公开(公告)号：US07001729B2

公开(公告)日：2006-02-21

申请号：US09811131

申请日：2001-03-14

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N29/00 ,  G01N33/573 ,  C12N11/00

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906175B2

公开(公告)日：2005-06-14

申请号：US09809889

申请日：2001-03-16

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract translation: 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US06902908B2

公开(公告)日：2005-06-07

申请号：US09811094

申请日：2001-03-14

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley ,  Scott W. Miller ,  Tomas R. Szabo ,  Soumitra S. Ghosh ,  Walter H. Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C12N15/00 ,  C07H21/04 ,  C12N15/63

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract translation: 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。

公开(公告)号：US20050003352A1

公开(公告)日：2005-01-06

申请号：US09809827

申请日：2001-03-16

Applicant: Christen Anderson ,  Robert Davis ,  William Clevenger ,  Sandra Wiley ,  Scott Miller ,  Tomas Szabo ,  Soumitra Ghosh ,  Walter Moos ,  Yazhong Pei

Inventor： Christen Anderson ,  Robert Davis ,  William Clevenger ,  Sandra Wiley ,  Scott Miller ,  Tomas Szabo ,  Soumitra Ghosh ,  Walter Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04 ,  C12N9/10

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906174B2

公开(公告)日：2005-06-14

申请号：US09809827

申请日：2001-03-16

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07K1/00 ,  C07K14/00

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06906173B2

公开(公告)日：2005-06-14

申请号：US09185904

申请日：1998-11-03

Applicant: Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

Inventor： Christen M. Anderson ,  Robert E. Davis ,  William Clevenger ,  Sandra Eileen Wiley

IPC: C07K14/47 ,  C12N5/02 ,  C12N15/62 ,  C07K1/00 ,  C07K14/00

CPC classification number: C12N15/62 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US06562563B1

公开(公告)日：2003-05-13

申请号：US09434354

申请日：1999-11-03

Applicant: Anne N. Murphy ,  William Clevenger ,  Sandra Eileen Wiley ,  Alexander Y. Andreyev ,  Luciano G. Frigeri ,  Gonul Velecelebi ,  Robert E. Davis

Inventor： Anne N. Murphy ,  William Clevenger ,  Sandra Eileen Wiley ,  Alexander Y. Andreyev ,  Luciano G. Frigeri ,  Gonul Velecelebi ,  Robert E. Davis

IPC: C12N500

CPC classification number: G01N33/5079 ,  C07K14/43595 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/50 ,  C07K2319/60 ,  C12N9/90 ,  C12N15/62 ,  G01N33/542

Abstract: Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction between the mitochondrial adenine nucleotide translocator and cyclophilin D. Such agents may be used, for example, in the treatment of a variety of conditions associated with altered mitochondrial function.

Abstract translation: 提供组合物和方法用于鉴定改变线粒体膜通透性转换的药剂。 筛选方法通常检测改变线粒体腺嘌呤核苷酸转运体和亲环蛋白D之间的相互作用的试剂。这种试剂可用于例如治疗与线粒体功能改变相关的多种病症。

公开(公告)号：US06489095B2

公开(公告)日：2002-12-03

申请号：US09098079

申请日：1998-06-15

Applicant: Corinna Herrnstadt ,  Soumitra S. Ghosh ,  William Clevenger ,  Eoin D. Fahy ,  Robert E. Davis

Inventor： Corinna Herrnstadt ,  Soumitra S. Ghosh ,  William Clevenger ,  Eoin D. Fahy ,  Robert E. Davis

IPC: C12Q168

CPC classification number: C12Q1/6883 ,  C12Q1/6827 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: Compositions and methods based on quantification of extramitochondrial DNA (exmtDNA) sequences are provided that are useful for detecting the presence of or risk for having a disease associated with altered mitochondrial function, and for identifying agents suitable for treating such diseases. The exmtDNA sequences have strong homology to authentic mitochondrial DNA (mtDNA) sequences.

公开(公告)号：US20050019835A1

公开(公告)日：2005-01-27

申请号：US09811131

申请日：2001-03-14

Applicant: Christen Anderson ,  Robert Davis ,  William Clevenger ,  Sandra Wiley ,  Scott Miller ,  Tomas Szabo ,  Soumitra Ghosh ,  Walter Moos ,  Yazhong Pei

Inventor： Christen Anderson ,  Robert Davis ,  William Clevenger ,  Sandra Wiley ,  Scott Miller ,  Tomas Szabo ,  Soumitra Ghosh ,  Walter Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/554 ,  G01N33/567 ,  G01N33/569

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

公开(公告)号：US20050003353A1

公开(公告)日：2005-01-06

申请号：US09809889

申请日：2001-03-16

Applicant: Christen Anderson ,  Robert Davis ,  William Clevenger ,  Sandra Wiley ,  Scott Miller ,  Tomas Szabo ,  Soumitra Ghosh ,  Walter Moos ,  Yazhong Pei

Inventor： Christen Anderson ,  Robert Davis ,  William Clevenger ,  Sandra Wiley ,  Scott Miller ,  Tomas Szabo ,  Soumitra Ghosh ,  Walter Moos ,  Yazhong Pei

IPC: G01N33/50 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/7056 ,  A61K31/7064 ,  A61K45/00 ,  A61P3/00 ,  A61P3/10 ,  A61P17/06 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P27/16 ,  A61P35/00 ,  A61P43/00 ,  C07H15/256 ,  C07H15/26 ,  C07K1/22 ,  C07K14/47 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12N15/62 ,  C12P21/02 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  C07H21/04 ,  C12N9/10

CPC classification number: C07K14/47 ,  C07K2319/00 ,  C07K2319/07 ,  C07K2319/21 ,  C07K2319/23 ,  C12N15/62 ,  C12N2799/021

Abstract: Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the production and use of recombinant expression constructs having a regulated promoter. ANT ligands and compositions and methods for identifying ANT ligands, agents that bind ANT and agents that interact with ANT are also disclosed.

Abstract translation: 提供了用于产生腺嘌呤核苷酸转运蛋白（ANT）多肽和融合蛋白的组合物和方法，包括产生和使用具有调节启动子的重组表达构建体。 还公开了ANT配体以及用于鉴定ANT配体的组合物和方法，结合ANT的试剂和与ANT相互作用的试剂。