公开(公告)号：US11819837B2

公开(公告)日：2023-11-21

申请号：US18150909

申请日：2023-01-06

Applicant: UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

Inventor： Walter Baratta ,  Salvatore Baldino ,  Steven Giboulot

IPC: B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

CPC classification number: B01J31/2452 ,  B01J31/182 ,  B01J31/189 ,  B01J31/2433 ,  C07B41/02 ,  C07C29/14 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07F15/0053 ,  B01J2231/641 ,  B01J2531/0244 ,  B01J2531/821 ,  B01J2531/825 ,  C07C2602/10 ,  C07C29/143 ,  C07C33/22 ,  C07C29/14 ,  C07C33/22 ,  C07C29/143 ,  C07C33/24 ,  C07C29/14 ,  C07C33/46 ,  C07C29/14 ,  C07C33/30 ,  C07C29/145 ,  C07C33/22 ,  C07C29/145 ,  C07C35/36 ,  C07C29/145 ,  C07C33/20 ,  C07C41/26 ,  C07C43/23 ,  C07C29/145 ,  C07C33/26 ,  C07C29/145 ,  C07C31/125 ,  C07C201/12 ,  C07C205/19

Abstract: The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US11795138B2

公开(公告)日：2023-10-24

申请号：US17572688

申请日：2022-01-11

Applicant: Fujian Yongjing Technology Co., Ltd

Inventor： Changyue Zhou ,  Hongjun Du ,  Wenting Wu

IPC: C01B21/083 ,  C07C253/30 ,  C07C67/307 ,  C07C201/12 ,  C07C303/22 ,  C07D317/42 ,  C07B39/00 ,  C01C3/00

CPC classification number: C07C253/30 ,  C01B21/0832 ,  C01B21/0835 ,  C01C3/004 ,  C07B39/00 ,  C07C67/307 ,  C07C201/12 ,  C07C303/22 ,  C07D317/42 ,  C07C253/30 ,  C07C255/10 ,  C07C303/22 ,  C07C309/80 ,  C07C67/307 ,  C07C69/63 ,  C07C201/12 ,  C07C205/12 ,  C07C253/30 ,  C07C255/50 ,  C07C17/06 ,  C07C25/13

Abstract: The invention relates to a use of a fluorination gas, and the elemental fluorine (F2) is present in a high concentration, for example, in a concentration of elemental fluorine (F2), especially of equal to much higher than 15 or even 20% by volume, and to a process for the manufacture of a fluorinated compound by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F2) is present in a high concentration. The process of the invention is directed to the manufacture of a fluorinated compound, for the exception of fluorinated benzene, by direct fluorination. Especially the invention is of interest in the preparation of fluorinated organic compounds, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications. The fluorination process of the invention may be performed batch-wise or in a continuous manner.

公开(公告)号：US11691135B2

公开(公告)日：2023-07-04

申请号：US17071713

申请日：2020-10-15

Applicant: King Fahd University of Petroleum & Minerals ,  Saudi Arabian Oil Company

Inventor： Bassam El Ali ,  Waseem Mansour ,  Mohammed Fettouhi

IPC: C07C45/49 ,  C07C201/12 ,  C07D307/58 ,  C07F15/06 ,  B01J31/22 ,  C07C45/50 ,  C07F15/00

CPC classification number: B01J31/2273 ,  C07C45/50 ,  C07C201/12 ,  C07D307/58 ,  C07F15/006 ,  B01J2231/321 ,  C07C2601/14

Abstract: This disclosure relates to N-substituted Pd(II)-N-heterocyclic carbene-pyridine complexes, methods of preparing the complexes, and methods of using the complexes in Sonogashira coupling reactions.

公开(公告)号：US20230145668A1

公开(公告)日：2023-05-11

申请号：US18150909

申请日：2023-01-06

Applicant: UNIVERSITA DEGLI STUDI DI UDINE ,  INNOVATION FACTORY S.R.L.

Inventor： Walter BARATTA ,  Salvatore BALDINO ,  Steven GIBOULOT

IPC: B01J31/24 ,  C07B41/02 ,  C07F15/00 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/18

CPC classification number: B01J31/2452 ,  C07B41/02 ,  C07F15/0053 ,  C07C29/143 ,  C07C29/145 ,  C07C41/26 ,  C07C201/12 ,  C07C29/14 ,  B01J31/182 ,  B01J31/189 ,  B01J31/2433 ,  C07C2602/10 ,  B01J2231/641 ,  B01J2531/0244 ,  B01J2531/821 ,  B01J2531/825

Abstract: The invention relates to monocarbonyl complexes of ruthenium and osmium with bi- and tridentate nitrogen and phosphine ligands. The invention relates to methods for preparing these complexes and the use of these complexes, isolated or prepared in situ, as catalysts for reduction reactions of ketones and aldehydes both via transfer hydrogenation or hydrogenation with hydrogen.

公开(公告)号：US20230100722A1

公开(公告)日：2023-03-30

申请号：US17794003

申请日：2020-12-07

Applicant: University of Cincinnati

Inventor： Joel Andersen

IPC: C07D295/06 ,  C07C201/12 ,  C07C319/14

Abstract: The present invention involves a mechanochemical process in which at least two reactants are mixed without an additional solvent to produce an SNAr reaction product. In one embodiment, the mixing is achieved using a twin-screw extruder. In another embodiment, the mixing is achieved using dry mixing equipment. In one embodiment, the dry mixing equipment is selected from the group consisting of batch Paddle Mills, continuous Paddle Mills, V-Blenders, Twin Cone Blenders and Ribbon Blenders. In another embodiment, the mixing is achieved using a Fluidized Bed reactor.

公开(公告)号：US11542277B2

公开(公告)日：2023-01-03

申请号：US16451509

申请日：2019-06-25

Applicant: Angus Chemical Company

Inventor： Daniel M. Trauth ,  George D. Green ,  Raymond J. Swedo ,  Richard L. James ,  Ian A. Tomlinson

IPC: C07C201/12 ,  C07C201/08 ,  C07C215/28 ,  C07C215/20 ,  C07C215/08 ,  C07C215/42 ,  C07C205/05 ,  C07C205/04 ,  C07C205/16 ,  C07C205/15 ,  C07C205/18 ,  C07C205/02 ,  C07C205/06 ,  A01N43/76 ,  A01N43/90 ,  C07D263/04 ,  C07D263/52 ,  C07D498/04 ,  C07D498/10 ,  C07C239/10 ,  C08G18/32

Abstract: Provided is a process for the formation of nitrated compounds by the nitration of hydrocarbon compounds with dilute nitric acid. Also provided are processes for preparing industrially useful downstream derivatives of the nitrated compounds, as well as novel nitrated compounds and derivatives, and methods of using the derivatives in various applications.

公开(公告)号：US20220363619A1

公开(公告)日：2022-11-17

申请号：US17749293

申请日：2022-05-20

Applicant: NEONC Technologies, Inc.

Inventor： Thomas CHEN ,  Daniel LEVIN ,  Satish PUPPALI

IPC: C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  A61K31/045 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US20220194894A1

公开(公告)日：2022-06-23

申请号：US17429183

申请日：2020-02-10

Applicant: Nogra Pharma Limited

Inventor： Salvatore Demartis ,  Francesca Viti ,  Marie McNulty

IPC: C07C231/02 ,  C07C201/12 ,  C07C205/56 ,  C07C233/54

Abstract: The disclosure provides a process for the preparation of 3-(4′-aminophenyl)-2-methoxypropionic acid, and analogs and intermediates thereof, contemplated to be capable of modulating the activity of receptors, e.g., PPARs receptors.

公开(公告)号：US20220118435A1

公开(公告)日：2022-04-21

申请号：US17071713

申请日：2020-10-15

Applicant: King Fahd University of Petroleum & Minerals ,  Saudi Arabian Oil Company

Inventor： Bassam El Ali ,  Waseem Mansour ,  Mohammed Fettouhi

IPC: B01J31/22 ,  C07F15/00 ,  C07C45/50 ,  C07D307/58 ,  C07C201/12

Abstract: This disclosure relates to N-substituted Pd(II)-N-heterocyclic carbene-pyridine complexes, methods of preparing the complexes, and methods of using the complexes in Sonogashira coupling reactions.

公开(公告)号：US20220024850A1

公开(公告)日：2022-01-27

申请号：US17296544

申请日：2020-09-10

Applicant: ACCELA CHEMBIO CO., LTD. ,  QIDONG ACCELA CHEMBIO CO., LTD.

Inventor： Yang LIU ,  Duoqing XUE ,  Yong WU ,  Lihuang CHEN ,  Lianhua ZHAI

IPC: C07C201/08 ,  C07C201/12

Abstract: The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.