-
公开(公告)号：US20240342196A1
公开(公告)日：2024-10-17
申请号：US18634143
申请日：2024-04-12
IPC分类号： A61K31/64 , A61K31/202 , A61K31/4468 , A61P3/10
CPC分类号： A61K31/64 , A61K31/202 , A61K31/4468 , A61P3/10
摘要： Disclosed herein are lipid signaling pathways that can be targeted to prevent or delay the onset of type 1 diabetes (T1D). In particular, disclosed herein a pathway that can be modulated by a chemical inhibitor. Utilizing this inhibitor, evidence was generated suggesting that it is beneficial in reducing the incidence of T1D.
-
公开(公告)号：US12119882B2
公开(公告)日：2024-10-15
申请号：US17925786
申请日：2021-06-15
发明人： Sung-Joo Ben Yoo
CPC分类号： H04B10/677 , G02F7/00 , H03M7/3062 , H04B10/60 , H04B10/61 , H04B10/615 , H04B10/616 , H04B10/63
摘要： During operation, the system receives an optical input signal, and also receives a reference optical frequency comb (OFC) signal. Next, the system uses a gapless spectral demultiplexer to spectrally slice the optical input signal to produce a set of spectral slices. The system also uses a high-contrast demultiplexer to strongly isolate each combline of the reference OFC signal to produce a set of reference comblines. Next, in a parallel manner, the system demodulates each spectral slice in the set of spectral slices centered on a single reference combline in the set of reference comblines to produce a set of baseband I/Q signals, wherein each spectral slice is demodulated based on a known code sequence. The system then digitizes the set of baseband I/Q signals to produce a set of digitized signals. Finally, the system processes the set of digitized signals to directly reconstruct a waveform for the optical input signal.
-
公开(公告)号：US12109229B2
公开(公告)日：2024-10-08
申请号：US18441600
申请日：2024-02-14
摘要： The present invention provides a method of treating frontotemporal dementia, or a childhood genetic neurodegenerative disease such as Ataxia Telangiectasia (A-T), or neurodegenerative diseases such as Parkinson's disease or neuropsychiatric diseases comprising administering to a subject in need thereof an effective amount of chlorite composition, such as sodium chlorite. The present invention thereby provides a method of modulating the immune system in a subject in need thereof. Described herein are methods of administration and treatment.
-
公开(公告)号：US20240332613A1
公开(公告)日：2024-10-03
申请号：US18580879
申请日：2022-07-12
发明人： Liwei Lin , Peisheng He , Yande Peng , Yu Long
IPC分类号： H01M10/0565 , H01M4/02 , H01M4/04 , H01M4/485 , H01M4/58 , H01M50/474 , H01M50/486
CPC分类号： H01M10/0565 , H01M4/0404 , H01M4/0414 , H01M4/485 , H01M4/5815 , H01M50/474 , H01M50/486 , H01M2004/027 , H01M2004/028
摘要： A conformable battery including a first polymer substrate having a cathode, a second polymer substrate having an anode facing the cathode, and a hydrogel electrolyte in between the anode and cathode. A method of manufacturing a stretchable battery includes forming a cathode current collector on a first polymer substrate, depositing a cathode on the cathode current collector, forming an anode current collector on a second polymer substrate, depositing an anode on the anode current collector, depositing a hydrogel electrolyte on one of either the cathode or the anode, and joining the first polymer substrate and the second polymer substrate to form the battery.
-
公开(公告)号：US20240327866A1
公开(公告)日：2024-10-03
申请号：US18579829
申请日：2022-07-21
CPC分类号： C12N15/86 , A61P35/00 , C12N2740/13043 , C12N2800/40 , C12N2820/002 , C12N2830/001
摘要： Provided herein are recombinant virus systems comprising two or more coordinatedly regulated viral vectors. Methods for treating a cell proliferative disorder using these systems are also provided. The compositions and methods provided herein provide more efficient and coordinated delivery of larger transgenes and/or larger quantities of a tansgene than previous methods by avoiding receptor interference and/or superinfection resistance, thereby enabling progressive replication of both vectors and efficient gene delivery by each vector.
-
公开(公告)号：US20240327523A1
公开(公告)日：2024-10-03
申请号：US18034234
申请日：2021-11-15
发明人： LEWIS L. LANIER , James A. WELLS , Jia LIU , Janice ARAKAWA-HOYT
CPC分类号： C07K16/2851 , A61K47/6803 , A61K47/6849 , A61P35/00 , C07K16/2818 , C07K16/2827 , C07K2317/21 , C07K2317/24
摘要： Anti-CD94 antibodies and their use are described.
-
公开(公告)号：US20240327442A1
公开(公告)日：2024-10-03
申请号：US18294067
申请日：2022-07-21
IPC分类号： C07F15/06
CPC分类号： C07F15/065
摘要： Methods of synthesizing crystalline metal-organic frameworks (MOFs) having polytopic organic linkers and, cations, where each linker is connected, to two or more cations, are provided. In the disclosed methods, the linkers are reacted with one or more compounds of formula MnXm, where each M is independently cationic Be, Mg, Ca, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, Zr, Nb, Mo, Ru, Rh, Pd, Cd, or Hf, X is anionic, n and m are integers. The reaction is performed in the presence of a salicylate, salicylamide, 1,3-phthalate, or hydroxybenzoate based modulator.
-
公开(公告)号：US20240325788A1
公开(公告)日：2024-10-03
申请号：US18575470
申请日：2022-06-29
申请人： The Regents of the University of California , The Board of Regents of the University of Oklahoma
发明人： Liangzhong XIANG , Yong CHEN
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61N5/103 , A61N5/1064 , A61N5/1071 , A61N2005/1058 , A61N2005/1087 , A61N2005/1092
摘要： Proton beams can deliver a highly targeted radiation dose to a narrow volume defined by their Bragg peaks. However, Bragg peak range uncertainties persist during dose delivery. Fortunately, pulsed proton beams generate protoacoustic emissions proportional to absorbed proton energy, thereby encoding dosimetry information in a detectable acoustic wave. The present embodiments provide methods and apparatuses to derive and model protoacoustic imaging with an ultrasound transducer, and examine the frequency characteristics of protoacoustic emissions, which are crucial parameters in imaging resolution.
-
公开(公告)号：US12106211B2
公开(公告)日：2024-10-01
申请号：US16608006
申请日：2018-04-27
发明人： Dmitri Strukov , Farnood Merrikh Bayat , Mohammad Bavandpour , Mohammad Reza Mahmoodi , Xinjie Guo
IPC分类号： G06N3/049 , G06N3/065 , G11C16/04 , H01L29/423
CPC分类号： G06N3/065 , G06N3/049 , G11C16/0425 , G11C16/0458 , H01L29/42324 , H01L29/42328 , H01L29/42344
摘要： Building blocks for implementing Vector-by-Matrix Multiplication (VMM) are implemented with analog circuitry including non-volatile memory devices (flash transistors) and using in-memory computation. In one example, improved performance and more accurate VMM is achieved in arrays including multi-gate flash transistors when computation uses a control gate or the combination of control gate and word line (instead of using the word line alone). In another example, very fast weight programming of the arrays is achieved using a novel programming protocol. In yet another example, higher density and faster array programming is achieved when the gate(s) responsible for erasing devices, or the source line, are re-routed across different rows, e.g., in a zigzag form. In yet another embodiment a neural network is provided with nonlinear synaptic weights implemented with nonvolatile memory devices.
-
公开(公告)号：US20240319200A1
公开(公告)日：2024-09-26
申请号：US18736528
申请日：2024-06-07
发明人： Daniel K. Nomura , Qian Shao
IPC分类号： G01N33/58 , A61K31/407 , A61K31/4439 , C07D487/10
CPC分类号： G01N33/582 , A61K31/407 , A61K31/4439 , C07D487/10 , G01N2500/02
摘要： A novel drug discovery platform identifies compounds for therapeutically targeting 14-3-3 proteins and sequestering and inhibiting the activities of various disease-relevant proteins. Therapeutic compositions comprise a scaffold for therapeutically targeting 14-3-3 proteins and sequestering and inhibiting the activities of various disease-relevant proteins.
-
-
-
-
-
-
-
-
-
搜索结果
23932 条记录 (耗时 0.06 秒)
