circuit being supplied with a supply voltage and operable to generate at least two output voltages, a voltage comparator circuit adapted to compare each of the output voltages with the supply voltage to generate a driving signal, and an amplifier circuit being supplied with an analog input signal, the amplifier circuit including an analog-to-digital converter coupled to a power stage driver and power stage, wherein the power stage driver receives the driving signal from the voltage comparator.

摘要翻译： 一种多电平放大器，包括被提供有电源电压并可操作以产生至少两个输出电压的转换器电路，电压比较器电路，其适于将每个输出电压与电源电压进行比较以产生驱动信号;以及放大器 电路被提供有模拟输入信号，放大器电路包括耦合到功率级驱动器和功率级的模数转换器，其中功率级驱动器接收来自电压比较器的驱动信号。

公开(公告)号：US08855763B2

公开(公告)日：2014-10-07

申请号：US13077229

申请日：2011-03-31

申请人： Dan Li

发明人： Dan Li

IPC分类号： A61N1/362 ,  A61N1/365

CPC分类号： A61N1/3621 ,  A61N1/365

摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including ATP. When a tachyarrhythmia episode is detected, the implantable medical device analyzes the morphology of a cardiac signal to determine whether and/or when to deliver an ATP therapy. In various embodiments, the implantable medical device produces morphological parameters indicative of the likeliness of success of the ATP therapy and selects an anti-tachyarrhythmia therapy mode based on the morphological parameters. In various embodiments, the implantable medical device also controls the timing of the ATP therapy delivery using morphological features of the cardiac signal to maximize the probability that the ATP therapy is delivered into an ATP window during which a tachyarrhythmia episode can be effectively terminated by pacing.

摘要翻译： 心律管理（CRM）系统包括可植入医疗装置，其传递包括ATP在内的抗慢性心律失常治疗。 当检测到快速性心律失常发作时，可植入医疗装置分析心脏信号的形态以确定是否和/或何时递送ATP治疗。 在各种实施例中，可植入医疗装置产生指示ATP治疗成功的可能性的形态学参数，并且基于形态参数选择抗快速性心律失常治疗模式。 在各种实施例中，可植入医疗装置还使用心脏信号的形态学特征来控制ATP治疗递送的时间，以使ATP治疗被递送到ATP窗口的可能性最大化，在此期间可以通过起搏有效地终止快速性心律失常发作。

公开(公告)号：US08838240B2

公开(公告)日：2014-09-16

申请号：US12283234

申请日：2008-09-10

申请人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

发明人： Dan Li ,  Krzysztof Siejko ,  Abhilash Patangay

IPC分类号： A61N1/36 ,  A61N1/368 ,  A61B5/0464 ,  A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： Systems and methods provide for sensing, during an event of tachycardia, hemodynamic signals concurrently from at least two spatially separated locations within a patient, and quantifying a spatial relationship between the hemodynamic signals. Hemodynamic stability or state of the patient during the tachycardia event is determined based at least in part on the quantified spatial relationship. One or more anti-tachycardia therapies to treat the tachycardia may be selected based at least in part on the determined stability or state of patient hemodynamics, and the selected one or more anti-tachycardia therapies may be delivered to treat the tachycardia. The hemodynamic signals may comprise at least two, or a mixed combination, of cardiac impedance signals, cardiac chamber pressure signals, arterial pressure signals, heart sounds; and acceleration signals.

摘要翻译： 系统和方法提供在心动过速事件期间从患者内的至少两个空间上分离的位置同时感测血液动力学信号，并且量化血液动力学信号之间的空间关系。 至少部分地基于定量的空间关系确定在心动过速事件期间患者的血流动力学稳定性或状态。 可以至少部分地基于所确定的患者血液动力学的稳定性或状态来选择治疗心动过速的一种或多种抗心动过速疗法，并且可以递送所选择的一种或多种抗心动过速疗法以治疗心动过速。 血液动力学信号可以包括心脏阻抗信号，心室压力信号，动脉压信号，心音的至少两个或混合组合; 和加速度信号。

公开(公告)号：US08712525B2

公开(公告)日：2014-04-29

申请号：US12877583

申请日：2010-09-08

申请人： Dan Li ,  Cheng Zhang

发明人： Dan Li ,  Cheng Zhang

IPC分类号： A61N1/362

CPC分类号： A61N1/3622 ,  A61N1/3712

摘要： A cardiac rhythm management (CRM) system includes an implantable medical device that delivers anti-tachyarrhythmia therapies including anti-tachyarrhythmia pacing (ATP) and a hemodynamic sensor that senses a hemodynamic signal. The implantable medical device includes a hemodynamic sensor-controlled closed-loop ATP system that uses the hemodynamic signal for ATP capture verification. When ATP pulses are delivered according to a selected ATP protocol to terminate a tachyarrhythmia episode, the implantable medical device performs the ATP capture verification by detecting an effective cardiac contraction from the hemodynamic signal. The ATP protocol is adjusted using an outcome of the ATP capture verification.

摘要翻译： 心律管理（CRM）系统包括可植入的医疗装置，其传递抗心律失常疗法，包括抗心动过速起搏（ATP）和感测血液动力学信号的血液动力学传感器。 可植入医疗装置包括血液动力学传感器控制的闭环ATP系统，其使用血流动力学信号进行ATP捕获验证。 当根据选定的ATP方案递送ATP脉冲以终止快速性心律失常发作时，可植入医疗装置通过从血液动力学信号检测有效的心脏收缩来执行ATP捕获验证。 使用ATP捕获验证的结果调整ATP方案。