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公开(公告)号：US11129834B2
公开(公告)日：2021-09-28
申请号：US16541490
申请日：2019-08-15
发明人： George Hartman , Osvaldo Flores , Klaus Klumpp , Man Iu Lam , Jan Martin Berke
IPC分类号： A01N43/04 , A61K31/70 , A61K31/52 , A61K31/40 , A61K31/445 , A61K31/522 , A61K31/675 , A61K31/7072 , A61K31/03 , A61K31/095 , A61K31/18 , A61K31/706 , C12N7/06
摘要： The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.
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公开(公告)号：US10544141B2
公开(公告)日：2020-01-28
申请号：US16118760
申请日：2018-08-31
发明人： George D. Hartman , Scott Kuduk
IPC分类号： C07D471/04 , A61K38/21 , A61K39/29 , C12N7/00 , A61K31/437 , A61K31/5377 , A61K45/06 , A61K31/4545 , A61P31/12 , A61K31/501
摘要： Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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公开(公告)号：US10428041B2
公开(公告)日：2019-10-01
申请号：US16191199
申请日：2018-11-14
发明人： Ryan C. Clark , Yen Truong , Nicholas Stock , Jason Jacintho
IPC分类号： A61K45/06 , C07D213/81 , C07D231/18 , C07D333/26
摘要： The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
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公开(公告)号：US20190209541A1
公开(公告)日：2019-07-11
申请号：US16235210
申请日：2018-12-28
发明人： George D. Hartman
IPC分类号： A61K31/45 , A61K31/40 , A61K31/397 , A61K38/21 , A61K31/445
CPC分类号： A61K31/45 , A61K31/397 , A61K31/40 , A61K31/445 , A61K38/21 , A61K38/212 , A61K2300/00
摘要： Provided herein is a combination therapy comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog. The combination therapy is useful for the treatment of HBV infection. Also provided herein are compositions comprising a compound of Formula I and peginterferon alfa-2a, or another interferon analog.
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公开(公告)号：US20190194191A1
公开(公告)日：2019-06-27
申请号：US16226780
申请日：2018-12-20
发明人： George D. Hartman , Scott Kuduk
IPC分类号： C07D471/04 , A61K31/437 , A61K31/5377 , A61K31/4545 , A61K31/501 , A61K45/06 , A61K39/29 , A61P31/12 , C12N7/00 , A61K38/21
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/501 , A61K31/5377 , A61K38/212 , A61K39/292 , A61K45/06 , A61P31/12 , C12N7/00 , C12N2730/10111 , C12N2730/10134 , C12N2730/10171 , A61K2300/00
摘要： Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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公开(公告)号：US20190031653A1
公开(公告)日：2019-01-31
申请号：US16024954
申请日：2018-07-02
发明人： George D. Hartman , Scott Kuduk
IPC分类号： C07D471/04 , A61K31/501 , A61K31/437 , A61K45/06 , A61K31/5377 , A61K38/21 , A61K39/29 , C12N7/00 , A61P31/12 , A61K31/4545
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/501 , A61K31/5377 , A61K38/212 , A61K39/292 , A61K45/06 , A61P31/12 , C12N7/00 , C12N2730/10111 , C12N2730/10134 , C12N2730/10171 , A61K2300/00
摘要： Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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公开(公告)号：US09873671B2
公开(公告)日：2018-01-23
申请号：US15277421
申请日：2016-09-27
发明人： George D. Hartman , Scott Kuduk
IPC分类号： C07D223/08 , A61K31/55 , A61K45/06 , C07D267/10 , A61K31/553 , C07D223/32 , A61K31/439 , A61K31/551 , C07D221/22 , C07D223/06 , C07D243/08 , A61K38/21 , A61K47/48 , A61K31/554 , C07D283/00 , C07D295/26 , C07D403/12
CPC分类号： C07D223/08 , A61K31/439 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61K38/21 , A61K45/06 , A61K47/60 , C07D221/22 , C07D223/06 , C07D223/32 , C07D243/08 , C07D267/10 , C07D283/00 , C07D295/26 , C07D403/12 , A61K2300/00
摘要： Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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公开(公告)号：US20170340642A1
公开(公告)日：2017-11-30
申请号：US15488368
申请日：2017-04-14
发明人： George HARTMAN , Osvaldo FLORES , Klaus KLUMPP , Man Iu LAM , Jan Martin BERKE
摘要： The present disclosure is directed to capsid assembly inhibitor compositions and methods for use in the treatment of hepatitis B virus infection.
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公开(公告)号：US09400280B2
公开(公告)日：2016-07-26
申请号：US14670001
申请日：2015-03-26
发明人： George D. Hartman
IPC分类号： C07D211/96 , G01N33/569 , A61K31/445 , A61K31/5375 , A61K31/54 , C07D491/048 , A61K31/4355 , A61K45/06 , A61K31/4453 , A61K31/506
CPC分类号： G01N33/56988 , A61K31/4355 , A61K31/445 , A61K31/4453 , A61K31/506 , A61K31/5375 , A61K31/54 , A61K45/06 , C07D211/96 , C07D491/048 , A61K2300/00
摘要： Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
摘要翻译： 本文提供了可用于治疗有需要的受试者的HBV感染的化合物，其药物组合物，以及抑制，抑制或预防受试者中HBV感染的方法。
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公开(公告)号：US20160185748A1
公开(公告)日：2016-06-30
申请号：US14957008
申请日：2015-12-02
发明人： Ryan C. Clark , Yen Truong , Nicholas Stock , Jason Jacintho
IPC分类号： C07D333/26 , A61K31/44 , A61K45/06 , A61K31/415 , A61K31/381 , C07D213/81 , C07D231/18
CPC分类号： C07D333/26 , A61K45/06 , C07D213/81 , C07D231/18
摘要： The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the individual a therapeutically effective amount of at least one compound of the invention.
摘要翻译： 本发明包括在有需要的个体中抑制，抑制或预防HBV感染的方法，包括向个体施用治疗有效量的至少一种本发明的化合物。
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