公开(公告)号：US08573421B2

公开(公告)日：2013-11-05

申请号：US12259290

申请日：2008-10-27

Applicant: Daniel Py ,  Julian Chan ,  Jeffrey Willey

Inventor： Daniel Py ,  Julian Chan ,  Jeffrey Willey

IPC: A61J9/00 ,  A61J9/08

CPC classification number: B65D47/36 ,  A61J1/202 ,  A61J9/00 ,  A61J9/008 ,  A61J11/04 ,  B65B3/04 ,  B65D47/063 ,  B65D47/265 ,  B65D47/32 ,  B65D51/002

Abstract: A container including a body defining an outflow opening and at least one chamber adapted for storing a product, such as a fat containing liquid product, and a container closure including a primary seal for hermetically sealing the product within the chamber during storage. The container closure includes a sealing member forming a substantially fluid-tight seal between the container closure and the body, and a dispensing member in fluid communication with the chamber. The container closure and body move relative to each other between a first position where the primary seal is seated about the outflow port to hermetically seal the product in the chamber during storage, and a second position where the primary seal is displaced from the outflow port to allow product to pass from the chamber through the outflow port and into dispensing member to dispense the product.

Abstract translation: 一种容器，其包括限定流出开口的主体和适于储存产品（例如含脂肪的液体产品）的至少一个室，以及包含用于在储存期间气密地密封室内的产品的主密封件的容器盖。 容器封闭件包括在容器封闭件和主体之间形成基本上流体密封的密封件和与腔室流体连通的分配构件的密封构件。 容器封闭件和主体在第一位置和第二位置之间移动，第一位置和第二位置之间，第一位置处主要密封件围绕流出端口安置，以便在存储期间将产品气密地密封在腔室中;以及第二位置，其中主密封件从流出端口移位到 允许产品从腔室通过流出口并进入分配构件以分配产品。

公开(公告)号：US08448674B2

公开(公告)日：2013-05-28

申请号：US13045655

申请日：2011-03-11

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: B65B3/04 ,  A61L2/08 ,  A61L2/087 ,  A61L2/24 ,  A61L2202/14 ,  B65B3/003 ,  B65B7/16 ,  B65B7/161 ,  B65B55/025 ,  B65B55/08 ,  B65B55/16

Abstract: A sterile filling machine and related method are provided for sterile filling a container with a substance. The container includes a resealable stopper or portion and a chamber for receiving the substance therein. The sealed, empty containers are subjected to radiation capable of penetrating through the resealable portion and chamber for sterilizing the container. The previously sterilized containers are then transported through another sterilizing chamber, such as an e-beam chamber, to sterilize the penetrable surface. A filling member is moved into engagement with the resealable portion to pierce the sterilized penetrable surface of the resealable portion and inject the substance through the filling member and into the chamber of the container. Energy is then transmitted onto the stopper to hermetically re-seal the penetration in the resealable portion.

Abstract translation: 提供了一种无菌灌装机及相关方法，用于无菌填充具有物质的容器。 容器包括可重新密封的塞子或部分和用于在其中接收物质的室。 密封的空容器经受能够穿透可再密封部分和室的辐射以对容器进行灭菌。 先前灭菌的容器然后通过另一个灭菌室，如电子束室输送，以对可穿透表面进行消毒。 填充构件被移动成与可再密封部分接合以刺穿可再密封部分的消毒的可穿透表面，并且将物质通过填充构件注入到容器的室中。 然后将能量传递到塞子上以气密地重新密封可再密封部分中的穿透。

公开(公告)号：US08413854B2

公开(公告)日：2013-04-09

申请号：US13027401

申请日：2011-02-15

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65D88/54

CPC classification number: G01F11/021 ,  B05B11/3001 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3047 ,  B05B11/3074 ,  B65D47/2031 ,  B65D83/00 ,  B65D83/0033 ,  B65D83/0072 ,  G01F11/02

Abstract: A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressure and, in turn, dispensing substance through the one-way valve and out of the dispenser.

Abstract translation: 分配器具有壳体和形成在壳体内的可变容积的储存室，并且在壳体的室和外部之间限定基本上流体密封的密封，用于存储待分配的物质。 活塞安装在壳体内，并且单向阀安装在壳体内并且与可变容积存储室流体连通地联接。 压缩室在活塞和单向阀之间流体连通地联接，并且活塞和阀门中的至少一个在第一位置之间相对于另一个手动地相对地被压下，其中活塞位于至少部分外部 的压缩室，用于允许物质从可变容积的储存室流入压缩室，以及（ii）第二位置，其中活塞至少部分地位于压缩室内，用于将压缩室内的物质加压在压缩室的上方 打开阀门的压力，并通过单向阀分配物质并从分配器中分出物质。

公开(公告)号：USD674291S1

公开(公告)日：2013-01-15

申请号：US29415690

申请日：2012-03-13

Applicant: Daniel Py ,  Julian V. Chan ,  Luz Gladys Valencia

Designer： Daniel Py ,  Julian V. Chan ,  Luz Gladys Valencia

公开(公告)号：US08348104B2

公开(公告)日：2013-01-08

申请号：US11900335

申请日：2007-09-10

Applicant: Daniel Py ,  Brian Tulley ,  Jeff Willey ,  Norbert Assion ,  Nathaniel Houle ,  Julian Chan ,  Bing He

Inventor： Daniel Py ,  Brian Tulley ,  Jeff Willey ,  Norbert Assion ,  Nathaniel Houle ,  Julian Chan ,  Bing He

IPC: B65D37/00

CPC classification number: B67D1/10 ,  B05B11/0054 ,  B05B11/303 ,  B05B11/3032 ,  B65D75/5866 ,  B65D75/5883 ,  B65D77/067 ,  B67D1/0082 ,  B67D1/02 ,  B67D2001/0827

Abstract: An apparatus for storing fluid and dispensing multiple portions of the stored fluid has a container defining a variable-volume storage chamber; a dispensing valve including a valve inlet coupled in fluid communication with the variable-volume storage chamber, and an elastic valve member in fluid communication with the valve inlet and defining a normally-closed valve opening; a manually engageable actuator; and a pump including a compressible member defining a compression chamber coupled in fluid communication with the variable-volume storage chamber. Multiple portions of the stored fluid are hermetically sealed in the variable-volume storage chamber. The actuator is manually engageable and movable between (i) a first position wherein the compression chamber defines a first volume, and (ii) a second position wherein the compression chamber defines a second volume less than the first volume. In the second position the fluid in the compression chamber exceeds a valve opening pressure and, in turn, moves the elastic valve member between (i) a normally closed position hermetically sealing the one-way valve and variable-volume storage chamber with respect to ambient atmosphere, and (ii) an open position permitting fluid flow through the valve opening.

Abstract translation: 用于存储流体和分配存储流体的多个部分的装置具有限定可变容积存储室的容器; 分配阀，包括与可变容积存储室流体连通的阀入口和与阀入口流体连通并限定常闭阀开口的弹性阀构件; 可手动接合的致动器; 以及泵，其包括限定与所述可变容积存储室流体连通地联接的压缩室的可压缩构件。 存储流体的多个部分气密地密封在可变容积的储存室中。 致动器可手动地接合并且可在（i）第一位置和第二位置之间移动，其中压缩室限定第一容积，和（ii）第二位置，其中压缩室限定小于第一容积的第二容积。 在第二位置，压缩室中的流体超过阀打开压力，并且使弹性阀构件在（i）气密地将密闭单向阀和可变体积储存室的常闭位置相对于环境 （ii）允许流体流过阀门开口的打开位置。

公开(公告)号：US08318091B2

公开(公告)日：2012-11-27

申请号：US13454910

申请日：2012-04-24

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B01J19/00 ,  A61L2/04 ,  B65G25/00 ,  B66C17/08 ,  B65B11/52 ,  B65B53/00

CPC classification number: B65B31/024 ,  A61L2/04 ,  A61L2/081 ,  A61L2/087 ,  A61L2/26 ,  A61L2202/122 ,  A61L2202/182 ,  B65B5/045 ,  B65B7/02 ,  B65B55/02 ,  B65B55/08 ,  B65B55/16 ,  B65B69/0033 ,  B65B69/0066

Abstract: A sterile enclosure contains a transfer module defining a window. A port covers the window to maintain the inside of the enclosure as a sealed and sterile environment. A sliding, heated cutting element mounted on the port serves to sterilize and sever a portion of a sterile transfer bag assembly attached to the port. Preferably, the excised portion of the sterile transfer bag assembly is affixed to the port when the port opens. The sliding cutting element remains extended and heated to prevent contamination when the port is open. Further, a heating element is mounted about the window in order to sterilize around the opening when the port is open.

公开(公告)号：US20120261027A1

公开(公告)日：2012-10-18

申请号：US13450306

申请日：2012-04-18

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/04

CPC classification number: B65B3/003 ,  B65B39/004 ,  B65B39/12

Abstract: A needle has a hollow shaft, a tip formed at one end of the shaft, one or more ports in fluid communication with the interior of the hollow shaft, and a closure. The closure and/or the shaft is movable between (i) a first position wherein the closure closes the port(s), and (ii) a second position opening the port(s).

Abstract translation: 针具有中空轴，形成在轴的一端的尖端，与中空轴的内部流体连通的一个或多个端口和闭合件。 所述封闭件和/或所述轴可在（i）第一位置和第二位置之间移动，所述第一位置是所述封闭件关闭所述端口，以及（ii）打开所述端口的第二位置。

公开(公告)号：US20110297677A1

公开(公告)日：2011-12-08

申请号：US12984482

申请日：2011-01-04

Applicant: Daniel Py ,  Julian V. Chan

Inventor： Daniel Py ,  Julian V. Chan

IPC: B65D47/00 ,  B65B1/04 ,  B65D37/00

CPC classification number: B65D83/62 ,  A61J1/00 ,  A61J1/1443 ,  B65B3/30 ,  B65B31/044 ,  B65D83/425

Abstract: A dispenser for holding multiple doses of fluids or other substances, and for dispensing the substances, has a vial, a flexible bladder received within the vial, and a variable volume storage chamber formed between the bladder and vial. A filling valve is coupled in fluid communication with the storage chamber and defines (1) a normally closed, fluid-tight position hermetically sealing the storage chamber from the ambient atmosphere, and (2) an open position allowing the passage of fluid through the valve both to evacuate the storage chamber and to introduce fluid through the valve to fill the storage chamber. A pump is coupled in fluid communication with the storage chamber for pumping fluids out of the storage chamber. A dispensing valve is coupled in fluid communication with the pump and defines (1) a normally closed, fluid-tight position preventing the passage of fluid out of the dispenser, and (2) an open position for dispensing pumped fluid therethrough. The sealed, empty dispenser is sterilized, such as by applying gamma radiation thereto. Then, the sterilized, sealed, empty dispenser is filled with fluid by engaging the filling valve with an evacuating/dispensing member to evacuate the storage chamber, and by introducing fluid from the filling member through the open filling valve and into the storage chamber. The filling member is withdrawn from the valve, and a spring moves the valve to a closed position to hermetically seal the fluid within the dispenser.

Abstract translation: 用于保持多个剂量的流体或其它物质并用于分配物质的分配器具有小瓶，容纳在小瓶内的柔性囊，以及形成在膀胱和小瓶之间的可变体积存储室。 填充阀与储存室流体连通地联接并且限定（1）将储存室与环境大气密封的常闭密封的流体密封位置，和（2）允许流体通过阀门的打开位置 两者都抽真空储存室并引入流体通过阀门填充储存室。 泵与储存室流体连通地联接，用于将流体泵出储存室。 分配阀与泵流体连通地联接并限定（1）常闭的，流体密封的位置，防止流体从分配器通过，以及（2）用于分配泵送的流体通过的打开位置。 密封的空分配器被灭菌，例如通过对其施加γ射线。 然后，通过使填充阀与排气/分配构件接合以消除储存室，并且通过将来自填充构件的流体通过打开的填充阀引入并进入储存室，灭菌的密封的空分配器充满流体。 填充构件从阀中取出，并且弹簧将阀移动到关闭位置以将分配器内的流体气密地密封。

公开(公告)号：US07975453B2

公开(公告)日：2011-07-12

申请号：US12768885

申请日：2010-04-28

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B47/00

CPC classification number: B65B3/003 ,  B65B3/022 ,  B65B31/027

Abstract: A stopper and container body are molded in the same molding machine. An assembly device, such as a pick and place robot, transfers the stopper from one mold cavity into the opening in the container body located within another mold cavity, or vice versa, to assemble the stopper and container body. Then, the assembled container body and stopper are removed from the molding machine and transported to a needle filling and laser resealing station for filling and laser resealing. A laminar flow source directs a substantially laminar flow of air or sterile gas over the mold surfaces, stoppers and container bodies, and assembly device, to prevent contamination during assembly.

Abstract translation: 塞子和容器主体在相同的成型机中成型。 诸如拾放机器人的组装装置将止动器从一个模腔转移到位于另一个模腔内的容器主体中的开口中，反之亦然，以组装止动器和容器主体。 然后，将组装的容器主体和止动件从成型机中取出并输送到针填充和激光重新密封站，用于填充和激光重新密封。 层流源将空气或无菌气体的基本层流引导到模具表面，塞子和容器主体以及组装装置上，以防止组装过程中的污染。

公开(公告)号：US07967034B2

公开(公告)日：2011-06-28

申请号：US12401567

申请日：2009-03-10

Applicant: Daniel Py

Inventor： Daniel Py

IPC: B65B1/20

CPC classification number: A61J1/2096 ,  A61J1/1406 ,  A61J1/1468 ,  A61J1/18 ,  A61L2/08 ,  B29C65/16 ,  B29C65/1616 ,  B29C65/1619 ,  B29C65/1654 ,  B29C65/1677 ,  B29C65/18 ,  B29C66/001 ,  B29C66/1222 ,  B29C66/1224 ,  B29C66/12461 ,  B29C66/1312 ,  B29C66/342 ,  B29C66/534 ,  B29C66/5344 ,  B29C66/542 ,  B29C66/612 ,  B29C66/71 ,  B29C66/73755 ,  B29C66/7392 ,  B29C66/73921 ,  B29C66/7394 ,  B29C66/8322 ,  B29C67/004 ,  B29L2031/7158 ,  B29L2031/753 ,  B65B3/003 ,  B65B7/161 ,  B65D51/002 ,  B29C65/00 ,  B29K2025/08 ,  B29K2023/00

Abstract: A device and method are provided for needle penetrating and filling a chamber with a predetermined substance, and laser resealing a resulting needle hole in the device. A needle penetrable and laser resealable portion of the device is pierceable with a needle to form a needle aperture therethrough to fill the chamber through the needle, and is laser resealable to hermetically seal the needle aperture by applying laser radiation at a predetermined wavelength and power thereto. The needle penetrable and laser resealable portion defines a predetermined wall thickness in an axial direction thereof, and includes a thermoplastic that substantially prevents the formation of particles released into the chamber from the needle penetrable and laser resealable portion during penetration by and withdrawal of the needle. The thermoplastic includes a predetermined amount of pigment that allows the thermoplastic to substantially absorb laser radiation at the predetermined wavelength, substantially prevent the passage of radiation through the predetermined wall thickness thereof, and hermetically seal a needle aperture formed in the needle penetration region thereof in a predetermined time period.

Abstract translation: 提供了用于针刺穿并用预定物质填充腔室的装置和方法，并且激光将所得到的针孔重新密封在装置中。 装置的针穿透和激光可重新密封部分可用针刺穿以形成穿过其的针孔，以通过针填充腔室，并且可激光重新密封以通过施加预定波长的激光辐射和对其进行动力来气密地密封针孔 。 针穿透和激光可再密封部分在其轴向方向上限定预定的壁厚，并且包括热塑性材料，其基本上防止在针穿透和退出针时从针穿透和激光可再密封部分形成释放到腔室中的颗粒。 热塑性塑料包括预定量的颜料，其允许热塑性塑料基本上吸收预定波长的激光辐射，基本上防止辐射通过其预定壁厚，并将形成在其针穿入区域中的针孔密封在 预定时间段。