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公开(公告)号：US10912838B2
公开(公告)日：2021-02-09
申请号：US15902255
申请日：2018-02-22
发明人： Kazunori Kataoka , Yasutaka Anraku , Nobuhiro Nishiyama , Kanjiro Miyata , Takehiko Ishii , Yu Matsumoto , Yu Fukusato , Akihiro Mizoguchi , Takanori Yokota , Hiroya Kuwahara , Kazutaka Nishina , Hidehiro Mizusawa
IPC分类号： A61K47/60 , A61K9/127 , A61K31/7088 , B01J13/02 , A61K47/54 , C08G81/00 , C08G69/10 , C08G69/40 , C07K16/00 , A61K47/64 , A61K47/69 , A61K9/00 , A61K39/44 , A61K39/00
摘要： The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.
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22.发明申请公开(公告)号：US20210015592A1
公开(公告)日：2021-01-21
申请号：US17043048
申请日：2019-03-28
发明人： Manabu KANAZAWA , Yumika SOEDA , Maiko IWAKI , Toshio ARAKIDA , Tamaki HADA , Shunsuke MINAKUCHI
摘要： Removable denture data of a removable denture is produced, and disk frame data of a disk frame in which the removable denture is accommodated is produced, thereby building the disk frame based on the disk frame data. Next, a resin disk in which artificial teeth are embedded is produced by arranging the artificial teeth in the disk frame and curing a base resin, and a denture base is milled by milling the resin disk based on the removable denture data, thereby manufacturing the removable denture in which a base side of the artificial teeth is embedded in the denture base. As a result, artificial teeth having an excellent aesthetics may be used, it is possible to firmly join the artificial teeth and the denture base to each other, and it is possible to manufacture a removable denture with a favorable restoration accuracy of the artificial teeth.
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公开(公告)号：US20200283735A1
公开(公告)日：2020-09-10
申请号：US16644677
申请日：2018-09-28
发明人： Fumitoshi ISHINO , Jiyoung Lee
摘要： The present invention provides a method for producing a heart organoid and/or a lung organoid, comprising the step of: culturing an embryoid body in the presence of an FGF protein on a surface of a gel containing an extracellular matrix constituent protein.
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公开(公告)号：US20200237243A1
公开(公告)日：2020-07-30
申请号：US16756079
申请日：2018-08-21
IPC分类号： A61B5/04 , G01R33/035 , G01R33/26
摘要： An objective of the present invention is to provide a biomagnetism measurement device capable of three-dimensionally acquiring magnetism information of a living body with ease. This biomagnetism measurement device (101) is for measuring biomagnetism using a plurality of magnetic sensors (1) at the same time. The plurality of magnetic sensors (1) is retained by a retaining part (100) (a first retaining portion [11] and a second retaining portion [12]) so as to have different measurement directions. Furthermore, the retaining part (10) (the first retaining portion [11] and the second retaining portion [12]) has arranged thereon the plurality of magnetic sensors (1) so as to enable biomagnetism to be measured at a plurality of sites at the same time. The magnetic sensor (1) comprises a means for detecting the biomagnetism in a temperature environment commensurate with normal temperature.
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公开(公告)号：US20200157660A1
公开(公告)日：2020-05-21
申请号：US16634921
申请日：2018-07-24
摘要： An alloy for biomedical use includes Zr as a main component, Nb the content of which is not less than 0.1% by weight and not greater than 25% by weight, Mo the content of which is not less than 0.1% by weight and not greater than 25% by weight, and Ta the content of which is not less than 0.1% by weight and not greater than 25% by weight. A tensile strength of the alloy is not less than 1000 MPa. A total content of Nb, Mo, and Ta in the alloy is not less than 2% by weight and not greater than 50% by weight. Mass susceptibility of the alloy is not greater than 1.50×10−6 cm3/g. A Young's modulus of the alloy is not greater than 100 GPa. Also disclosed is a medical product including the alloy and a method for producing the alloy.
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公开(公告)号：US20200038483A1
公开(公告)日：2020-02-06
申请号：US16457308
申请日：2019-06-28
申请人： Toshihiro AKAIKE , PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITY , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY , SOMAR CORPORATION
摘要： A material for treatment of brain injury, a method for treatment of brain injury, a material for regeneration of brain neurons, and a method for regeneration of brain neurons are provided. The material for treatment of brain injury contains a carrier on which at least one selected from the group consisting of N-cadherin, a fusion protein containing an entire or partial region of N-cadherin, and a fusion protein containing an entire or partial region of a protein having homology to N-cadherin is immobilized or coated.
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公开(公告)号：US20200022600A1
公开(公告)日：2020-01-23
申请号：US16335583
申请日：2017-09-22
IPC分类号： A61B5/04 , A61B5/00 , A61B5/0456 , A61B5/0488
摘要： A wireless biological signal communication terminal is provided with: a sensor unit which detects a biological signal; an A/D converting unit which performs A/D conversion of the biological signal in accordance with a set sampling frequency to obtain biological signal data; a recording unit which records a plurality of items of A/D converted biological signal data; a control unit which processes the plurality of items of biological signal data recorded by the recording unit in a prescribed period of time; a wireless module unit and an antenna which wirelessly transmit the result of the processing performed by the control unit to an external device; and a power supply unit which supplies power to drive the devices.
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公开(公告)号：US10406243B2
公开(公告)日：2019-09-10
申请号：US14913978
申请日：2014-08-18
发明人： Atsushi Tamura , Nobuhiko Yui
摘要： A medicinal composition for diseases caused by dyslipidemia and/or autophagy dysfunction, etc., said medicinal composition comprising polyrotaxane that carries bulky substituents introduced, via intracellularly degradable bonds, into both ends of a linear molecule penetrating through plural cyclic molecules.
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公开(公告)号：US20190247414A1
公开(公告)日：2019-08-15
申请号：US16335017
申请日：2017-09-25
发明人： Takanori Yokota , Tetsuya Nagata
IPC分类号： A61K31/711 , A61K47/22 , A61K47/28 , C12N15/113 , A61K47/54 , A61P27/02 , A61P25/00 , A61K31/7125 , A61K9/00
CPC分类号： A61K31/711 , A61K9/0019 , A61K31/7088 , A61K31/7125 , A61K47/22 , A61K47/28 , A61K47/542 , A61K47/554 , A61K48/00 , A61P25/00 , A61P27/02 , C12N15/09 , C12N15/113
摘要： The present invention provides a composition and a method for efficiently delivering a nucleic acid agent to the central nervous system and/or the retina and bringing about antisense effects. Provided is a composition for reducing the expression level of a target transcription product in the central nervous system and/or retina of a subject, the composition including a nucleic acid complex that includes a first nucleic acid strand and a second nucleic acid strand, wherein: the first nucleic acid strand comprises a base sequence capable of hybridizing with at least part of the target transcription product and has an antisense effect on the target transcription product; the second nucleic acid strand comprises a base sequence complementary to the first nucleic acid strand and is conjugated to tocopherol, cholesterol, or an analog thereof; and the first nucleic acid strand is annealed to the second nucleic acid strand.
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公开(公告)号：US20190240352A1
公开(公告)日：2019-08-08
申请号：US16337808
申请日：2017-09-29
发明人： Takanori Yokota , Kotaro Yoshioka
CPC分类号： A61K48/0066 , A61K9/0019 , A61K9/7023 , A61K31/7088 , A61K31/7125 , A61K48/00 , A61P25/28 , A61P35/00 , C12N15/09 , C12N15/113
摘要： Provided is a nucleic acid strand that can efficiently deliver an antisense oligonucleotide into the body, particularly a nucleic acid complex comprising a first nucleic acid strand and a second nucleic acid strand, wherein the first nucleic acid strand includes a base sequence that is capable of hybridizing with at least a portion of a target transcription product, and exerts an antisense effect on the target transcription product; the second nucleic acid strand includes a complementary region having a base sequence complementary to the first nucleic acid strand and at least one overhang region located on the 5′ and/or 3′ side of the complementary region; and the first nucleic acid strand is annealed to the complementary region in the second nucleic acid strand.
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