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135 条记录 (耗时 0.024 秒)

    Austenitic nitinol medical devices
    24.
    发明申请
    Austenitic nitinol medical devices 有权
    奥氏体镍钛诺医疗器械

    公开(公告)号：US20040059410A1

    公开(公告)日：2004-03-25

    申请号：US10657768

    申请日：2003-09-08

    发明人： Daniel L. Cox

    IPC分类号： A61F002/06

    CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2210/0014 ,  A61L31/022 ,  A61L2400/16 ,  Y10S623/924

    摘要： A medical device for use within a body lumen that is made from a binary nickel-titanium alloy that remains in its austenitic phase throughout its operational range is disclosed. The medical device, such as an intraluminal stent, is made from superelastic nickel-titanium and may optionally be alloyed with a ternary element. By adding the ternary element and/or through heat treatment, it is possible to lower the phase transformation temperature between the austenitic phase and the martensitic phase of the nickel-titanium alloy. By lowering the phase transformation temperature, the martensite deformation temperature is likewise depressed. It is possible then to depress the martensite deformation temperature below body temperature such that when the device is used in a body lumen for medical treatment, the nickel-titanium device remains completely in the austenitic phase without appearance of stress-induced martensite even if the device is placed under stress.

    摘要翻译： 公开了一种在体腔内使用的由二元镍钛合金制成的医疗装置，其在整个其操作范围内保持其奥氏体相。 诸如管腔内支架的医疗装置由超弹性镍钛制成，并且可任选地与三元元素合金化。 通过添加三元元素和/或通过热处理，可以降低镍 - 钛合金的奥氏体相和马氏体相之间的相变温度。 通过降低相变温度，同样地抑制马氏体变形温度。 然后可以将马氏体变形温度降低到体温以下，使得当将该装置用于用于医疗的体腔时，镍钛装置在奥氏体相中完全保持，而不会出现应力诱发的马氏体，即使该装置 被置于压力之下。

    Austenitic nitinol medical devices
    25.
    发明授权
    Austenitic nitinol medical devices 有权
    奥氏体镍钛诺医疗器械

    公开(公告)号：US06626937B1

    公开(公告)日：2003-09-30

    申请号：US09713708

    申请日：2000-11-14

    申请人： Daniel L. Cox

    发明人： Daniel L. Cox

    IPC分类号： A61F206

    CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2210/0014 ,  A61L31/022 ,  A61L2400/16 ,  Y10S623/924

    摘要： A medical device for use within a body lumen that is made from a binary nickel-titanium alloy that remains in its austenitic phase throughout its operational range is disclosed. The medical device, such as an intraluminal stent, is made from superelastic nickel-titanium and may optionally be alloyed with a ternary element. By adding the ternary element and/or through heat treatment, it is possible to lower the phase transformation temperature between the austenitic phase and the martensitic phase of the nickel-titanium alloy. By lowering the phase transformation temperature, the martensite deformation temperature is likewise depressed. It is possible then to depress the martensite deformation temperature below body temperature such that when the device is used in a body lumen for medical treatment, the nickel-titanium device remains completely in the austenitic phase without appearance of stress-induced martensite even if the device is placed under stress.

    摘要翻译： 公开了一种在体腔内使用的由二元镍钛合金制成的医疗装置，其在整个其操作范围内保持其奥氏体相。 诸如管腔内支架的医疗装置由超弹性镍钛制成，并且可任选地与三元元素合金化。 通过添加三元元素和/或通过热处理，可以降低镍 - 钛合金的奥氏体相和马氏体相之间的相变温度。 通过降低相变温度，同样地抑制马氏体变形温度。 然后可以将马氏体变形温度降低到体温以下，使得当将该装置用于用于医疗的体腔时，镍钛装置在奥氏体相中完全保持，而不会出现应力诱发的马氏体，即使该装置 被置于压力之下。

    Medication device with protein stabilizing surface coating
    27.
    发明授权
    Medication device with protein stabilizing surface coating 有权
    具有蛋白质稳定表面涂层的药物装置

    公开(公告)号：US6443942B2

    公开(公告)日：2002-09-03

    申请号：US87656901

    申请日：2001-06-06

    申请人： MINIMED INC

    发明人： VAN ANTWERP WILLIAM PETER ,  GULATI POONAM S ,  ADOMIAN GERALD E

    IPC分类号： A61L29/08 ,  A61L31/10 ,  A61L33/06 ,  A61M5/142 ,  A61L33/00 ,  A61L2/02 ,  A61L17/00

    CPC分类号： A61M5/14276 ,  A61L29/085 ,  A61L31/10 ,  A61L33/06 ,  Y10S623/924 ,  Y10T428/31678 ,  Y10T428/31855 ,  C08L75/04

    摘要： The present invention provides medical devices such as medication infusion pumps having internal surfaces that are treated to inhibit protein denaturation. In accordance with the invention, hydrophilic internal surfaces and related coating methods are provided to reduce or eliminate accumulation of medication deposits which can otherwise occur when handling complex protein-based medications. Preferred hydrophilic pump surfaces include hydrophilic surfactants (PEO) or (PEG) coatings which exhibit very low protein adsorption characteristics. Several methods are disclosed for producing such treated surfaces including the covalent attachment of hydrophilic surfactants.

    摘要翻译： 本发明提供了诸如药物输注泵的医疗装置，其具有被处理以抑制蛋白质变性的内表面。 根据本发明，提供亲水内表面和相关的涂覆方法以减少或消除当处理复杂的基于蛋白质的药物时可能发生的药物沉积物的积累。 优选的亲水泵表面包括表现出非常低的蛋白质吸附特性的亲水性表面活性剂（PEO）或（PEG）涂层。 公开了几种用于生产这样的处理表面的方法，包括亲水性表面活性剂的共价连接。

    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same
    28.
    发明授权
    Biodegradable compositions comprising poly(cycloaliphatic phosphoester) compounds, articles, and methods for using the same 失效
    包含聚（脂环族磷酸酯）化合物的生物可降解组合物，制品及其使用方法

    公开(公告)号：US06403675B1

    公开(公告)日：2002-06-11

    申请号：US09070204

    申请日：1998-04-30

    申请人： Wenbin Dang ,  Hai-quan Mao ,  Irina Kadiyala ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    发明人： Wenbin Dang ,  Hai-quan Mao ,  Irina Kadiyala ,  Kam W. Leong ,  Zhong Zhao ,  James P. English

    IPC分类号： A61K3180

    CPC分类号： C08G79/04 ,  A61K47/34 ,  A61L27/18 ,  A61L31/06 ,  Y10S623/924 ,  C08L85/02

    摘要： Biodegradable, flowable or flexible polymer compositions are described comprising a polymer having the recurring monomeric units shown in formula I: wherein: each of R and R′ is independently straight or branched alkylene, either unsubstituted or substituted with one or more non-interfering substituents; L is a divalent cycloaliphatic group; R″ is selected from the group consisting of H, alkyl, alkoxy, aryl, aryloxy, heterocyclic or heterocycloxy; and n is 5 to 1,000, wherein said biodegradable polymer is biocompatible before and upon biodegradation. In one embodiment, one or more of R, R′ or R″ is a biologically active substance. Amorphous compositions containing a biologically active substance, in addition to the polymer, and methods for controllably releasing biologically active substances using the compositions, are also described.

    摘要翻译： 描述了可生物降解的，可流动的或柔性的聚合物组合物，其包含具有式I所示的重复单体单元的聚合物：其中：R和R'各自独立地为未取代的或被一个或多个非干扰取代基取代的直链或支链亚烷基; L是二价脂环族基团; R“选自H，烷基，烷氧基，芳基，芳氧基，杂环或杂环氧基; andn为5至1,000，其中所述生物可降解聚合物在生物降解之前和之后是生物相容的。 在一个实施方案中，R，R'或R“中的一个或多个是生物活性物质。 还描述了除了聚合物之外含有生物活性物质的无定形组合物以及使用该组合物可控地释放生物活性物质的方法。

    Medical device
    30.
    发明授权
    Medical device 失效
    医疗装置

    公开(公告)号：US5928206A

    公开(公告)日：1999-07-27

    申请号：US950800

    申请日：1997-10-15

    申请人： Masao Miyake ,  Naomi Fujimori

    发明人： Masao Miyake ,  Naomi Fujimori

    IPC分类号： A61L29/06 ,  C08G18/62 ,  A01N1/00 ,  B32B15/08

    CPC分类号： C08G18/6266 ,  A61L29/06 ,  Y10S623/924 ,  Y10T428/31576

    摘要： Disclosed is a medical device in which a surface of a base material for constructing the medical device is coupled to a high-molecular weight compound composed of N-substituted alkylacrylamide by the aid of a reaction between a reactive functional group such as isocyanate group, epoxy group, and aldehyde group existing on the surface and a functional group which is possessed by the high-molecular weight compound and which is reactive with the first reactive functional group.

    摘要翻译： 公开了一种医疗装置，其中用于构建医疗装置的基材的表面与由N-取代的烷基丙烯酰胺组成的高分子量化合物通过反应性官能团如异氰酸酯基团，环氧基 基团和醛基，以及由高分子量化合物所具有的与第一反应性官能团反应的官能团。