Biphenylyl ethers and method of use
    22.
    发明授权
    Biphenylyl ethers and method of use 失效
    联苯醚和使用方法

    公开(公告)号:US4060609A

    公开(公告)日:1977-11-29

    申请号:US518811

    申请日:1974-10-29

    CPC分类号: C07D295/088

    摘要: Biphenylyl ethers of the formula R--O--CH.sub.2 --CR.sub.1 (OH)--CH.sub.2 Z wherein R.sub.1 is H or CH.sub.3 ; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino; R is either biphenylyl substituted by at least one of F, Cl, Br, I, CF.sub.3, NO.sub.2 and piperidino or, when R.sub.1 is CH.sub.3 or when Z is homopiperidino, hydroxypyrrolidino, hydroxypiperidino or hydroxyhomopiperidino, unsubstituted biphenyl, and the physiologically acceptable acid addition salts thereof, possess cholesterol blood-level-lowering activity and can be produced by reacting a compound of the formula R--O--CH.sub.2 --Y wherein Y is ##STR1## or --CR.sub.1 (OH)--CH.sub.2 X, X being Cl, Br, I or a free or functionally modified OH-group, with an amine of the formula H-Z.

    摘要翻译: 式R-O-CH 2 -CR 1(OH)-CH 2 Z的联苯基醚,其中R 1是H或CH 3; Z是2-8个碳原子的二烷基氨基,吗啉代,吡咯烷子基,哌啶子基,高哌啶基,羟基吡咯烷基,羟基哌啶子基或羟基高哌啶子基; R是由F,Cl,Br,I,CF 3,NO 2和哌啶子中至少一种取代的联苯基,或当R 1为CH 3或Z为高哌啶基,羟基吡咯烷基,羟基哌啶子基或羟基高哌啶子基,未取代的联苯基和生理上可接受的酸加成 其盐具有胆固醇血液中降低水平的活性,并且可以通过使式RO-CH2-Y的化合物(其中Y是或-CR1(OH)-CH2X,X是Cl,Br,I或 游离的或官能改性的OH-基团与式HZ的胺反应。