公开(公告)号：US11185851B2

公开(公告)日：2021-11-30

申请号：US16074473

申请日：2017-02-16

Applicant: TAKASAGO INTERNATIONAL CORPORATION

Inventor： Yoshimasa Matsushima ,  Takashi Ohshima

IPC: B01J31/16 ,  C07J9/00 ,  C07D473/16 ,  C07C68/06 ,  C07C69/96 ,  C07C43/23 ,  C07C69/145 ,  C07C31/125 ,  C07C33/32 ,  C07C201/12 ,  B01J31/06 ,  C07C33/02 ,  C07C205/43 ,  C07C213/06 ,  C07C219/14 ,  C07C67/03 ,  C07C39/20 ,  C07C69/24 ,  C07C33/22 ,  C07C69/78 ,  C07F7/18 ,  C07D317/38 ,  C07C69/14 ,  C07C37/055 ,  C07C41/16 ,  C07C69/157 ,  B01J37/04 ,  C07C29/128 ,  C07C67/02 ,  C07C67/08 ,  C07D317/36 ,  C07B61/00

Abstract: A macromolecules containing a metal and a use thereof as a catalyst are disclosed. The macromolecules containing a metal may be obtained by causing a ligand to react with a zinc compound or a cobalt compound. The ligand has an imidazole group that is bonded to a macromolecule via a linker. The metal-containing macromolecules are highly active as a catalyst, stable, and easy to recover and reuse.

公开(公告)号：US11136286B2

公开(公告)日：2021-10-05

申请号：US16868657

申请日：2020-05-07

Applicant: WINGO TECHNOLOGY CO., LTD.

Inventor： Toshiyuki Goshima ,  Win Maw Soe

IPC: C08G73/10 ,  C07C229/60 ,  C07C201/12 ,  C07C227/04 ,  C08G69/26 ,  C08G73/16

Abstract: [Problems to be solved] The present invention provides a novel diamine compound which allows for the synthesis of a polyimide compound having a high solubility in an organic solvent and a high melt moldability.
[Solution] The diamine compound according to the present invention is characterized by being represented by the following general formula (1): (wherein R1 to R8 are each independently selected from the group consisting of a hydrogen atom, a fluorine atom, a substituted or unsubstituted alkyl group, and a substituted or unsubstituted aromatic group; and at least one of R1 to R8 is a substituted or unsubstituted aromatic group).

公开(公告)号：US20210114994A1

公开(公告)日：2021-04-22

申请号：US17113540

申请日：2020-12-07

Applicant: MannKind Corporation

Inventor： Kelly Sullivan Kraft ,  John J. Freeman ,  Paul Serwinski ,  Vincent Pavia ,  Otto Phanstiel ,  Navneet Kaur

IPC: C07D241/08 ,  C07C201/12 ,  C07C67/39 ,  C07C67/30

Abstract: Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphophoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.

公开(公告)号：US20210087131A1

公开(公告)日：2021-03-25

申请号：US15733763

申请日：2019-04-17

Applicant: The Scripps Research Institute

Inventor： Jin-quan Yu ,  Peng-Xiang Shen

IPC: C07C51/353 ,  C07C67/343 ,  C07C201/12 ,  C07C253/30 ,  C07F9/40 ,  C07D307/54 ,  C07D333/24 ,  C07D209/49 ,  C07D209/48 ,  B01J31/22 ,  B01J27/232

Abstract: The invention includes procedures for stereoselective β-acylation of carboxylic acids having a β-carbon atom. For example, stereoselective acylation procedures include the following reactions: (I)

公开(公告)号：US20210053911A1

公开(公告)日：2021-02-25

申请号：US16907188

申请日：2020-06-20

Applicant: Fujian Yongjing Technology Co., Ltd

Inventor： Changyue Zhou ,  Hongjun DU ,  Wenting WU

IPC: C07C253/30 ,  C07C303/22 ,  C07D317/42 ,  C01B21/083 ,  C07C67/307 ,  C07C201/12

Abstract: The invention relates to a use of a fluorination gas, and the elemental fluorine (F2) is present in a high concentration, for example, in a concentration of elemental fluorine (F2), especially of equal to much higher than 15 or even 20% by volume, and to a process for the manufacture of a fluorinated compound by direct fluorination employing a fluorination gas, wherein the elemental fluorine (F2) is present in a high concentration. The process of the invention is directed to the manufacture of a fluorinated compound, for the exception of fluorinated benzene, by direct fluorination. Especially the invention is of interest in the preparation of fluorinated organic compounds, final products and as well intermediates, for usage in agro-, pharma-, electronics-, catalyst, solvent and other functional chemical applications. The fluorination process of the invention may be performed batch-wise or in a continuous manner.

公开(公告)号：US10457618B2

公开(公告)日：2019-10-29

申请号：US15220135

申请日：2016-07-26

Applicant: NEONC Technologies, Inc.

Inventor： Thomas Chen ,  Daniel Levin ,  Satish Puppali

IPC: C07C29/92 ,  A61K31/045 ,  C07C67/14 ,  C07C201/12 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

Abstract: The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US10399917B2

公开(公告)日：2019-09-03

申请号：US15763846

申请日：2016-10-06

Applicant: Technion Research & Development Foundation Limited

Inventor： Mark Gandelman ,  Gennady Nisnevich ,  Kseniya Kulbitski ,  Alexander Artaryan

IPC: C07C17/363 ,  C07C19/075 ,  C07C23/10 ,  C07C25/02 ,  C07C67/32 ,  C07C41/22 ,  C07C201/12 ,  C07B39/00 ,  C07C45/67 ,  C07D205/04 ,  C07C253/30 ,  C07D209/48 ,  C07D211/38 ,  C07J9/00 ,  C07C255/65 ,  C07C409/34

Abstract: The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

公开(公告)号：US20190256459A1

公开(公告)日：2019-08-22

申请号：US16302103

申请日：2017-05-01

Applicant: Biophore India Pharmaceuticals PVT. Ltd.

Inventor： Manik Reddy PULLAGURLA ,  Mecheril Valsan NANDA KUMAR ,  Bhaskar Reddy PITTA ,  Jagadeesh Babu RANGISETTY

IPC: C07C303/38 ,  C07C303/40 ,  C07C303/44 ,  C07C201/12 ,  C07C209/32

Abstract: The present invention provides a novel and commercially viable process with high yield for the preparation of (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as Belinostat (I). The invention also provides process for purification and novel crystalline form of Belinostat in substantially pure form.

公开(公告)号：US10377723B2

公开(公告)日：2019-08-13

申请号：US16265386

申请日：2019-02-01

Applicant: KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

Inventor： Bassam El Ali ,  Rami Khalid Suleiman ,  Mansur Bala Ibrahim

IPC: B01J31/18 ,  C07D263/14 ,  C07F15/00 ,  C07C1/32 ,  C07C2/86 ,  C07C45/68 ,  C07C201/12 ,  C07D317/50 ,  C07D263/12 ,  C07C41/30 ,  C07C209/68 ,  C07C253/30 ,  C07C17/269 ,  C07C41/32

Abstract: A solid-supported catalyst ligand which chelates palladium (II) species to form a complex that functions as a heterogeneous catalyst that is stable and can be recycled without significantly losing any catalytic activity in a variety of chemical transformations, a method for producing the solid-supported catalyst ligand and a method for catalyzing a palladium cross-coupling reaction, such as the Suzuki-Miyaura, Mizoroki-Heck, and Sonagashira reactions.

公开(公告)号：US10358412B2

公开(公告)日：2019-07-23

申请号：US15239523

申请日：2016-08-17

Applicant: SAMHWA PAINTS INDUSTRIES CO., LTD.

Inventor： Da Eun Kwon ,  Myeng Chan Hong ,  Chong Yun Kwag

IPC: C07C253/30 ,  C07C29/14 ,  C07C41/26 ,  C07C201/12 ,  C07C29/64

Abstract: A method of preparing a difluorinated alcohol compound is provided. The difluorinated alcohol compound can be easily synthesized when an aldehyde and N-fluorobenzenesulfonimide are reacted in the presence of L-proline, and thus the method has advantage in that preparation processes are simple and reagents are economical and safe, compared to the related-art methods. Therefore, the preparation method can be effectively applied to prepare a difluorinated alcohol used in various applications for raw materials such as functional medicines, agricultural chemicals, polymerizable compounds, etc.