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21.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases 有权与精氨酸-trna合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09593322B2
公开(公告)日：2017-03-14
申请号：US14593620
申请日：2015-01-09
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： A61K39/3955 , A61K9/19 , A61K38/00 , A61K38/53 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2319/00 , C12N9/1085 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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22.发明申请Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases 审中-公开用于治疗自身免疫性和炎性疾病的组氨酰-tRNA合成酶公开(公告)号：US20160369259A1
公开(公告)日：2016-12-22
申请号：US14998077
申请日：2015-12-23
发明人： Kyle P. Chiang , Elisabeth Gardiner , Ching-Fun Lau , Wing-Sze Lo , Jeffrey Greve , Melissa Ashlock , John D. Mendlein
IPC分类号： C12N9/00 , C12Q1/68 , A61K39/00 , G01N33/573
CPC分类号： C12N9/93 , A61K38/16 , A61K38/17 , A61K38/53 , A61K39/0008 , A61K48/00 , A61K48/005 , C12Q1/6883 , C12Q2600/158 , C12Y601/01021 , G01N33/573 , G01N2333/9015 , G01N2800/52 , Y02A50/473
摘要： The present invention relates generally to compositions and methods comprising histidyl-tRNA synthetase polypeptides or other specific blocking agents for the treatment autoimmune diseases and other inflammatory diseases, including those related to Jo-1 antibodies.
摘要翻译： 本发明一般涉及包含组氨酰-tRNA合成酶多肽或用于治疗自身免疫疾病和其它炎性疾病的其它特异性阻断剂的组合物和方法，包括与Jo-1抗体相关的那些。
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23.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetasis 有权与甲硫氨酰-tRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09422538B2
公开(公告)日：2016-08-23
申请号：US14619713
申请日：2015-02-11
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K38/53 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N5/0602 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/0101 , G01N33/573 , G01N33/68 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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24.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF LEUCYL-tRNA SYNTHETASES 有权与LEUCYL-tRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20160010075A1
公开(公告)日：2016-01-14
申请号：US14688822
申请日：2015-04-16
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , A61K2039/505 , C07K16/40 , C12Q1/527 , C12Y601/01 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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25.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF GLUTAMINYL-TRNA SYNTHETASES 有权与谷氨酰胺-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150361412A1
公开(公告)日：2015-12-17
申请号：US14689900
申请日：2015-04-17
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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26.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ALANYL TRNA SYNTHETASES 有权与ALANYL TRNA合成蛋白质蛋白相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150290305A1
公开(公告)日：2015-10-15
申请号：US14620817
申请日：2015-02-12
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： A61K38/53 , C07K14/00 , C12N9/00 , A61K35/12 , G01N33/573
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C12N5/0602 , C12N9/18 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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27.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ASPARTYL-TRNA SYNTHETASES 有权与ASPARTYL-TRNA合成蛋白片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20150252349A1
公开(公告)日：2015-09-10
申请号：US14598717
申请日：2015-01-16
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
CPC分类号： C07K16/40 , A61K38/00 , A61K38/53 , C07K2317/24 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US10196629B2
公开(公告)日：2019-02-05
申请号：US15700751
申请日：2017-09-11
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09796972B2
公开(公告)日：2017-10-24
申请号：US14620565
申请日：2015-02-12
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K14/245 , C07K14/195 , C12N15/01 , C12N9/00 , A61K38/53 , C07K16/40 , G01N33/573
CPC分类号： C12N9/93 , A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/76 , C07K2317/92 , C12Y601/00 , C12Y601/01014 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09790482B2
公开(公告)日：2017-10-17
申请号：US14688822
申请日：2015-04-16
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： G01N33/566 , C12N9/00 , C12Q1/527 , G01N33/573 , C07K16/40 , A61K38/00 , A61K39/00 , A61K38/53
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , A61K2039/505 , C07K16/40 , C12Q1/527 , C12Y601/01 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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