公开(公告)号：US20050280416A1

公开(公告)日：2005-12-22

申请号：US11144779

申请日：2005-06-06

申请人： Martin Hofmann ,  Pius Fink

发明人： Martin Hofmann ,  Pius Fink

IPC分类号： G01R33/30 ,  G01V3/00

CPC分类号： G01R33/307

摘要： A method for introducing a liquid sample into an NMR spectrometer to measure an NMR spectrum of the liquid sample, wherein the liquid sample is injected into a supply line and wherein further liquids are supplied into the supply line following the liquid sample, which are separated from each other and from the liquid sample by gas bubbles is characterized in that the liquid sample is supplied via an injection inlet to a valve configuration whose output side can be connected to the supply line and the further liquids and gas are supplied to the valve configuration via supply lines, wherein a desired sequence of sample segments, gas bubbles and further liquid segments is generated through temporally matched switching of the valve configuration in the supply line and is supplied to the NMR spectrometer. The inventive method realizes supply of a liquid sample into an NMR spectrometer with rapid sample transfer while thereby preventing mixing and dilution of the individual segments.

摘要翻译： 一种用于将液体样品引入NMR光谱仪中以测量液体样品的NMR光谱的方法，其中将液体样品注入供应管线，并且其中进一步的液体被供应到液体样品之后的供应管线中， 其特征在于，液体样品通过注射入口供给到阀构造，其输出侧可以连接到供应管线，并且进一步的液体和气体经由 供应管线，其中通过供应管线中的阀配置的时间匹配切换产生样品段，气泡和另外的液体段的期望序列，并将其提供给NMR光谱仪。 本发明的方法实现了将液体样品供应到具有快速样品转移的NMR光谱仪中，从而防止各个片段的混合和稀释。

公开(公告)号：US07250767B2

公开(公告)日：2007-07-31

申请号：US11144779

申请日：2005-06-06

申请人： Martin Hofmann ,  Pius Fink

发明人： Martin Hofmann ,  Pius Fink

IPC分类号： G01V3/00

CPC分类号： G01R33/307

摘要： A method for introducing a liquid sample into an NMR spectrometer to measure an NMR spectrum of the liquid sample, wherein the liquid sample is injected into a supply line and wherein further liquids are supplied into the supply line following the liquid sample, which are separated from each other and from the liquid sample by gas bubbles is characterized in that the liquid sample is supplied via an injection inlet to a valve configuration whose output side can be connected to the supply line and the further liquids and gas are supplied to the valve configuration via supply lines, wherein a desired sequence of sample segments, gas bubbles and further liquid segments is generated through temporally matched switching of the valve configuration in the supply line and is supplied to the NMR spectrometer. The inventive method realizes supply of a liquid sample into an NMR spectrometer with rapid sample transfer while thereby preventing mixing and dilution of the individual segments.

摘要翻译： 一种用于将液体样品引入NMR光谱仪中以测量液体样品的NMR光谱的方法，其中将液体样品注入供应管线，并且其中进一步的液体被供应到液体样品之后的供应管线中， 其特征在于，液体样品通过注射入口供给到阀构造，其输出侧可以连接到供应管线，并且进一步的液体和气体经由 供应管线，其中通过供应管线中的阀配置的时间匹配切换产生样品段，气泡和另外的液体段的期望序列，并将其提供给NMR光谱仪。 本发明的方法实现了将液体样品供应到具有快速样品转移的NMR光谱仪中，从而防止各个片段的混合和稀释。

公开(公告)号：US09023996B2

公开(公告)日：2015-05-05

申请号：US13518779

申请日：2010-12-23

申请人： Ludger Grosse-Hovest ,  Hans-Joerg Buehring ,  Martin Hofmann ,  Steffen Aulwurm ,  Grundram Jung

发明人： Ludger Grosse-Hovest ,  Hans-Joerg Buehring ,  Martin Hofmann ,  Steffen Aulwurm ,  Grundram Jung

IPC分类号： C07K16/28 ,  C07K16/30 ,  C12N5/10 ,  C12N15/13 ,  A61K39/00

CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/72 ,  C07K2317/732

摘要： The present invention relates to anti-FLT3 antibodies with a modified Fc region comprising the amino acid substitutions 239D and 332E to enhance antibody-dependent cell cytotoxicity (ADCC) of these antibodies. The invention further relates to pharmaceutical compositions containing these antibodies, nucleic acids encoding these antibodies as well as methods of using such antibodies.

摘要翻译： 本发明涉及具有包含氨基酸取代239D和332E的修饰的Fc区的抗FLT3抗体以增强这些抗体的抗体依赖性细胞毒性（ADCC）。 本发明还涉及含有这些抗体的药物组合物，编码这些抗体的核酸以及使用这些抗体的方法。

公开(公告)号：US07248050B2

公开(公告)日：2007-07-24

申请号：US11144777

申请日：2005-06-06

申请人： Martin Hofmann ,  Manfred Spraul

发明人： Martin Hofmann ,  Manfred Spraul

IPC分类号： G01V3/00

CPC分类号： G01R33/307 ,  G01R33/31

摘要： The invention concerns an NMR apparatus (1) comprising an NMR spectrometer (2) for sequential investigation of several samples in sample containers (6) of substantially identical geometrical design, at a measuring position (10) in the NMR spectrometer (2) comprising a supply line (8) for pneumatic supply of the sample containers (6) from a magazine (3) to the measuring position (10). The apparatus is characterized in that the magazine (3) is disposed within a temperature-controlled cabinet, in particular, a cold chamber (4) and the supply line (8) can be heated. This substantially increases the throughput of samples of the NMR apparatus (1) with simple technical means.

摘要翻译： 本发明涉及一种NMR装置（1），其包括NMR光谱仪（2），用于在NMR光谱仪（2）中的测量位置（10）处对具有基本相同几何设计的样品容器（6）中的若干样品进行顺序研究，所述测量位置包括 用于将样品容器（6）从料盒（3）向测量位置（10）气动供给的供应管线（8）。 该装置的特征在于，盒（3）设置在温度控制的柜内，特别是冷室（4）中，并且可以加热供应管线（8）。 这通过简单的技术手段大大增加了NMR装置（1）的样品的通过量。

公开(公告)号：US07096886B2

公开(公告)日：2006-08-29

申请号：US10650111

申请日：2003-08-26

申请人： Martin Hofmann

发明人： Martin Hofmann

IPC分类号： F16K11/072

CPC分类号： G01N30/20 ,  G01N2030/201 ,  G01N2030/204 ,  Y10T137/5762 ,  Y10T137/86863

摘要： A multiport switching valve for a liquid flow system is described, comprising a first member having a plurality of ports for connecting liquid lines thereto, a second member, connected with a first member and movable relative to the first member, the second member comprising a plurality of channels, wherein the channels are arranged such that, according to a selected relative position between the first and second member, one or more of said channel connect predetermined ones of the ports of the first member with one another in a liquid conducting manner. The first member comprises at least one group of ports arranged in one substantially straight line or at least two adjacent substantially parallel and substantially straight lines, and the second member comprises a plurality of segments, wherein the segments have one or more channels arranged therein, the channel or channels of each segment representing a predetermined connection scheme for connecting predetermined ones of the ports with one another.

摘要翻译： 描述了一种用于液体流动系统的多端口切换阀，包括具有用于连接液体管线的多个端口的第一部件，与第一部件连接并可相对于第一部件移动的第二部件，第二部件包括多个 的通道，其中所述通道被布置成使得根据所述第一和第二构件之间的选定的相对位置，所述通道中的一个或多个将所述第一构件的所述端口中的预定端口以液体导通方式彼此连接。 第一构件包括布置在一个基本上直线或至少两个相邻的基本上平行和基本上直线的至少一组端口，并且第二构件包括多个段，其中段具有布置在其中的一个或多个通道， 每个段的通道或通道表示用于将预定端口彼此连接的预定连接方案。

公开(公告)号：US06671053B1

公开(公告)日：2003-12-30

申请号：US10009589

申请日：2001-12-11

申请人： Arno Euteneuer ,  Harald Giessen ,  Martin Hofmann

发明人： Arno Euteneuer ,  Harald Giessen ,  Martin Hofmann

IPC分类号： G01B902

CPC分类号： G01J9/04 ,  G01J11/00

摘要： In a method for influencing and measuring pulsed electromagnetic illumination, e.g. parallel laser light (L), said illumination or light can be spatially divided, in particular, in an autocorrelator comprising a beam receptor (12), can be recombined behind said beam receptor by a superposition or focusing device (18 or 58) and can be detected in the recombinant area by a detector (20). As the transmission system (52), the beam receptor comprises beam profile dividers in a penetrable housing (50), in the form of at least two transmission parts (54; 56), with or in which separate, preferably parallel component beams (S, T) can be modified in their time-based beam characteristics, before being recombined. The inventive beam receptor (12) preferably has at least a two-part mirror (22), plate (32), chamber or crystal system (42) comprising a beam profile divider (14, 24, 34, 44) which creates or leaves unchanged a base component beam (S), whilst the time-based characteristics of this or every other component beam (T) in a neighbouring beam profile divider (16, 26, 36, 46) can be controlled in a different manner, in order to effect, in particular, reflection or transmission delays and/or changes to the optical paths.

摘要翻译： 在用于影响和测量脉冲电磁照明的方法中，例如， 平行激光（L），所述照明或光可以在空间上划分，特别是在包括光束接收器（12）的自相关器中，可以通过叠加或聚焦装置（18或58）在所述光束接收器的后面重新组合，并且可以 通过检测器（20）在重组区域中检测。 作为传动系统（52），梁接收器包括在可穿透壳体（50）中的梁型材分隔件，其形式为至少两个传动部件（54; 56），其具有或分开的，优选地平行的部件梁（S ，T）可以在其重新组合之前以其基于时间的光束特性进行修改。 本发明的光束接收器（12）优选地具有至少两部分反射镜（22），板（32），室或晶体系统（42），其包括产生或离开的光束分布分隔器（14,24,34,44） 基本分量光束（S）不变，而相邻光束分布分割器（16,26,36,46）中的该或每个其它分量光束（T）的基于时间的特性可以以不同的方式按照 特别是影响光路的反射或传输延迟和/或变化。

公开(公告)号：US5118186A

公开(公告)日：1992-06-02

申请号：US652663

申请日：1991-02-08

申请人： Josef Schratzenstaller ,  Otto Ambrosius ,  Martin Hofmann ,  Heinz-Gunther Franz ,  Horst Laucht ,  Robert Rieger ,  Reinhard Seiferth

发明人： Josef Schratzenstaller ,  Otto Ambrosius ,  Martin Hofmann ,  Heinz-Gunther Franz ,  Horst Laucht ,  Robert Rieger ,  Reinhard Seiferth

IPC分类号： F41G3/32

CPC分类号： F41G3/326 ,  F41G3/323

摘要： A method and apparatus for adjusting an aiming telescope and a laser range finder with a weapon system which is equipped with a weapon computer, a data memory and a computer-controlled graticule adjusting device. Laser beams are fired consecutively by a collimation line testing device and by the laser range finder, into a collimator. A reference reticle or an aiming graticule of the aiming telescope are aligned with the laser beam images in the collimator, and the aligned position is stored in the data memory.

摘要翻译： 一种用于调整瞄准望远镜和具有武器系统的激光测距仪的方法和装置，其配备有武器计算机，数据存储器和计算机控制的刻度调节装置。 激光束由准直线测试装置和激光测距仪连续射出成准直仪。 瞄准望远镜的参考掩模版或瞄准刻线与准直仪中的激光束图像对准，对准位置存储在数据存储器中。

公开(公告)号：US08766631B2

公开(公告)日：2014-07-01

申请号：US12998713

申请日：2009-11-27

申请人： Martin Hofmann ,  Simon Benedict Duckett ,  Antonio Gianotti ,  Gary George Reginald Green

发明人： Martin Hofmann ,  Simon Benedict Duckett ,  Antonio Gianotti ,  Gary George Reginald Green

IPC分类号： G01V3/00

CPC分类号： G01R33/307 ,  G01R33/282 ,  G01R33/5605

摘要： The invention relates to a device (1, 21, 31, 41, 64) for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (10), including—a flow-through NMR probehead (2), with a first tube (3) and a second tube (14) each for the supply and removal of a liquid NMR measurement sample (10),—at least one chamber (4, 22, 32) which is connected to one of the tubes (3, 14),—a sample inlet (5) for introducing the liquid measurement sample (10) into the device (1, 21, 31, 41, 64), wherein at least one chamber (4, 22, 32) has at least one connection for increasing (9, 24, 25, 42, 43, 46, 47) and releasing (8, 23, 27, 48a, 48b) the gas pressure, and in which at least one chamber (4, 22, 32) comprises means for mixing the liquid measurement sample (10) contained in the chamber (4, 22, 32) with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.

摘要翻译： 本发明涉及一种用于制备和测量核自旋共振（NMR）测量样品（10）的装置（1,21,31,41,64），其包括流通的NMR探针头（2），其中具有 第一管（3）和第二管（14），每个用于供应和去除液体NMR测量样品（10）; - 至少一个室（4,22,32），其连接到管中的一个 ，14）， - 用于将所述液体测量样品（10）引入所述装置（1,21,31,41,64）中的样品入口（5），其中至少一个室（4,22,32）至少具有 一个用于增加（9,24,25,42,43,46,47）和释放（8,23,27,48a，48b）气体压力的连接，并且其中至少一个室（4,22,32） 包括用于将容纳在腔室（4,22,32）中的液体测量样品（10）与气体混合的装置利用本发明的装置，当对其中的液体测量样品进行NMR光谱测量时，可以减少测量样品消耗， 旋转 可以催化转移。

公开(公告)号：US20110006770A1

公开(公告)日：2011-01-13

申请号：US12923321

申请日：2010-09-15

申请人： Martin Hofmann ,  Thorsten Marquardsen

发明人： Martin Hofmann ,  Thorsten Marquardsen

IPC分类号： G01R33/48

CPC分类号： G01R33/307 ,  B01L3/565 ,  B01L2300/02 ,  B01L2300/0838 ,  G01N30/6026 ,  G01N30/6039 ,  G01N30/6078

摘要： A method for measuring an sample in an NMR spectrometer uses a coupling configuration (1; 30) comprising a coupling element (3) and a supply capillary (2), wherein the coupling element (3) has a funnel-shaped section (5) which clamps an end (6) of the supply capillary (2). An envelope capillary (10) is provided into which the supply capillary (2) is inserted, wherein the end (6) of the supply capillary (2) projects past an end (11) of the envelope capillary (10), and the end (11) of the envelope capillary (10) is also clamped in the funnel-shaped section (5).

摘要翻译： 用于在NMR光谱仪中测量样品的方法使用包括耦合元件（3）和供应毛细管（2）的耦合结构（1; 30），其中耦合元件（3）具有漏斗形截面（5） 其夹紧供应毛细管（2）的端部（6）。 提供了一种信封毛细管（10），其中插入供应毛细管（2），其中供应毛细管（2）的端部（6）突出穿过包络毛细管（10）的端部（11），并且端部 信封毛细管（10）的（11）也夹在漏斗形部分（5）中。

公开(公告)号：US07608462B2

公开(公告)日：2009-10-27

申请号：US11114150

申请日：2005-04-26

申请人： Martin Hofmann ,  Werner Maas

发明人： Martin Hofmann ,  Werner Maas

IPC分类号： G01N33/50 ,  G01N21/27

CPC分类号： G01N1/405 ,  F26B21/007 ,  G01N30/6043 ,  G01N30/6091 ,  G01N2001/4061 ,  G01N2030/009 ,  G01R33/30 ,  Y10T436/143333 ,  Y10T436/25 ,  Y10T436/25125 ,  Y10T436/25375 ,  Y10T436/255

摘要： A method for spectrometric investigation of a plurality of samples dissolved in a solvent comprises: (a) guiding a first solvent with a sample through an SPE cartridge for concentrating the sample in the cartridge; (b) positioning the cartridge in a carrier for a plurality of cartridges; (c) repeating steps (a) and (b) for a desired number of samples; (d) drying the concentrated samples through removal of the residual first solvent, in particular, dehydration or evaporation; (e) dissolving each sample in a second solvent, transferring these dissolved samples from the cartridges to a spectrometer and acquiring a spectrum of each sample. All samples are dried together in step (d) subsequent to steps (b) and (c) while the cartridges with samples are positioned in the carrier. The drying process is thereby considerably accelerated in a straightforward technical manner.

摘要翻译： 用于溶解在溶剂中的多个样品的光谱测量方法包括：（a）通过SPE柱引导具有样品的第一溶剂，以将样品集中在所述盒中; （b）将盒定位在用于多个盒的载体中; （c）对所需数量的样品重复步骤（a）和（b）; （d）通过除去残留的第一溶剂，特别是脱水或蒸发来干燥浓缩的样品; （e）将每个样品溶解在第二溶剂中，将这些溶解的样品从筒中转移到光谱仪中并获取每个样品的光谱。 所有样品在步骤（b）和（c）之后的步骤（d）中一起干燥，而样品盒位于载体中。 因此，干燥过程以直接的技术方式大大加速。