公开(公告)号：US06682498B2

公开(公告)日：2004-01-27

申请号：US09816629

申请日：2001-03-22

Applicant: John Ross

Inventor： John Ross

IPC: A61M3700

CPC classification number: A61M1/3653 ,  A61M1/3659 ,  A61M25/0029 ,  A61M2025/0031 ,  A61M2025/0034 ,  A61M2025/0037 ,  A61M2210/125

Abstract: The present invention provides improved methods for establishing vascular access to a patient's body lumen or other target location, particularly blood vessels, for performing extracorporeal treatments, such as hemodialysis, hemofiltration, hemodiafiltration, plasmapheresis, apheresis, and the like, on circulating blood. In particular, the present invention provides improved methods which may enhance extracorporeal blood flow rates, reduce instances of fibrin sheath or thrombosis formation, and minimize recirculation effects. Methods for recirculating blood to a patient include placing a draw catheter so that a distal tip thereof is positioned in a right atrium of the patient's heart. A return catheter is placed so that a distal tip thereof is positioned in a superior vena cava. Extracorporeal blood flow from the draw catheter to the return catheter may then be established.

Abstract translation: 本发明提供了用于在循环血液上建立对患者的体腔或其他目标位置，特别是血管的血管通路的改进方法，用于进行体外治疗，例如血液透析，血液滤过，血液透析滤过，血浆置换术，血浆置换术等。 特别地，本发明提供了改进的方法，其可以增强体外血流速度，减少纤维蛋白鞘或血栓形成的发生，并使再循环效应最小化。 将血液再循环到患者的方法包括放置牵引导管，使得其远端位于患者心脏的右心房中。 将返回导管放置成使其远端位于上腔静脉中。 然后可以建立从抽吸导管到返回导管的体外血流量。

公开(公告)号：US06676634B1

公开(公告)日：2004-01-13

申请号：US09631422

申请日：2000-08-03

Applicant: Michael A. Spohn ,  Robert J. Ashcraft, Jr. ,  Craig John Bowser ,  P. Eric Pavlik ,  Albert John Yarzebinski ,  David M. Reilly ,  Joseph B. Havrilla

Inventor： Michael A. Spohn ,  Robert J. Ashcraft, Jr. ,  Craig John Bowser ,  P. Eric Pavlik ,  Albert John Yarzebinski ,  David M. Reilly ,  Joseph B. Havrilla

IPC: A61M3700

CPC classification number: A61M5/14546 ,  A61M5/14566

Abstract: The present syringe adapter (100), which permits use of syringes (40) of various types, sizes and configurations to be used with a front-loading injector (10), includes a removable injector face plate (120) having a releasable mounting mechanism (122a, 122b) for attaching the adapter face plate (120) to a front-load injector (10), a reducing sleeve (140) having a recess (190) for receiving the distal flange (44) of syringe (40), locking pivot arms (220, 240) pivotly attached to the reducing sleeve (140) to releasably engage syringe flange (44), and a piston extension (320) provided for extending the injector drive piston (16) for engagement with syringe plunger (46).

Abstract translation: 本注射器适配器（100），其允许使用与前装载注射器（10）一起使用的各种类型，尺寸和构造的注射器（40），其包括可移除的注射器面板（120），其具有可释放的安装机构 用于将适配器面板（120）附接到前负载喷射器（10）的减压套筒（122a，122b），具有用于接收注射器（40）的远端凸缘（44）的凹部（190） 枢转地附接到所述还原套筒（140）以可释放地接合注射器凸缘（44）的枢转臂（220,240）和设置用于延伸所述注射器驱动活塞（16）以与注射器柱塞（46）接合的活塞延伸部 ）。

公开(公告)号：US06648854B1

公开(公告)日：2003-11-18

申请号：US09311446

申请日：1999-05-14

Applicant: Marlowe E. Patterson ,  Thomas Yung-Hui Chien ,  Hanh Doan ,  Hong Doan ,  Huey Quoc Chan ,  Henry Nita

Inventor： Marlowe E. Patterson ,  Thomas Yung-Hui Chien ,  Hanh Doan ,  Hong Doan ,  Huey Quoc Chan ,  Henry Nita

IPC: A61M3700

CPC classification number: A61M25/0052 ,  A61M25/005 ,  A61M25/0053 ,  A61M25/10 ,  A61M2025/0042 ,  A61M2025/1063

Abstract: A single lumen balloon-tipped micro catheter, wherein the distal portion of the shaft is reinforced and extends into the balloon to eliminate abrupt transitions in stiffness in the balloon region. The balloon may be formed of a thermoplastic polyisoprene rubber such as hydrogenated polyisoprene which has superior performance and manufacturing attributes.

Abstract translation: 单腔气囊尖微导管，其中轴的远端部分被加强并延伸到气囊中以消除气囊区域中刚度的突然过渡。 气囊可以由具有优异性能和制造特性的热塑性聚异戊二烯橡胶如氢化聚异戊二烯形成。

公开(公告)号：US06648845B1

公开(公告)日：2003-11-18

申请号：US09003798

申请日：1998-01-07

Applicant: Frank A. Gotch ,  Thomas I. Folden

Inventor： Frank A. Gotch ,  Thomas I. Folden

IPC: A61M3700

CPC classification number: A61M1/3653 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/361 ,  A61M1/3612 ,  A61M1/3655 ,  A61M1/3656 ,  A61M1/3658 ,  A61M1/3661 ,  A61M2202/0498 ,  A61M2205/15 ,  A61M2205/3317 ,  A61M2205/3324 ,  A61M2205/3368 ,  A61M2205/50

Abstract: This invention provides a method and apparatus for calculating a hemodialysis parameter, especially blood access flow rate, using multiple dialysance values. The dialysance values may be calculated based upon either sodium or urea concentrations. One dialysance value can be determined for conditions in which a patient's arterial line withdraws blood from an upstream location in a patient's fistula and treated blood is returned by a venous line to a downstream location in a patient's fistula. The second dialysance value can be determined when the lines have been reconfigured so that the arterial line withdraws blood from a downstream portion of a patient's fistula and the venous line returns treated blood to an upstream portion of a patient's fistula. Since it is possible to determine the dialysance values solely from concentration measurements made on the dialysate side of the dialysis apparatus, the present method and apparatus provide a non-invasive means for determining hemodialysis parameters such as blood access flow rate and recirculation.

Abstract translation: 本发明提供一种使用多个透析值计算血液透析参数，特别是血液存取流量的方法和装置。 透析值可以基于钠或尿素浓度来计算。 可以确定患者的动脉线从患者瘘管中的上游位置抽出血液的情况下的一个透析值，并且将经处理的血液通过静脉管线返回到患者瘘管的下游位置。 当线重新配置时，可以确定第二透析值，使得动脉线从患者瘘的下游部分抽出血液，并且静脉线将经处理的血液返回到患者瘘的上游部分。 由于可以仅通过在透析装置的透析液侧进行的浓度测定来确定透析值，因此本方法和装置提供用于确定血液透析参数如血液存取流量和再循环的非侵入性手段。

公开(公告)号：US06645171B1

公开(公告)日：2003-11-11

申请号：US09194873

申请日：1999-03-16

Applicant: Grenville Arthur Robinson ,  Michael Anthony Hobbs ,  Martyn Omar Rowlands ,  John Richard Calvert

Inventor： Grenville Arthur Robinson ,  Michael Anthony Hobbs ,  Martyn Omar Rowlands ,  John Richard Calvert

IPC: A61M3700

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2051 ,  A61J1/2065 ,  A61J1/2089 ,  A61J3/002

Abstract: A device for reconstituting liquid for medical use by bringing together a first liquid medium contained in a first vessel in the form of a cartridge (3) and a second medium, such as a drug in solid form, contained in a second vessel in the form of a vial (7), the device (19) comprising means (41) for supporting the first and second vessels, and a movable operating member (50) for applying a force to cause the first liquid medium to be delivered at a controlled rate from the first vessel into the second vessel. The first and second vessels may be provided in a pack (70) having liquid transfer means in the form of a needle (10).

公开(公告)号：US06645166B2

公开(公告)日：2003-11-11

申请号：US09940389

申请日：2001-08-27

Applicant: Peter Scheunert ,  Martin Lauer ,  Manfred Weis ,  Josef Beden ,  Martin Herklotz ,  Joachim Manke ,  Uwe Hahmann

Inventor： Peter Scheunert ,  Martin Lauer ,  Manfred Weis ,  Josef Beden ,  Martin Herklotz ,  Joachim Manke ,  Uwe Hahmann

IPC: A61M3700

CPC classification number: A61M1/3621 ,  A61M1/16 ,  A61M1/30 ,  A61M1/302 ,  A61M1/303 ,  A61M2205/128

Abstract: A blood treatment device, in particular a dialysis machine, which permits both single-needle and dual-needle operation. The device has a blood treatment unit, in particular a dialyzer that has an inlet connected to a feed line and an outlet connected to a return line. The feed line has two parallel line branches with a positive displacement pump being connected into the first and second line branches. To produce a fluid connection between the outlet of the dialyzer and one of the two pumps, a connection line is provided. For dual-needle operation, the feed and return lines are connected to an arterial and a venous needle. For single-needle operation, the feed and return lines are brought together and connected to a common needle. The connection line permits single-needle operation without great changes to the structure of the blood treatment device.

公开(公告)号：US06635030B1

公开(公告)日：2003-10-21

申请号：US09289289

申请日：1999-04-09

Applicant: Kyongtae T. Bae ,  Huy Q. Tran ,  James R. Small

Inventor： Kyongtae T. Bae ,  Huy Q. Tran ,  James R. Small

IPC: A61M3700

CPC classification number: A61M5/007 ,  A61M5/14546 ,  A61M31/005 ,  A61M2005/14208 ,  G06F19/00 ,  G06F19/3468

Abstract: A contrast medium injector for injecting a patient with contrast medium for a CT scan is programmed to provide an injection protocol that is a representation of an ideally defined exponential curve with an initial injection rate decaying at an exponential rate. This has been found to produce a uniform vascular enhancement for the scanning of a patient's blood vessels. The particular exponential decay coefficient which has been found to be optimal is directly proportional to the cardiac output divided by the patient's weight and is approximated at 0.01 for a typical human.

Abstract translation: 用于向患者注射用于CT扫描的造影剂的造影剂注射器被编程以提供注射方案，其是以指数速率衰减的初始注射速率的理想定义的指数曲线的表示。 已经发现已经发现用于扫描患者血管的均匀的血管增强。 已经发现是最佳的特定指数衰减系数与心输出量除以患者体重成正比，对于典型的人而言，其近似为0.01。

公开(公告)号：US06623452B2

公开(公告)日：2003-09-23

申请号：US09741278

申请日：2000-12-19

Applicant: Thomas Yung-Hui Chien ,  Henry Nita ,  Alain Cornil

Inventor： Thomas Yung-Hui Chien ,  Henry Nita ,  Alain Cornil

IPC: A61M3700

CPC classification number: A61M25/10184 ,  A61M25/10 ,  A61M25/10185 ,  A61M25/1029 ,  A61M25/104 ,  A61M2025/105 ,  A61M2025/1052

Abstract: An intravascular drug delivery balloon catheter incorporating a highly compliant balloon having a plurality of infusion holes. The highly compliant balloon elastically expands at a low inflation pressure (e.g., less than 1.0 ATM), and preferably has a compliance of 2.0 mm/ATM or more at pressures less than 2.0 ATM. A pressure relief valve may be incorporated into the catheter to avoid over pressurization. The infusion holes may be open when the balloon is deflated and may enlarge when the balloon is inflated. The balloon may define a single lobe or two inflatable lobes with the infusion holes disposed therebetween.

公开(公告)号：US06623443B1

公开(公告)日：2003-09-23

申请号：US09477198

申请日：2000-01-04

Applicant: Hans-Dietrich Polaschegg

Inventor： Hans-Dietrich Polaschegg

IPC: A61M3700

CPC classification number: A61M1/3639 ,  A61M1/16 ,  A61M1/3656 ,  A61M2205/3344

Abstract: Stenosis in a blood access circuit (graft, fistula) or in an extracorporeal circuit are detected by monitoring pressure pulses in the extracorporeal circuit created either by the heart or by the peristaltic blood pump of the extracorporeal circuit. By monitoring pressure pulses created by the. peristaltic blood pump loss of occlusion of the blood pump can be detected. Measurement of the pressure pulses is done either with sensors already built into the blood treatment equipment or, according to the invention, with sensors mechanically coupled to the wall of the blood tubing. The deviation of a pressure pulse amplitude proportional signal from a predetermined value indicates stenosis or loss of occlusion, respectively.

Abstract translation: 通过监测由心脏或体外循环的蠕动血液泵产生的体外循环中的压力脉冲来检测血液存取回路（移植物，瘘管）或体外循环中的狭窄。 通过监测由...产生的压力脉冲。 可以检测到血液泵的蠕动性血液泵堵塞的损失。 压力脉冲的测量可以通过已经内置在血液处理设备中的传感器进行，或者根据本发明，机械耦合到血管的壁上的传感器。 来自预定值的压力脉冲幅度比例信号的偏差分别表示狭窄或闭塞丧失。

公开(公告)号：US06623441B1

公开(公告)日：2003-09-23

申请号：US09744808

申请日：2001-04-06

Applicant: Kazuhiko Kihara ,  Akio Yamada

Inventor： Kazuhiko Kihara ,  Akio Yamada

IPC: A61M3700

CPC classification number: A61M1/3693 ,  A61M1/3479 ,  A61M1/3696

Abstract: An artificial kidney capable of cleaning blood, like a kidney of a healthy body, by any person even at home which is small in the size and simple in the structure and handling, without requiring any pharmaceutical solution. A metabolic end product separation chamber (9) is placed to the center of a cylindrical centrifugator (7) for circulating blood continuously and separating it into blood cell ingredients and plasma ingredients for conducting ultrafiltration of the separated plasmas and intaking water, serum electrolytes and unnecessary metabolic end products, in which a water re-absorbing module (11) capable of flowing the concentrated plasma ingredients and re-absorbing the water content and the serum electrolytes to obtain a cleaned plasma ingredient is placed, and the obtained cleaned blood ingredients are mixed with the blood cell ingredients separated by the centrifugator (7) to obtain cleaned blood.

Abstract translation: 一种人造肾，能够清洁血液，如健康身体的肾脏，甚至在家中，尺寸小，结构简单，处理方便，无需任何药物溶液。代谢终产物分离室（9 ）放置在圆柱形离心机（7）的中心，用于连续循环血液，并将其分离成血细胞成分和血浆成分，用于对分离的血浆进行超滤并吸入水，血清电解质和不必要的代谢终产物，其中水 放置能够使浓缩的等离子体成分流通并再吸收含水量的再吸收组件（11）和血清电解质以获得清洁的血浆成分，并且将获得的清洁的血液成分与由 离心机（7）以获得清洁的血液。