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    Fatty acid synthase mRNA binding protein
    21.
    发明授权
    Fatty acid synthase mRNA binding protein 失效

    公开(公告)号：US06528637B1

    公开(公告)日：2003-03-04

    申请号：US09551268

    申请日：2000-04-18

    Applicant: Clay F. Semenkovich

    Inventor： Clay F. Semenkovich

    IPC: C07H2102

    CPC classification number: C07K14/4702

    Abstract: Disclosed is a 178 kDa glucose-inducible human fatty acid synthase (FAS) mRNA binding protein which has been purified to homogeneity and its binding element characterized. This large phosphoprotein binds to a novel repetitive element in the 3′ untranslated region (UTR) of the FAS mRNA. In particular, the binding has been mapped to a 37 nucleotide stretch within the first 65 bases of the 3′ UTR of mRNA. The binding protein is useful for mediating FAS expression, for regulating lipoprotein secretion and cell growth and for screening of test compounds for activity as inhibitors of FAS.

    Utrophin gene expression
    22.
    发明授权
    Utrophin gene expression 失效
    Utrophin基因表达

    公开(公告)号：US06518413B1

    公开(公告)日：2003-02-11

    申请号：US09091501

    申请日：1998-07-14

    Applicant: Jonathon M. Tinsley ,  Kay E. Davies

    Inventor： Jonathon M. Tinsley ,  Kay E. Davies

    IPC: C07H2102

    CPC classification number: C07K14/4708 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00

    Abstract: Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic muscle phenotype in an animal model, indicating usefulness in treatment of muscular dystrophy. The nucleic acid and encoded polypeptides are also useful in screening for substances to modulate utrophin binding to actin and/or the dystrophin protein complex.

    Abstract translation: 具有utrophin功能的多肽可以从其中表达的核酸，特别是微型基因和嵌合体构建体。 表达显着降低动物模型中营养不良肌肉表型的严重程度，表明在治疗肌营养不良症中的有用性。 核酸和编码的多肽也可用于筛选调节utrophin结合肌动蛋白和/或肌营养不良蛋白复合物的物质。

    Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
    23.
    发明授权
    Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders 失效
    提供载脂蛋白A-1激动剂的基因治疗方法及其用于治疗血脂异常的疾病

    公开(公告)号：US06518412B1

    公开(公告)日：2003-02-11

    申请号：US08940136

    申请日：1997-09-29

    Applicant: Jean-Louis Dasseux ,  Renate Sekul ,  Klaus Büttner ,  Isabelle Cornut ,  Günther Metz ,  Jean Dufourcq

    Inventor： Jean-Louis Dasseux ,  Renate Sekul ,  Klaus Büttner ,  Isabelle Cornut ,  Günther Metz ,  Jean Dufourcq

    IPC: C07H2102

    CPC classification number: A61K48/005 ,  A61K38/00 ,  A61K48/00 ,  A61K51/08 ,  C07K14/775

    Abstract: The invention relates to genetic approaches to supply nucleotide sequences encoding modified forms of the native forms of apolipoprotein A-I (ApoA-I): mature ApoA-I, preproApoA-I and proApoA-I; including native ApoA-I modified to contain ApoA-I agonists, peptides which mimic the activity of ApoA-I; ApoA-I superagonists, peptides which exceed the activity of native ApoA-I; and modified native ApoA-I having one or more amphipathic helices replaced by the nucleotide sequences of one or more ApoA-I agonists; for the treatment of disorders associated with dyslipoproteinemia, including cardiovascular disease, atherosclerosis, restenosis, hyperlipidemia, and other disorders such as septic shock.

    Abstract translation: 本发明涉及提供编码载脂蛋白A-I（ApoA-I）的天然形式的修饰形式的核苷酸序列的遗传方法：成熟ApoA-I，preproApoA-I和proApoA-I; 包括修饰为含有ApoA-1激动剂的天然ApoA-I，其模拟ApoA-I的活性的肽; ApoA-I超级拮抗剂，超过天然ApoA-I活性的肽; 和具有由一个或多个ApoA-1激动剂的核苷酸序列替代的一个或多个两亲性螺旋的修饰的天然ApoA-I; 用于治疗与脂蛋白血症相关的疾病，包括心血管疾病，动脉粥样硬化，再狭窄，高脂血症和其它疾病如败血性休克。

    Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based DNA library: application to the detection of mycobacteria
    24.
    发明授权
    Method for isolating a polynucleotide of interest from the genome of a mycobacterium using a bac-based DNA library: application to the detection of mycobacteria 失效
    使用基于bac的DNA文库从分枝杆菌基因组分离目的多核苷酸的方法：应用于检测分枝杆菌

    公开(公告)号：US06492506B1

    公开(公告)日：2002-12-10

    申请号：US09670314

    申请日：2000-09-26

    Applicant: Stewart Cole ,  Roland Buchrieser-Brosch ,  Stephen Gordon ,  Alain Billault

    Inventor： Stewart Cole ,  Roland Buchrieser-Brosch ,  Stephen Gordon ,  Alain Billault

    IPC: C07H2102

    CPC classification number: C12Q1/689 ,  C07K14/35 ,  C12N15/1072 ,  C12Q1/6809

    Abstract: A method for isolating a polynucleotide of interest that is present in the genome of a first mycobacterium strain and/or is expressed by the first mycobacterium strain, where the polynucleotide of interest is also absent or altered in the genome of a second mycobacterium strain and/or is not expressed in the second mycobacterium. The method includes (a) contacting the genomic DNA of the first mycobacterium strain under hybridizing conditions with the DNA of a least one clone that belongs to a bacterial artificial chromosome (BAC) genomic DNA library of the second mycobacterium strain, and (b) isolating the polynucleotide of interest that does not form a hybrid with the DNA of the second mycobacterium strain. This invention further pertains to a Mycobacterium tuberculosis strain H37Rv genomic DNA library, as well as a Mycobactetium bovis BCG strain Pasteur genomic DNA library, and the recombinant BAC vectors that belong to those genomic DNA libraries. This invention also relates to mycobacterial nucleic acids, and methods and kits for using these nucleic acids to detect mycobacteria in a biological sample.

    Abstract translation: 用于分离存在于第一分枝杆菌菌株的基因组中和/或由第一分枝杆菌菌株表达的目标多核苷酸的方法，其中感兴趣的多核苷酸在第二分枝杆菌菌株的基因组中也不存在或改变，和/ 或不在第二分枝杆菌中表达。 该方法包括（a）在杂交条件下将第一分枝杆菌菌株的基因组DNA与属于第二分枝杆菌菌株的细菌人造染色体（BAC）基因组DNA文库的至少一个克隆的DNA接触，和（b）分离 不与第二分枝杆菌菌株的DNA形成杂交的感兴趣的多核苷酸。 本发明还涉及结核分枝杆菌菌株H37Rv基因组DNA文库以及牛分枝杆菌BCG菌株巴斯德基因组DNA文库和属于这些基因组DNA文库的重组BAC载体。 本发明还涉及分枝杆菌核酸，以及使用这些核酸来检测生物样品中的分枝杆菌的方法和试剂盒。

    Nucleotide sequence of mammastatin and methods of use
    25.
    发明授权
    Nucleotide sequence of mammastatin and methods of use 失效
    哺乳类动物的核苷酸序列和使用方法

    公开(公告)号：US06492504B2

    公开(公告)日：2002-12-10

    申请号：US09369912

    申请日：1999-08-06

    Applicant: Paul R. Ervin, Jr.

    Inventor： Paul R. Ervin, Jr.

    IPC: C07H2102

    CPC classification number: C07K14/4703 ,  A61K48/00

    Abstract: A nucleic acid sequence encoding Mammastatin, a specific mammary cell growth inhibitor. Mammastatin is encoded by a single nucleic acid sequence and has an approximate molecular weight of 44 kDa in its inactive, non-phosphorylated form. Normal mammary cells express functional phosphorylated forms having approximate molecular weights of 53 kDa and 49 kDa. Metastatic mammary cells either do not express Mammastatin at all, or do not express the 53 kDa or 49 kDa, phosphorylated forms. Mammary cancer cells are inhibited in their growth by the administration of phosphorylated Mammastatin.

    Abstract translation: 编码哺乳动物抑制素（特异性乳腺细胞生长抑制剂）的核酸序列。 Mammastatin由单个核酸序列编码，其非活性，非磷酸化形式的近似分子量为44kDa。 正常的乳腺细胞表达具有近似分子量为53kDa和49kDa的功能性磷酸化形式。 转移性乳腺细胞根本不表达母乳喂养，或不表达53kDa或49kDa磷酸化形式。 乳腺癌细胞通过施用磷酸化的Mammastatin在其生长中被抑制。

    DNA molecules encoding human CLAX proteins and their soluble fusion proteins
    29.
    发明授权
    DNA molecules encoding human CLAX proteins and their soluble fusion proteins 有权
    编码人类CLAX蛋白的DNA分子及其可溶性融合蛋白

    公开(公告)号：US06455683B1

    公开(公告)日：2002-09-24

    申请号：US09531056

    申请日：2000-03-20

    Applicant: Guchen Yang ,  Xiaorong Chen ,  Patricia M. Davis ,  Peter A. Kiener

    Inventor： Guchen Yang ,  Xiaorong Chen ,  Patricia M. Davis ,  Peter A. Kiener

    IPC: C07H2102

    CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/4726 ,  C07K14/7056 ,  C07K2319/00

    Abstract: Isolated novel cDNA sequences encoding a human C-type lectin and three homologues are provided. They are referred to herein as “CLAX” (C-type Lectin, Activation Expressed) proteins. The invention also includes methods of using the nucleic acid sequences, polypeptides encoded by the nucleic acid sequences disclosed herein, fusion proteins having all or a portion (e.g., an extracellular region) of the CLAX proteins, antibodies specific for the novel CLAXs, ligands and inhibitors for the novel CLAXs. The genes of CLAX are specifically expressed in lymphoid tissues and activated T lymphocytes but not resting T lymphocytes. The invention concerns the utility in pharmaceutical compositions for the prevention and treatment of infectious, inflammatory and allergic diseases.

    Abstract translation: 提供了编码人C型凝集素和三个同系物的分离的新型cDNA序列。 它们在本文中称为“CLAX”（C型凝集素，激活表达的）蛋白质。 本发明还包括使用核酸序列的方法，由本文公开的核酸序列编码的多肽，具有CLAX蛋白的全部或部分（例如细胞外区域）的融合蛋白，对于新型CLAXs具有特异性的抗体，配体和 新型CLAXs的抑制剂。 CLAX的基因在淋巴组织和活化的T淋巴细胞中特异性表达，但不是休息的T淋巴细胞。 本发明涉及用于预防和治疗感染性，炎性和过敏性疾病的药物组合物中的应用。

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