公开(公告)号：USD674291S1

公开(公告)日：2013-01-15

申请号：US29415690

申请日：2012-03-13

Applicant: Daniel Py ,  Julian V. Chan ,  Luz Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Luz Gladys Valencia

公开(公告)号：US08348104B2

公开(公告)日：2013-01-08

申请号：US11900335

申请日：2007-09-10

Applicant: Daniel Py ,  Brian Tulley ,  Jeff Willey ,  Norbert Assion ,  Nathaniel Houle ,  Julian Chan ,  Bing He

Inventor： Daniel Py ,  Brian Tulley ,  Jeff Willey ,  Norbert Assion ,  Nathaniel Houle ,  Julian Chan ,  Bing He

IPC: B65D37/00

CPC classification number: B67D1/10 ,  B05B11/0054 ,  B05B11/303 ,  B05B11/3032 ,  B65D75/5866 ,  B65D75/5883 ,  B65D77/067 ,  B67D1/0082 ,  B67D1/02 ,  B67D2001/0827

Abstract: An apparatus for storing fluid and dispensing multiple portions of the stored fluid has a container defining a variable-volume storage chamber; a dispensing valve including a valve inlet coupled in fluid communication with the variable-volume storage chamber, and an elastic valve member in fluid communication with the valve inlet and defining a normally-closed valve opening; a manually engageable actuator; and a pump including a compressible member defining a compression chamber coupled in fluid communication with the variable-volume storage chamber. Multiple portions of the stored fluid are hermetically sealed in the variable-volume storage chamber. The actuator is manually engageable and movable between (i) a first position wherein the compression chamber defines a first volume, and (ii) a second position wherein the compression chamber defines a second volume less than the first volume. In the second position the fluid in the compression chamber exceeds a valve opening pressure and, in turn, moves the elastic valve member between (i) a normally closed position hermetically sealing the one-way valve and variable-volume storage chamber with respect to ambient atmosphere, and (ii) an open position permitting fluid flow through the valve opening.

Abstract translation: 用于存储流体和分配存储流体的多个部分的装置具有限定可变容积存储室的容器; 分配阀，包括与可变容积存储室流体连通的阀入口和与阀入口流体连通并限定常闭阀开口的弹性阀构件; 可手动接合的致动器; 以及泵，其包括限定与所述可变容积存储室流体连通地联接的压缩室的可压缩构件。 存储流体的多个部分气密地密封在可变容积的储存室中。 致动器可手动地接合并且可在（i）第一位置和第二位置之间移动，其中压缩室限定第一容积，和（ii）第二位置，其中压缩室限定小于第一容积的第二容积。 在第二位置，压缩室中的流体超过阀打开压力，并且使弹性阀构件在（i）气密地将密闭单向阀和可变体积储存室的常闭位置相对于环境 （ii）允许流体流过阀门开口的打开位置。

公开(公告)号：US08318091B2

公开(公告)日：2012-11-27

申请号：US13454910

申请日：2012-04-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B01J19/00 ,  A61L2/04 ,  B65G25/00 ,  B66C17/08 ,  B65B11/52 ,  B65B53/00

CPC classification number: B65B31/024 ,  A61L2/04 ,  A61L2/081 ,  A61L2/087 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/182 ,  B65B5/045 ,  B65B7/02 ,  B65B55/02 ,  B65B55/08 ,  B65B55/16 ,  B65B69/0033 ,  B65B69/0066

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

公开(公告)号：US20120261027A1

公开(公告)日：2012-10-18

申请号：US13450306

申请日：2012-04-18

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: B65B3/003 ,  B65B39/004 ,  B65B39/12

Abstract: A needle has a hollow shaft, a tip formed at one end of the shaft, one or more ports in fluid communication with the interior of the hollow shaft, and a closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s).

Abstract translation: 针具有中空轴，形成在轴的一端的尖端，与中空轴的内部流体连通的一个或多个端口和闭合件。 所述封闭件和/或所述轴可在（i）第一位置和第二位置之间移动，所述第一位置是所述封闭件关闭所述端口，以及（ii）打开所述端口的第二位置。

公开(公告)号：US20120138186A1

公开(公告)日：2012-06-07

申请号：US13352235

申请日：2012-01-17

Applicant: Daniel Py ,  Benoit Adamo ,  John Guthy

Inventor： Daniel Py ,  Benoit Adamo ,  John Guthy

IPC: B65B1/04

CPC classification number: B65B3/006 ,  A61L2/10 ,  A61M5/1782 ,  B29C66/80 ,  B65B3/003 ,  B65B43/00 ,  B65B51/00 ,  Y10T29/49716

Abstract: An assembly includes a support and drive assembly, a first structure and a second structure. The first structure is in operable communication with and supported by the support and drive assembly. The first structure includes at least one filling or needle assembly and is adjustable to receive a plurality of filling or needle assemblies. The second structure is supported by the support and drive assembly. The second structure includes at least one seal assembly and is adjustable to receive a plurality of seal assemblies. A method includes determining a number of containers or vials that are to be filled concurrently and adjusting an assembly to include at least one filling or needle assembly and at least one seal assembly. A number of the filling or needle assemblies and the seal assemblies equals the number of containers or vials.

Abstract translation: 组件包括支撑和驱动组件，第一结构和第二结构。 第一结构与支撑和驱动组件可操作地连通并由其支撑。 第一结构包括至少一个填充物或针头组件，并且可调节以容纳多个填充物或针头组件。 第二个结构由支撑和驱动组件支撑。 第二结构包括至少一个密封组件，并且可调节以接收多个密封组件。 一种方法包括确定要同时填充的多个容器或小瓶，并且调整组件以包括至少一个填充物或针组件和至少一个密封组件。 许多填充物或针组件和密封组件等于容器或小瓶的数量。

公开(公告)号：US08104644B2

公开(公告)日：2012-01-31

申请号：US12901422

申请日：2010-10-08

Applicant: Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

Inventor： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

IPC: B65D37/00

CPC classification number: B67D1/108 ,  B05B11/00444 ,  B65B39/004 ,  B65D51/002 ,  B65D51/1616 ,  B67D1/0004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/0801 ,  B67D1/10 ,  B67D1/1279 ,  B67D3/0067 ,  B67D3/04 ,  B67D2001/0827 ,  F04B53/1037

Abstract: A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

Abstract translation: 提供了一种柔性袋和阀组件，用于无菌存储物质，从其中分配多部分储存物质，并将残留在袋中的物质保持在相对于环境大气密封的无菌状态。 柔性袋和阀组件可接收在相对刚性的壳体内，并且适于与泵协作，用于泵送物质的离散部分并且通过单向阀从其分配物质。 组件包括柔性袋，其中限定有相对于环境大气密封的可变容积存储室，用于将物质的多个部分无菌存储。 组件的单向阀包括限定轴向延伸的阀座的阀体和延伸穿过阀体和/或阀座的至少一个流动孔。

公开(公告)号：US20110297677A1

公开(公告)日：2011-12-08

申请号：US12984482

申请日：2011-01-04

Applicant: Daniel Py ,  Julian V. Chan

Inventor： Daniel Py ,  Julian V. Chan

IPC: B65D47/00 ,  B65B1/04 ,  B65D37/00

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：US07975453B2

公开(公告)日：2011-07-12

申请号：US12768885

申请日：2010-04-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B47/00

CPC classification number: B65B3/003 ,  B65B3/022 ,  B65B31/027

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US07967034B2

公开(公告)日：2011-06-28

申请号：US12401567

申请日：2009-03-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: A61J1/2096 ,  A61J1/1406 ,  A61J1/1468 ,  A61J1/18 ,  A61L2/08 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/542 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08 ,  B29K2023/00

Abstract: A device and method are provided for needle penetrating and filling a chamber with a predetermined substance, and laser resealing a resulting needle hole in the device. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation at a predetermined wavelength and power thereto. The needle penetrable and laser resealable portion defines a predetermined wall thickness in an axial direction thereof, and includes a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and laser resealable portion during penetration by and withdrawal of the needle. The thermoplastic includes a predetermined amount of pigment that allows the thermoplastic to substantially absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness thereof, and hermetically seal a needle aperture formed in the needle penetration region thereof in a predetermined time period.

Abstract translation: 提供了用于针刺穿并用预定物质填充腔室的装置和方法，并且激光将所得到的针孔重新密封在装置中。 装置的针穿透和激光可重新密封部分可用针刺穿以形成穿过其的针孔，以通过针填充腔室，并且可激光重新密封以通过施加预定波长的激光辐射和对其进行动力来气密地密封针孔 。 针穿透和激光可再密封部分在其轴向方向上限定预定的壁厚，并且包括热塑性材料，其基本上防止在针穿透和退出针时从针穿透和激光可再密封部分形成释放到腔室中的颗粒。 热塑性塑料包括预定量的颜料，其允许热塑性塑料基本上吸收预定波长的激光辐射，基本上防止辐射通过其预定壁厚，并将形成在其针穿入区域中的针孔密封在 预定时间段。

公开(公告)号：US07966746B2

公开(公告)日：2011-06-28

申请号：US11789507

申请日：2007-04-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: F26B11/00

CPC classification number: F26B5/06

Abstract: A device and related method are provided for lyophilizing a substance within the device and storing therein the lyophilized substance. The device is penetrable by a needle for filling the device with the substance to be lyophilized, and a resulting needle hole in the device is laser resealable by transmitting thereon laser radiation from a laser source. The device defines a chamber for receiving therein the substance to be lyophilized. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber with the substance to be lyophilized through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation thereto. A filter is connectable in fluid communication between an interior and exterior of the chamber for permitting fluid to flow therethrough in a direction from the interior to the exterior of the chamber, and for substantially preventing contaminants from flowing therethrough in a direction from the exterior to the interior of the chamber.

Abstract translation: 提供了一种装置和相关方法，用于冻结装置内的物质并将其中的冻干物质储存在其中。 该装置可以用针将待冷冻干燥的物质填充到装置上，并且通过从激光源发射激光辐射来激光重新密封该装置中的针孔。 该装置限定用于在其中接收待冻干物质的室。 装置的针穿透和可激光重新密封部分可用针刺穿以形成穿过其中的针孔，以通过针将待冷冻干燥的物质填充到腔室中，并且通过施加激光辐射可激光重新密封以密封针孔 。 过滤器可连接在室的内部和外部之间的流体连通中，以允许流体从腔室的内部到外部的方向流过其中，并且用于基本上防止污染物沿着从外部到外部的方向流过 室内