公开(公告)号：US10221446B1

公开(公告)日：2019-03-05

申请号：US15283594

申请日：2016-10-03

Applicant: Carl Brown, III ,  Steven Wayde Graves ,  Darko Stefanovic ,  Matthew Richard Lakin

Inventor： Carl Brown, III ,  Steven Wayde Graves ,  Darko Stefanovic ,  Matthew Richard Lakin

IPC: C12Q1/68 ,  C12Q1/6818 ,  C07H21/02 ,  C07H21/04

Abstract: This disclosure describes a structured polynucleotide, devices that include the structured polynucleotide, and methods involving the structured polynucleotide and/or devices. Generally, the structured polynucleotide includes five domains. A first domain acts as a toehold for an input DNA logic gate to initiate binding to an SCS biomolecule. A second domain acts as a substrate recognition sequence for an upstream DNA logic gate. A third domain acts as a toehold for a output DNA logic gate to initiate binding of the SCS biomolecule to the gate. A fourth domain acts as an effector sequence to alter the state of the output logic gate. A fifth domain acts as a cage sequence to lock the effector sequence in an inactive state until an input gate binds to the structured polynucleotide.

公开(公告)号：US10141469B1

公开(公告)日：2018-11-27

申请号：US15692541

申请日：2017-08-31

Applicant: STC.UNM

Inventor： Francesca Cavallo ,  Vijay Saradhi Mangu

IPC: H01L31/18 ,  H01L31/0725 ,  H01L31/0352 ,  H01L31/0392 ,  H01L31/032 ,  H01L31/0224 ,  H01L31/054 ,  H01L31/0236

Abstract: A solar cell for collecting solar radiation can include a barrier layer such as a dielectric barrier layer and a heterostructure including a first light absorbing layer and at least a second light absorbing layer. A method for forming the solar cell can include forming a sacrificial layer on a support substrate and forming the barrier layer on the sacrificial layer. The barrier layer is formed to have a strain gradient through its thickness. The heterostructure is attached to the barrier layer and the sacrificial layer is removed, thereby separating the barrier layer and the heterostructure from the support substrate. During the removal of the sacrificial layer, the strain gradient causes the barrier layer and heterostructure, to roll, curl, or spiral, thereby resulting in a radially stacked heterostructure that provides a light concentrating optical cavity having multiple light absorbing layers with different band gaps.

公开(公告)号：US10128398B1

公开(公告)日：2018-11-13

申请号：US14720249

申请日：2015-05-22

Applicant: STC.UNM

Inventor： Majeed M. Hayat ,  Payman Zarkesh-Ha

IPC: H03F3/08 ,  H01L31/107 ,  H01L25/16

Abstract: Systems and methods implementing a resonance circuit, including an avalanche photodiode, in which a resonance frequency of the resonance circuit is matched with the frequency of a dynamic biasing signal of the avalanche photodiode, can be used in a variety of applications. In various embodiments, a method for blocking and/or compensating current injection associated with the parasitic capacitance of APDs operated under dynamic biasing may be substantially realized by the matching of the resonance frequency of a resonance circuit including the avalanche photodiode with the frequency of an applied dynamic biasing signal. Additional systems and methods are described that can be used in a variety of applications.

公开(公告)号：US20180311302A1

公开(公告)日：2018-11-01

申请号：US15962067

申请日：2018-04-25

Applicant: STC.UNM

Inventor： Jeff Wade Hill

IPC: A61K38/06 ,  C07K14/715 ,  A61K45/06

CPC classification number: A61K38/06 ,  A61K38/00 ,  A61K45/06 ,  C07K5/0823 ,  C07K14/7158

Abstract: The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.

公开(公告)号：US10106727B2

公开(公告)日：2018-10-23

申请号：US14488989

申请日：2014-09-17

Applicant: National Technology & Engineering Solutions of Sandia LLC ,  CARBO Ceramics Inc. ,  STC.UNM

Inventor： Chad Cannan ,  Terrence Palisch ,  Richard A. Kemp ,  Timothy J. Boyle ,  Bernadette A. Hernandez-Sanchez ,  James E. Miller

IPC: C09K8/80 ,  E21B43/267 ,  E21B49/08 ,  E21B47/10

Abstract: Proppant compositions for use in hydraulic fracturing and methods of using same are disclosed herein. The proppant compositions include a plurality of proppant particulates and at least one particulate of the plurality of proppant particulates containing at least one tracer, wherein the at least one tracer separates from the at least one particulate located inside a fracture of a subterranean formation after a period of time.

公开(公告)号：US10089660B2

公开(公告)日：2018-10-02

申请号：US14849227

申请日：2015-09-09

Applicant: STC.UNM

Inventor： Shuang Luan ,  Abdullah Mueen ,  Michalis Faloutsos ,  Amanda J. Minnich

IPC: G06Q30/02

Abstract: Multiple sources of reviews for the same product or service (e.g. hotels, restaurants, clinics, hair saloon, etc.) are utilized to provide a trustworthiness score. Such a score can clearly identify hotels with evidence of review manipulation, omission and fakery and provide the user with a comprehensive understanding of the reviews of a product or establishment. Three types of information are used in computing the score: spatial, temporal and network or graph-based. The information is blended to produce a representative set of features that can reliably produce the trustworthiness score. The invention is self-adapting to new reviews and sites. The invention also includes a validation mechanism by crowd-sourcing and fake review generation to ensure reliability and trustworthiness of the scoring.

公开(公告)号：US20180209910A1

公开(公告)日：2018-07-26

申请号：US15743204

申请日：2016-07-11

Applicant: STC.UNM

Inventor： Mani Hossein-Zadeh

IPC: G01N21/77 ,  G02B6/122 ,  G01J3/453 ,  G01J3/02 ,  G01N33/543

CPC classification number: G01N21/7703 ,  G01J3/0224 ,  G01J3/0256 ,  G01J3/42 ,  G01J3/453 ,  G01N33/54373 ,  G01N2201/0638 ,  G02B6/1223 ,  G02B6/1225 ,  G02B6/125

Abstract: The present invention provides a sensor having, one or more optical slab waveguides having one or more target regions. The target regions may interact with gas molecules or trap, entrain or capture one or more targets of interest. The optical slab waveguides are adapted to receive one or more input optical beams from one or more light sources to create a plurality of propagating optical waves in optical slab waveguide. The propagating optical waves interact with said one or more target regions to create an optical output wavefront that may be in the form of a diffraction pattern. The target regions may be functionalized with an antibody, polymer, cell, tissue, or biological material.

公开(公告)号：USRE46953E1

公开(公告)日：2018-07-17

申请号：US14020500

申请日：2013-09-06

Applicant: University of Maryland, Baltimore ,  STC.UNM ,  University of Notre Dame du Lac

Inventor： Cedric X. Yu ,  Shuang Luan ,  Danny Z. Chen ,  Matthew A. Earl ,  Chao Wang

IPC: A61N5/10 ,  G21K1/02 ,  H05G1/42

CPC classification number: A61N5/10 ,  G21K1/02 ,  H05G1/42

Abstract: Provided herein are methods and systems for designing a radiation treatment for a subject using single arc dose painting. The methods and systems comprise an algorithm or a computer-readable product having the same, to plan the radiation treatment. The algorithm converts pairs of multiple leaf collimation (MLC) leaves to sets of leaf aperture sequences that form a shortest path single arc thereof where the pairs of MLC leaves each aligned to an intensity profile of densely-spaced radiation beams, and connects each single arc of leaf apertures to form a final treatment single arc. Also provided is a method for irradiating a tumor in a subject using single arc dose painting.

公开(公告)号：US10022327B2

公开(公告)日：2018-07-17

申请号：US14970998

申请日：2015-12-16

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： C. Jeffrey Brinker ,  Eric C. Carnes ,  Carlee Erin Ashley ,  Cheryl L. Willman

IPC: A61K9/127 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K39/05 ,  C12N15/113 ,  C07K14/47 ,  C12N15/88 ,  A61K45/06 ,  A61K47/62 ,  A61K47/69 ,  A61K38/00 ,  A61K48/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：US20180177722A1

公开(公告)日：2018-06-28

申请号：US15738512

申请日：2016-06-24

Applicant: STC.UNM ,  RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Jason Thomas McConville ,  Thiago Carvalho ,  Kristina Schonhoff

IPC: A61K9/00 ,  A61K31/122 ,  A61K47/14 ,  A61K47/26

CPC classification number: A61K9/0078 ,  A61K31/122 ,  A61K47/14 ,  A61K47/26

Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nano dispersion that can be readily aerosolized for inhalation.