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    Synthesis of ursolic acid nanoparticles
    22.
    发明授权
    Synthesis of ursolic acid nanoparticles 有权

    公开(公告)号：US10947266B2

    公开(公告)日：2021-03-16

    申请号：US16552670

    申请日：2019-08-27

    申请人： KING SAUD UNIVERSITY

    发明人： Rabab Abd El Moneim Khalil El Dib ,  Shaza Mohamed Adel Al-Massarani ,  Manal Ahmed Gasmelseed Awad ,  Ali Ali Hasan Elgamal

    IPC分类号： A61K36/00 ,  C07J63/00 ,  A01N65/00 ,  B82Y40/00

    摘要： The synthesis of ursolic acid nanoparticles includes dissolving ursolic acid powder in methanol, boiling water for five minutes, and adding the methanol solution to the boiled water dropwise at a flow rate of 0.1-0.3 ml/min under ultrasonic conditions. After sonication for 20 minutes, the contents are stirred for about 15 minutes, and then dried. Particle size distribution studies and TEM micrographs confirm the resulting product comprises nanoparticles. In vitro testing confirms the ursolic acid nanoparticles exhibit greater anticancer activity than conventional-size particles, and that the nanoparticles exhibit antimicrobial effect against gram positive and gram negative bacteria, as well as fungi.

    Oral delivery system and method
    23.
    发明授权
    Oral delivery system and method 有权

    公开(公告)号：US10918596B2

    公开(公告)日：2021-02-16

    申请号：US16182445

    申请日：2018-11-06

    申请人： MEDICAL FOODS RX, LLC

    发明人： Todd Rosenbaum ,  Jim Klemaszewski

    IPC分类号： A61K9/00 ,  A61K36/28 ,  G01N21/25 ,  A61K31/05 ,  G01N33/15 ,  A61K31/352 ,  B65D65/46 ,  A01N65/00

    摘要： A system and method for infusion of active ingredients into a delivery device is disclosed. The active ingredients can be loaded into a variety of oral delivery devices, including but not limited to toothpicks, tongue depressors, ice cream sticks and cocktail stirrers. In an embodiment, these delivery devices might be made from various types of wood, one non-limiting example being birchwood. These oral delivery devices can be used to deliver various of the following active ingredients along with inactive ingredients such as flavor, natural, and/or artificial sweeteners, as well as other items not explicitly shown in this list: nicotine, smoking cessation products, caffeine, tetra hydro cannabinol (hereinafter referred to as THC), cannabidiol (hereinafter referred to as CBD), and dietary supplements.

    METHOD FOR USING MUSTARD MEAL OR AN EXTRACT THEREOF
    29.
    发明申请
    METHOD FOR USING MUSTARD MEAL OR AN EXTRACT THEREOF 审中-公开

    公开(公告)号：US20200221710A1

    公开(公告)日：2020-07-16

    申请号：US16750818

    申请日：2020-01-23

    申请人： University of Idaho

    发明人： Matthew J. Morra ,  Inna E. Popova ,  Jeremiah Dubie

    IPC分类号： A01N65/00 ,  A01N65/08

    摘要： Disclosed are embodiments of a method of using mustard meal or mustard meal extract. Certain embodiments concern controlling vegetable sprouting, such as potato sprouting. Vegetables, such as potatoes, may be exposed to products resulting from mustard meal, or an extract thereof, contacting water. Other embodiments concern a process for controlling plant pests, such as insects, nematodes, fungi, weeds, and combinations thereof, with specific embodiments being particularly useful for weed suppression. Certain embodiments comprise extracting glucosinolates from plant material, or processed plant material, selected from the family Brassicaceae, particularly from the genera Brassica and Sinapis. Extracted glucosinolates can be hydrolyzed to form active compounds, or alternatively, they can be hydrolyzed in situ, by simultaneously or sequentially applying myrosinase. The extract can be applied to plants, to the soil adjacent to the plant.