公开(公告)号：US20090079429A1

公开(公告)日：2009-03-26

申请号：US12232395

申请日：2008-09-17

申请人： Peter Hofer ,  Patrick Carl

发明人： Peter Hofer ,  Patrick Carl

IPC分类号： G01N24/10

CPC分类号： G01R33/60 ,  G01N24/085 ,  G01R33/44

摘要： In a method for determining an absolute number of electron spins in an extended sample (3) with the assistance of an apparatus for measuring magnetic resonance, the extended sample (3) is disposed within a measurement volume (2) of a radiofrequency RF resonator (1) of the apparatus during an electron spin resonance measurement (ESR). The method has the following steps: determining a spatial sensitivity profile f of the RF resonator (1) over the measurement volume (2); determining a resonator sensitivity constant c by means of a comparison to the measurement volume (2) of small calibration sample having a known number of electron spins at a particular position within the measurement volume (2); measuring a magnetic resonance signal RS of the extended sample (3) in the apparatus with a known spatial distribution of extended sample (3) within the measurement volume (2); weighting the magnetic resonance signal RS with the integral of the spatial sensitivity profile f of the RF resonator over the partial volume of the measurement volume (2) occupied by the extended sample (3); and determining the number of electron spins NS in extended sample (3) as a quotient between the weighted resonance signal and the resonator sensitivity constant c. The method facilitates a simpler determination of the absolute number of electron spins in the sample.

公开(公告)号：US07430872B2

公开(公告)日：2008-10-07

申请号：US11281442

申请日：2005-11-18

申请人： Marco Strobel

发明人： Marco Strobel

IPC分类号： F25B19/00 ,  F25B19/02 ,  F25D23/12

CPC分类号： H01F6/04 ,  F25B9/10 ,  F25B9/145 ,  F25B25/005 ,  F25D19/006 ,  F25D2500/02 ,  G01R33/3815

摘要： An NMR apparatus comprising a superconducting magnet coil system, in particular, an NMR spectrometer, with a cryostat which comprises an outer shell and a helium tank which contains the magnet coil system, and with an NMR probe head which is disposed in a room temperature bore of the cryostat and which contains a cooled RF resonator for receiving NMR signals from a sample to be examined and is cooled, together with the NMR probe head, by a cold head of a common, multi-stage, compressor-operated refrigerator, is characterized in that the cold head of the refrigerator is disposed in a neck tube, the upper end of which is connected to the outer shell of the cryostat and the lower end of which is connected to the helium tank in such a manner that the neck tube and the helium tank delimit a helium space, with at least one cooling circuit with thermally insulated transfer lines being provided between the helium space and the NMR probe head, wherein the cryogenic helium in the helium space is used as coolant for the cooling circuit. This produces an NMR apparatus which cools a plurality of elements at different temperature levels using only one single cryocooler to optimally utilize the cooling resources of the refrigerator.

摘要翻译： 一种NMR装置，包括超导磁体线圈系统，特别是NMR光谱仪，其具有低温恒温器，该低温恒温器包括外壳和包含磁体线圈系统的氦气罐，以及配置在室温膛内的NMR探针头 的低温恒温器，并且其包含用于从待检查的样品接收NMR信号的冷却的RF谐振器，并且与NMR探针头一起被公用的多级压缩机操作的冰箱的冷头冷却，其特征在于 因为冰箱的冷头设置在颈管中，颈管的上端连接到低温恒温器的外壳，其下端以氦气罐连接到颈管和 氦气罐限定氦空间，在氦空间和NMR探头之间至少有一个具有绝热传输线的冷却回路，其中氦气空间中的低温氦气是 用作冷却回路的冷却剂。 这产生了一种NMR装置，其使用仅一个单个低温冷却器来冷却在不同温度水平下的多个元件，以最佳地利用冰箱的冷却资源。

公开(公告)号：US07430871B2

公开(公告)日：2008-10-07

申请号：US11266360

申请日：2005-11-04

申请人： Marco Strobel

发明人： Marco Strobel

IPC分类号： F25B19/00 ,  B01D59/44 ,  H01J49/40 ,  H01F6/04

CPC分类号： F25B9/02 ,  F25B9/10 ,  F25B9/14 ,  F25B9/145 ,  F25B2309/1407 ,  F25B2309/1413 ,  F25D19/006 ,  G01R33/31 ,  H01F6/04

摘要： An NMR spectrometer comprising a magnet coil system disposed in the helium tank (8) of a cryostat and an NMR probe head (4) which is disposed in a room temperature bore of the cryostat and contains a cooled RF resonator (13) for receiving NMR signals from a sample to be examined, wherein the helium tank (8) and the NMR probe head (4) are cooled by a common, multi-stage, compressor-operated refrigerator, is characterized in that the common refrigerator comprises a cold head (6) and several heat exchangers (21, 24, 25, 28, 31, 33, 34) at different temperature levels, wherein the refrigerator is disposed at a spatial separation from the cryostat in a separate, evacuated and thermally insulated housing (5), and several cooling circuits (1a, 1b, 1c, 1d, 2a, 2b, 3a, 3b) having thermally insulated transfer lines (14a, 14b, 15) are provided between the housing (5) containing the heat exchangers (21, 24, 25, 28, 31, 33, 34) and the cryostat, and also between the housing (5) and the NMR probe head (4). The probe head and magnet cryostat of the inventive NMR spectrometer can thereby be cooled by a common refrigerator, wherein the cooling resources of the used refrigerator are optimally utilized.

摘要翻译： 一种NMR光谱仪，包括设置在低温恒温器的氦罐（8）中的磁体线圈系统和设置在低温恒温器的室温孔中的NMR探头（4），并且包含用于接收NMR的冷却的RF谐振器（13） 来自待检样品的信号，其中氦罐（8）和NMR探针头（4）由共同的多级压缩机操作的冰箱冷却，其特征在于，普通冰箱包括冷头 6）和多个不同温度水平的热交换器（21,24,25,28,31,33,34），其中所述冰箱设置在与所述低温恒温器在与分离的抽真空且隔热的壳体（5）中的空间分离处， ，并且具有隔热传输线（14a，14b，15）的几个冷却回路（1a，1b，1c，1d，2a，b，3a，3b）设置在壳体 5）包含热交换器（21,24,25,28,31,33,34）和低温恒温器，以及在 壳体（5）和NMR探针头（4）。 本发明的NMR光谱仪的探针头和磁体低温恒温器由此能够被普通的冰箱冷却，其中最佳地利用所用的冷藏库的冷却资源。

公开(公告)号：US07397247B2

公开(公告)日：2008-07-08

申请号：US11346613

申请日：2006-02-02

申请人： Marian Kloza ,  Dieter Schmalbein ,  Diether Maier

发明人： Marian Kloza ,  Dieter Schmalbein ,  Diether Maier

IPC分类号： G01V3/00

CPC分类号： G01N24/08 ,  G01R33/30

摘要： An apparatus for determining a quantitative property of a sample substance by means of magnetic resonance is disclosed. The apparatus comprises a conveyor for conveying sample containers containing the sample substance through a measuring station. The measuring station comprises a magnet system for generating a constant magnetic field of high homogeneity. The measuring station, further, comprises a probe head adapted for letting sample containers be conveyed therethrough and for generating a high frequency magnetic field. A magnetic resonance measuring unit determines the quantitative property of the sample substance contained in the probe head. The probe head excites and detects, resp., the magnetic resonance essentially only within that section of the sample container which contains the sample substance. The probe head comprises a split-ring resonator which, as seen in a conveying direction of the conveyor, has a passage cross-section for letting run the sample containers therethrough. The high frequency magnetic field is generated essentially only in an area of the passage cross-section through which the sample containers run during conveying.

摘要翻译： 公开了一种用于通过磁共振确定样品物质的定量性质的装置。 该装置包括用于通过测量站传送包含样品物质的样品容器的输送机。 测量站包括用于产生高均匀性的恒定磁场的磁体系统。 此外，测量站还包括探头，其适于使样品容器通过其传送并产生高频磁场。 磁共振测量单元确定包含在探头中的样品物质的定量性质。 探针头基本上仅在包含样品物质的样品容器的该部分内激发和检测磁共振。 探头包括开环谐振器，从输送机的输送方向看，该环形谐振器具有用于使样品容器通过的通道横截面。 高频磁场基本上仅在样品容器在传送过程中运行的通道横截面的区域中产生。

公开(公告)号：US20080011108A1

公开(公告)日：2008-01-17

申请号：US11812821

申请日：2007-06-22

申请人： Martin Hofmann

发明人： Martin Hofmann

IPC分类号： G01N35/10 ,  B01L3/00

CPC分类号： G01R33/307 ,  B01L3/565 ,  B01L2300/02 ,  B01L2300/0838 ,  G01N30/6026 ,  G01N30/6039 ,  G01N30/6078

摘要： A coupling configuration (1; 30) comprising a coupling element (3) and a supply capillary (2), wherein the coupling element (3) has a funnel-shaped section (5) which clamps an end (6) of the supply capillary (2), is characterized in that an envelope capillary (10) is provided into which the supply capillary (2) is inserted, wherein the end (6) of the supply capillary (2) projects past an end (11) of the envelope capillary (10), and the end (11) of the envelope capillary (10) is also clamped in the funnel-shaped section (5). The supply capillary is properly fixed in the coupling element and safely protected from capillary breakage.

摘要翻译： 包括耦合元件（3）和供应毛细管（2）的联接结构（1; 30），其中所述耦合元件（3）具有漏斗形部分（5），所述漏斗形截面（5）夹持所述供应毛细管 （2）的特征在于，提供包封毛细管（10），所述供应毛细管（2）插入其中，其中所述供应毛细管（2）的端部（6）突出通过所述外壳的端部（11） 毛细管（10）和包络毛细管（10）的端部（11）也夹在漏斗状部分（5）中。 供应毛细管被适当地固定在联接元件中，并且安全地防止毛细管破裂。

公开(公告)号：US20070268077A1

公开(公告)日：2007-11-22

申请号：US11438076

申请日：2006-05-19

申请人： Heinz Zeiger ,  Baudouin Dillmann

发明人： Heinz Zeiger ,  Baudouin Dillmann

IPC分类号： H03B5/12

CPC分类号： H01Q7/00 ,  G01R33/34046 ,  G01R33/34053 ,  G01R33/3635

摘要： A radio frequency coil arrangement for magnetic resonance measurements as well as a probe head for measuring resonance signals by utilizing such a radio frequency arrangement are disclosed. The radio frequency coil arrangement comprises a scroll coil having a stripe being spirally wound about a longitudinal axis, and having ends being provided with terminals for feeding and/or receiving radio frequency signals. The stripe, as seen in a plane unwound view, is configured in a Z-shape with a middle, broad section as well as two lateral, narrow sections being offset with respect to each other in a lateral direction, such that the lateral sections do not overlap in the lateral direction when the stripe is wound.

摘要翻译： 公开了一种用于磁共振测量的射频线圈装置以及通过利用这种射频布置来测量谐振信号的探头。 无线电频率线圈装置包括具有围绕纵向轴线螺旋缠绕的条带的涡旋线圈，并且端部设置有用于馈送和/或接收射频信号的端子。 如在平面展开视图中看到的条纹被配置为具有中间宽广部分的Z形，以及两个横向狭窄部分在横向方向上相对于彼此偏移，使得侧部部分 当条带缠绕时不在横向方向上重叠。

公开(公告)号：US07279900B2

公开(公告)日：2007-10-09

申请号：US11488765

申请日：2006-07-19

申请人： Gerhard Roth

发明人： Gerhard Roth

IPC分类号： G01V3/00

CPC分类号： G01R33/3815 ,  F25B9/145 ,  F25B2309/1418 ,  F25B2500/13 ,  G01R33/3804

摘要： A magnetic resonance apparatus comprising a superconducting magnet coil which is disposed in a cryostat, and a refrigerator for cooling the magnet coil, which comprises a compressor for compressing a working gas, and a high-pressure line and a low-pressure line between the compressor and a control valve, which periodically connects the high-pressure line and the low-pressure line to a connecting line from the control valve to a cold head of the refrigerator, thereby generating pressure pulses via the connected working gas, wherein the control valve is mechanically rigidly connected to the cryostat, is characterized in that one pressure reservoir is provided in the high-pressure line and/or in the low pressure line, which is mechanically rigidly connected to the cryostat and which is connected to the compressor via a mechanically flexible line section. This permits supply of a working gas to a cold head using a compressor in such a manner that the artifacts in the NMR signals caused by the pressure pulses of the working gas are minimized.

摘要翻译： 一种包括设置在低温恒温器中的超导磁体线圈和用于冷却磁体线圈的冰箱的磁共振装置，其包括用于压缩工作气体的压缩机，以及压缩机之间的高压线路和低压线路 以及控制阀，其将高压管线和低压管线周期性地连接到从控制阀到冷藏库的冷头的连接管线，从而经由连接的工作气体产生压力脉冲，其中控制阀为 机械地刚性地连接到低温恒温器，其特征在于，在高压管线和/或低压管线中设置一个压力储存器，该压力储存器机械地刚性地连接到低温恒温器，并且通过机械灵活地连接到压缩机 线段。 这允许使用压缩机向工作气体供应工作气体，使得由工作气体的压力脉冲引起的NMR信号中的伪影最小化。

公开(公告)号：US07250767B2

公开(公告)日：2007-07-31

申请号：US11144779

申请日：2005-06-06

申请人： Martin Hofmann ,  Pius Fink

发明人： Martin Hofmann ,  Pius Fink

IPC分类号： G01V3/00

CPC分类号： G01R33/307

摘要： A method for introducing a liquid sample into an NMR spectrometer to measure an NMR spectrum of the liquid sample, wherein the liquid sample is injected into a supply line and wherein further liquids are supplied into the supply line following the liquid sample, which are separated from each other and from the liquid sample by gas bubbles is characterized in that the liquid sample is supplied via an injection inlet to a valve configuration whose output side can be connected to the supply line and the further liquids and gas are supplied to the valve configuration via supply lines, wherein a desired sequence of sample segments, gas bubbles and further liquid segments is generated through temporally matched switching of the valve configuration in the supply line and is supplied to the NMR spectrometer. The inventive method realizes supply of a liquid sample into an NMR spectrometer with rapid sample transfer while thereby preventing mixing and dilution of the individual segments.

摘要翻译： 一种用于将液体样品引入NMR光谱仪中以测量液体样品的NMR光谱的方法，其中将液体样品注入供应管线，并且其中进一步的液体被供应到液体样品之后的供应管线中， 其特征在于，液体样品通过注射入口供给到阀构造，其输出侧可以连接到供应管线，并且进一步的液体和气体经由 供应管线，其中通过供应管线中的阀配置的时间匹配切换产生样品段，气泡和另外的液体段的期望序列，并将其提供给NMR光谱仪。 本发明的方法实现了将液体样品供应到具有快速样品转移的NMR光谱仪中，从而防止各个片段的混合和稀释。

公开(公告)号：US20070022761A1

公开(公告)日：2007-02-01

申请号：US11488776

申请日：2006-07-19

申请人： Klaus Schlenga ,  Claus Hanebeck

发明人： Klaus Schlenga ,  Claus Hanebeck

IPC分类号： F25B19/00

CPC分类号： F25B9/14 ,  F17C2270/0527 ,  F25B9/145 ,  F25B2309/1421 ,  F25B2400/17 ,  F25B2500/06 ,  F25D19/00 ,  F25D19/006 ,  H01F6/04 ,  Y02E60/321

摘要： A superconducting magnet system with a superconducting magnet coil system disposed in a cryogenic fluid tank (2) of a cryostat (1), and a refrigerator (6) for cooling the cryogenic fluid that cools the magnet, is characterized in that a radiation shield (5; 21; 31; 41; 51) is provided which separates a refrigerator space (4) from the cryogenic fluid tank (2), wherein the entire cooling region (9) of the refrigerator (6) is disposed in the refrigerator space (4), and wherein the radiation shield (5; 21; 31; 41; 51) has openings (11; 22; 44, 45; 53) for gas or fluid exchange between the refrigerator space (4) and the cryogenic fluid tank (2). Should the refrigerator fail, the thermal input into the cryostat is reduced, and the safety of the maintenance staff is improved in case of a quench.

摘要翻译： 具有设置在低温恒温器（1）的低温流体箱（2）中的超导磁体线圈系统的超导磁体系统和用于冷却冷却磁体的低温流体的冰箱（6）的特征在于，辐射屏蔽 5; 21; 31; 41; 51），其将冰箱空间（4）与低温流体箱（2）分开，其中，冰箱（6）的整个冷却区域（9）设置在冰箱空间 4），并且其中所述辐射屏蔽（5; 21; 31; 41; 51）具有用于在所述冰箱空间（4）和所述低温流体箱（...）之间进行气体或流体交换的开口（11; 22; 44,45; 53） 2）。 如果冰箱故障，则降低对低温恒温器的热量输入，并且在淬火的情况下维修人员的安全性得到改善。

公开(公告)号：US20060254288A1

公开(公告)日：2006-11-16

申请号：US11330163

申请日：2006-01-12

申请人： Klaus Schlenga

发明人： Klaus Schlenga

IPC分类号： F25B9/00 ,  F25B19/00 ,  F25D19/00

CPC分类号： F25B9/14 ,  F25B2309/006 ,  F25B2500/13 ,  G01R33/3815

摘要： A magnetic resonance apparatus comprising a superconducting magnet coil disposed in a cryostat, and a refrigerator for cooling same comprising a compressor (1) for compressing a working gas, and a high-pressure line (2) and a low-pressure line (3) disposed between the compressor (1) and a control valve (5), which periodically connects the high-pressure line (2) and the low-pressure line (3) to at least one connecting line (6) between the control valve (5) and a cold head (4) of the refrigerator, thereby producing pressure pulses through the switched working gas, wherein the control valve (5) and/or connecting line (6) and cold head (4) components are rigidly mechanically coupled to the cryostat, is characterized in that at least one of the above-mentioned lines (2, 3, 6) is branched on the compressor side upstream of the rigidly coupled components, and is symmetrically joined at one of the coupled components in such a manner that the pressure pulses through the working gas are vectorially compensated for at the component where the branched line is joined, thereby minimizing vibrations of the cryostat. The inventive magnetic resonance apparatus greatly reduces transmission of oscillations to the magnet coil and thereby the number and strength of artefacts in the spectra or images acquired with this magnetic resonance apparatus, to ensure high-quality magnetic resonance recordings.

摘要翻译： 一种磁共振装置，包括设置在低温恒温器中的超导磁体线圈和用于冷却的冷冻机，其包括用于压缩工作气体的压缩机（1）和高压管线（2）和低压管线（3） 设置在压缩机（1）和控制阀（5）之间，其将高压管线（2）和低压管线（3）周期性地连接到控制阀（5）之间的至少一个连接管线 ）和冰箱的冷头（4），由此产生通过切换的工作气体的压力脉冲，其中控制阀（5）和/或连接管线（6）和冷头（4）部件刚性机械地联接到 低温恒温器的特征在于，上述管线（2,3,6）中的至少一个在刚性耦合部件的上游的压缩机侧分支，并且在耦合部件之一对称地接合，使得 压力脉冲通过 在分支线连接的部件处对工作气体进行矢量补偿，从而使低温恒温器的振动最小化。 本发明的磁共振装置极大地减少了对磁体线圈的振荡传输，从而大大降低了使用该磁共振装置获得的光谱或图像中的伪影的数量和强度，以确保高质量的磁共振记录。