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公开(公告)号：US20130245028A1
公开(公告)日：2013-09-19
申请号：US13803317
申请日：2013-03-14
发明人： Shuichan Xu , Kristen Mae Hege , Heather Raymon , Toshiya Tsuji , Lisa Sapinoso
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61K31/502 , C12Q1/485 , G01N33/57434 , G01N2800/52 , G01N2800/56
摘要： Provided herein are methods for treating or preventing ETS overexpressing castration-resistant prostate cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having ETS overexpressing castration-resistant prostate cancer.
摘要翻译： 本文提供了用于治疗或预防过表达阉割抗性前列腺癌的ETS的方法，包括向具有过表达去钙抗性前列腺癌的ETS患者施用有效量的TOR激酶抑制剂。
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22.发明申请公开(公告)号：US20110224217A1
公开(公告)日：2011-09-15
申请号：US13113135
申请日：2011-05-23
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Steven Spencer Clareen , Kimberly Lyn Schwarz , Jason Simon Parnes , Jennifer R. Riggs , Patrick William Papa , Sayee Gajanan Hegde , Jeffrey Mark McKenna
IPC分类号： A61K31/519 , C12N9/99 , A61K31/522 , A61P35/00 , A61P29/00 , A61P37/02 , A61P3/00 , A61P17/06 , A61P11/06 , A61P11/02 , A61P11/08 , A61P11/00 , A61P3/04 , A61P3/10 , A61P1/00 , A61P25/28 , A61P19/02
CPC分类号： C07D473/00 , C07D473/28 , C07D473/32 , C07D475/00
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R3, R4, L, X, Y, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供了具有以下结构的杂芳基化合物：其中R 1，R 3，R 4，L，X，Y，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症， ，免疫条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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23.发明授权公开(公告)号：US07981893B2
公开(公告)日：2011-07-19
申请号：US11975652
申请日：2007-10-18
申请人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
发明人： Deborah Sue Mortensen , Maria Mercedes Delgado Mederos , John Joseph Sapienza , Ronald J. Albers , Branden G. Lee , Roy Leonard Harris, III , Graziella Isabel Shevlin , Dehua Huang , Kimberly Lyn Schwarz , Garrick K. Packard , Jason Simon Parnes , Patrick William Papa , Lida Radnia Tehrani , Sophie Perrin-Ninkovic , Jennifer R. Riggs
IPC分类号： A61K31/4985
CPC分类号： C07D471/04 , C07D487/04 , C07D498/04
摘要： Provided herein are Heteroaryl Compounds having the following structure: wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.
摘要翻译： 本文提供具有以下结构的杂芳基化合物：其中R1，R2，L，X，Y，Z，Q，A和B如本文所定义，包含有效量的杂芳基化合物的组合物和治疗或预防癌症的方法， 炎性病症，免疫学条件，代谢条件和通过抑制激酶途径可治疗或可预防的病症，包括向有需要的患者施用有效量的杂芳基化合物。
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24.发明授权Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof a JNK inhibitors and compositions and methods related thereto 失效异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物，JNK抑制剂及其组合物和方法公开(公告)号：US07354947B2
公开(公告)日：2008-04-08
申请号：US11159592
申请日：2005-06-22
IPC分类号： A61K31/403 , C07D209/80
CPC分类号： C07D275/04 , C07D417/12
摘要： Isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, —O—, —SO2—, or —S—; compositions comprising the iazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.
摘要翻译： 异噻唑鎓，异恶唑酮，异吲哚酮及其衍生物及其药学上可接受的盐，其中R 0为-CH 2 - ， - SO - ， - O- ，-SO 2 - ， - 或-S-; 包含重氮芳烃，异恶唑酮，异吲哚酮及其衍生物的组合物; 本文描述了通过给予异噻唑酮，异恶唑酮，异吲哚酮及其衍生物来抑制Jun N末端激酶（JNK）减轻的疾病的治疗或预防方法。
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25.发明申请Methods for treating, preventing and managing chronic lymphocytic leukemia with indazole compounds 审中-公开用吲唑化合物治疗，预防和控制慢性淋巴细胞性白血病的方法公开(公告)号：US20070060616A1
公开(公告)日：2007-03-15
申请号：US11512836
申请日：2006-08-30
申请人： Brydon Bennett , Shripad Bhagwat
发明人： Brydon Bennett , Shripad Bhagwat
IPC分类号： A61K31/454
CPC分类号： A61K31/454 , A61K31/416 , C07D231/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/12
摘要： This invention is generally directed to the use of Indazole Compounds for treating or preventing chronic lymphocytic leukemia. The methods comprise the treatment or prevention of chronic lymphocytic leukemia comprising administering an effective amount of an indazole compound, or a pharmaceutically acceptable salt or composition thereof, to a patient in need thereof.
摘要翻译： 本发明一般涉及使用吲唑化合物治疗或预防慢性淋巴细胞性白血病。 所述方法包括治疗或预防慢性淋巴细胞性白血病，包括向有需要的患者施用有效量的吲唑化合物或其药学上可接受的盐或组合物。
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26.发明授权Pyrazoloanthrone and derivatives thereof as JNK inhibitors and compositions and methods related thereto 失效吡唑烷酮及其衍生物作为JNK抑制剂及其组合物和方法公开(公告)号：US07119114B1
公开(公告)日：2006-10-10
申请号：US09642557
申请日：2000-08-18
申请人： Brydon L. Bennett , Shripad S. Bhagwat , Anthony M. Manning , Brion W. Murray , Eoin C. O'Leary , Yoshitaka Satoh
发明人： Brydon L. Bennett , Shripad S. Bhagwat , Anthony M. Manning , Brion W. Murray , Eoin C. O'Leary , Yoshitaka Satoh
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： A61K31/416 , C07D231/54 , C07D401/12 , C07D409/12
摘要： Compounds having activity as selective inhibitors of JNK are disclosed The compounds of this invention are pyrazoloanthrone and derivatives thereof having the following structure: wherein R1 and R2 are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.
摘要翻译： 公开了具有JNK选择性抑制剂活性的化合物。本发明化合物是具有以下结构的吡唑啉酮及其衍生物：其中R 1和R 2 2如本文所定义。 这些化合物可用于治疗对JNK抑制作用有响应的广泛范围的病症。 因此，还公开了治疗这些病症的方法，以及含有一种或多种上述化合物的化合物的药物组合物。
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27.发明申请公开(公告)号：US20060142352A1
公开(公告)日：2006-06-29
申请号：US11357774
申请日：2006-02-17
IPC分类号： A61K31/44 , A61K31/40 , A61K31/277 , A61K31/195 , A61K31/165 , A61K31/137 , A61K31/18 , A61K31/175
CPC分类号： A61K31/351 , A61K31/135 , A61K31/4025
摘要： The present invention generally relates to compounds and compositions useful for the modulation of ligase activity. The invention further relates to Compounds of the Invention, compositions thereof, and methods for treating or preventing cancer, a neoplastic disorder, acute or chronic renal failure, an inflammatory disorder, an immune disorder, a cardiovascular disease, an effect of aging or an infectious disease comprising administering an effective amount of a Compound of the Invention. The invention further relates to the use of a Compound of the Invention as a preservative of a cell, blood, tissue or an organ or as an agent to modulate stem cells.
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28.发明授权Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones and derivatives thereof as JNK inhibitors and compositions and methods related 失效异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物作为JNK抑制剂及其组合物和方法相关公开(公告)号：US06987184B2
公开(公告)日：2006-01-17
申请号：US10071390
申请日：2002-02-07
IPC分类号： C07D417/00 , C07D275/04
CPC分类号： C07D275/04 , C07D417/12
摘要： Isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, —O—, —SO2—, or —S—; compositions comprising the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.
摘要翻译： 异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物及其药学上可接受的盐，其中R 0为-CH 2 - ， - SO - ， - O- ，-SO 2 - 或-S-; 包含异噻唑烷，异恶唑酮，异吲哚酮及其衍生物的组合物; 本文描述了通过施用异噻唑酮，异恶唑酮，异吲哚酮及其衍生物来抑制Jun N末端激酶（JNK）减轻的病症的治疗或预防方法。
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公开(公告)号：US20050037495A1
公开(公告)日：2005-02-17
申请号：US10813203
申请日：2004-03-29
申请人： Dinah Sah , Fred Gage , Jasodhara Ray
发明人： Dinah Sah , Fred Gage , Jasodhara Ray
IPC分类号： G01N33/50 , A61K45/00 , A61K48/00 , A61P25/00 , C12N5/0797 , C12N5/10 , C12N15/09 , C12Q1/02 , G01N33/15 , G01N33/68 , C12N5/08 , C12N15/85
CPC分类号： C12N5/0623 , A61K48/00 , C12N2501/11 , C12N2501/13 , C12N2501/135
摘要： Conditionally-immortalized human CNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons and/or astrocytes. Such cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of CNS-related diseases. Such cell lines and/or differentiated cells may also be used in assays and for the general study of CNS cell development, death and abnormalities.
摘要翻译： 提供有条件永生化的人类CNS祖细胞系。 这些可能是克隆的细胞系可用于产生神经元和/或星形胶质细胞。 这样的细胞系和/或分化细胞可用于开发治疗剂以预防和治疗各种CNS相关疾病。 此类细胞系和/或分化细胞也可用于测定和CNS细胞发育，死亡和异常的一般研究。
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公开(公告)号：US20230338370A1
公开(公告)日：2023-10-26
申请号：US17976471
申请日：2022-10-28
发明人： Shuichan Xu , Kristen Mae Hege , Heather Raymon , Rama K. Narla
IPC分类号： A61K31/4985
CPC分类号： A61K31/4985
摘要： Provided herein are methods for treating or preventing triple negative breast cancer or hormone receptor positive breast cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having triple negative breast cancer or hormone receptor positive breast cancer.
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