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634 条记录 (耗时 0.049 秒)

    Cyclic GMP phosphodiesterase
    21.
    发明申请
    Cyclic GMP phosphodiesterase 失效
    循环GMP磷酸二酯酶

    公开(公告)号：US20020007046A1

    公开(公告)日：2002-01-17

    申请号：US09802741

    申请日：2001-03-08

    申请人： Incyte Pharmaceuticals, Inc.

    发明人： Douglas A. Fisher ,  Douglas H. Gooding ,  David Gray Streeter

    IPC分类号： C12Q001/68 ,  C12Q001/42 ,  C12N009/16

    CPC分类号： C12N9/16 ,  A61K38/00

    摘要： The invention provides a human cyclic GMP phosphodiesterase (PDE9A) and polynucleotides which identify and encode PDE9A. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for treating or preventing disorders associated with expression of PDE9A.

    摘要翻译： 本发明提供了人类环状GMP磷酸二酯酶（PDE9A）和识别和编码PDE9A的多核苷酸。 本发明还提供表达载体，宿主细胞，抗体，激动剂和拮抗剂。 本发明还提供了治疗或预防与PDE9A表达相关的病症的方法。

    Novel subunits of NADH dehydrogenase
    22.
    发明申请
    Novel subunits of NADH dehydrogenase 审中-公开
    NADH脱氢酶的新亚基

    公开(公告)号：US20010041356A1

    公开(公告)日：2001-11-15

    申请号：US09726899

    申请日：2000-11-29

    申请人： Incyte Pharmaceuticals, Inc

    发明人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    IPC分类号： C12P021/08 ,  C07K016/44 ,  A61K039/395

    CPC分类号： C12N9/0036 ,  A61K38/00

    摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.

    摘要翻译： 本发明提供四种NADH脱氢酶亚基（分别称为NDS-1，NDS-2，NDS-3和NDS-4，统称为NDS）和鉴定和编码NDS的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码NDS的核酸序列和产生NDS的方法的宿主细胞。 本发明还提供使用NDS和特异性结合NDS的激动剂，抗体或拮抗剂来预防和治疗与NDS表达相关的疾病。 另外，本发明提供反义分子用于编码NDS的多核苷酸用于治疗与NDS表达相关的疾病。 本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合NDS的抗体的诊断测定法。

    Histone fusion protein
    26.
    发明授权
    Histone fusion protein 失效
    组蛋白融合蛋白

    公开(公告)号：US6136314A

    公开(公告)日：2000-10-24

    申请号：US353688

    申请日：1999-07-14

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12P21/06 ,  C07H21/04 ,  C07K1/00 ,  C12N1/20 ,  C12N15/00

    CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00

    摘要： The present invention provides a human histone fusion protein (HFP) and polynucleotides which identify and encode HFP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing HFP and for treating or preventing disorders associated with expression of HFP.

    摘要翻译： 本发明提供了人组蛋白融合蛋白（HFP）和识别和编码HFP的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明还提供了用于生产HFP和用于治疗或预防与HFP表达相关的病症的方法。

    Human cytochrome b5
    29.
    发明授权
    Human cytochrome b5 失效
    人细胞色素b5

    公开(公告)号：US6083704A

    公开(公告)日：2000-07-04

    申请号：US178881

    申请日：1998-10-26

    申请人： Jennifer L. Hillman ,  Surya K. Goli ,  David Gray Streeter

    发明人： Jennifer L. Hillman ,  Surya K. Goli ,  David Gray Streeter

    IPC分类号： A61K38/00 ,  C07K14/80 ,  C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C07K14/80 ,  A61K38/00

    摘要： The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCBS. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.

    摘要翻译： 本发明提供人细胞色素b5（HCB5）和编码HCB5的多核苷酸。 本发明还提供基因工程表达载体和宿主细胞以及生产HCBS的方法。 本发明还提供HCB5的激动剂，反义分子，抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。 本发明还提供了一种检测编码HCB5的多核苷酸的方法。