公开(公告)号：US07354947B2

公开(公告)日：2008-04-08

申请号：US11159592

申请日：2005-06-22

申请人： Steven T. Sakata ,  Heather K. Raymon

发明人： Steven T. Sakata ,  Heather K. Raymon

IPC分类号： A61K31/403 ,  C07D209/80

CPC分类号： C07D275/04 ,  C07D417/12

摘要： Isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, —O—, —SO2—, or —S—; compositions comprising the iazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isaothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.

摘要翻译： 异噻唑鎓，异恶唑酮，异吲哚酮及其衍生物及其药学上可接受的盐，其中R 0为-CH 2 - ， - SO - ， - O- ，-SO 2 - ， - 或-S-; 包含重氮芳烃，异恶唑酮，异吲哚酮及其衍生物的组合物; 本文描述了通过给予异噻唑酮，异恶唑酮，异吲哚酮及其衍生物来抑制Jun N末端激酶（JNK）减轻的疾病的治疗或预防方法。

公开(公告)号：US06987184B2

公开(公告)日：2006-01-17

申请号：US10071390

申请日：2002-02-07

申请人： Steven T. Sakata ,  Heather K. Raymon

发明人： Steven T. Sakata ,  Heather K. Raymon

IPC分类号： C07D417/00 ,  C07D275/04

CPC分类号： C07D275/04 ,  C07D417/12

摘要： Isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula: and pharmaceutically acceptable salts thereof, wherein R0 is —CH2—, —SO—, —O—, —SO2—, or —S—; compositions comprising the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isothiazoloanthrones, isooxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.

摘要翻译： 异噻唑烷酮，异恶唑酮，异吲哚酮及其衍生物及其药学上可接受的盐，其中R 0为-CH 2 - ， - SO - ， - O- ，-SO 2 - 或-S-; 包含异噻唑烷，异恶唑酮，异吲哚酮及其衍生物的组合物; 本文描述了通过施用异噻唑酮，异恶唑酮，异吲哚酮及其衍生物来抑制Jun N末端激酶（JNK）减轻的病症的治疗或预防方法。

公开(公告)号：US06913925B1

公开(公告)日：2005-07-05

申请号：US09134771

申请日：1998-08-12

申请人： Dinah W. Y. Sah ,  Heather K. Raymon

发明人： Dinah W. Y. Sah ,  Heather K. Raymon

IPC分类号： G01N33/50 ,  A61K35/12 ,  A61K35/30 ,  A61K48/00 ,  A61P25/16 ,  C12N5/0797 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/04 ,  C12Q1/68 ,  C12R1/91 ,  G01N33/15 ,  C12N5/08 ,  C12N5/00 ,  C12N15/00 ,  C12N15/63 ,  C12P21/06

CPC分类号： C12N5/0623 ,  A61K35/12 ,  A61K48/00 ,  C12N2501/115 ,  C12N2503/02 ,  C12N2510/04

摘要： Conditionally-immortalized human mesencephalon cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including dopaminergic neurons. The cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of neurological diseases such as Parkinson's disease. The cell lines and/or differentiated cells may also be used in assays and for the general study of mesencephalon cell development and differentiation.

公开(公告)号：US06835567B1

公开(公告)日：2004-12-28

申请号：US09060409

申请日：1998-04-14

申请人： Dinah W. Y. Sah ,  Heather K. Raymon

发明人： Dinah W. Y. Sah ,  Heather K. Raymon

IPC分类号： C12N500

CPC分类号： C07K14/82 ,  C12N5/0623 ,  C12N2503/00 ,  C12N2510/04 ,  C12N2740/13043 ,  G01N33/5058

摘要： Conditionally-immortalized PNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons. The cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of PNS-related diseases. The cell lines and/or differentiated cells may also be used in assays and for the general study of PNS cell development, death and abnormalities.

摘要翻译： 提供有条件永生化的PNS祖细胞系。 可以使用克隆的这种细胞系来产生神经元。 细胞系和/或分化细胞可用于开发治疗剂以预防和治疗各种PNS相关疾病。 细胞系和/或分化细胞也可用于测定和PNS细胞发育，死亡和异常的一般研究。