公开(公告)号：US5703085A

公开(公告)日：1997-12-30

申请号：US537770

申请日：1995-10-20

申请人： Fumio Suzuki ,  Nobuaki Koike ,  Junichi Shimada ,  Joji Nakamura ,  Shizuo Shiozaki ,  Shigeto Kitamura ,  Shunji Ichikawa ,  Hiroshi Kase ,  Hiromi Nonaka

发明人： Fumio Suzuki ,  Nobuaki Koike ,  Junichi Shimada ,  Joji Nakamura ,  Shizuo Shiozaki ,  Shigeto Kitamura ,  Shunji Ichikawa ,  Hiroshi Kase ,  Hiromi Nonaka

IPC分类号： C07D473/06 ,  A61K31/52 ,  C07D473/10 ,  C07D473/12

CPC分类号： C07D473/06

摘要： The present invention relates to novel xanthine derivatives and pharmaceutically acceptable salts thereof, represented by Formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 independently represent hydrogen, lower alkyl, lower alkenyl, or lower alkynyl, R.sup.4 represents lower alkyl, or substituted or unsubstituted aryl, R.sup.5 and R.sup.6 independently represent hydrogen, lower alkyl, and lower alkoxy, or R.sup.5 and R.sup.6 are combined together to represent --O--(CH.sub.2)p--O-- (p is an integer of 1 to 3), n represents 0, 1, or 2, and m represents 1 or 2. The compounds of the present invention have an adenosine A.sub.2 receptor antagonistic activity, and are useful for the treatment or prevention of various kinds of diseases caused by hyperergasia of adenosine A.sub.2 receptors (for example, Parkinson's disease, senile dementia, depression, asthma, and osteoporosis).

摘要翻译： PCT No.PCT / JP95 / 00267 Sec。 371 1995年10月20日第 102（e）1995年10月20日日期PCT提交1995年2月23日PCT公布。 公开号WO95 / 23148 日期：1995年8月31日本发明涉及由式（I）表示的新颖的黄嘌呤衍生物及其药学上可接受的盐：其中R1，R2和R3独立地表示氢，低级烷基，低级链烯基或 低级炔基，R 4表示低级烷基或取代或未取代的芳基，R 5和R 6独立地表示氢，低级烷基和低级烷氧基，或者R 5和R 6结合在一起代表-O-（CH 2）p O-（p是整数 1〜3），n表示0,1或2，m表示1或2.本发明化合物具有腺苷A2受体拮抗活性，可用于治疗或预防各种疾病 腺苷A2受体（例如帕金森病，老年性痴呆，抑郁症，哮喘和骨质疏松症）的过度高血症。

公开(公告)号：US5470858A

公开(公告)日：1995-11-28

申请号：US901628

申请日：1992-06-19

申请人： Cristina Fraire ,  Massimo Bani ,  Ermes Vanotti ,  Vincenzo Olgiati

发明人： Cristina Fraire ,  Massimo Bani ,  Ermes Vanotti ,  Vincenzo Olgiati

IPC分类号： A61K31/19 ,  A61K31/235 ,  A61K31/395 ,  A61K31/40 ,  A61K31/415 ,  A61K31/42 ,  A61K31/421 ,  A61K31/423 ,  A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/496 ,  A61K31/52 ,  A61K31/522 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7052 ,  A61K31/7076 ,  A61K31/708 ,  A61P3/06 ,  C07C69/24 ,  C07C323/19 ,  C07C323/20 ,  C07C323/22 ,  C07C323/62 ,  C07D207/36 ,  C07D213/70 ,  C07D233/84 ,  C07D235/24 ,  C07D235/26 ,  C07D235/28 ,  C07D239/38 ,  C07D249/12 ,  C07D263/38 ,  C07D263/46 ,  C07D263/58 ,  C07D263/60 ,  C07D277/62 ,  C07D277/74 ,  C07D413/12 ,  C07D473/00 ,  C07D473/08 ,  C07D473/12 ,  C07D473/34 ,  C07H19/16 ,  C07H19/167 ,  C07H19/20

CPC分类号： C07D213/70 ,  C07C323/20 ,  C07D233/84 ,  C07D235/26 ,  C07D235/28 ,  C07D239/38 ,  C07D249/12 ,  C07D263/46 ,  C07D263/58 ,  C07D263/60 ,  C07D277/74 ,  C07D413/10 ,  C07D473/08 ,  C07D473/12 ,  C07D473/34 ,  C07H19/16 ,  C07H19/20

摘要： A compound represented by the following formula I:(HET)Ar--X--CH.sub.2 --Y--CH.sub.2 --O--R (I)wherein:(HET)Ar represents a bicyclic hetero aryl nucleus which is unsubstituted or is substituted;X represents --S--;Y represents --CO--, --C.dbd.N--R.sub.2, in which R.sub.2 is hydrogen or a linear or branched alkyl having 1 to 10 carbon atoms, OH, an alkoxy having 1 to 10 carbon atoms, aryloxy, arylalkoxy, --NH.sub.2, --NHCONH.sub.2, --NHCSNH.sub.2 ; and R represents a phenyl substituted at para position with a carboxyl or a (C.sub.1 -C.sub.20) alkoxycarbonyl group in which the alkoxy group is linear or branched.

摘要翻译： 由下式I表示的化合物：（HET）Ar-X-CH 2 -Y-CH 2 -O-R（I）其中：（HET）Ar表示未被取代或被取代的双环杂芳基核; X表示-S-; Y表示-CO-，-C = N-R2，其中R2是氢或具有1-10个碳原子的直链或支链烷基，OH，具有1-10个碳原子的烷氧基，芳氧基，芳基烷氧基，-NH2， NHCONH 2，-NHCSNH 2; 并且R表示在对位被羧基或（C1-C20）烷氧基羰基取代的苯基，其中烷氧基是直链或支链的。

公开(公告)号：US5153015A

公开(公告)日：1992-10-06

申请号：US815895

申请日：1991-12-31

申请人： Peter Theissing ,  Peter Saamer ,  Jorg-Peter Korner

发明人： Peter Theissing ,  Peter Saamer ,  Jorg-Peter Korner

IPC分类号： A23F3/36 ,  A23F5/20 ,  B01D11/02 ,  C07D473/12 ,  C07G99/00 ,  C11B9/02

CPC分类号： B01D11/0203 ,  A23F3/366 ,  A23F5/206 ,  C07D473/12

摘要： A process and apparatus for extracting ingredient substances from natural products by means of a pressurized fluid, particularly for decaffeinating tea leaves by means of carbon dioxide, wherein the ingredient substances are bound by an adsorbent, preferably activated carbon. The fluid is conducted through a product layer, the thickness of which in flow direction is small in comparision with that transversely of the flow direction and the fluid is passed through the product layer with changing, especially increasing, velocity. The apparatus includes a cylindrical high-pressure vessel with annular cylindrical baskets for accommodating the natural product and/or the adsorbent, and the gas flows from a cylindrical outer range to a cylindrical inner range. The time required for the treatment of leafy natural product is reduced, the flow paths of the fluid are shortened, thus diminishing the risk of clogging, and the fluid flow velocity is reduced.

摘要翻译： 一种通过加压流体，特别是通过二氧化碳去除咖啡因的茶叶从天然产物中提取成分物质的方法和装置，其中成分物质被吸附剂，优选活性炭结合。 流体通过产品层传导，其厚度与流动方向的横向相比在流动方向上较小，并且流体以改变，特别是增加的速度通过产品层。 该装置包括一圆柱形高压容器，其具有用于容纳天然产物和/或吸附剂的环形圆柱形篮，并且气体从圆柱形外部范围流动到圆柱形内部范围。 减少叶片天然产物处理所需的时间，流体的流动路径缩短，从而降低堵塞的风险，降低流体流动速度。

公开(公告)号：US4885181A

公开(公告)日：1989-12-05

申请号：US300722

申请日：1989-01-25

申请人： Louris Kaper

发明人： Louris Kaper

IPC分类号： A23F5/22 ,  C07D473/12

CPC分类号： A23F5/223 ,  C07D473/12

摘要： A process for decaffeinating green coffee by extraction of the coffee with water and treatment of the aqueous extract with activated carbon whereby the caffeine is largely absorbed by the activated carbon. The resulting caffeine-loaded activated carbon is then treated with a selected acid whereby the caffeine is largely removed from the activated carbon. The carbon is then washed with water until it has pH in the range of 3 to 6, determined by the standard test method for pH of activated carbon (ASTM D 3838-80). The activated carbon is then ready to be reused more than ten times in the process without further treatment.

公开(公告)号：US4755391A

公开(公告)日：1988-07-05

申请号：US86171

申请日：1987-08-03

申请人： Giovanni L. Bigalli ,  Robert D. Houseal, Jr.

发明人： Giovanni L. Bigalli ,  Robert D. Houseal, Jr.

IPC分类号： A23G1/02 ,  C07D473/10 ,  C07D473/12 ,  A23G1/00

CPC分类号： C07D473/10 ,  A23G1/02 ,  C07D473/12

摘要： A process is disclosed for removing substantially all of the theobromine normally present in cacao beans. The process includes a water extraction of cacao nibs at from about 45.degree. C. to about 55.degree. C. followed by a series of water extraction steps at from about 90.degree. C. to about 105.degree. C. Theobromine and caffeine are separated in the filtrates and the final methylxanthine extracted fraction is returned to the cacao nibs mass from which a methylxanthine extracted cacao liquor is obtained.

摘要翻译： 公开了用于去除可可豆中通常存在的基本上所有可可碱的方法。 该方法包括在约45℃至约55℃的水中提取可可可可，然后在约90℃至约105℃下进行一系列水提取步骤。将可可碱和咖啡因在 滤液并将最终的甲基黄嘌呤提取的馏分返回到获得甲基黄嘌呤提取的可可液的可可可可块。

公开(公告)号：US4548827A

公开(公告)日：1985-10-22

申请号：US363714

申请日：1982-03-30

申请人： Saul N. Katz ,  George E. Proscia ,  George L. Clisura

发明人： Saul N. Katz ,  George E. Proscia ,  George L. Clisura

IPC分类号： A23F5/22 ,  C07D473/12

CPC分类号： A23F5/223 ,  C07D473/12

摘要： The present invention relates to a method of separately recovering caffeine and non-caffeine solids adsorbed on activated carbon. Activated carbon containing the adsorbed solids is contacted with an aqueous basic solution to elute the non-caffeine coffee solids. The two components are separated. The activated carbon is subsequently contacted with a concentrated aqueous acidic solution to elute the relatively pure caffeine. The two components are separated. The non-caffeine solids in the basic solution may be re-adsorbed onto the activated carbon. Essentially pure caffeine may be refined from the aqueous acidic solution.

摘要翻译： 本发明涉及分别回收吸附在活性炭上的咖啡因和非咖啡因固体的方法。 将含有吸附固体的活性炭与碱性水溶液接触以洗脱非咖啡因咖啡固体。 两个组件分开。 随后将活性炭与浓缩的酸性水溶液接触以洗脱相对纯的咖啡因。 两个组件分开。 碱性溶液中的非咖啡因固体可以被再吸附到活性炭上。 可以从酸性水溶液中精制出本质上纯的咖啡因。

公开(公告)号：US4506072A

公开(公告)日：1985-03-19

申请号：US485766

申请日：1983-04-18

申请人： Manfred Gehrig ,  Manfred Barthels ,  Hans Wienges

发明人： Manfred Gehrig ,  Manfred Barthels ,  Hans Wienges

IPC分类号： C07D473/12

CPC分类号： C07D473/12

摘要： The invention relates to a process for recovering caffeine adsorbed to activated carbon with simultaneous regeneration of the activated carbon in which the caffeine-loaded activated carbon is treated with water at a pressure of at least 86 bar and at a temperature of at least 300.degree. C.

摘要翻译： 本发明涉及一种在至少86巴的压力和至少300℃的温度下同时再生活性炭的活性炭再生中回收咖啡因的方法，所述活性炭在其中用水处理含咖啡因的活性炭 。

公开(公告)号：US4444798A

公开(公告)日：1984-04-24

申请号：US397978

申请日：1982-07-14

申请人： Daniele Magnolato ,  Alain Isely

发明人： Daniele Magnolato ,  Alain Isely

IPC分类号： A23G1/02 ,  C07D473/10 ,  C07D473/12 ,  A23G1/00

CPC分类号： A23G1/02 ,  C07D473/10 ,  C07D473/12

摘要： In a process for depurinizing cocoa, green or roasted cocoa beans are extracted with water at a temperature of from 40.degree. to 60.degree. C., the extract is treated with an adsorbent based on desugared and activated carob particles in order to remove the purines therefrom, and the beans are dried and roasted. The dried beans are preferably rehydrated using the depurinized extract after being concentrated and before final roasting.The treated cocoa is useful for the production of beverages containing cocoa and, when the variant with reincorporation of the non-purine solids is applied, for the production of chocolate.

摘要翻译： 在可可粉的除草方法中，用40℃至60℃的水提取绿色或焙炒的可可豆，该提取物用基于去除和活化的角豆颗粒的吸附剂处理，以从其中除去嘌呤 ，豆类被烘干和烘烤。 干燥的豆优选在浓缩后和最终焙烧之前使用去污化的提取物再水合。 经处理的可可可用于生产含有可可的饮料，并且当应用非嘌呤固体重新组合的变体用于生产巧克力时。

公开(公告)号：US4416878A

公开(公告)日：1983-11-22

申请号：US327712

申请日：1981-12-04

申请人： Josef Klosa

发明人： Josef Klosa

IPC分类号： A61K31/52 ,  A61K31/522 ,  A61P35/00 ,  C07D473/12 ,  C07F15/00 ,  A61K31/515

CPC分类号： C07D473/12 ,  C07F15/0093

摘要： New [8-(dialkylamino alkoxy)-caffeine]-platinum complex compounds of the general formula ##STR1## are prepared from 8-(dialkylamino alkoxy)-caffeine and hexachloro platinic acid. The complex compounds are nonpoisonous, stable and infinitely durable. In pharmacological test series distinct cytostatic activity of the complex compounds is observed and they are suitable for use as active components in pharmaceutical products.

摘要翻译： 由8-（二烷基氨基烷氧基） - 咖啡因和六氯铂酸制备具有通式“IMAGE”的新的[8-（二烷基氨基烷氧基） - 咖啡因] - 铂络合物。 复合化合物是无毒的，稳定的和无限耐久的。 在药理试验系列中，观察到复合化合物的不同细胞抑制活性，并且它们适合用作药物产品中的活性成分。

公开(公告)号：US4380631A

公开(公告)日：1983-04-19

申请号：US359839

申请日：1982-03-19

申请人： Kaspar Bott

发明人： Kaspar Bott

IPC分类号： C07D473/12

CPC分类号： C07D473/12

摘要： Caffeine is prepared from theophylline, carbon monoxide and methanol.

摘要翻译： 咖啡因由茶碱，一氧化碳和甲醇制成。