公开(公告)号：US20190125769A1

公开(公告)日：2019-05-02

申请号：US16092742

申请日：2017-04-10

Applicant: Yeda Research and Development Co. Ltd. ,  Memorial Sloan-Kettering Cancer Center

Inventor： Avigdor SCHERZ ,  Yoram SALOMON ,  LiIach AGEMY ,  Rachel HAMRI ,  Dina PREISE ,  Kwanghee KIM ,  Jonathan COLEMAN

IPC: A61K31/675 ,  A61K31/409 ,  A61K31/7068 ,  A61K31/7135 ,  A61P35/00

Abstract: An anti-myeloid-derived suppressor cells agent (“anti-MDSCs agent”) and a bacteriochlorophyll derivative (hereinafter “Bchl-D) for use in combination therapy for cancer, wherein the anti-MDSC agent and the Bchl-D are administered sequentially and the administration of the Bchl-D is followed by photodynamic therapy (PDT) or vascular targeted PDT (VTP).

公开(公告)号：US10258651B2

公开(公告)日：2019-04-16

申请号：US15468020

申请日：2017-03-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A61K48/00 ,  A61K35/30 ,  C12N5/0793 ,  C12N5/079 ,  G01N33/50

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US20190048053A1

公开(公告)日：2019-02-14

申请号：US16074086

申请日：2017-02-03

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Varda ROTTER ,  Moshe OREN ,  Perry TAL ,  Shay EIZENBERGER ,  Avi BEN-SHIMON

IPC: C07K14/47 ,  A61P35/00 ,  C07K7/06 ,  C07K7/08 ,  A61K9/00

Abstract: An isolated peptide is provided. The peptide comprises an amino acid sequence arranged in a space and configuration that allow interaction of the peptide with the DNA Binding Domain (DBD) of p53 through at least one residue of the DBD by which pCAP 250 (SEQ ID NO: 1) binds the DBD, wherein the peptide at least partially reactivates a mutant p53 protein, with the proviso that the peptide is not SEQ ID NO: 59-382.

公开(公告)号：US20190046497A1

公开(公告)日：2019-02-14

申请号：US16077511

申请日：2017-02-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yifat MERBL ,  Ron BENYAIR

IPC: A61K31/35 ,  A61P35/00 ,  A61K31/472 ,  A61K31/365 ,  C12Q1/6883 ,  C12Q1/6886 ,  A61P37/06

Abstract: A method of modulating protein exocytosis is provided. The method comprising contacting a cell with an agent that modulates the ubiquitin pathway in the Golgi, thereby modulating protein secretion.

公开(公告)号：US10204176B2

公开(公告)日：2019-02-12

申请号：US15188104

申请日：2016-06-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Noam Sobel ,  Lavi Secundo ,  Kobi Snitz ,  Kineret Weissler ,  Liron Pinchover ,  Idan Frumin ,  Dana Shoshana Bar Zvi Mildworf ,  Sagit Shushan

IPC: A61B5/00 ,  G06F17/30 ,  G06F19/00 ,  G16H10/20

Abstract: A method of determining olfactory perception signature of a subject is disclosed. The method comprises: providing the subject with a plurality of physical odorant samples for sniffing; for each sniffed odorant sample, presenting to the subject, by a user interface, a set of odorant descriptors and a respective set of rating controls, and receiving ratings entered by the subject using the rating controls. Each rating is indicative of a descriptiveness of a respective odorant descriptor for the odorant sample, thereby obtaining a set of descriptiveness levels for the odorant sample. The method also comprises calculating, by a computer, relations between pairs of sets of descriptiveness levels corresponding to pairs of odorant samples, to provide a vector of relations, wherein the vector represents the olfactory perception signature of the subject.

公开(公告)号：US20190033312A1

公开(公告)日：2019-01-31

申请号：US16082296

申请日：2017-03-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yifat MERBL ,  Hila WOLF-LEVY ,  Yishai LEVIN ,  Bareket DASSA

IPC: G01N33/573

Abstract: A method of isolating barrel-like proteases is disclosed. The method comprising isolating barrel-like proteases from a biological sample containing the barrel-like proteases under conditions that maintain the content of the barrel-like protease-processed peptides in the barrel-like proteases upon isolation. A method of isolating barrel-like protease-processed peptides and a method of identifying barrel-like protease-processed peptides are also disclosed.

公开(公告)号：US20190032027A1

公开(公告)日：2019-01-31

申请号：US16162427

申请日：2018-10-17

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Arren Bar-Even ,  Ron Milo ,  Elad Noor ,  Oren Yishai

IPC: C12N9/02 ,  C12N15/52 ,  C12N13/00 ,  C12N9/06 ,  C12P7/40 ,  C12M1/42 ,  C12N9/00 ,  C12N9/78

CPC classification number: C12N9/0008 ,  C12M35/02 ,  C12N9/0028 ,  C12N9/78 ,  C12N9/93 ,  C12N13/00 ,  C12N15/52 ,  C12P7/40 ,  C12Y102/01002 ,  C12Y105/01005 ,  C12Y105/01015 ,  C12Y305/04009 ,  C12Y603/04003

Abstract: An isolated microorganism that expresses enzymes of the reductive glycine pathway is disclosed. The microorganism is capable of converting formate to pyruvate or glycerate via the formation of glycine and serine. Methods of generating same are further described.

公开(公告)号：US20190023981A1

公开(公告)日：2019-01-24

申请号：US15758344

申请日：2016-09-08

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Milko E. VAN DER BOOM ,  Michal LAHAV ,  Neta ELOOL DOV

IPC: C09K9/02 ,  B05D1/00 ,  B05D7/00 ,  C07F15/02 ,  C09D5/29

Abstract: The invention is directed to methods for making an EC material comprising providing a substrate, applying at least one metal linker to the substrate, applying at least one metal-coordinated organic complex to form a layer, washing the layer, drying the layer, and repeating the applying steps to obtain a multiple layer EC material. The invention is further directed to EC materials made by the methods of this invention.

公开(公告)号：US10159717B2

公开(公告)日：2018-12-25

申请号：US14685628

申请日：2015-04-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Vivian I. Teichberg ,  Angela Ruban

IPC: A61K38/43 ,  A61K38/45 ,  A61K31/194 ,  A61K31/495 ,  A61K38/44 ,  A61K31/19 ,  A61K38/51 ,  A61K38/52 ,  A61K38/53 ,  A61K31/198

Abstract: A method of treating a cancer of the central nervous system in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent which reduces blood glutamate levels and enhances brain to blood glutamate efflux to thereby treat the cancer of the central nervous system in the subject.

公开(公告)号：US10159670B2

公开(公告)日：2018-12-25

申请号：US14612034

申请日：2015-02-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Hornstein ,  Anna Maria Emde

IPC: A61K31/496 ,  A61K31/538 ,  A61K45/06

Abstract: A method of treating a cellular stress-related disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent capable of enhancing processing of a pre-miRNA, thereby treating the cellular stress-related disease in the subject. Methods for treating motor neuron disease (MND) are also provided as well as pharmaceutical compositions.