STEP-Derived Peptide for Brain Injury Treatment

    公开(公告)号:US20190169583A1

    公开(公告)日:2019-06-06

    申请号:US16116117

    申请日:2018-08-29

    Applicant: Surojit Paul

    Inventor: Surojit Paul

    Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and/or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

    Synthetic long read DNA sequencing
    294.
    发明授权

    公开(公告)号:US10266904B2

    公开(公告)日:2019-04-23

    申请号:US15027069

    申请日:2014-09-24

    Applicant: STC.UNM

    Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

    Composite wellbore seal system with sensing and self-healing capabilities

    公开(公告)号:US10190370B1

    公开(公告)日:2019-01-29

    申请号:US14965356

    申请日:2015-12-10

    Abstract: The present invention provides a self-healing wellbore seal system comprising a casing, a fiber reinforced polymer layer, and layer of polymer cement. The layers are bonded together and configured to create a low permeable and ductile seal at discrete locations of the wellbore or along the wellbore. The polymer layer may be chemically bonded to the casing and inhibits the formation of a microannulus at the casing. The polymer layer may be an aramid fiber reinforced polymer, a fiber reinforced polymer layer, or a glass reinforced polymer layer.

    Systems and methods for integrating distributed energy resources

    公开(公告)号:US10158234B2

    公开(公告)日:2018-12-18

    申请号:US15112252

    申请日:2015-01-16

    Abstract: The present invention is an apparatus and method for using aggregated loads from a plurality of distributed energy resources to perform a function at a power distribution feeder. The invention includes a plurality of distributed energy resources, wherein at least one distributed energy resource includes a renewable energy resource, a communication network, a control device, a power distribution feeder coupled to the control device, and an energy storage system coupled to the power distribution feeder. The control device sends a signal to the plurality of distributed energy resources via the communication network. The signal is a request to switch a status of one or more of the distributed energy resources if one or more distributed energy resources is within a predetermined condition. Loads from the one or more of the distributed energy resources that switched status are aggregated to perform a function at the power distribution feeder.

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