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    Cytotoxic annonaceous acetogenins from Annona muricata
    21.
    发明授权
    Cytotoxic annonaceous acetogenins from Annona muricata 失效
    来自Annona muricata的细胞毒性annonaceous acetogenins

    公开(公告)号：US07223792B2

    公开(公告)日：2007-05-29

    申请号：US10005324

    申请日：2001-12-07

    申请人： Yang-Chang Wu

    发明人： Yang-Chang Wu

    IPC分类号： A61K31/34 ,  C07D307/34 ,  C07D307/26

    CPC分类号： A61K31/365 ,  A61K36/185

    摘要： Acetogenins isolated from Annona muricata of the family Annonaceae are described. The substantially pure compounds of the invention exhibit to human tumor cell lines as well as selective cytotoxicity for various human tumor cell lines.

    摘要翻译： 描述了分离自家Ann科的Annona muricata的醋to素。 本发明的基本上纯的化合物对于人类肿瘤细胞系以及对各种人类肿瘤细胞系的选择性细胞毒性表现出来。

    Synthesis of cyclic compounds
    25.
    发明申请
    Synthesis of cyclic compounds 失效
    环状化合物的合成

    公开(公告)号：US20040110966A1

    公开(公告)日：2004-06-10

    申请号：US10312155

    申请日：2003-04-10

    发明人： Naresh Kumar ,  Roger Wayne Read

    IPC分类号： C07D307/26

    CPC分类号： C07D307/58 ,  C07C59/347 ,  C07D307/60 ,  C08F224/00

    摘要： A method for the preparation of a compound of formula (II) wherein R1 and R2 are independently H, alkyl, alkoxy, oxoalkyl, alkenyl, aryl or arylalkyl whether unsubstituted or substituted, optionally interrupted by one or more hetero atoms, straight chain or branched chain, hydrophilic, hydrophobic or fluorophilic; R3, R4, R5 and R6 are independently or all hydrogen or halogen; provided that at least two of the R3, R4, R5 and R6 are halogens.

    摘要翻译： 一种制备式（II）化合物的方法，其中R 1和R 2独立地为H，烷基，烷氧基，氧代烷基，烯基，芳基或芳基烷基，无论是未取代的还是被取代的，任选地被一个或多个杂原子中断，直链或支链 链，亲水，疏水或富含荧光; R3，R4，R5和R6独立地或全部是氢或卤素; 条件是R 3，R 4，R 5和R 6中的至少两个为卤素。

    .gamma.-butyrolactone derivatives, process for preparing the same and immunomodulating compositions containing the same as active ingredients
    28.
    发明授权
    .gamma.-butyrolactone derivatives, process for preparing the same and immunomodulating compositions containing the same as active ingredients 失效
    γ-丁内酯衍生物，其制备方法和含有该活性成分的免疫调节组合物

    公开(公告)号：US4613613A

    公开(公告)日：1986-09-23

    申请号：US647979

    申请日：1984-09-06

    申请人： Tomei Oguri ,  Yasuhiro Morinaka ,  Shuichiro Kadowaki

    发明人： Tomei Oguri ,  Yasuhiro Morinaka ,  Shuichiro Kadowaki

    IPC分类号： A61K31/365 ,  A61P29/00 ,  C07D307/33 ,  C07D307/58 ,  C07D307/94 ,  A61K31/34 ,  C07D307/10 ,  C07D307/26

    CPC分类号： C07D307/33 ,  C07D307/58 ,  C07D307/94

    摘要： A .gamma.-butyrolactone derivative represented by the following formula: ##STR1## wherein R.sup.1 represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a phenyl group; R.sup.2 and R.sup.3 may be the same or different and each represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a cycloalkyl group having 3-10 carbon atoms, a benzyl group, a phenyl group, a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, an alkoxy group, a nitro group, an amino group, an alkyl group having 1-4 carbon atoms, a nitrile group and an alkoxycarbonyl group; R.sup.2 and R.sup.3 may be linked to form an alkylene group having 4-6 carbon atoms; X represents a hydrogen atom, a straight or branched alkyl group having 1-8 carbon atoms, a cycloalkyl group having 3-10 carbon atoms, a benzyl group or a substituent represented by the formula ##STR2## (wherein R.sup.4 represents a straight or branched alkyl group having 1-8 carbon atoms, a cycloalkyl group having 3-10 carbon atoms, a benzyl group, a phenyl group or a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, an alkoxy group, a nitro group, an alkylthio group, a nitrile group, an alkoxycarbonyl group and an alkyl group having 1-4 carbon atoms) or a salt thereof. The invention also provides an immunomodulating composition wherein the aforedescribed compound is the active component.

    摘要翻译： 由下式表示的γ-丁内酯衍生物：其中R1表示氢原子，具有1-8个碳原子的直链或支链烷基，苯基; R2和R3可以相同或不同，各自表示氢原子，具有1-8个碳原子的直链或支链烷基，具有3-10个碳原子的环烷基，苄基，苯基，苯基 被选自卤素原子，烷氧基，硝基，氨基，具有1-4个碳原子的烷基，腈基和烷氧羰基组成的组中的取代基取代; R2和R3可以连接形成具有4-6个碳原子的亚烷基; X表示氢原子，具有1-8个碳原子的直链或支链烷基，具有3-10个碳原子的环烷基，苄基或由式“IMAGE”表示的取代基（其中R4表示直链或支链 具有1-8个碳原子的烷基，具有3-10个碳原子的环烷基，苄基，苯基或被选自卤素原子，烷氧基，硝基的取代基取代的苯基 基团，烷硫基，腈基，烷氧基羰基和具有1-4个碳原子的烷基）或其盐。 本发明还提供一种免疫调节组合物，其中上述化合物是活性成分。