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    Method for coating pharmaceutical dosage forms
    22.
    发明申请
    Method for coating pharmaceutical dosage forms 有权

    公开(公告)号：US20010012519A1

    公开(公告)日：2001-08-09

    申请号：US09754665

    申请日：2001-01-04

    Inventor： Michael L. Cappola

    IPC: B01J013/00 ,  A61K009/44

    CPC classification number: A61K9/2886 ,  A61K9/2072

    Abstract: The invention provides a process for coating a branded pharmaceutical dosage form for the purpose of covering any embossed or printed matter or any colored coating by the application of an amount of a sugar based coating which is sufficient to obscure any identifying indicia without compromising the stability or releasability of the drug that is contained in the dosage form.

    Nanocomposites of dendritic polymers
    26.
    发明申请
    Nanocomposites of dendritic polymers 失效
    树枝状聚合物的纳米复合材料

    公开(公告)号：US20040070094A1

    公开(公告)日：2004-04-15

    申请号：US10682646

    申请日：2003-10-09

    Inventor： Donald A. Tomalia ,  Lajos Balogh

    IPC: B01J013/00

    CPC classification number: B82Y30/00 ,  C08G83/003 ,  C08J3/02 ,  C08J2300/00 ,  C08J2300/202 ,  Y10S977/753 ,  Y10S977/754 ,  Y10S977/788 ,  Y10S977/835

    Abstract: In the present invention, an inorganic reactant is, or reactants are, localized with respect to a dendritic polymer by physical constraint within or by a non-covalent conjugation to the dendritic polymer. The localized inorganic reactant or reactants is/are subsequently transformed to form a reaction product which is immobilized with respect to the dendritic polymer. This immobilization occurs on a nanoscopic scale as a consequence of the combined effects of structural, chemical and physical changes without having covalent bonds between the product(s) and the dendritic container and results in new compositions of matter called dendritic nanocomposites. The resulting nanocomposite material can be used to produce revolutionary products such as water soluble elemental metals, with specific applications including magnetic resonance imaging, catalytic, magnetic, optical, photolytic and electroactive applications.

    Abstract translation: 在本发明中，无机反应物是或反应物相对于树枝状聚合物通过物理约束在非共价共轭结合到树枝状聚合物内或通过非共价共轭结合到树枝状聚合物。 随后将局部无机反应物或反应物转化成相对于树枝状聚合物固定的反应产物。 由于结构，化学和物理变化的组合效应，在产品和树枝状容器之间没有共价键并导致称为树枝状纳米复合材料的新组合物，这种固定在纳米尺度上发生。 所得的纳米复合材料可用于生产诸如水溶性元素金属的革命性产品，其具体应用包括磁共振成像，催化，磁性，光学，光解和电活性应用。

    Production process for polymeric micelle charged therein with drug and polymeric micelle composition
    27.
    发明申请
    Production process for polymeric micelle charged therein with drug and polymeric micelle composition 有权
    用药物和聚合物胶束组合物填充聚合物胶束的生产方法

    公开(公告)号：US20040056372A1

    公开(公告)日：2004-03-25

    申请号：US10666384

    申请日：2003-09-22

    Inventor： Masayuki Yokoyama ,  Eiichi Honzawa ,  Yasuaki Ogawa

    IPC: B01J013/00

    CPC classification number: A61K9/1075

    Abstract: Provided are a production process for a polymeric micelle which is stable and has a high drug content and a composition containing such polymeric micelle. Disclosed are a production process for a polymeric micelle, comprising the steps of dissolving a drug and a specific copolymer in a water non-miscible organic solvent to prepare a solution, mixing the resulting solution with water to form an O/W type emulsion and then slowly volatilizing the organic solvent from the solution, and a polymeric micelle composition charged therein with a water-scarcely soluble drug, which can be obtained by the above production process.

    Abstract translation: 提供稳定且具有高药物含量的聚合胶束的生产方法和含有这种聚合胶束的组合物。 公开了一种聚合物胶束的制备方法，包括以下步骤：将药物和特定共聚物溶解在水不混溶的有机溶剂中以制备溶液，将所得溶液与水混合以形成O / W型乳液，然后 从溶液中缓慢挥发有机溶剂，以及在其中装入难溶于水的药物的聚合胶束组合物，其可以通过上述制备方法获得。

    Encapsulation of sensitive components using pre-emulsification
    29.
    发明申请
    Encapsulation of sensitive components using pre-emulsification 有权
    使用预乳化包装敏感组分

    公开(公告)号：US20040017017A1

    公开(公告)日：2004-01-29

    申请号：US10205146

    申请日：2002-07-24

    Inventor： Bernhard H. Van Lengerich ,  Lily Leung ,  Steven C. Robie ,  Young Kang ,  Jamileh Lakkis ,  Thomas M. Jarl

    IPC: B01J013/00

    CPC classification number: A23L33/115 ,  A23P10/30 ,  Y10T428/2984

    Abstract: A stabilized emulsion is employed to produce shelf stable, controlled release, discrete, solid particles or pellets which contain an encapsulated and/or embedded component, such as a readily oxidizable component, such as omega-3 fatty acids. An oil encapsulant component which contains an active, sensitive encapsulant, dissolved and/or dispersed in an oil is admixed with an aqueous component and a film-forming component to form an emulsion. An antioxidant for prevention of oxidation of the active, sensitive encapsulant, and a film-softening component or plasticizer for the film-forming component may be included in the emulsion. The emulsion is stabilized by subjecting it to homogenization. The pellets are produced by first reducing the water content of the stabilized emulsion so that the film-forming component forms a film around the oil droplets and encapsulates the encapsulant. In embodiments of the invention, the water content of the homogenized emulsion may be reduced by spray-drying to produce a powder. In other embodiments of the invention, after homogenization, the water content of the emulsion may be reduced by admixing the emulsion with at least one matrix material to thereby encapsulate the film-coated oil droplets within the matrix material. After the water content of the emulsion is reduced, a protective coating is applied on the film-coated oil droplets to obtain pellets.

    Abstract translation: 使用稳定化的乳液来制备搁置稳定的，控制释放的，离散的，固体颗粒或颗粒，其含有包封和/或嵌入的组分，例如容易氧化的组分，例如ω-3脂肪酸。 将含有溶解和/或分散在油中的活性敏感密封剂的油包封剂组分与水性组分和成膜组分混合以形成乳液。 用于防止活性敏感性密封剂氧化的抗氧化剂，以及用于成膜组分的薄膜软化组分或增塑剂可以包括在乳液中。 通过使乳液均匀化使乳液稳定。 通过首先降低稳定的乳液的含水量使得成膜组分在油滴周围形成膜并封装密封剂来制备颗粒。 在本发明的实施方案中，均匀乳液的含水量可以通过喷雾干燥来降低以产生粉末。 在本发明的其它实施方案中，在均化之后，可以通过将乳液与至少一种基质材料混合从而将包膜的油滴包封在基质材料内，从而降低乳液的含水量。 在乳液的含水量减少之后，在涂覆有油滴的油滴上施加保护涂层以获得颗粒。

    Method of moulding a pharmaceutical composition in a packaging material
    30.
    发明申请
    Method of moulding a pharmaceutical composition in a packaging material 审中-公开
    在包装材料中成型药物组合物的方法

    公开(公告)号：US20030234466A1

    公开(公告)日：2003-12-25

    申请号：US10341142

    申请日：2003-01-13

    Inventor： Thomas Buch Rasmussen ,  Aasmul Soren ,  Jens Ulrik Poulsen ,  James M. Flink ,  Philip Hansen ,  Juul Mortensen Claus

    IPC: B01J013/00 ,  A61J001/00 ,  B05D003/00 ,  D04H001/00 ,  B27N003/00

    CPC classification number: A61K9/0024 ,  A61J3/00 ,  A61K9/2095

    Abstract: The present invention relates to a method of producing a pharmaceutical composition directly in a packaging material, a moulded packaging material comprising the pharmaceutical composition, a cassette comprising the packaging material, as well as a method of administering a dosage of the pharmaceutical composition for example directly from the packaging material. The packaging material defines the predetermined geometry of the pharmaceutical composition, in that a melt of the pharmaceutical composition is injected directly into the packaging material, whereby the method comprises establishing a mould, moulding, in said mould, the packaging material from a melt, whereby the packaging material is provided with at least one cavity, said cavity having at least one side wall and optionally a bottom wall, moulding in a moulding compartment, said compartment having a predetermined form being defined by at least a part of said at least one cavity, the pharmaceutical composition from a melt consisting of the ingredients of the pharmaceutical composition having a predetermined temperature, and cooling the pharmaceutical composition, whereby the packaging material comprising the pharmaceutical composition having a predetermined form is obtained.

    Abstract translation: 本发明涉及直接在包装材料中生产药物组合物的方法，包含该药物组合物的成型包装材料，包含该包装材料的盒子以及例如直接施用该药物组合物的剂量的方法 从包装材料。 包装材料限定了药物组合物的预定几何形状，因为药物组合物的熔体直接注射到包装材料中，由此该方法包括在熔体中建立模具，在模具中模制包装材料，由此 所述包装材料设置有至少一个空腔，所述空腔具有至少一个侧壁和任选的底壁，在模制隔间中成型，所述隔室具有预定形式，所述预定形式由所述至少一个空腔的至少一部分 由药物组合物组成的药物组合物由具有预定温度的药物组合物的成分组成，并冷却药物组合物，从而获得包含具有预定形式的药物组合物的包装材料。

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