公开(公告)号：US07025730B2

公开(公告)日：2006-04-11

申请号：US10419465

申请日：2003-04-21

申请人： Yong K. Cho ,  Mark K. Erickson ,  H. Toby Markowitz

发明人： Yong K. Cho ,  Mark K. Erickson ,  H. Toby Markowitz

IPC分类号： A61B5/08

CPC分类号： A61N1/3601 ,  A61N1/36514

摘要： The invention relates generally to a system and method for monitoring and automatically delivering a therapy for sleep-related disordered breathing. In one form the present invention relates to an external device for monitoring for sleep-related disordered breathing in communication with an implantable medical device for delivering an electrical stimulation therapy. In another form the present invention relates to an implantable medical device for detecting sleep-related disordered breathing episode(s) and an external apparatus (e.g., a CPAP machine) for providing therapy to terminate, and/or reduce, said episode(s). In this form of the invention, the implantable medical device communicates with the external apparatus so that the therapy provided corresponds in magnitude and duration to the severity and/or length of the episode(s). In yet another form, an implantable apparatus detects said disordered breathing episode(s) and a hybrid therapy is provided by both the implantable apparatus and an external apparatus.

摘要翻译： 本发明一般涉及用于监测和自动递送针对睡眠相关无序呼吸的治疗的系统和方法。 在一种形式中，本发明涉及一种用于监测与可植入医疗装置进行通信以进行电刺激治疗的与睡眠有关的无序呼吸的外部装置。 在另一种形式中，本发明涉及一种用于检测睡眠相关的无序呼吸发作的可植入医疗装置和用于提供终止和/或减少所述发作的治疗的外部装置（例如，CPAP机） 。 在本发明的这种形式中，可植入医疗装置与外部装置通信，使得所提供的治疗的大小和持续时间与发作的严重性和/或长度相对应。 在另一种形式中，可植入装置检测所述无序呼吸事件，并且可植入装置和外部装置都提供混合治疗。

公开(公告)号：US20110105858A1

公开(公告)日：2011-05-05

申请号：US12609688

申请日：2009-10-30

申请人： Yong K. Cho ,  Mark K. Erickson ,  Todd M. Zielinski

发明人： Yong K. Cho ,  Mark K. Erickson ,  Todd M. Zielinski

IPC分类号： A61B5/0205

CPC分类号： A61B5/0205 ,  A61B5/0215 ,  A61B5/08 ,  A61B5/4809 ,  A61B5/4818 ,  A61N1/3601

摘要： An implantable medical device and associated method detect obstructed inspiration by monitoring an blood pressure signal. A respiration signal is monitored and a phase of respiratory inspiration is detected from the respiration signal. A trend in the pressure signal is measured during the inspiration phase. Obstructed inspiration for the inspiration phase is detected in response to the measured the trend.

摘要翻译： 可植入医疗装置和相关方法通过监测血压信号来检测受阻的吸气。 监测呼吸信号，并从呼吸信号检测呼吸吸气的一个阶段。 在吸气阶段测量压力信号的趋势。 响应于测量趋势，检测到灵感阶段的阻碍灵感。

公开(公告)号：US07160252B2

公开(公告)日：2007-01-09

申请号：US10419467

申请日：2003-04-21

申请人： Yong K. Cho ,  Steven L. Ning ,  Luc R. Mongeon ,  Scott W. Davie ,  Todd J. Sheldon ,  Mark K. Erickson ,  H. Toby Markowitz

发明人： Yong K. Cho ,  Steven L. Ning ,  Luc R. Mongeon ,  Scott W. Davie ,  Todd J. Sheldon ,  Mark K. Erickson ,  H. Toby Markowitz

IPC分类号： A61B5/02 ,  A61B5/05 ,  A61B5/00

CPC分类号： A61B5/145 ,  A61B5/0205 ,  A61B5/029 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/091 ,  A61B5/4818 ,  A61M2016/0021 ,  A61M2230/04 ,  A61M2230/205 ,  A61M2230/60 ,  A61M2230/63 ,  A61M2230/65 ,  G06F19/00

摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.

摘要翻译： 一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。 该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。 可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。 呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。 心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

公开(公告)号：US07027865B2

公开(公告)日：2006-04-11

申请号：US10414908

申请日：2003-04-16

申请人： Mark K. Erickson ,  H. Toby Markowitz

发明人： Mark K. Erickson ,  H. Toby Markowitz

IPC分类号： A61N1/36

CPC分类号： A61N1/365

摘要： A method and apparatus for cardiac pacing are provided in which pacing pulses are delivered at an increased rate in response to a detected intrinsic heart rate drop and a special rate drop response detection scheme is temporarily disabled until an intrinsic heart rate exceeds a predetermined threshold value. If the pacing rate reaches the lower pacing rate without sensing intrinsic activity, heart rate drop detection remains disabled and lower rate pacing continues. Rate drop detection is re-enabled whenever sufficient sensed intrinsic activity indicates that a sudden intrinsic rate drop could occur again. Thus, the subsequent reduction in heart rate requiring therapy is declared only if a sensed intrinsic heart rate drops from above an intermediate value (herein defined as a re-enable rate) that is set above the lower pacing rate and an upper pacing rate.

摘要翻译： 提供了一种用于心脏起搏的方法和装置，其中响应于检测到的固有心率下降，以增加的速率递送起搏脉冲，并且临时禁用特殊速率下降响应检测方案，直到内在心率超过预定阈值。 如果起搏速率达不到较低的起搏速率，而不检测内在活动，心率下降检测仍然被禁用，并且较低的起搏速度继续下去。 只要足够的感知内在活动表明突然内在速率下降可能再次发生，速率下降检测就会重新启用。 因此，仅当感测到的固有心率从设定在较低起搏速率和较高起搏速率以上的中间值（在此被定义为重新启用率）上降低时才宣布要求治疗的心率的随后降低。

公开(公告)号：US5176137A

公开(公告)日：1993-01-05

申请号：US663985

申请日：1991-03-01

申请人： Mark K. Erickson ,  Tom D. Bennett

发明人： Mark K. Erickson ,  Tom D. Bennett

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/39

CPC分类号： A61N1/3962 ,  A61N1/3622 ,  A61N1/36557

摘要： A method and apparatus for discriminating between stable and unstable ventricular tachycardias based on a measurement of oxygen saturation. Reference values for average oxygen saturation level and of the pulsatile characteristic of the oxygen saturation level are taken while a patient is in a resting condition. Measurements of oxygen saturation are also taken in response to the detection of a high heart rate, and are compared to the reference measurements to discriminate between stable and unstable ventricular tachyarrhythmias. An unstable tachyarrhythmia is diagnosed if a tachycardia is diagnosed and the current oxygen saturation level is similar to the reference average oxygen saturation level or if the oxygen saturation as presently measured displays a decreased pulsatile characteristic as compared to the reference measurements. The discriminator is intended for use in conjunction with or as part of an automated cardioverter of the type capable of delivering differing therapies for termination of stable and unstable ventricular tachyarrhythmias, such as antitachycardia pacing, cardioversion and defibrillation.

摘要翻译： 一种基于氧饱和度测量来区分稳定性和不稳定性室性心动过速的方法和装置。 当患者处于静止状态时，采用平均氧饱和度水平和氧饱和度的脉动特性的参考值。 响应于高心率的检测也测量氧饱和度，并且与参考测量值进行比较以区分稳定和不稳定的室性快速性心律失常。 如果诊断出心动过速并且目前的氧饱和度水平与参考平均氧饱和度水平相似，或如果目前测量的氧饱和度与参考测量值相比显示出降低的脉动特性，则诊断出不稳定的快速性心律失常。 鉴别器旨在与能够递送用于终止稳定和不稳定的室性快速性心律失常的类型的自动心律转复器的一部分一起使用，例如抗心动过速起搏，复律和除颤。