公开(公告)号：US20100241024A1

公开(公告)日：2010-09-23

申请号：US12440266

申请日：2007-09-06

Applicant: Christoph König ,  Wolfgang Kleinekofort

Inventor： Christoph König ,  Wolfgang Kleinekofort

IPC: A61B5/05 ,  B01D61/30

CPC classification number: A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3669

Abstract: The present invention relates to a device and a method for monitoring an access to a patient, in particular a vascular access in extracorporeal blood treatment, in which a patient's blood is withdrawn from the patient via an arterial conduit and is returned to the patient via a venous conduit. In the device according to the present invention and in the method according to the present invention, an alternating voltage signal, relative to a common ground potential, is coupled in and out of the arterial and venous conduits, and the blood flowing through the arterial and venous conduits is at ground potential. In this way, disturbances, which can be attributed particularly to movements of the conduits, are reduced.

Abstract translation: 本发明涉及一种用于监测对患者的访问的装置和方法，特别是在体外血液处理中的血管通路，其中通过动脉导管将患者的血液从患者中取出并经由动脉导管返回给患者 静脉导管。 在根据本发明的装置和根据本发明的方法中，相对于公共地电位的交流电压信号耦合进入和离开动脉和静脉导管，并且血液流过动脉和 静脉导管处于地下潜力。 以这种方式，可以特别归因于导管的运动的干扰减少。

公开(公告)号：US07788047B2

公开(公告)日：2010-08-31

申请号：US11741162

申请日：2007-04-27

Applicant: Karl G. Schick ,  David Uhen

Inventor： Karl G. Schick ,  David Uhen

IPC: G01N25/18 ,  G06F17/00 ,  G06K7/10

CPC classification number: G01N27/10 ,  A61M1/3621 ,  A61M1/3669 ,  A61M2205/6018

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated conductivity sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor on in a barcode printed on the sensor. The sensors are calibrated using 0.100 molar potassium chloride (KCl) solutions at 25 degrees Celsius. These sensors may be utilize with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances.

Abstract translation: 提供一次性，预消毒和预校准的预验证的电导率传感器。 这些传感器被设计为将传感器特定信息（例如校准和生产信息）存储在印刷在传感器上的条形码上的传感器上的非易失性存储器芯片中。 传感器在25摄氏度下使用0.100摩尔氯化钾（KCl）溶液进行校准。 这些传感器可以利用在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统。

公开(公告)号：US20100185132A1

公开(公告)日：2010-07-22

申请号：US12727993

申请日：2010-03-19

Applicant: James Han ,  Thomas P. Hartranft ,  Thomas D. Kelly ,  Angel Lasso

Inventor： James Han ,  Thomas P. Hartranft ,  Thomas D. Kelly ,  Angel Lasso

IPC: A61M1/36

CPC classification number: A61M1/3669 ,  A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  Y10S439/909

Abstract: An extracorporeal blood system includes: an extracorporeal blood machine including an extracorporeal blood circuit; an access device enabling the extracorporeal blood circuit to be connected to a patient; first and second tube connecting members for connecting respectively to first and second tubes of the extracorporeal circuit; first and second electrodes held, at least in part, by the first and second tube connecting members so as to contact blood flowing through the extracorporeal blood circuit, the first and second electrodes enabling an electrical signal to be injected into the extracorporeal blood circuit; first and second contact members contacting the first and second electrodes respectively; and electronics coupled operably to the first and second contact members for applying the electrical signal, the signal used to monitor the access device.

Abstract translation: 体外血液系统包括：体外血液机器，包括体外血液回路; 允许体外血液回路连接到患者的进入装置; 第一和第二管连接构件，用于分别连接到体外回路的第一和第二管; 第一和第二电极至少部分地由第一和第二管连接构件保持以接触流过体外血液回路的血液，第一和第二电极能够将电信号注射到体外血液回路中; 分别与第一和第二电极接触的第一和第二接触构件; 以及可操作地耦合到第一和第二接触构件的电子装置，用于施加电信号，用于监测接入装置的信号。

公开(公告)号：US20100170848A1

公开(公告)日：2010-07-08

申请号：US12500077

申请日：2009-07-09

Applicant: Alan Robert Brunsman

Inventor： Alan Robert Brunsman

IPC: B01D61/34

CPC classification number: A61M1/0281 ,  A61M1/1682 ,  A61M1/3669 ,  B01D61/32

Abstract: A system for removing cryoprotectant from a cryoprotectant-containing liquid stored a container comprises a cryoprotectant removal device that receives the cryoprotectant-containing liquid and a cryoprotectant-free dialysate liquid and that is operable to transfer cryoprotectant to the dialysate liquid. A differential conductivity device is arranged to continuously measure the difference in conductivity between dialysate liquid entering the device and dialysate liquid that has received cryoprotectant transferred by the dialyzer discharged from the device. A controller is operable to control the flow of the liquids through the device in response to the measured difference in conductivity, and particularly to stop the flow of the cryoprotectant-containing liquid when the measured differential conductivity indicates that the cryoprotectant has been substantially removed from the liquid.

Abstract translation: 从含有冷冻保护剂的液体中除去冷冻保护剂的系统存储容器包括冷冻保护剂去除装置，其接收含冷冻保护剂的液体和无冷冻保护剂的透析液，并且可操作以将冷冻保护剂转移到透析液中。 差分电导率装置被设置为连续地测量进入装置的透析液和已经接收了从装置排出的透析器转移的冷冻保护剂的透析液之间的电导率差。 控制器可操作以响应于测量的导电性差异来控制液体通过装置的流动，特别是当测量的差分电导率表明冷冻保护剂已经从 液体。

公开(公告)号：US20090134882A1

公开(公告)日：2009-05-28

申请号：US11780685

申请日：2007-07-20

Applicant: Karl G. Schick ,  David Uhen

Inventor： Karl G. Schick ,  David Uhen

IPC: G01R35/00 ,  G01R27/08 ,  G01K7/22

CPC classification number: G01N27/10 ,  A61M1/3621 ,  A61M1/3669 ,  A61M2205/6018

Abstract: Disposable, pre-sterilized, and pre-calibrated, pre-validated conductivity sensors are provided. These sensors are designed to store sensor-specific information, such as calibration and production information, in a non-volatile memory chip on the sensor. The sensors are calibrated using 0.100 molar potassium chloride (KCl) solutions at 25 degrees Celsius. These sensors may be utilize with in-line systems, closed fluid circuits, bioprocessing systems, or systems which require an aseptic environment while avoiding or reducing cleaning procedures and quality assurance variances.

Abstract translation: 提供一次性，预消毒和预校准的预验证的电导率传感器。 这些传感器设计用于将传感器特定信息（如校准和生产信息）存储在传感器上的非易失性存储器芯片中。 传感器在25摄氏度下使用0.100摩尔氯化钾（KCl）溶液进行校准。 这些传感器可以利用在线系统，封闭流体回路，生物处理系统或需要无菌环境同时避免或减少清洁程序和质量保证差异的系统。

公开(公告)号：US07473371B2

公开(公告)日：2009-01-06

申请号：US11104947

申请日：2005-04-13

Applicant: Nikolai M. Krivitski ,  David R. MacGibbon

Inventor： Nikolai M. Krivitski ,  David R. MacGibbon

IPC: A61B5/026 ,  A61B5/0275 ,  A61B8/06

CPC classification number: A61M1/3653 ,  A61B5/0275 ,  A61M1/16 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669 ,  A61M1/367

Abstract: The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

Abstract translation: 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。

公开(公告)号：US07297280B2

公开(公告)日：2007-11-20

申请号：US10871319

申请日：2004-06-18

Applicant: Nikolai M. Krivitski ,  David R. MacGibbon

Inventor： Nikolai M. Krivitski ,  David R. MacGibbon

IPC: A61B5/026 ,  A61B5/0275 ,  A61B8/06

CPC classification number: A61M1/3653 ,  A61B5/0275 ,  A61M1/16 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669 ,  A61M1/367

Abstract: The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

Abstract translation: 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。

公开(公告)号：US07052480B2

公开(公告)日：2006-05-30

申请号：US10120684

申请日：2002-04-10

Applicant: James Han ,  Thomas P. Hartranft ,  Thomas D. Kelly ,  Angel Lasso

Inventor： James Han ,  Thomas P. Hartranft ,  Thomas D. Kelly ,  Angel Lasso

IPC: A61M37/00 ,  B01D11/00 ,  C02F1/00 ,  A61B5/00

CPC classification number: A61M1/3669 ,  A61M1/30 ,  A61M1/3653 ,  A61M1/3656 ,  A61M1/3659 ,  A61M1/3661 ,  A61M2205/13 ,  Y10S439/909

Abstract: Apparatuses, devices, systems and methods for detecting access disconnection during medical therapy are provided. The present invention includes an electric circuit coupled to, for example, a blood circuit used during dialysis therapy. The electric circuit can inject an electrical signal into the blood circuit such that changes in an electrical value in response to access disconnection, such as needle drop-out or catheter drop-out, can be effectively detected.

Abstract translation: 提供了用于在药物治疗期间检测进入断开的装置，装置，系统和方法。 本发明包括耦合到例如在透析治疗期间使用的血液回路的电路。 电路可以将电信号注入到血液回路中，使得可以有效地检测出响应于诸如针脱落或导管脱出的进入断开的电值的变化。

公开(公告)号：US06932786B2

公开(公告)日：2005-08-23

申请号：US09914348

申请日：2000-12-22

Applicant: Sara Giacomelli ,  Ivan Rossi ,  Enrico Canini

Inventor： Sara Giacomelli ,  Ivan Rossi ,  Enrico Canini

IPC: A61M1/14 ,  A61M1/16 ,  A61M1/36 ,  A61M37/00 ,  C02F1/44

CPC classification number: A61M1/3669 ,  A61M1/16 ,  A61M1/3656 ,  A61M1/367 ,  A61M2205/13 ,  A61M2205/50

Abstract: A device for monitoring the access to the cardiovascular system of a patient undergoing an extracorporeal treatment of blood in a machine (1) comprising a treatment device (4) and an extracorporeal circuit (2), comprises: a voltage generator (16) for generating a potential difference between a part of the machine (1) and a first point (B) of a venous branch (8) of the extracorporeal circuit (2), connecting the patient to the treatment device (4); a detector (17) for detecting the value (dV) of a quantity that correlates with the electric current along at least one section (10a; 10b; 10c) of the venous branch (10) between the first point (B) and a venous needle (13) fitted at the end of the venous branch (8) and inserted in the vascular system of the patient (P); calculating means (15) for comparing the detected value (dV) with a reference range (I).

Abstract translation: 一种用于监测在包括治疗装置（4）和体外电路（2）的机器（1）中进行血液体外处理的患者的心血管系统的通路的装置，包括：电压发生器（16），用于产生 所述机器（1）的一部分与所述体外回路（2）的静脉分支（8）的第一点（B）之间的电位差，将所述患者连接到所述治疗装置（4）; 检测器（17），用于检测与第一点（B）之间的静脉分支（10）的至少一个部分（10a; 10b; 10c）的电流相关的量的值（dV） 以及安装在静脉分支（8）的端部并插入患者（P）的血管系统中的静脉针（13）; 用于将检测值（dV）与参考范围（I）进行比较的计算装置（15）。

公开(公告)号：US20050051496A1

公开(公告)日：2005-03-10

申请号：US10871319

申请日：2004-06-18

Applicant: Nikolai Krivitski ,  David MacGibbon

Inventor： Nikolai Krivitski ,  David MacGibbon

IPC: A61B5/0275 ,  A61M1/16 ,  A61M1/36 ,  A61B5/026 ,  A61M31/00

CPC classification number: A61M1/3653 ,  A61B5/0275 ,  A61M1/16 ,  A61M1/3655 ,  A61M1/3658 ,  A61M1/3663 ,  A61M1/3669 ,  A61M1/367

Abstract: The measurement of blood flow in a dialysis shunt is obtained by injection of an indicator material into a venous line leading from dialysis equipment to the shunt. The blood flow in an arterial line leading from the shunt at a location downstream of the venous line to the dialysis equipment is monitored by an arterial line sensor for the presence of the indicator material. A detector connected to the sensor provides a dilution curve in response to the presence of the indicator material and the blood flow in the shunt is calculated from the area under the dilution curve. The locations of the arterial and venous lines in the shunt can be reversed to obtain a measurement of blood recirculation from the venous line into the arterial line.

Abstract translation: 通过将指示剂材料注射到从透析设备引导到分流器的静脉管线中，可以测量透析分流器中的血流量。 通过动脉线传感器监测从静脉线下游位置到分离设备的分流处的动脉线中的血液流动，以指示物质的存在。 连接到传感器的检测器响应于指示剂材料的存在而提供稀释曲线，并且根据稀释曲线下的面积计算分流器中的血流量。 分流器中的动脉和静脉线的位置可以反转，以获得从静脉线进入动脉线的血液再循环的测量。