公开(公告)号：US20130217105A1

公开(公告)日：2013-08-22

申请号：US13845725

申请日：2013-03-18

Applicant: Argos Therapeutics, Inc.

Inventor： Simon Jonathon Spence ,  Richard Alexander Grant

IPC: G01N1/34

CPC classification number: G01N35/0099 ,  B01L1/00 ,  B01L1/02 ,  B01L3/021 ,  B01L3/0293 ,  B01L3/5085 ,  B01L7/52 ,  B01L9/06 ,  B01L9/523 ,  B01L2200/02 ,  B01L2200/0642 ,  B01L2200/142 ,  B01L2300/046 ,  B01L2300/06 ,  B01L2300/0838 ,  B01L2300/123 ,  B01L2400/0481 ,  G01L1/00 ,  G01N1/34 ,  G01N35/00732 ,  G01N35/00871 ,  G01N2021/0378 ,  Y10T436/11 ,  Y10T436/2575

Abstract: An apparatus for transfer of a liquid using a diaphragm that separates a working fluid volume from a working air volume and can controllably induce a change pressure to draw or expel a target fluid into a tube. The apparatus is particularly suitable for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or other sample manipulation device can be attached to the inside of the barrier under the diaphraghm, and the barrier can include an interface for a robotic arm or other device. When the barrier is sealed over the tray, the barrier separates the contents of the tray from the robot or other manipulation device.

Abstract translation: 一种用于使用将工作流体体积与工作空气体积分离并可以可控制地引起变化压力以将目标流体吸入或排出到管中的隔膜传送液体的装置。 该装置特别适用于核酸的自动处理，其它样品包括一个包含托盘和柔性屏障的一次性容器。 阻挡件被构造成与托盘的顶部边缘密封，在密封托盘内提供封闭的无菌工作区域。 移液管头和/或其他样品操纵装置可以在隔膜下面附着到阻挡层的内侧，并且阻挡层可以包括用于机器臂或其它装置的界面。 当屏障被密封在托盘上时，屏障将托盘的内容物与机器人或其他操纵装置分开。

公开(公告)号：US08376172B2

公开(公告)日：2013-02-19

申请号：US12380330

申请日：2009-02-26

Applicant: Burgess M. Allen, Jr.

Inventor： Burgess M. Allen, Jr.

IPC: B65D51/18

CPC classification number: G21F7/047 ,  B01L1/02 ,  Y10T156/10

Abstract: An apparatus and a process for forming a protective barrier seal along a “ring of concern” of a transfer container used with double door systems is provided. A protective substrate is supplied between a “ring of concern” and a safety cover in which an adhesive layer of the substrate engages the “ring of concern”. A compressive foam strip along an opposite side of the substrate engages a safety cover such that a compressive force is maintained between the “ring of concern” and the adhesive layer of the substrate.

Abstract translation: 提供了一种用于沿着与双门系统一起使用的转移容器的关注环形成保护性屏障密封件的装置和方法。 保护衬底被提供在关注环和安全盖之间，其中衬底的粘合剂层与所​​关注的环接合。 沿着衬底的相对侧的压缩泡沫带与安全盖接合，使得在所关注的环和衬底的粘合剂层之间保持压缩力。

公开(公告)号：US08328042B2

公开(公告)日：2012-12-11

申请号：US12353771

申请日：2009-01-14

Applicant: Thomas M. Canty ,  Richard Marinelli

Inventor： Thomas M. Canty ,  Richard Marinelli

IPC: B65D25/54 ,  B65D43/26 ,  B65D51/00 ,  H02G3/14

CPC classification number: B01L1/02

Abstract: A port and closure device for a vessel that is configured for use with a glove bag. The port comprising includes a first annular flange with an opening, a second annular flange disposed a predetermined distance from the first flange and also having an opening, and a seal ring disposed adjacent the first annular flange and having an additional opening. At least a portion of the openings are aligned so that a path is provided through the flanges and the seal ring. A slideable door is included in the port between the seal ring and the second annular flange. The slideable door has a first position that obstructs the path and a second position that is outside of the path. Springs are disposed between the first flange and the seal ring that urge the seal ring toward the slideable door. To reduce contamination sites, the springs may be sealed within an annular interface between the first annular flange and the seal ring. Alternatively, or in addition, a funnel pipe may be used with the port disposed in the openings of the first and second flange and the seal ring. The port may also include an adapter configured to hold a glove bag thereon.

Abstract translation: 用于容器的用于与手套袋一起使用的端口和封闭装置。 所述端口包括具有开口的第一环形凸缘，与所述第一凸缘隔开预定距离并且还具有开口的第二环形凸缘以及邻近所述第一环形凸缘设置并具有附加开口的密封环。 开口的至少一部分对准，使得通过凸缘和密封环设置路径。 密封环和第二环形凸缘之间的端口中包括可滑动的门。 可滑动门具有妨碍路径的第一位置和位于路径外侧的第二位置。 弹簧设置在第一凸缘和密封环之间，该密封环将密封环推向可滑动的门。 为了减少污染部位，弹簧可以密封在第一环形凸缘和密封环之间的环形界面内。 或者或另外，可以使用漏斗管，其中端口设置在第一和第二凸缘和密封环的开口中。 端口还可以包括配置成在其上容纳手套袋的适配器。

公开(公告)号：US20110209410A1

公开(公告)日：2011-09-01

申请号：US13127294

申请日：2009-11-05

Applicant: Paul H. Norton ,  Edward Vander Bush ,  W. Edward Hill ,  Robert Nase

Inventor： Paul H. Norton ,  Edward Vander Bush ,  W. Edward Hill ,  Robert Nase

IPC: E06B3/70 ,  E05B65/00

CPC classification number: G21F7/005 ,  B01L1/02 ,  Y10T292/102 ,  Y10T292/205

Abstract: A barrier isolator port assembly for connecting to a conventional docking port of an isolated enclosure is provided. The port assembly includes an annular body, a door assembly and a lock. The annular body is configured to engage a docking port of the isolated enclosure. The port assembly also includes a door assembly mountable within the annular body and a lock operatively connected to the annular body. The lock includes a lever and a pin. The lever is pivotably connected to the annular body about a pivoting member and configured to pivot about the pivoting member to removably insert the pin into the recess of the door assembly.

Abstract translation: 提供了用于连接到隔离外壳的常规对接端口的隔离隔离器端口组件。 端口组件包括环形体，门组件和锁。 环形体配置成接合隔离外壳的对接端口。 端口组件还包括可安装在环形体内的门组件和可操作地连接到环形体的锁。 锁包括一个杠杆和一个销。 所述杠杆围绕枢转构件枢转地连接到所述环形体，并且构造成围绕所述枢转构件枢转以可拆卸地将所述销插入所述门组件的凹部中。

公开(公告)号：US20100314960A1

公开(公告)日：2010-12-16

申请号：US11585631

申请日：2006-10-24

Applicant: Robert H. Polsky

Inventor： Robert H. Polsky

IPC: H02K49/10 ,  B01L1/04

CPC classification number: A61G10/02 ,  B01L1/02 ,  H02K49/104

Abstract: The invention concerns an isolation chamber for isolating substances from the ambient. The isolation chamber comprises a first container surrounding and defining an isolation space for holding the substances and a second container surrounding the first container. A barrier space is positioned between the first and the second containers. Preferably, the pressure of the isolation space is lower than the pressure of the barrier space.

Abstract translation: 本发明涉及用于将物质与环境隔离的隔离室。 隔离室包括围绕并限定用于保持物质的隔离空间的第一容器和围绕第一容器的第二容器。 隔离空间位于第一和第二容器之间。 优选地，隔离空间的压力低于阻挡空间的压力。

公开(公告)号：US07847455B1

公开(公告)日：2010-12-07

申请号：US11585631

申请日：2006-10-24

Applicant: Robert H. Polsky

Inventor： Robert H. Polsky

IPC: H02K47/10

CPC classification number: A61G10/02 ,  B01L1/02 ,  H02K49/104

Abstract: The invention concerns an isolation chamber for isolating substances from the ambient. The isolation chamber comprises a first container surrounding and defining an isolation space for holding the substances and a second container surrounding the first container. A barrier space is positioned between the first and the second containers. Preferably, the pressure of the isolation space is lower than the pressure of the barrier space.

Abstract translation: 本发明涉及用于将物质与环境隔离的隔离室。 隔离室包括围绕并限定用于保持物质的隔离空间的第一容器和围绕第一容器的第二容器。 隔离空间位于第一和第二容器之间。 优选地，隔离空间的压力低于阻挡空间的压力。

公开(公告)号：US07282176B2

公开(公告)日：2007-10-16

申请号：US10499654

申请日：2003-01-07

Applicant: Charles Glachet ,  Jean-Pierre Brossard

Inventor： Charles Glachet ,  Jean-Pierre Brossard

IPC: A61L2/02

CPC classification number: G21F7/047 ,  B01L1/02 ,  B25J21/02 ,  G21Y2002/304 ,  G21Y2002/50 ,  G21Y2004/40 ,  Y10T29/49826 ,  Y10T29/49877 ,  Y10T29/53096

Abstract: A method to mount handling equipment on an interface of a confinement chamber that is to contain a sterile environment. In the method a unit including the handling equipment is prepared and sterilized, and the chamber and a hidden part of the interface are sterilized after coupling impervious tooling to a chamber flange and partially opening the chamber door. The unit is then coupled to the interface. Finally, the double door formed by the equipment door and the chamber door connected to one another is opened, using a handle provided for this purpose on the equipment door.

Abstract translation: 将处理设备安装在包含无菌环境的约束室的界面上的方法。 在该方法中，制备并处理包括处理设备的单元并消毒，并且将不透水工具连接到腔室凸缘并部分地打开室门之后，将腔室和界面的隐藏部分消毒。 然后将该单元耦合到该接口。 最后，由设备门和室门连接的双门打开，使用设备门上提供的手柄。

公开(公告)号：US20050079602A1

公开(公告)日：2005-04-14

申请号：US10958543

申请日：2004-10-06

Applicant: Laurent Mimaud ,  Veronique Ollivier

Inventor： Laurent Mimaud ,  Veronique Ollivier

IPC: C12M1/38 ,  B01L1/00 ,  B01L1/02 ,  B01L99/00 ,  C12M1/00 ,  F25D23/02 ,  C12M1/34

CPC classification number: C12M41/14 ,  B01L1/02 ,  B01L9/52 ,  B01L13/02

Abstract: This enclosure comprises a body which itself comprises: a structure which internally delimits a processing space which opens at the outer side of the structure by way of an opening, at least one framework element which is fixed in a removable manner to the structure in order to delimit, in the opening (13), at least two zones for access to separate regions of the processing space. At least two gates are mounted so as to be movable on the structure in order selectively to close and open the access zones. Application, for example, to CO2 incubators.

Abstract translation: 该外壳包括本体，该主体本身包括：内部限定通过开口在该结构的外侧开口的处理空间的结构，至少一个框架元件，该框架元件以可拆卸的方式固定到该结构，以便 在开口（13）中限定用于访问处理空间的单独区域的至少两个区域。 安装至少两个门，以便能够在结构上移动以便有选择地关闭和打开接入区。 例如，应用于二氧化碳培养箱。

公开(公告)号：US06591662B1

公开(公告)日：2003-07-15

申请号：US09857061

申请日：2001-08-02

Applicant: Jean-Pierre Grimard ,  Jean-Yves Porret

Inventor： Jean-Pierre Grimard ,  Jean-Yves Porret

IPC: G07M308

CPC classification number: G01M3/2869 ,  B01L1/02

Abstract: A sealed connection device in which, two chambers (“A” and “B”), each has an access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated with its flange (4). The detection device comprises two grooves (30, 35), formed in the external face of the flange (4) of chamber (A), a seal (36) placed in the groove (35), a network of ducts (31, 32, 33) formed in flange (4) and connecting the inner groove (30) to a coupling (34), a vacuum pump (38) the intake (37) of which is connected to the said coupling, and a sensor (44) measuring the strength of the partial vacuum in the pneumatic circuit leading to the groove (30) and reacting on alarm means (47, 48) if ever the partial vacuum does not reach an appropriate value.

Abstract translation: 一种密封连接装置，其中两个室（“A”和“B”）各自具有配备有与凸缘（4,5）配合的门（2,3）的进入开口，插入密封装置（12） ，14），两个门中的一个（2）与其凸缘（4）铰接。 检测装置包括形成在腔室（A）的凸缘（4）的外表面中的两个凹槽（30,35），放置在凹槽（35）中的密封件（36），管道网（31,32） ，33），其形成在凸缘（4）中并将内凹槽（30）连接到联接器（34）;真空泵（38），其进气口（37）连接到所述联轴器，传感器（44） 如果部分真空没有达到适当的值，则测量导致凹槽（30）的气动回路中的部分真空的强度并在报警装置（47,48）上作出反应。

公开(公告)号：US06571540B1

公开(公告)日：2003-06-03

申请号：US09622463

申请日：2000-10-23

Applicant: Claude Imbert ,  Jean-Yves Porret

Inventor： Claude Imbert ,  Jean-Yves Porret

IPC: B65B3100

CPC classification number: B01L1/02

Abstract: Device (10) for achieving communication, via a coupling means, between a first chamber (1) and a second chamber (2). The coupling means comprises, on the same side as the first chamber (1), a first shut-off member (41), and, on the same side as the second chamber (2), a second shut-off member (4) comprising a second flange (52) forming a seat for a second removable shutter element (72). The coupling means further comprises means of sealed connection between two flanges (51) and (52). The second chamber (2) being defined by the inside of a flexible and sealed bag (15), the border of the mouth of which is connected in a sealed way to the second flange (52). When the coupling, means is in an uncoupled position, the flexible bag (15) comprises a band (15d) extending the bag (15) continuously beyond the second flange (52), defining a closed (15f) and sealed, but openable envelope (12) for protecting the second shut-off member (42).

Abstract translation: 用于通过联接装置在第一室（1）和第二室（2）之间实现通信的装置（10）。 联接装置在与第一室（1）相同的一侧上包括第一切断构件（41），并且在与第二室（2）相同的一侧具有第二切断构件（4） 包括形成用于第二可拆卸快门元件（72）的座的第二凸缘（52）。 联接装置还包括在两个凸缘（51）和（52）之间的密封连接装置。 第二室（2）由柔性和密封的袋（15）的内部限定，其口部的边界以密封的方式连接到第二凸缘（52）。 当联接装置处于非耦合位置时，柔性袋（15）包括连续地将袋（15）延伸超出第二凸缘（52）的带（15d），限定封闭（15f）且密封但可开启的信封 （12），用于保护第二截止部件（42）。