公开(公告)号：US5211657A

公开(公告)日：1993-05-18

申请号：US267564

申请日：1988-11-07

Applicant: Yoshihiko Yamada ,  Makoto Sasaki ,  Hynda K. Kleinman ,  George R. Martin

Inventor： Yoshihiko Yamada ,  Makoto Sasaki ,  Hynda K. Kleinman ,  George R. Martin

IPC: C12N15/09 ,  A61K38/00 ,  A61L27/22 ,  A61L27/34 ,  A61L31/04 ,  A61L31/10 ,  A61P9/00 ,  A61P27/02 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/435 ,  C07K14/78 ,  C07K16/18 ,  C07K19/00 ,  C12P21/02 ,  C12R1/19

CPC classification number: A61L31/10 ,  A61L27/227 ,  A61L27/34 ,  A61L31/047 ,  C07K14/78 ,  C07K16/18 ,  A61K38/00

Abstract: The present invention relates to peptides and derivatives thereof having laminin-like activity. The invention further relates to pharmaceutical compositions containing these peptides, to antibodies effective against these peptides, and to vectors containing a DNA sequence of cDNA coding for the A chain of laminin. The peptides of the invention may be used to treat diseases such as cancer.

Abstract translation: 本发明涉及具有层粘连蛋白样活性的肽及其衍生物。 本发明还涉及含有这些肽的药物组合物，对抗这些肽有效的抗体，以及含有编码层粘连蛋白A链的cDNA的DNA序列的载体。 本发明的肽可用于治疗诸如癌症的疾病。

公开(公告)号：US5183015A

公开(公告)日：1993-02-02

申请号：US873362

申请日：1992-04-24

Applicant: Shoji Morita ,  Yoshihiko Yamada ,  Seinosuke Hara

Inventor： Shoji Morita ,  Yoshihiko Yamada ,  Seinosuke Hara

IPC: F01L13/00 ,  F01L1/26

CPC classification number: F01L1/267

Abstract: A valve operating apparatus for an engine is disclosed. The apparatus includes a rocker arm operated by a first cam and a free cam follower operated by a second cam. The rocker arm has an integral barrel having a lost motion mechanism. A prop is slidably received by the free cam follower for movement between a first position in which the prop supports the free cam follower on the lost motion mechanism and a second position in which the prop supports the free cam follower on the barrel. A hydraulically operated piston moves the prop.

Abstract translation: 公开了一种用于发动机的气门操作装置。 该装置包括由第一凸轮操作的摇臂和由第二凸轮操作的自由凸轮从动件。 摇臂具有一个具有迷失机构的整体桶。 支架可滑动地被自由凸轮从动件接收，用于在第一位置和第二位置之间运动，在第一位置，第一位置支撑着迷失运动机构上的自由凸轮从动件和第二位置，在第二位置，支架支撑筒上的自由凸轮从动件。 液压操作的活塞移动支柱。

公开(公告)号：US08801178B2

公开(公告)日：2014-08-12

申请号：US13286357

申请日：2011-11-01

Applicant: Hideo Mukai ,  Yoshihiko Yamada ,  Masaaki Hanebuchi

Inventor： Hideo Mukai ,  Yoshihiko Yamada ,  Masaaki Hanebuchi

IPC: A61B3/10 ,  A61B3/14 ,  A61B3/113

CPC classification number: A61B3/1015 ,  A61B3/113 ,  A61B3/14 ,  A61B3/156

Abstract: A fundus photographing apparatus includes a wavefront detecting optical system having a wavefront sensor for receiving reflection light from a fundus and measuring wavefront aberration of an eye, a wavefront compensating device for compensating the wavefront aberration, and a deviation detecting part for detecting deviation information corresponding to deviation between an effective region in which aberration compensation by the wavefront compensating device is effective, and a wavefront measuring region in which the wavefront aberration is measured by the wavefront detecting optical system, with respect to a direction perpendicular to an optical axial direction.

Abstract translation: 眼底摄影装置包括：波前检测光学系统，具有用于接收来自眼底的反射光并测量眼睛的波前像差的波前传感器，用于补偿波前像差的波前补偿装置;以及偏差检测部，用于检测对应于 相对于与光轴方向垂直的方向，由波前补偿装置进行像差补偿的有效区域和由波前检测光学系统测量波面像差的波前测量区域之间的偏差。

公开(公告)号：US20060201460A1

公开(公告)日：2006-09-14

申请号：US11369839

申请日：2006-03-08

Applicant: Yoshihiko Yamada

Inventor： Yoshihiko Yamada

IPC: F01L1/34

CPC classification number: F01L13/0026 ,  F01L1/022 ,  F01L1/205 ,  F01L13/0063 ,  F01L2013/0073 ,  F01L2101/00 ,  F01L2820/032

Abstract: A variable valve apparatus for an internal combustion engine including a cylinder set comprising a plurality of cylinders. The variable valve apparatus includes: a control shaft adapted for rotation; a valve actuating mechanism provided for each cylinder of the cylinder set and adapted to vary a valve lift characteristic of an engine valve of the each cylinder of the cylinder set in accordance with a rotational position of the control shaft; and a valve lift adjusting mechanism provided for each cylinder of a first subset of the cylinder set and adapted to adjust the valve lift characteristic of the engine valve of the each cylinder of the first subset in accordance with a standard valve lift characteristic determined in accordance with the valve lift characteristic of the engine valve of each cylinder of a second subset of the cylinder set.

Abstract translation: 一种用于内燃机的可变气门装置，包括包括多个气缸的气缸组。 可变气门装置包括：适于旋转的控制轴; 气缸致动机构，其设置在气缸组的每个气缸上，并适于根据控制轴的旋转位置改变气缸组的每个气缸的发动机气门的气门升程特性; 以及气缸升程调节机构，其被设置用于所述气缸组的第一子集的每个气缸，并且适于根据根据第一子集确定的标准气门升程特性来调节第一子集的每个气缸的发动机气门的气门升程特性 气缸组的第二子集的每个气缸的发动机气门的气门升程特性。

公开(公告)号：US07032551B2

公开(公告)日：2006-04-25

申请号：US11068928

申请日：2005-03-02

Applicant: Kaoru Eguchi ,  Masaru Nemoto ,  Yoshihiko Yamada ,  Tamotsu Todo

Inventor： Kaoru Eguchi ,  Masaru Nemoto ,  Yoshihiko Yamada ,  Tamotsu Todo

IPC: F01L1/34

CPC classification number: F01L13/0021 ,  F01L1/143 ,  F01L13/0026 ,  F01L2013/0073 ,  F01L2103/00

Abstract: A rocker arm 13 is rocked with respect to a control shaft 32 through a link arm 14 by rotation of a drive shaft 3. With this configuration, a rocking cam 7 is rocked with respect to the drive shaft 3 through a link member 15. A valve lifter 6 is pushed downward by rocking of the rocking cam 7. The control shaft 32 is integrally provided with a control cam which is eccentric with respect to an axis of the control shaft 32. If the control cam is rotated, a rocking fulcrum position of the rocker arm 13 is changed, thereby varying a valve-lift amount. An eccentric bush 22 is provided on an inner peripheral surface of the rocker arm 13 on an outer periphery side of the control cam. The eccentric bush 22 meshes with an inner peripheral gear formed on an inner periphery of the rocker arm 13 by an outer peripheral gear 39b, and is coupled to the rocker arm 13. This coupled state is released by moving the eccentric bush 22 in the axial direction. In this state, the eccentric bush 22 is rotated by a predetermined amount with respect to the control cam and the rocker arm 13, thereby adjusting the valve-lift amount.

Abstract translation: 通过驱动轴3的旋转，摇臂13相对于控制轴32通过连杆臂14摇摆。 利用这种构造，摆动凸轮7通过连杆构件15相对于驱动轴3摆动。 通过摇摆凸轮7的摆动来向下推动气门挺杆6。 控制轴32一体地设置有相对于控制轴32的轴线偏心的控制凸轮。 如果控制凸轮旋转，则摇臂13的摆动支点位置改变，从而改变气门升程量。 偏心衬套22设置在控制凸轮的外周侧的摇臂13的内周面上。 偏心衬套22与通过外周齿轮39b形成在摇臂13的内周上的内周齿轮啮合，并且联接到摇臂13。 通过使偏心衬套22沿轴向移动来释放该联接状态。 在这种状态下，偏心衬套22相对于控制凸轮和摇臂13旋转预定量，从而调节气门升程量。

公开(公告)号：US20050211205A1

公开(公告)日：2005-09-29

申请号：US11079187

申请日：2005-03-15

Applicant: Yoshihiko Yamada ,  Mikihiro Kajiura ,  Shigeru Kawakami

Inventor： Yoshihiko Yamada ,  Mikihiro Kajiura ,  Shigeru Kawakami

IPC: F01L1/46 ,  F01L1/34 ,  F01L9/04 ,  F01L13/00

CPC classification number: F01L1/022 ,  F01L1/34 ,  F01L13/0026 ,  F01L2013/0073 ,  F01L2101/00 ,  F01L2820/032 ,  F01L2820/041

Abstract: A variable valve system varies an operation condition of an engine valve by controlling an angular position of a control shaft in accordance with an operation condition of the engine. The system has an actuating mechanism for actuating the control shaft. The actuating mechanism comprises a mounting member that is connected to one end of the control shaft by means of bolts and has a projection projected axially in an opposite direction of the control shaft; a permanent magnet piece that is mounted on the projection thereby to rotate together with the control shaft; and a sensing device that senses a rotation condition of the permanent magnet piece.

Abstract translation: 可变阀系统通过根据发动机的操作条件控制控制轴的角位置来改变发动机气门的操作状态。 该系统具有用于致动控制轴的致动机构。 所述致动机构包括安装构件，所述安装构件通过螺栓连接到所述控制轴的一端，并且具有沿所述控制轴的相反方向轴向突出的突出部; 安装在突起上的永磁体片，与控制轴一起旋转; 以及感测永磁体片的旋转状态的感测装置。

公开(公告)号：US06305336B1

公开(公告)日：2001-10-23

申请号：US09565493

申请日：2000-05-05

Applicant: Seinosuke Hara ,  Katsuhisa Todoroki ,  Yoshihiko Yamada ,  Tsutomu Hibi

Inventor： Seinosuke Hara ,  Katsuhisa Todoroki ,  Yoshihiko Yamada ,  Tsutomu Hibi

IPC: F01L904

CPC classification number: F01L9/04

Abstract: An electromagnetic driving device of engine valve for internal combustion engine comprising an electromagnetic deriving mechanism includes a first and second electromagnets positioned opposite each other, an armature disposed in a gap formed between the electromagnets for moving therebetween, a follower having a first and second followers that are positioned opposite each other is for moving in relation to the armature, a valve associated with the armature for closing and opening an intake or exhaust passage, a first and second cams having gradually varied their profile are pivoted for contacting respective the first and second followers, a spring is disposed between the follower and the cams for urge the first and second cams toward the first and second followers, respectively. Thereby, the armature is prevented from colliding the electromagnet, and the valve capable of seating a valve seat smoothly and gently, so that the valve is possible to indicate an ideal valve lift characteristic at the end period of the valve. Therefore, this invention is possible to prevent noise, wearing and damage caused by the collision between the valve and the valve seat and between the armature and the electromagnet.

Abstract translation: 一种用于内燃机的发动机阀的电磁驱动装置，包括电磁导出机构，包括彼此相对定位的第一和第二电磁体，设置在形成在电磁体之间的间隙中的电枢，用于在它们之间移动;跟随器，具有第一和第二从动件， 彼此相对定位用于相对于电枢移动，与衔铁相关联的阀，用于关闭和打开进气或排气通道;逐渐变化其轮廓的第一和第二凸轮枢转以接触第一和第二跟随件 在所述从动件和所述凸轮之间设置弹簧，用于将所述第一和第二凸轮分别推向所述第一和第二从动件。 由此，防止电枢与电磁铁碰撞，并且能够平稳且轻轻地安置阀座的阀，使得阀可以在阀的结束期间指示理想的气门升程特性。 因此，本发明可以防止由阀和阀座之间以及电枢和电磁体之间的碰撞引起的噪声，磨损和损坏。

公开(公告)号：US06257182B1

公开(公告)日：2001-07-10

申请号：US09430131

申请日：1999-10-29

Applicant: Seinosuke Hara ,  Makoto Nakamura ,  Yoshihiko Yamada ,  Tsutomu Hibi ,  Katsuhisa Todoroki ,  Yoshiaki Miyazato

Inventor： Seinosuke Hara ,  Makoto Nakamura ,  Yoshihiko Yamada ,  Tsutomu Hibi ,  Katsuhisa Todoroki ,  Yoshiaki Miyazato

IPC: F01L904

CPC classification number: F01L9/04

Abstract: An electromagnetic drive system for repeatedly opening and closing a valve of an internal combustion engine is comprised of an electromagnetic drive mechanism and a damper mechanism. The electromagnetic drive mechanism comprises a pair of electromagnets, an armature disposed between the electromagnets and a pair of springs setting the armature at a neutral position between the electromagnets when both the electromagnets are de-energized. The electromagnets are alternately energized and de-energized according to a control signal. The damper mechanism is interlocked with the electromagnetic drive mechanism and functions to decrease a speed of displacement of the valve at a terminating period of each of a valve-closing stroke and a valve-opening stroke of the valve.

Abstract translation: 用于反复打开和关闭内燃机的阀的电磁驱动系统包括电磁驱动机构和阻尼机构。 电磁驱动机构包括一对电磁体，电枢设置在电磁体和一对弹簧之间的电枢，当两个电磁体断电时，一对弹簧将电枢设置在电磁体之间的中间位置。 电磁铁根据控制信号被交替地通电和断电。 阻尼器机构与电磁驱动机构互锁，并且用于在阀关闭行程和阀的开阀行程的终止期间减小阀的位移速度。

公开(公告)号：US6055949A

公开(公告)日：2000-05-02

申请号：US219774

申请日：1998-12-23

Applicant: Makoto Nakamura ,  Seinosuke Hara ,  Yoshihiko Yamada ,  Keisuke Takeda ,  Shinichi Takemura

Inventor： Makoto Nakamura ,  Seinosuke Hara ,  Yoshihiko Yamada ,  Keisuke Takeda ,  Shinichi Takemura

IPC: F01L13/00

CPC classification number: F01L13/0026 ,  F01L13/0021

Abstract: A variable valve actuation (VVA) apparatus for an internal combustion engine comprises a drive cam fixed to a drive shaft, a valve operating (VO) cam supported by the drive shaft for pivotal motion, and a motion transmitting mechanism interconnecting the drive cam and the VO cam. The VO cam having a cam surface that extends at least from a cam lift start point to a maximum cam lift point. The cam surface includes a first section providing a ramp section, a second section providing a positive acceleration section, and a third section providing a zero acceleration section that includes a situation where acceleration continuously vary within a predetermined infinitesimal window about zero.

Abstract translation: 用于内燃机的可变气门致动装置（VVA）包括固定在驱动轴上的驱动凸轮，由驱动轴支承以枢转运动的气门操作（VO）凸轮以及将驱动凸轮和 VO凸轮。 该VO凸轮具有至少从凸轮升程起点延伸到最大凸轮升程点的凸轮表面。 凸轮表面包括提供斜坡部分的第一部分，提供正加速部分的第二部分和提供零加速度部分的第三部分，其包括加速度在大约零的预定无限小窗口内连续变化的情况。

公开(公告)号：US6041746A

公开(公告)日：2000-03-28

申请号：US208003

申请日：1998-12-09

Applicant: Shinichi Takemura ,  Seinosuke Hara ,  Makoto Nakamura ,  Yoshihiko Yamada ,  Keisuke Takeda ,  Tetsuro Goto

Inventor： Shinichi Takemura ,  Seinosuke Hara ,  Makoto Nakamura ,  Yoshihiko Yamada ,  Keisuke Takeda ,  Tetsuro Goto

IPC: F01L13/00

CPC classification number: F01L13/0021 ,  F01L13/0026 ,  F01L13/0063 ,  Y10T74/2102

Abstract: A variable valve actuation (VVA) apparatus comprises a supporting arm to support a pivot center of a rocker arm. The rocker arm operates a valve operating (VO) cam in response to operation of a drive cam on an engine driven drive shaft. The supporting arm is mounted for angular motion about an axis of rotation of the drive shaft to move the pivot center of the rocker arm along a circle about the drive shaft axis. The VO cam is mounted for pivot motion about the drive shaft axis. A supporting arm (SA) actuator is provided to position the pivot center of the rocker arm to any angular position to shift mode of operation of the VVA apparatus.

Abstract translation: 可变气门致动（VVA）装置包括支撑臂以支撑摇臂的枢转中心。 响应于发动机驱动的驱动轴上的驱动凸轮的操作，摇臂操作阀操作（VO）凸轮。 支撑臂被安装成围绕驱动轴的旋转轴线进行角运动，以使摇臂的枢转中心沿着围绕驱动轴轴线的圆周移动。 VO凸轮被安装成围绕驱动轴轴线枢转运动。 提供支撑臂（SA）致动器以将摇臂的枢转中心定位到任何角度位置以移动VVA装置的操作模式。