公开(公告)号：US10971677B2

公开(公告)日：2021-04-06

申请号：US16709965

申请日：2019-12-11

Applicant: Academia Sinica

Inventor： Hsin Lin ,  Shih-Yu Wu ,  Chuang-Han Hsu

IPC: H01L43/04 ,  H01L43/06 ,  H01L27/22

Abstract: An electrically controlled nanomagnet and a spin orbit torque magnetic random access memory (SOT-MRAM) including the same are provided. The electrically controlled nanomagnet includes: a first spin-Hall material layer including a first spin-Hall material; a second spin-Hall material layer including a second spin-Hall material; and a first magnetic layer disposed between the first spin-Hall material layer and the second spin-Hall material layer, wherein the first spin-Hall material and the second spin-Hall material are substantially mirror image to each other.

公开(公告)号：US10967361B2

公开(公告)日：2021-04-06

申请号：US15940122

申请日：2018-03-29

Applicant: ACADEMIA SINICA ,  National Taiwan University

Inventor： Kuei-Hsien Chen ,  Indrajit Shown ,  Wei-Fu Chen ,  Li-Chyong Chen Lin

IPC: B01J27/04 ,  B01J35/00 ,  B01J35/08 ,  B01J35/02 ,  B01J37/10 ,  B01J37/34 ,  B01J19/12 ,  C01B3/04 ,  C01B13/02 ,  C07C45/00 ,  C07C1/02 ,  B01J21/18 ,  C07C29/159 ,  C07C45/45 ,  B01J27/20 ,  B01J23/14 ,  B01J37/03 ,  B01J37/04

Abstract: Disclosed herein are carbon doped tin disulphide (C—SnS2) and other SnS2 composites as visible light photocatalyst for CO2 reduction to solar fuels. The in situ carbon doped SnS2 photocatalyst provide higher efficiency than the undoped pure SnS2. Also disclosed herein are methods for preparing the catalysts.

公开(公告)号：US20210070843A1

公开(公告)日：2021-03-11

申请号：US16757460

申请日：2018-10-19

Applicant: ACADEMIA SINICA

Inventor： An-Suei YANG ,  Ing-Chien CHEN ,  Yi-Kai CHIU ,  Chung-Ming YU ,  Cheng-Chung LEE ,  Chao-Ping TUNG ,  Yueh-Liang TSOU ,  Yi-Jen HUANG ,  Chia-Lung LIN ,  Hong-Sen CHEN ,  Hwei-Jiung WANG

IPC: C07K16/10

Abstract: Disclosed herein are methods for high-throughput screening of a virus-specific neutralizing antibody. According to certain embodiments of the present disclosure, the virus is an influenza virus. Also disclosed herein are the antibodies selected by the high-throughput screening method, and the uses thereof in the prophylaxis and/or treatment of viral infection.

公开(公告)号：US10912777B2

公开(公告)日：2021-02-09

申请号：US16470952

申请日：2017-12-19

Applicant: Academia Sinica

Inventor： Yuh-Shan Jou ,  Roger Shen

IPC: A61K31/519 ,  A61P35/04 ,  A61K31/44

Abstract: A pharmaceutical composition comprising (i) a therapeutically effective amount of an inhibitor of the oncogene SLC29A2; and (ii) a pharmaceutically acceptable carrier, for use in suppressing proliferation, occurrence, and metastasis of cancer cells overexpressing the oncogene SLC29A2 in a cancer patient, and/or prolonging cancer patient survival. The inhibitor of the oncogene SLC29A2 may be at least one selected from the group consisting of dipyridamole, dilazep, draflzine, nitorbenzylthioinosine, and the derivatives thereof. The composition for use may further comprise sorafenib for the same use.

公开(公告)号：US10796788B2

公开(公告)日：2020-10-06

申请号：US16011079

申请日：2018-06-18

Applicant: ACADEMIA SINICA

Inventor： Chi-Kung Ni ,  Shang-Ting Tsai ,  Hsu-Chen Hsu ,  Chia-Yen Liew ,  Shih-Pei Huang

IPC: H01J49/00 ,  G16C20/20 ,  G16C20/90 ,  G01N33/53 ,  G16C20/70 ,  H01J49/26

Abstract: This invention discloses a method for constructing a set of database of one or more saccharides, a logical procedure for automatic determination of sequential mass spectra, and a method, program and system for determination the structures of oligosaccharides and glycoconjugates by the set of database. In one aspect, the sequential mass spectra measured by the method, program or system of the invention maybe instructed according to the logical procedure automatically or manually determined. By comparing the sequential mass spectra to the set of database, the structure of the carbohydrate comprising linkage position, anomeric configuration, composed monosaccharide and branch location of the carbohydrate sample can be identified. In another aspect, the method, program may be used to control one or more mass spectrometer automatically or manually.

公开(公告)号：US20200289454A1

公开(公告)日：2020-09-17

申请号：US16087093

申请日：2017-03-17

Applicant: Ning-Sun Yang ,  ACADEMIA, Sinica

Inventor： Ning-Sun Yang ,  Yueh-Hsiung Kuo ,  Shu-Yi Yin ,  Yung-Hsiang Chen

IPC: A61K31/343 ,  A61K31/337 ,  A61P35/04

Abstract: A method for suppressing tumor metastasis, in which an effective amount of a compound of formula (I) is administered to a subject in need thereof. Also disclosed is a method of treating cancer, in which an effective amount of a chemotherapy agent and an effective amount of a compound of formula (I) is administered to a subject in need thereof. Further disclosed are pharmaceutical compositions for suppressing tumor metastasis and for treating cancer, each of the compositions containing a compound of formula (I).

公开(公告)号：US20200165649A1

公开(公告)日：2020-05-28

申请号：US16591229

申请日：2019-10-02

Applicant: Academia Sinica

Inventor： Chi-Huey WONG ,  Chung-Yi WU ,  Che MA

IPC: C12P19/14 ,  C12N9/24 ,  C07K16/32 ,  C07K16/30 ,  C07K16/28 ,  C07K16/24 ,  C07K16/10 ,  C07K16/00 ,  A61K45/06 ,  A61K39/42 ,  A61K39/395 ,  C07K16/18

Abstract: The present disclosure relates to glycoproteins, particularly monoclonal antibodies, comprising a glycoengineered Fc region, wherein said Fc region comprises an optimized N-glycan having the structure of Sia2(α2-6)Gal2GlcNAc2Man3GlcNAc2. The glycoengineered Fc region binds FcγRIIA or FcγRIIIA with a greater affinity, relative to comparable monoclonal antibodies comprising the wild-type Fc region. The monoclonal antibodies of the invention are particularly useful in preventing, treating, or ameliorating one or more symptoms associated with a disease, disorder, or infection where an enhanced efficacy of effector cell function (e.g., ADCC) mediated by FcγR is desired, e.g., cancer, autoimmune, infectious disease, and in enhancing the therapeutic efficacy of therapeutic antibodies the effect of which is mediated by ADCC.

公开(公告)号：US10604747B2

公开(公告)日：2020-03-31

申请号：US15750753

申请日：2016-08-05

Applicant: Academia Sinica

Inventor： Steve Roffler ,  Huai-Yao Chuang

IPC: C12N9/24 ,  C12Q1/40 ,  A61K38/00

Abstract: An engineered enzyme, comprising an amino acid sequence that is at least 80% identical to the amino acid sequence of a human beta-glucuronidase, wherein the engineered enzyme exhibits a higher level of alpha-iduronidase enzymatic activity as compared to the human beta-glucuronidase.

公开(公告)号：US20200095233A1

公开(公告)日：2020-03-26

申请号：US16081490

申请日：2017-02-28

Applicant: Academia Sinica ,  National Taiwan University

Inventor： Chi-Huey Wong ,  Pan-Chyr Yang ,  Rong-Jie Chein ,  Szu-Hua Pan ,  Ting-Jen R. Cheng

IPC: C07D405/12 ,  C07D413/12 ,  C07D307/92 ,  C07D403/12

Abstract: The present disclosure provides compounds of Formulas (I), (II), and pharmaceutically acceptable salts thereof. The compounds described herein are useful in treating proliferative diseases, for example, cancer (e.g., lung cancer), and infectious diseases (e.g., bacterial infections).

公开(公告)号：US10577621B2

公开(公告)日：2020-03-03

申请号：US16179052

申请日：2018-11-02

Applicant: ACADEMIA SINICA

Inventor： Hsou-Min Li ,  Chiung-Chih Chu

IPC: C12N15/82

Abstract: The present invention provides a recombinant DNA molecule encoding a fusion protein, comprising a first DNA sequence encoding a high-efficiency transit peptide operably linked to a second DNA sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors of translocon at the inner envelope membrane of chloroplasts 40 kD (prTic40), chaperonin 10-2 (prCpn10-2), Fibrillin 1B (prFibrillin), ATP sulfurylase 1 (prAPS1), ATP sulfurylase 3 (prAPS3), 5′-adenylylsulfate reductase 3 (prAPR3), stromal ascorbate peroxidase (prsAPX), prTic40-E2A (a prTic40 variant), prCpn10-1-ΔC7C37S (a chaperonin 10-1 variant), a functional fragment of any of the transit peptides and an equivalent thereof. And the present invention also provides a method of high efficiency delivery of a protein into plastids using the high-efficiency transit peptides.