公开(公告)号：US20140356911A1

公开(公告)日：2014-12-04

申请号：US14445790

申请日：2014-07-29

Applicant: Katharine Lacy Cain

Inventor： Katharine Lacy Cain

IPC: C07K16/00

CPC classification number: C07K16/00 ,  C07K2317/14 ,  C12N5/0682 ,  C12N2510/00

Abstract: The present invention relates to a recombinant host cell, wherein the cell is modified to increase the expression levels of Ero1 and XBP1 relative to the expression levels of Ero1 and XBP1 in an unmodified cell. The present invention also relates to a method of producing a recombinant protein of interest comprising expressing the recombinant protein of interest in the recombinant host cell.

Abstract translation: 本发明涉及重组宿主细胞，其中修饰细胞以相对于未修饰的细胞中Ero1和XBP1的表达水平增加Ero1和XBP1的表达水平。 本发明还涉及生产重组蛋白质的方法，包括在重组宿主细胞中表达重组蛋白质。

公开(公告)号：US20140242625A1

公开(公告)日：2014-08-28

申请号：US14275055

申请日：2014-05-12

Applicant: UCB PHARMA, S.A.

Inventor： BRYAN JOHN SMITH ,  HELEN MARIE KIRKE

IPC: C12Q1/37

CPC classification number: C12Q1/37 ,  G01N33/6857 ,  G01N2333/96433

Abstract: A method of measuring acidic species generated by degradation of a Fab or Fab′ component of a Fab-PEG or a Fab′-PEG is provided. The method involves: a) cleaving PEG and a linker from the Fab-PEG or Fab′-PEG with an enzyme; b) optionally separating the PEG and linker from the Fab or Fab′ to provide isolated Fab or Fab′; and c) quantitatively analyzing acidic species associated with the cleaved Fab or Fab′ and/or the cleaved PEG.

Abstract translation: 提供了测量由Fab-PEG或Fab'-PEG的Fab或Fab'成分降解而产生的酸性物质的方法。 该方法包括：a）用酶切割PEG和Fab-PEG或Fab'-PEG的接头; b）任选地将PEG和接头与Fab或Fab'分离以提供分离的Fab或Fab'; 和c）定量分析与切割的Fab或Fab'和/或切割的PEG相关的酸性物质。

公开(公告)号：US08785628B2

公开(公告)日：2014-07-22

申请号：US13254964

申请日：2010-03-02

Applicant: Daniel Rees Allen ,  Roland Bürli ,  Alan Findlay Haughan ,  Jonathan David MacDonald ,  Mizio Matteucci ,  David John Nash ,  Andrew Pate Owens ,  Gilles Raphy ,  Elizabeth Anne Saville-Stones ,  Andrew Sharpe

Inventor： Daniel Rees Allen ,  Roland Bürli ,  Alan Findlay Haughan ,  Jonathan David MacDonald ,  Mizio Matteucci ,  David John Nash ,  Andrew Pate Owens ,  Gilles Raphy ,  Elizabeth Anne Saville-Stones ,  Andrew Sharpe

IPC: C07D401/14 ,  C07D403/14 ,  A61K31/53 ,  A61K31/495 ,  A61K31/4709 ,  A61K31/4545 ,  A61P19/02

CPC classification number: A61K31/47 ,  C07D401/14

Abstract: A series of substituted [1,3,5]triazin-2-yl derivatives, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract translation: 因此，作为PI3激酶的选择性抑制剂的一系列取代的[1,3,5]三嗪-2-基衍生物在医学中是有益的，例如在治疗炎症，自身免疫，心血管，神经变性，代谢，肿瘤学 ，伤害感受器或眼科疾病。

公开(公告)号：US08653272B2

公开(公告)日：2014-02-18

申请号：US13124947

申请日：2009-10-21

Applicant: Kerry Jenkins ,  Christopher James Lock ,  Andrew James Ratcliffe

Inventor： Kerry Jenkins ,  Christopher James Lock ,  Andrew James Ratcliffe

IPC: A61K31/4365 ,  C07D417/02

CPC classification number: C07D495/04

Abstract: A series of heteroaryl-substituted fused pyridine derivatives, in particular heteroaryl-substituted thieno[3,2-6]pyridine derivatives, being selective inhibitors of PO kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract translation: 一系列杂芳基取代的稠合吡啶衍生物，特别是杂芳基取代的噻吩并[3,2-6]吡啶衍生物，是PO激酶的选择性抑制剂，因此在医学中有益，例如在治疗炎症，自身免疫 ，心血管，神经变性，代谢，肿瘤，伤害性或眼科疾病。

公开(公告)号：US08653105B2

公开(公告)日：2014-02-18

申请号：US13508956

申请日：2010-11-11

Applicant: Daniel Rees Allen ,  Roland Bürli ,  Alan Findlay Haughan ,  Mizio Matteucci ,  Andrew Pate Owens ,  Gilles Raphy ,  Andrew Sharpe

Inventor： Daniel Rees Allen ,  Roland Bürli ,  Alan Findlay Haughan ,  Mizio Matteucci ,  Andrew Pate Owens ,  Gilles Raphy ,  Andrew Sharpe

IPC: A61K31/4709 ,  C07D401/14 ,  C07D215/50

CPC classification number: C07D403/04 ,  C07D487/04

Abstract: A series of quinoline derivatives, substituted by an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings attached via an alkylene chain optionally linked to a heteroatom, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract translation: 由任选取代的双环杂芳基部分取代的一系列喹啉衍生物，其由通过任选连接于杂原子的亚烷基链连接的两个稠合六元芳环构成，作为PI3激酶的选择性抑制剂，因此在医学中是有益的，对于 例如治疗炎症，自身免疫，心血管，神经变性，代谢，肿瘤，伤害性或眼科疾病。

公开(公告)号：US20140024077A1

公开(公告)日：2014-01-23

申请号：US13928458

申请日：2013-06-27

Applicant: UCB Pharma S.A.

Inventor： Richard Evan Gelinas ,  Mitra Choudhury Singhal ,  Yi Zhang ,  Andrew George Popplewell ,  Ralph Adams

IPC: C07K16/24

CPC classification number: A61K39/3955 ,  A61K2039/505 ,  C07K16/248 ,  C07K2316/96 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。

公开(公告)号：US08617847B2

公开(公告)日：2013-12-31

申请号：US13632702

申请日：2012-10-01

Applicant: UCB Pharma S.A.

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki

IPC: C12P21/08

CPC classification number: C07K16/468 ,  A61K39/3955 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。

公开(公告)号：US08586623B2

公开(公告)日：2013-11-19

申请号：US13441410

申请日：2012-04-06

Applicant: Benoit Kenda ,  Yannick Quesnel ,  Ali Ates ,  Philippe Michel ,  Laurent Turet ,  Joel Mercier

Inventor： Benoit Kenda ,  Yannick Quesnel ,  Ali Ates ,  Philippe Michel ,  Laurent Turet ,  Joel Mercier

IPC: A01N43/36 ,  A61K31/40 ,  C07D409/00 ,  C07D411/00

CPC classification number: C07D513/04 ,  C07D401/06 ,  C07D403/06 ,  C07D413/06 ,  C07D417/06 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04

Abstract: The present invention concerns 2-oxo-1-pyrrolidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

Abstract translation: 本发明涉及2-氧代-1-吡咯烷衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。

公开(公告)号：US08580265B2

公开(公告)日：2013-11-12

申请号：US13348456

申请日：2012-01-11

Applicant: Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

Inventor： Ralph Adams ,  Terence Seward Baker ,  Alastair David Griffiths Lawson

IPC: A61K39/395

CPC classification number: C07K16/244 ,  C07K2317/33 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对IL-17A和IL-17F的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途和产生所述抗体分子的方法。

公开(公告)号：US08579866B2

公开(公告)日：2013-11-12

申请号：US12317833

申请日：2008-12-29

Applicant: Darrell P. Morgan ,  Alex Lee ,  Dan Formosa ,  Steven Vordenberg ,  Joern Vicari ,  Eric Freitag ,  Boris Kontorvich

Inventor： Darrell P. Morgan ,  Alex Lee ,  Dan Formosa ,  Steven Vordenberg ,  Joern Vicari ,  Eric Freitag ,  Boris Kontorvich

IPC: A61M5/00

CPC classification number: A61M5/3202 ,  A61M5/3134 ,  A61M5/3137 ,  A61M5/31511 ,  A61M5/3204 ,  A61M2005/3139 ,  A61M2205/585 ,  A61M2205/586

Abstract: The syringe systems disclosed herein provide in part devices for allowing patients with comprised joint strength to more easily administer medicine. Certain exemplary syringe embodiments include a handle forming a handgrip, a syringe barrel that magnifies the dosage marks located on an inner barrel, and a tip cap slidably engageable with the syringe barrel for shielding a needle.