公开(公告)号：US07678544B2

公开(公告)日：2010-03-16

申请号：US11131952

申请日：2005-05-18

申请人： Ulla M. Wewer ,  Bent Nørgaard-Pedersen ,  Michael Christiansen ,  Jennie Laigaard ,  Camilla Fröhlich ,  Kevin Spencer

发明人： Ulla M. Wewer ,  Bent Nørgaard-Pedersen ,  Michael Christiansen ,  Jennie Laigaard ,  Camilla Fröhlich ,  Kevin Spencer

IPC分类号： G01N33/53 ,  C07K14/00

CPC分类号： G01N33/689 ,  G01N2333/4745 ,  G01N2333/96486 ,  G01N2800/36 ,  G01N2800/368 ,  G01N2800/385 ,  G01N2800/387 ,  Y10T436/143333

摘要： The present invention provides a method, an assay and a kit for providing an indication of abnormal cell function. It was surprisingly found that the change in the serum ADAM12 concentration in individuals was useful as a prognostic tool to predict the clinical outcome, complications and mortality following an abnormal cell function.The present inventors describes ADAM12 as a overall general marker for abnormal cell function, and the present inventor for the first time demonstrate that ADAM12 is an important indicator of fetal chromosomal disease and placenta function. Specifically ADAM12 is a good marker for e.g. Downs's syndrome, trisomy 18, preeclampsia, Turner syndrome in both first and second trimester.The present inventors developed an enzyme-linked immunosorbent assay (ELISA) and a time-resolved immunofluorometric assay for the quantification of ADAM12 in serum.The present application demonstrates in several examples the variation of the ADAM12 level in fetal abnormality and/or adverse pregnancy outcomes correlated gestational age when compared to normal controls. It is an object of the invention to provide an improvement of the existing marker tests that exhibits a decreased false positive rate.

摘要翻译： 本发明提供了用于提供异常细胞功能指示的方法，测定和试剂盒。 惊奇地发现，个体中血清ADAM12浓度的变化可用作预测异常细胞功能后的临床结果，并发症和死亡率的预后工具。 本发明人描述了ADAM12作为异常细胞功能的总体标准，本发明人首次证明ADAM12是胎儿染色体病和胎盘功能的重要指标。 具体地说，ADAM12是例如， 唐氏综合征，18三体，先兆子痫，特纳综合征在第一和第二个三个月。 本发明人开发了用于定量血清中ADAM12的酶联免疫吸附测定（ELISA）和时间分辨免疫荧光测定法。 本申请在几个例子中表明，与正常对照相比，胎儿异常和/或不良妊娠结局中ADAM12水平的变化与孕龄相关。 本发明的一个目的是提供现有标记物测试的改进，其显示出降低的假阳性率。

公开(公告)号：US20090307788A1

公开(公告)日：2009-12-10

申请号：US12305266

申请日：2007-06-19

申请人： Henrik Nielsen

发明人： Henrik Nielsen

IPC分类号： A01K67/027 ,  A01H5/00 ,  C07H21/04 ,  C07H21/02 ,  C12N15/63 ,  C12N5/10 ,  C12N5/08 ,  C12P21/06 ,  A61K35/12 ,  C12N5/02 ,  C12N1/21 ,  C12N1/19 ,  C12N1/15

CPC分类号： C12N15/111 ,  C12N9/00 ,  C12N15/113 ,  C12N2310/124 ,  C12N2330/10

摘要： The present invention relates to the production of novel, recombinant polynucleotides comprising the GIR1 ribozyme, or a variant thereof, vectors comprising such polynucleotides and recombinant host cells comprising such polynucleotides and/or such vectors. The invention furthermore relates to the use of said polynucleotides in the treatment of an individual suffering from a disease associated with or caused by instability of a transcript of said second subsequence such as cancer, cachexia, α-Thallasemia or leukaemia.

摘要翻译： 本发明涉及包含GIR1核酶或其变体的包含此类多核苷酸的载体和包含此类多核苷酸和/或此类载体的重组宿主细胞的新型重组多核苷酸的生产。 本发明还涉及所述多核苷酸在治疗患有与所述第二子序列（例如癌症，恶病质，α-硫代血症或白血病）的转录物不稳定相关或由其引起的疾病的个体中的用途。

公开(公告)号：US20080182323A1

公开(公告)日：2008-07-31

申请号：US12102976

申请日：2008-04-15

申请人： Claus Felby ,  Jan Larsen ,  Henning Jergensen ,  Jakob Vibe-Pedersen

发明人： Claus Felby ,  Jan Larsen ,  Henning Jergensen ,  Jakob Vibe-Pedersen

IPC分类号： C08B37/00

CPC分类号： C12P19/12 ,  C12P7/10 ,  C12P19/14 ,  Y02E50/16 ,  Y02E50/343

摘要： Disclosed are processes for liquefaction and saccharification of polysacharide containing biomasses having high dry matter content (>20%) and preferably possessing large average particle size. The polysaccharide containing biomasses are subject to enzymatic hydrolysis in a mixer that utilizes “free fall” mixing. “Free fall” mixing provides mechanical degradation of the biomass during hydrolysis and, in the case of lignocellulosic biomass, promotes movement of cellulase enzymes along cellulose chains, which improves enzymatic hydrolysis at high dry matter.

摘要翻译： 公开了具有高干物质含量（> 20％）且优选具有大的平均粒度的含有多糖的生物质的液化和糖化的方法。 含有多糖的生物质在利用“自由落体”混合的混合器中进行酶水解。 “自由落体”混合在水解期间提供生物质的机械降解，并且在木质纤维素生物质的情况下促进纤维素酶沿着纤维素链的移动，这改善了在高干物质下的酶水解。

公开(公告)号：US20080138862A1

公开(公告)日：2008-06-12

申请号：US11720079

申请日：2005-11-07

申请人： Claus Felby ,  Jan Larsen ,  Henning Jorgensen ,  Jakob Vibe-Pedersen

发明人： Claus Felby ,  Jan Larsen ,  Henning Jorgensen ,  Jakob Vibe-Pedersen

IPC分类号： C12P19/00

CPC分类号： C12P19/12 ,  C12P7/10 ,  C12P19/14 ,  Y02E50/16 ,  Y02E50/343

摘要： The present invention relates to a process for liquefaction and saccharification of polysaccharide containing biomasses, having a relatively high dry matter content. The present invention combines enzymatic hydrolysis with a type of mixing relying on the principle of gravity ensuring that the biomasses are subjected to mechanical forces, primarily shear and tear forces. Furthermore, the present invention relates to the further utilisation of such processed biomasses, e.g. for subsequent fermentation into bio-ethanol, bio-gas, specialty carbohydrates for food and fees as well as carbon feedstock for processing into plastics and chemicals.

摘要翻译： 本发明涉及具有相对高的干物质含量的含多糖的生物质的液化和糖化方法。 本发明根据重力原理将酶水解与一种混合相结合，确保生物质受到机械力，主要是剪切力和撕裂力。 此外，本发明涉及进一步利用这种经处理的生物质，例如， 用于随后发酵成生物乙醇，生物气体，特殊碳水化合物用于食品和费用以及用于加工成塑料和化学品的碳原料。

公开(公告)号：US20020150914A1

公开(公告)日：2002-10-17

申请号：US09957113

申请日：2001-09-19

申请人： Kobenhavns Universitet

发明人： Peter Sejer Andersen ,  Soren Buus ,  Jan Engberg ,  Lars Fugger ,  Anette Stryhn

IPC分类号： C12Q001/68 ,  C07H021/04 ,  C12P019/34 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K16/00 ,  A61K38/00 ,  C07K14/70539

摘要： The invention relates to a method of producing an antibody or an antibody fragment specifically recognizing a peptide-MHC complex. It also relates to antibodies and antibody fragments according to the invention that are conjugated to a pharmaceutical or to a superantigen. The invention relates to a pharmaceutical composition comprising antibodies or antibody fragments a according to the invention for the prevention or treatment of infectious and autoimmune diseases, cancer and to compositions for the diagnosis of said diseases.

摘要翻译： 本发明涉及产生抗体或特异性识别肽-MHC复合物的抗体片段的方法。 它还涉及与药物或超抗原缀合的根据本发明的抗体和抗体片段。 本发明涉及包含根据本发明的用于预防或治疗感染性和自身免疫疾病，癌症和用于诊断所述疾病的组合物的抗体或抗体片段a的药物组合物。

公开(公告)号：US09660721B2

公开(公告)日：2017-05-23

申请号：US14328871

申请日：2014-07-11

申请人： Kobenhavns Universitet

发明人： Eugene Simon Polzik ,  Albert Schliesser ,  Silvan Schmid ,  Anders Sondberg Sorensen ,  Jacob M. Taylor ,  Koji Usami ,  Tolga Bagci ,  Anders Simonsen ,  Luis Guillermo Villanueva ,  Emil Zeuthen ,  Juergen Appel

IPC分类号： H04B10/00

CPC分类号： H04B10/00 ,  H04B2210/006

摘要： An optical detector for detecting radio frequency (RF) signals, the optical detector comprising a light source and a photodetector, and an electrical circuit comprising a position dependent capacitor and a bias voltage source adapted for providing a bias voltage for biasing the position dependent capacitor, the position dependent capacitor comprising an electrode and a membrane being displaceable in reaction to RF signals incident on the membrane, the membrane being metallized, has a thickness of less than 1 μm and a quality factor, Qm, of at least 20,000, and the distance between the membrane and the electrode being less than 10 μm.

公开(公告)号：US09573984B2

公开(公告)日：2017-02-21

申请号：US14585369

申请日：2014-12-30

申请人： Rigshospitalet ,  Kobenhavns Universitet ,  Syddansk Universitet

发明人： Peter Garred ,  Tina Hummelshoj Glue ,  Mikkel-Ole Skjodt

IPC分类号： A61K38/36 ,  A61K38/00 ,  A61P7/08 ,  A61P43/00 ,  A61K38/14 ,  A61K35/14 ,  A61K38/16 ,  C07K1/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C12P21/08 ,  C07K14/47 ,  A61K38/17 ,  A61K45/06

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K38/1725 ,  A61K45/06 ,  C07K14/472 ,  C07K14/4726 ,  C07K14/70596 ,  C07K14/8121 ,  C07K2319/01 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/70 ,  Y02A50/385 ,  Y02A50/411

摘要： The present invention relates to novel chimeric molecules of ficolin-associated polypeptides, such as fusion polypeptides for the use in the treatment of conditions associated with inflammation, apoptosis, autoimmunity, coagulation, thrombotic or coagulopathic related diseases. The present invention further relates to nucleic acid molecules encoding such fusion polypeptides, vectors and host cells used in the production of the fusion polypeptides.

摘要翻译： 本发明涉及ficolin相关多肽的新型嵌合分子，例如用于治疗与炎症，细胞凋亡，自身免疫，凝血，血栓形成或凝血病相关疾病相关的病症的融合多肽。 本发明还涉及编码这种融合多肽的核酸分子，用于产生融合多肽的载体和宿主细胞。

公开(公告)号：US20160011044A1

公开(公告)日：2016-01-14

申请号：US14328871

申请日：2014-07-11

申请人： Kobenhavns Universitet

发明人： Eugene Simon POLZIK ,  Albert SCHLIESSER ,  Silvan SCHMID ,  Anders Sondberg SORENSEN ,  Jacob M. TAYLOR ,  Koji USAMI ,  Tolga BAGCI ,  Anders SIMONSEN ,  Luis Guillermo VILLANUEVA ,  Emil ZEUTHEN ,  Juergen APPEL

IPC分类号： G01J1/44 ,  G01J1/46

CPC分类号： H04B10/00 ,  H04B2210/006

摘要： An optical detector for detecting radio frequency (RF) signals, the optical detector comprising a light source and a photodetector, and an electrical circuit comprising a position dependent capacitor and a bias voltage source adapted for providing a bias voltage for biasing the position dependent capacitor, the position dependent capacitor comprising an electrode and a membrane being displaceable in reaction to RF signals incident on the membrane, the membrane being metallized, has a thickness of less than 1 μm and a quality factor, Qm, of at least 20,000, and the distance between the membrane and the electrode being less than 10 μm.

摘要翻译： 一种用于检测射频（RF）信号的光学检测器，所述光学检测器包括光源和光电检测器，以及包括位置相关电容器和偏置电压源的电路，该偏置电压源适于提供用于偏置位置相关电容器的偏置电压， 所述位置相关电容器包括电极和膜，其可以与入射在膜上的RF信号反应而移位，所述膜被金属化，具有小于1μm的厚度和至少20,000的品质因数Qm，以及距离 在膜和电极之间小于10μm。

公开(公告)号：US08637465B2

公开(公告)日：2014-01-28

申请号：US13322307

申请日：2009-05-27

申请人： Vladimir Berezin ,  Elisabeth Bock ,  Artur Kochoyan

发明人： Vladimir Berezin ,  Elisabeth Bock ,  Artur Kochoyan

IPC分类号： A61K38/17

CPC分类号： C07K16/42 ,  A61K38/179 ,  C07K2317/70

摘要： The present invention relates to the use of peptides that are capable of binding to, and modulating the activity of NCAM. The peptides are peptide fragments of FGFRs. They are derived from two distinct binding sites for binding of the immunoglobulin-like module 2 of FGFR to NCAM F3 modules 1-2. The invention further relates to use of said peptides for the production of a medicament for the treatment of different pathological conditions, wherein NCAM and/or FGFRs play a prominent role.

摘要翻译： 本发明涉及能够结合并调节NCAM活性的肽的用途。 肽是FGFR的肽片段。 它们衍生自用于结合FGFR的免疫球蛋白样模块2与NCAM F3模块1-2的两个不同的结合位点。 本发明还涉及所述肽在生产用于治疗不同病理状况的药物中的用途，其中NCAM和/或FGFRs起着重要作用。

公开(公告)号：US08633007B2

公开(公告)日：2014-01-21

申请号：US13140496

申请日：2009-12-18

申请人： Morten Rønn Petersen ,  Anders Miki Bojesen

发明人： Morten Rønn Petersen ,  Anders Miki Bojesen

IPC分类号： C12N1/20

CPC分类号： G01N33/56911 ,  G01N2333/21 ,  G01N2333/245 ,  G01N2333/295 ,  G01N2333/31 ,  G01N2333/315 ,  G01N2800/364

摘要： The present invention relates to methods for diagnosing and treatment of a dormant infection of at least one pathogen. The invention further relates to a composition comprising an anti-dormancy factor as well as to said composition for use in a method of diagnosis or treatment and also to a method for manufacturing said composition. The invention further relates to a kit of parts comprising, inter alia, said composition. The invention also relates to a method for activating a dormant infection.

摘要翻译： 本发明涉及用于诊断和治疗至少一种病原体的休眠感染的方法。 本发明还涉及包含抗休眠因子以及用于诊断或治疗方法的所述组合物的组合物，还涉及制备所述组合物的方法。 本发明还涉及包括所述组合物的试剂盒。 本发明还涉及一种激活休眠感染的方法。